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Semisynthesis of homogeneous spike RBD glycoforms from SARS-CoV-2 for profiling the correlations between glycan composition and function

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National Science Review 2024年第2期11卷 145-154页

作者： Farong Ye Cheng Li Feng-Liang Liu Xinliang Liu Peng Xu Rong-Hua Luo Wenping Song Yong-tang Zheng Tianlei Ying Biao yu Ping Wang Center for Chemical Glycobiology Frontiers Science Center for Transformative Molecules Zhangjiang Institute for Advanced Study School of Chemistry and Chemical Engineering Shanghai Jiao Tong University MOE/NHC/CAMS Key Laboratory of Medical Molecular Virology Shanghai Frontiers Science Center of Pathogenic Microorganisms and Infection Shanghai Institute of Infectious Disease and BiosecurityShanghai Engineering Research Center for Synthetic ImmunologySchool of Basic Medical Sciences Shanghai Medical College Fudan University Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of yunnan Province Center for Biosafety Mega-Science Kunming Institute of ZoologyChinese Academy of Sciences State Key Laboratory of Bioorganic and Natural Products Chemistry Center for Excellence in Molecular Synthesis Shanghai Institute of Organic Chemistry Chinese Academy of Sciences Shenzhen Research Institute of Shanghai Jiao Tong University

Vaccines have been the primary remedy in the global fight against coronavirus disease 2019（COVID-19）.The receptor-binding domain（RBD） of the spike protein, a critical viral immunogen, is affected by the heterogeneity of its glycan structures and relatively low immunogenicity. Here, we describe a scalable synthetic platform that enables the precise synthesis of homogeneously glycosylated RBD, facilitating the elucidation of carbohydrate structure–function relationships. Five homogeneously glycosylated RBDs bearing biantennary glycans were prepared, three of which were conjugated to T-helper epitope(Tpep) from tetanus toxoid to improve their weak immune response. Relative to natural HEK293-derived RBD, synthetic RBDs with biantennary N-glycan elicited a higher level of neutralising antibodies against SARS-CoV-2 in mice. Furthermore, RBDs containing Tpepelicited significant immune responses in transgenic mice expressing human angiotensin-converting enzyme 2. Our collective data suggest that trimming the N-glycans and Tpepconjugation of RBD could potentially serve as an effective strategy for developing subunit vaccines providing efficient protection.

关键词： peptide ligation glycosylation glycoprotein

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Interface optimization of graphene paper-Cu composite prepared by electrodeposition

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Journal of Iron and Steel Research International 2024年第1期31卷 64-73页

作者： Jing Guo Hai-jing Wang Shuang-juan Liu Peng Zhang Jing-yu tang Wei-yang Zhang Han-jie Guo Peng-cheng Wang Cai Meng School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing100083China Institute of High Energy Physics Chinese Academy of SciencesBeijing100049China Advanced Technology and Materials Co. Ltd.Beijing100083China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei230027AnhuiChina

A room-temperature electrodeposition method with an organic electrolyte was developed to fabricate a HNO3-pretreated graphene paper Cu(GP'-Cu)*** improve the interfacial bonding of GP'-Cu composite,magnetron sputtering technology was used to create a"sandwich"structural gradient GP'-Cu *** selection of the intermediate transition layer metal was based on two-dimensional *** electron microscopy,X-ray photoelectron spectroscopy,and other analytical methods confirmed that the addition of an intermediate transition metal(Cr,Ni)layer reduced the gap distance and enhanced the interfacial bonding of the GP'and Cu deposited *** GP'-Ni-Cu composite exhibited the largest increase in tensile strength and *** addition,it had the highest thermal diffusivity and elongation at break among the GP'-Cu,GP'-Cr-Cu and GP'-Ni-Cu composites.

关键词： Graphene paper Two-dimensional disregistry Magnetron sputtering Metal composite

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Protective Effect of Silibinin on Lipopolysaccharide-Induced Endotoxemia by Inhibiting Caspase-11-Dependent Cell Pyroptosis

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Chinese Journal of Integrative Medicine 2024年第10期30卷 917-926页

作者： OU Jin-ying LIU Shan-hong tang Dong-kai SHI Ling-zhu YAN Li-jun HUANG Jing-yan ZOU Li-fang QUAN Jing-yu YOU Yan-ting CHEN yu-yao yu Lin-zhong LU Zi-bin Third Level Research Laboratory of State Administration of Traditional Chinese Medicine School of Traditional Chinese MedicineSouthern Medical UniversityGuangzhou510515China Guangdong Provincial Key Laboratory of Chinese Medicine Pharmaceutics Guangzhou510515China School of Traditional Chinese Medicine Southern Medical UniversityGuangzhou510515China

Objective:To explore the protective effect and the underlying mechanism of silibinin(SIB),one of the active compounds from Silybum marianum(L.)Gaertn in ***:Mouse peritoneal macrophage were isolated via intraperitoneally injection of BALB/c mice with thioglycolate *** viability was assessed using the cell counting kit-8,while cytotoxicity was determined through lactate dehydrogenase cytotoxicity *** protein expressions of interleukin(IL)-1α,IL-1β,and IL-18 were determined by enzyme-linked immunosorbent *** lipopolysaccharide(LPS)levels were measured by employing both the limulus amoebocyte lysate assay and flow ***,proximity ligation assay was employed for the LPS and caspase-11 *** were divided into 4 groups:the control,LPS,high-dose-SIB(100 mg/kg),and low-dose-SIB(100 mg/kg)groups(n=8).Zebrafish were divided into 4 groups:the control,LPS,high-dose-SIB(200μmol/L),and low-dose-SIB(100μmol/L)groups(n=30 for survival experiment and n=10 for gene expression analysis).The expression of caspase-11,gasdermin D(GSDMD),and N-GSDMD was determined by Western blot and the expressions of caspy2,gsdmeb,and IL-1βwere detected using quantitative real-time *** observation was performed through hematoxylineosin staining,and protein levels in bronchoalveolar lavage fluid were quantified using the bicinchoninicacid protein ***:SIB noticeably decreased caspase-11 and GSDMD-mediated pyroptosis and suppressed the secretion of IL-1α,IL-1β,and IL-18 induced by LPS(P<0.05).Moreover,SIB inhibited the translocation of LPS into the cytoplasm and the binding of caspase-11 and intracellular LPS(P<0.05).SIB also attenuated the expression of caspase-11 and N-terminal fragments of GSDMD,inhibited the relative cytokines,prolonged the survival time,and up-regulated the survival rate in the endotoxemia models(P<0.05).Conclusions:SIB can inhibit pyroptosis in the LPS-mediated endotoxemia model,at l

关键词： silibinin caspase-11 endotoxemia pyroptosis inflammation

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Cardioprotective Potential of Cymbopogon citratus Essential Oil against Isoproterenol-induced Cardiomyocyte Hypertrophy:Possible Involvement of NLRP3 Inflammasome and Oxidative Phosphorylation Complex Subunits

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Current Medical Science 2024年第2期44卷 450-461页

作者： Xiao-yun DING Hao ZHANG yu-mei QIU Meng-die XIE Hu WANG Zheng-yu XIONG Ting-ting LI Chun-ni HE Wei DONG Xi-lan tang School of Pharmacy Jiangxi Science&Technology Normal UniversityNanchang 330013China Key Laboratory of Modern Preparation of Chinese Medicine Ministry of EducationJiangxi University of Chinese MedicineNanchang 330004China Jiangxi Provincial Key Laboratory of Drug Design and Evaluation Nanchang 330013China

Objective:Cymbopogon citratus(DC.)Stapf is a medicinal and edible herb that is widely used for the treatment of gastric,nervous and hypertensive *** this study,we investigated the cardioprotective effects and mechanisms of the essential oil,the main active ingredient of Cymbopogon citratus,on isoproterenol(ISO)-induced cardiomyocyte ***:The compositions of Cymbopogon citratus essential oil(CCEO)were determined by gas chromatography-mass *** were pretreated with 16.9µg/L CCEO for 1 h followed by 10µmol/L ISO for 24 *** hypertrophy-related indicators and NLRP3 inflammasome expression were ***,transcriptome sequencing(RNA-seq)and target verification were used to further explore the underlying ***:Our results showed that the CCEO mainly included citronellal(45.66%),geraniol(23.32%),and citronellol(10.37%).CCEO inhibited ISO-induced increases in cell surface area and protein content,as well as the upregulation of fetal gene ***,CCEO inhibited ISO-induced NLRP3 inflammasome expression,as evidenced by decreased lactate dehydrogenase content and downregulated mRNA levels of NLRP3,ASC,CASP1,GSDMD,and IL-1β,as well as reduced protein levels of NLRP3,ASC,pro-caspase-1,caspase-1(p20),GSDMD-FL,GSDMD-N,and pro-IL-1β.The RNA-seq results showed that CCEO inhibited the increase in the mRNA levels of 26 oxidative phosphorylation complex subunits in ISO-treated *** further experiments confirmed that CCEO suppressed ISO-induced upregulation of mt-Nd1,Sdhd,mt-Cytb,Uqcrq,and mt-Atp6 but had no obvious effects on mt-Col ***:CCEO inhibits ISO-induced cardiomyocyte hypertrophy through the suppression of NLRP3 inflammasome expression and the regulation of several oxidative phosphorylation complex subunits.

关键词： Cymbopogon citratus essential oil cardiac hypertrophy NLRP3 inflammasome oxidative phosphorylation complex subunits

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Tropical cyclone activities in the Western North Pacific in 2022

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Tropical Cyclone Research and Review 2024年第2期13卷 125-135页

作者： Xin Huang Lina Bai Zifeng yu Johnny C.L.Chan Hui yu Jie tang Rong Guo Rijin Wan Shanghai Typhoon Institute China Meteorological AdministrationShanghaiChina Asia-Pacific Typhoon Collaborative Research Center ShanghaiChina School of Energy and Environment City University of Hong KongHong KongChina

Based on the best-track dataset from the Shanghai Typhoon Institute/China Meteorological Administration,the paper provides a compre-hensive summary and analysis of tropical cyclone(TC)activities in the Western North Paciﬁc(WNP)and the South China Sea(SCS)for *** the historical climatology from 1951 to 2020,the anomalous conditions during 2022 in TC frequency,origin locations,tracks,intensity,and duration for the entire ocean basin as well as landfall events in China are *** show that the overall TC frequency is slightly lower than normal,but the multiple TC events have a very high frequency of *** locations of TCs,which mark the starting points of their paths,show a large westward and northward deviation from *** 40%of the named TCs exhibit a shift in their direction of movement from westerly to ***,comparisons of the means,medians,upper and lower quartiles all indicate that the intensity of TCs in 2022 is generally lower than the climatology,with the duration of TCs at tropical storm intensity or above being shorter than usual.A notable observation is the fewer incidence of TC landfalls in China,but with a geographical concentration in Guangdong *** anomalous annual TC activities are inﬂuenced by related atmospheric and oceanic environmental conditions modulated by multi-scale climate ***ﬁndings provide useful information for enhancing disaster mitigation strategies in the Asia-Paciﬁc region.

关键词： Tropical cyclone Western North Pacific Anomalous characteristics Annual report

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Discovery of TK-642 as a highly potent,selective,orally bioavailable pyrazolopyrazine-based allosteric SHP2 inhibitor

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3624-3642页

作者： Kai tang Shu Wang Siqi Feng Xinyu Yang yueyang Guo Xiangli Ren Linyue Bai Bin yu Hong-Min Liu Yihui Song School of Pharmaceutical Sciences&Key Laboratory of Advanced Drug Preparation Technologies Ministry of EducationZhengzhou UniversityZhengzhou 450001China College of Chemistry Pingyuan LaboratoryState Key Laboratory of Antiviral DrugsZhengzhou UniversityZhengzhou 450001China Tianjian Laboratory of Advanced Biomedical Sciences Institute of Advanced Biomedical SciencesZhengzhou UniversityZhengzhou 450000China State Key Laboratory of Pharmaceutical Biotechnology Nanjing UniversityNanjing 210023China

Src homology-2-containing protein tyrosine phosphatase 2(SHP2)is a promising therapeutic target for cancer *** this work,we presented the structure-guided design of 5,6-fused bicyclic allosteric SHP2 inhibitors,leading to the identification of pyrazolopyrazine-based TK-642 as a highly potent,selective,orally bioavailable allosteric SHP2 inhibitor(SHP2WT IC_(50)=2.7 nmol/L)with favorable pharmacokinetic profiles(F=42.5%;t_(1.2)=2.47 h).Both dual inhibition biochemical assay and docking analysis indicated that TK-642 likely bound to the“tunnel”allosteric site of ***-642 could effectively suppress cell proliferation(KYSE-520 cells IC_(50)=5.73μmol/L)and induce apoptosis in esophageal cancer cells by targeting the SHP2-mediated AKT and ERK signaling ***,oral administration of TK-642 also demonstrated effective anti-tumor effects in the KYSE-520 xenograft mouse model,with a T/C value of 83.69%.Collectively,TK-642 may warrant further investigation as a promising lead compound for the treatment of esophageal cancer.

关键词： Protein tyrosine phosphatase Pyrazolopyrazine SHP2 inhibitor Esophageal cancer

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Hydrogen-bonded organic framework modified separator for simultaneously enhancing the safety and electrochemical performance of Ni-rich lithium-ion battery

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Journal of Energy Chemistry 2024年第9期96卷 72-78页

作者： Chengyu Han yu Cao Ming Yang yuhan Wang Di tang Shaojie Zhang Yiran Jia Yiming Zhang Hern Kim Fusheng Pan Zhongyi Jiang Jie Sun Key Laboratory for Green Chemical Technology of Ministry of Education School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China Science and Technology on Power Sources Laboratory Tianjin Institute of Power SourcesTianjin 300384China Haihe Laboratory of Sustainable Chemical Transformations Tianjin 300192China Quzhou Institute for Innovation in Resource Chemical Engineering Quzhou 324000ZhejiangChina Department of Energy Science and Technology Director Environmental Waste Recycle InstituteYongin 17058Republic of Korea School of Chemistry and Chemical Engineering Hainan UniversityHaikou 570228HainanChina

Nickel-rich layered oxide cathode(LiNi_(x)Co_(y)Mn_(1−x−y)O_(2),x>0.5,NCM)shows substantial potential for applications in longer-range electrical ***,the rapid capacity decay and serious safety concerns impede its practical *** work provides a hydrogen-bonded organic framework(HOF)modification strategy to simultaneously improve the electrochemical performance,thermal stability and incombustibility of *** cyanurate(MCA),as a low-cost and reliable flame-retardant HOF,was implemented in the separator modification layer,which can prevent the battery short circuit even at a high *** addition,the supermolecule properties of MCA provide unique physical and chemical microenvironment for regulating ion-transport behavior in *** MCA coating layer enabled the nickel-rich layered oxide cathode with a high-capacity retention of 90.3%after 300 cycles at 1.0 ***,the usage of MCA in lithium-ion batteries(LIBs)affords a simple,low-cost and efficient strategy to improve the security and service life of nickel-rich layered cathodes.

关键词： Hydrogen-bonded organic framework Modified separator Ni-richlayered oxide cathode Thermal runaway Li^(+)transference number

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Cdc42 deletion yielded enamel defects by disrupting mitochondria and producing reactive oxygen species in dental epithelium

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Genes & Diseases 2024年第5期11卷 335-349页

作者： Jinxuan Zheng Rongcheng yu Yiqi tang Sihui Su Sainan Wang Chenxi Liao Xuecong Li Jiabin Liao Dongsheng yu Tingting Ai Wei Zhao Vicky Yau Chufeng Liu Liping Wu Yang Cao Hospital of Stomatology Guanghua School of StomatologyGuangdong Provincial Key Laboratory of StomatologySun Yat-sen UniversityGuangzhouGuangdong 510055China Guangdong Provincial Key Laboratory of Oral Diseases GuangzhouGuangdong 510055China Department of Cariology and Endodontology Peking University School and Hospital of Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical DevicesBeijing 100081China Department of Oral and Maxillofacial Surgery University at BuffaloBuffaloNY 14214USA Department of Orthodontics Stomatological HospitalSouthern Medical UniversityGuangzhouGuangdong 510280China

Developmental defects of enamel are common due to genetic and environmental factors before and after ***42,a Rho family small GTPase,regulates prenatal tooth development in ***,its role in postnatal tooth development,especially enamel formation,remains ***,we investigated Cdc42 functions in mouse enamel development and tooth repair after ***42 showed highly dynamic temporospatial patterns in the developing incisors,with robust expression in ameloblast and odontoblast ***,epithelium-specific Cdc42 deletion resulted in enamel defects in *** differentiation was inhibited,and hypomineralization of enamel was observed upon epithelial Cdc42 *** analysis showed that abnormal mitochondrial components,phosphotransferase activity,and ion channel regulator activity occurred in the Cdc42 mutant dental *** oxygen species accumulation was detected in the mutant mice,suggesting that abnormal oxidative stress occurred after Cdc42 ***,Cdc42 mutant mice showed delayed tooth repair and generated less calcified *** dysfunction and abnormal oxygen consumption were evidenced by reduced Apool and Timm8a1 expression,increased Atp5j2 levels,and reactive oxygen species overproduction in the mutant repair ***-specific Cdc42 deletion attenuated ERK1.2 signaling in the labial cervical *** Sox2 expression in the mutant labial cervical loop after clipping might lead to delayed tooth *** findings suggested that mitochondrial dysfunction,up-regulated oxidative stress,and abnormal ion channel activity may be among multiple factors responsible for the observed enamel defects in Cdc42 mutant ***,Cdc42 exerts multidimensional and pivotal roles in enamel development and is particularly required for ameloblast differentiation and enamel matrix formation.

关键词： Cdc42 Enamel defects Mitochondrial dysfunction Rho GTPase Tooth repair

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Nutrient enrichment driven by canopy rainfall redistribution:Mechanism,quantification,and pattern

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Science China Earth Sciences 2024年第5期67卷 1529-1544页

作者： Chuan yuAN Xiaoping yuE Yafeng ZHANG yu ZHANG Yanting HU Qiang tang Li GUO Shuai WANG Xingwu DUAN Wenhua XIANG Xiaohua WEI Xiaoyan LI College of Forestry and Biotechnology Zhejiang A&F UniversityHangzhou 311300China Chongqing Jinfo Mountain Karst Ecosystem National Observation and Research Station School of Geographical SciencesSouthwest UniversityChongqing 400715China Shapotou Desert Research and Experiment Station Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China School of Geographical Sciences Hebei Normal UniversityShijiazhuang 050024China Faculty of Life Science and Technology Central South University of Forestry and TechnologyChangsha 410004China State Key Laboratory of Hydraulics and Mountain River Engineering College of Water Resource and HydropowerSichuan UniversityChengdu 610065China State Key Laboratory of Earth Surface Processes and Resource Ecology Faculty of Geographical ScienceBeijing Normal UniversityBeijing 100875China yunnan Key Laboratory of Soil Erosion Prevention and Green Development Institute of International Rivers and Eco-securityYunnan UniversityKunming 650091China Department of Earth Environmental and Geographic SciencesUniversity of British Columbia(Okanagan)KelownaBritish Columbia V1V 1V7Canada

Vegetation canopies intercept and redistribute rainfall into throughfall and stemflow,which transfer substantial amounts of elements into the soil,influencing soil microbial community,plant survival,and plant community *** advancements in ecohydrological research,the implication of nutrient enrichment resulting from this redistribution of rainfall by canopies remains largely *** address this gap,we conducted a systematic review of 1.20 papers published between 2000 and 2022,gathering data on nutrient concentration and enrichment for critical ions(including K^(+),Na^(+),Ca^(2+),Mg^(2+),NH_(4)^(+),Cl^(-),NO_(3)^(-)and SO_(4)^(2-))from the Web of Science and Chinese Knowledge Infrastructure *** aimed to synthesize the mechanisms,quantify the enrichments,and identify global patterns of nutrient enrichment in stemflow and throughfall across climate zones,and vegetation types and *** results of this study indicate that stemflow exhibits,on average,2.1times greater ion concentration(6.13 mg L^(-1))compared to *** particular,among the investigated ions,SO_(4)^(2-)(12.45and 6.32 mg L^(-1))for stemflow and throughfall,respectively,and Cl^(-)(9.21 and 4.81 mg L^(-1))exhibit the highest concentrations in both rainfall redistribution components,while K^(+)(13.7 and 5.8)and Mg^(2+)(5.6 and 2.8)have the highest enrichment *** climate zones,throughfall and stemflow show the lowest ion concentrations but the highest enrichment factors in extremely humid *** the temperature gradient,ion concentrations are the highest in cold climates with no clear patterns observed for enrichment factors with increasing *** addition,shrubs,conifers,mixed forests,and artificial ecosystems demonstrate enrichment factors 1.1 to 3.0 times greater than those of trees,broad-leaved plants,pure forests,and natural *** findings emphasize the need for increased attentions to artificial ecosystems,such as urban

关键词： Ecohydrology Rainfall redistribution Nutrients transport Enrichment characteristics Climate zones

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In-situ fabrication of on-chip 1T'-MoTe_(2)/Ge Schottky junction photodetector for self-powered broadband infrared imaging and position sensing

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Nano Research 2024年第6期17卷 5587-5594页

作者： Menglei Zhu Kunxuan Liu Di Wu yunrui Jiang Xue Li Pei Lin Zhifeng Shi Xinjian Li Ran Ding Yalun tang Xuechao yu Longhui Zeng School of Physics and Microelectronics and Key Laboratory of Material PhysicsZhengzhou UniversityZhengzhou 450052China Department of Electrical and Computer Engineering University of California San DiegoLa JollaCA 92093USA State Key Laboratory of Integrated Optoelectronics College of Electronic Science and EngineeringJilin UniversityChangchun 130012China Key Laboratory of Multifunctional Nanomaterials and Smart Systems Suzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhou 215123China

High-sensitivity room-temperature multi-dimensional infrared(IR)detection is crucial for military and civilian ***,the gapless electronic structures and unique optoelectrical properties have made the two-dimensional(2D)topological semimetals promising candidates for the realization of multifunctional optoelectronic ***,we demonstrated the in-situ construction of high-performance 1T’-MoTe_(2)/Ge Schottky junction device by inserting an ultrathin AlOx passivation *** good detection performance with an ultra-broadband detection wavelength range of up to 10.6 micron,an ultrafast response time of~160 ns,and a large specific detectivity of over 109 Jones in mid-infrared(MIR)range surpasses that of most 2D materials-based IR sensors,approaching the performance of commercial IR *** on-chip integrated device arrays with 64 functional detectors feature high-resolution imaging capability at room *** these outstanding detection features have enabled the demonstration of position-sensitive detection *** demonstrates an exceptional position sensitivity of 14.9 mV/mm,an outstanding nonlinearity of 6.44%,and commendable trajectory tracking and optoelectronic demodulation *** study not only offers a promising route towards room-temperature MIR optoelectronic applications,but also demonstrates a great potential for application in optical sensing systems.

关键词： MoTe_(2) broadband photodetection Schottky junction imaging position sensitive detector

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