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不同复热方式对预制品莲藕肉圆品质的影响

食品安全导刊 2024年第16期 159-162页

作者：余雪松曹仲文扬州大学食品科学与工程学院江苏扬州225127 扬州大学中餐非遗技艺传承文化和旅游部重点实验室江苏扬州225127 江苏省淮扬菜产业化工程中心江苏扬州225127

目的:研究不同复热方式(强制对流湿热蒸汽与热辐射耦合解冻-复热、强制沸水热对流传递耦合解冻-复热、微波加热耦合解冻-复热)对冷冻莲藕肉圆品质的影响。方法:对比莲藕肉圆pH值、感官、质构、色度及硫代巴比妥酸值等指标的变化。结果:... 详细信息

目的:研究不同复热方式(强制对流湿热蒸汽与热辐射耦合解冻-复热、强制沸水热对流传递耦合解冻-复热、微波加热耦合解冻-复热)对冷冻莲藕肉圆品质的影响。方法:对比莲藕肉圆pH值、感官、质构、色度及硫代巴比妥酸值等指标的变化。结果:微波加热后的莲藕肉圆水分损失最为严重;微波加热、湿热蒸汽加热可增强莲藕肉圆的硬度和弹性,但会降低其咀嚼性;湿热蒸汽加热方式感官评分最高。结论:湿热蒸汽加热方式是最佳的复热方式,既能有效控制水分损失,减缓脂肪氧化和非酶褐变反应,还能保持食品质感和提升感官体验。

关键词：复热方式莲藕肉圆品质

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自拟清肺方对妊娠咳嗽患者临床症状的改善效果

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首都食品与医药 2024年第11期31卷 155-157页

作者：于雪松王慧颖天津市和平区妇产科医院天津300041 济南市第一人民医院山东济南250011

目的探讨自拟清肺方对妊娠咳嗽患者临床症状的改善效果。方法采用随机对照试验方法,将2022年4月-2023年5月在天津市和平区妇产科医院就诊的82例妊娠咳嗽患者随机分为对照组和观察组,每组41人。对照组予以常规西药治疗,观察组在西药治疗... 详细信息

目的探讨自拟清肺方对妊娠咳嗽患者临床症状的改善效果。方法采用随机对照试验方法,将2022年4月-2023年5月在天津市和平区妇产科医院就诊的82例妊娠咳嗽患者随机分为对照组和观察组,每组41人。对照组予以常规西药治疗,观察组在西药治疗基础上应用自拟清肺方治疗。观察比较两组中医症状积分变化、临床症状改善总有效率、不良反应情况等指标。结果观察组治疗后的中医症状积分明显低于对照组(P<0.05);观察组患者临床症状改善总有效率为92.68%,明显高于对照组的73.17%(P<0.05);观察组的不良反应发生率较对照组明显降低(P<0.05)。结论自拟清肺方治疗妊娠咳嗽患者可有效提高治疗效果,改善中医症状积分,并有效缓解咳嗽等临床症状,且安全性良好。

关键词：妊娠咳嗽自拟清肺方临床症状呼吸系统不良反应

Na^(+),K^(+)//CO_(3)^(2-),SO_(4)^(2-)-H_(2)O四元水盐体系相平衡综合实验设计

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实验室研究与探索 2024年第5期43卷 192-195,229页

作者：杨小俊于雪松龚美玲王雪茹闫志国武汉工程大学化工与制药学院磷资源开发利用教育部工程研究中心武汉430205

针对相平衡理论知识抽象难懂,相律、相图等内容难教难学的问题,设计了四元水盐体系相平衡综合实验。采用等温溶解平衡法研究了353~373 K下交互四元体系Na^(+),K^(+)//CO_(3)^(2-),SO_(4)^(2-)-H_(2)O的固液相平衡,并绘制出等温干基相图... 详细信息

针对相平衡理论知识抽象难懂,相律、相图等内容难教难学的问题,设计了四元水盐体系相平衡综合实验。采用等温溶解平衡法研究了353~373 K下交互四元体系Na^(+),K^(+)//CO_(3)^(2-),SO_(4)^(2-)-H_(2)O的固液相平衡,并绘制出等温干基相图和对应水图,确定硫酸钠相区随着温度的增加而上移。依据相图指导碱灰溶解-蒸发结晶工艺设计,解决了高CO_(3)^(2-)浓度下结晶参数的优化问题,实现Na2SO4在高温下溶解,随后降温结晶析出的循环回收过程。该实验将相平衡数据的测量、相图的绘制、相图的分析融合一体,有利于增强学生用相平衡基本理论解决工程问题的能力,实现对理论知识的融会贯通,激发其科研兴趣和探索精神。

关键词：综合实验相平衡水盐体系结晶

Mulberry leaf flavonoids protect against glucotoxicity-induced INS-1 cell apoptosis

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Journal of Traditional Chinese Medicine 2019年第2期39卷 153-159页

作者： Wang Ying Li Ming yu xuesong He Sheng Wu Xinrong Wang Yan School of Chemistry Engineering Guangdong Pharmaceutical University School of Biosciences and Biopharmaceutics Guangdong Pharmaceutical University Department of Pharmacy General Hospital of Guangzhou Military Command of People's Liberation Army School of Traditional Chinese Medicine Guangdong Pharmaceutical University

OBJECTIVE:To investigate the effect of mulberry leaf flavonoids (MLF) on apoptosis of pancreatic cells induced by high ***:Long exposure to high glucose induces apoptosis of pancreaticβcells, which can lead to diabetes. In this study, we used the rat insulinoma cell line, INS-1. High glucose (33.3 mM) was used to establish a glucotoxicity model. The MTT assay was used to evaluate the MLF effect on cell ***-1 cells were treated with various concentra-tions of MLF (125, 250 and 500 mg/L) for 24 h, and then stimulated with 5.5 or 33.3 mM glucose for 48 ***, the cell supernatants were collected for enzyme-linked immunosorbent assay to determine the level of superoxide dismutase (SOD), catalase(CAT), glutathione peroxidase (GSH-Px), malondialdehyde (MDA), monocyte chemoattractant protein1 (MCP-1), tumor necrosis factor a (TNF-α) and interleukin 6 (IL-6). Western blotting was used to determine the expression of Bcl-2, Bax, caspase-3 and Caspase-9. Cell apoptosis was measured by Annexin V-FITC/propidium iodide double staining and flow ***:MLF (125-500 mg/L) improved cell viability. Furthermore, MLF (250 and 500 mg/L) inhibited apoptosis induced by high glucose. The anti-apoptosis effect of MLF was associated with increased SOD, CAT and GSH-Px expression, as well as reduced MDA levels in high-glucose-treated INS-1cells. Moreover, MLF upregulated Bcl-2 expression,downregulated Bax expression, and reduced the expression of caspase-3 and Caspase-9. Finally, MLF decreased the secretion of inflammatory cytokines and insulin in high-glucose-induced INS-1 ***:MLF is a potential therapeutic agent for preventing diabetes and related disorders.

关键词： Morus Plant leaves In suli no ma Flavon oids Toxicity Apoptosis

Identification and expression of amphioxus AmphiSmad1/5/8 and AmphiSmad4

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Science China(Life Sciences) 2011年第3期54卷 220-226页

作者： yu xuesong LI JianWei LIU Hui LI XiaoDan CHEN ShangWu ZHANG HongWei XU AnLong State Key Laboratory of Biocontrol Open Laboratory for Marine Functional Genomics of State High- Tech Development Program Guangdong Key Laboratory of Pharmaceutical Functional Genes College of Life Sciences Sun Yat-Sen University Guangzhou 510275 China Institute of Developmental Biology College of Life Sciences Shandong University Jinan 250100 China

Smad family proteins are identified as intracellular signal mediators of the TGF-β *** this study,we identified two novel members of the Smad family,termed as AmphiSmad1/5/8 and AmphiSmad4,from Chinese *** AmphiSmad1/5/8 and AmphiSmad4 showed a typical domain structure of Smad proteins consisting of conserved MH1 and MH2 *** analysis placed AmphiSmad1/5/8 in the Smad1,5 and 8 subgroup of the R-Smad subfamily,and AmphiSmad4 in the Co-Smad *** spatial and temporal gene expression patterns of AmphiSmad1/5/8 and AmphiSmad4 showed that they may be involved in the embryonic development of notochord,myotome and alimentary canal,and may help to establish the specification of dorsal-ventral axis of ***,AmphiSmad1/5/8 and AmphiSmad4 showed extensive distribution in all adult tissues examined,suggesting that these two genes may play important roles in the morphogenesis of a variety of tissues especially notochord and gonad.

关键词： amphioxus Smad AmphiSmad1/5/8 AmphiSmad4 expression patterns organogenesis dorsal-ventral patterning

Role of liquid–liquid phase separation in cancer:Mechanisms and therapeutic implications

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Cancer Innovation 2024年第5期3卷 37-49页

作者： xuesong Li Zhuo yu School of Clinical Medicine Tsinghua UniversityBeijingChina Department of Medical Oncology Beijing Tsinghua Changgung HospitalBeijingChina

Liquid–liquid phase separation(LLPS)has emerged as a pivotal biological phenomenon involved in various cellular processes,including the formation of membrane‐less organelles and the regulation of biomolecular condensates through precise spatiotemporal coordination of signaling pathways in *** of LLPSs results in aberrant biomolecular condensates,which are widely implicated in tumorigenesis and cancer ***,we comprehensively summarize the multifaceted roles of LLPS in tumor biology from the perspective of cancer hallmarks,including genomic stability,metabolic reprogramming progression,ferroptosis,and metastasis,to unveil the intricate mechanisms by which LLPS occurs in *** discuss current discoveries related to therapeutic involvement and potential clinical applications of LLPS in cancer treatment,highlighting the potential of targeting LLPS‐driven processes as novel therapeutic ***,we discuss the challenges associated with new approaches for cancer treatment based on *** in‐depth discussion of the impact of LLPS on fundamental aspects of tumor biology provides new insights into overcoming cancer.

关键词： cancer liquid-liquid phase separation mechanism

Comprehensive treatment of von Hippel-Lindau disease:A case report

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Cancer Innovation 2024年第2期3卷 63-67页

作者： xuesong Li Zheng Mo Zhuo yu School of Clinical Medicine Tsinghua UniversityBeijingChina Department of Oncology Beijing Tsinghua Changgung HospitalBeijingChina

von Hippel-Lindau(VHL)disease is a rare autosomal dominant multiorgan disease characterized by several benign and malignant tumors rich in vascular,as well as cysts in other organs.A great clinical treatment strategy is significantly warranted for good prognosis of patients with VHL ***,we reported a case of a 45-year-old woman diagnosed with VHL disease with spinal hemangioblastoma(HB)and clear cell renal cell carcinoma(ccRCC).Four years after the resection of the right kidney,a recurrent RCC in the right kidney and a malignant lesion in the left kidney were *** patient was started on sorafenib(800 mg,daily)and tislelizumab(200 mg per 3 weeks).After 6 months of treatment,the size of renal cell carcinoma was dramatically reduced and renal function *** importantly,she achieved partial response during the whole ***,intramedullary masses resection was done and the HB in T4-5 thoracic spinal was *** symptoms such as numbness and pain were remarkably ***,tislelizumab-induced elevation in liver transaminase levels and hypothyroidism were revered by hepatoprotector and levothyroxine,*** short,comprehensive treatment strategies may benefit patients with VHL disease,especially with HB and ccRCC.

关键词： sorafenib surgery tislelizumab treatment von Hippel-Lindau disease

Studying the variable energy band structure for energy storage materials in charge/discharge process

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Chinese Chemical Letters 2024年第2期35卷 584-589页

作者： Xuancheng Chen yu Huan Ningqiang Sun yuanhui Su xuesong Shen Guoqing Li Jiaqi Zhang Tao Wei University of Jinan Ji'nan 250022China Weichai Power Co. Ltd.Weifang 261061China

So far,a clear understanding about the relationship of variable energy band structure with the corresponding charge-discharge process of energy storage materials is still ***,using optical spectroscopy(red-green-blue(RGB)value,reflectivity,transmittance,UV-vis,XPS,UPS)to studyα-Co(OH)_(2) electrode working in KOH electrolyte as the research object,we provide direct experimental evidence that:(1)The intercalation of OH-ions will reduce the valence/conduction band(VB and CB)and band gap energy(Eg)values;(2)The deintercalation of OH-ions corresponds with the reversion of VB,CB and E_(g) to the initial values;(3)The color of Co(OH)_(2) electrode also exhibit regular variations in RGB value during the charge-discharge process.

关键词： Variable energy band structure Energy storage materials Charge-discharge process Optical spectroscopy Supercapacitors

Minimizing interfacial energy losses in inverted perovskite solar cells by a dipolar stereochemical 2D perovskite interface

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Journal of Energy Chemistry 2024年第3期90卷 496-503,I0011页

作者： Junjie Qian Jingjing He Qihang Zhang Chenyue Zhu Shilin Chen Zhanpeng Wei xuesong Leng Ziren Zhou Benben Shen yu Peng Qiang Niu Shuang Yang yu Hou Key Laboratory for Ultrafine Materials of Ministry of Education Shanghai Engineering Research Center of Hierarchical NanomaterialsSchool of Materials Science and EngineeringEast China University of Science and TechnologyShanghai 200237China National Enterprise Technology Center Inner Mongolia Erdos Electric Power and Metallurgy Group Company LimitedOrdos 016064Inner MongoliaChina

Inverted perovskite solar cells(PSCs) have attracted broad research and industrial interest owing to their suppressed hysteresis,cost-effectiveness,and ***,the issue of non-radiative recombination losses at the n-type interface between the perovskite and fullerene has impeded further improvement of photovoltaic ***,we modify the n-type interface of FAPbI_(3) perovskite films by constructing a stereochemical two-dimensional(2D) perovskite interlayer,in which the organic cations comprise both pyridine and ammonium *** pyridine N donor can create stable bonding with the surface-uncoordinated Pb on the perovskite,thereby passivating the shallow-level defects and enhancing the air stability of the ***,the pyridine N donor also offers a positive polar interface to decrease the surface work function of the perovskite film,enabling n-type ***,we employ a p-i-n photovoltaic(PV) device with the positive dipole interlayer at perovskite/fullerene contact and achieve remarkable photoelectric conversion efficiency(PCE) of 22.0%.

关键词： Perovskite solar cells Dipole interlayer Stereochemistry Non-radiative recombination