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The first facile total synthesis of natural (3R,4R,6S)-3,4-epoxybisabola-7(14),10-dien-2-one

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Chinese Chemical Letters 2009年第9期20卷 1017-1018页

作者： Zhi Yong Tang Chen Xi Zhang li Jing Fang yu lin li State Key Laboratory of Applied Organic Chemistry and Institute of Organic Chemistry Lanzhou University Lanzhou 730000 China

3,4-Epoxybisabola-7（14）,10-dien-2-one, a natural sesquiterpoind, was first synthesized from （-）-carvone through 7 steps, in an overall yield of 35.9%. The key step was the allylation and then a substrate-directable epoxidation was committed successfully. 2009 Zhi Yong Tang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

关键词： Alkylation Epoxidation Synthesis

An enantioselective formal synthesis of (-)-thujopsene

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Chinese Chemical Letters 2008年第3期19卷 256-258页

作者： Chen Xi Zhang li Jing Fang Fu Qiang Bi yu lin li State Key Laboratory of Applied Organic Chemistry and Institute of Organic Chemistry Lanzhou University Lanzhou 730000 China

Dihydromayurone （3）, a key intermediate to synthesize （-）-thujopsene （1）, was efficient enantiocontrolled synthesized from （＋）-dihydrocarvone through 9 steps in an overall yield of 19.3%. The key step was the... 详细信息

关键词： Thujopsene Dihydromayurone Synthesis Dihydrocarvone Simmons-Smith reaction

First total synthesis of 10α-hydroxy-4-muurolen-3-one and its C_(10)-isomer

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Chinese Chemical Letters 2008年第11期19卷 1265-1267页

作者： Fu Qiang Bi li Jing Fang Chen Xi Zhang yu lin li State Key Laboratory of Applied Organic Chemistry and Institute of Organic Chemistry Lanzhou University Lanzhou 730000 China

An efficient synthetic route to muurolane type sesquiterpenes starting from （R）-carvone, employing allylic diazene rearrangement and the ring closing methesis （RCM） reaction as key steps, is described. The first asymmetric total synthesis of （-）-10α- hydroxy-4-muurolen-3-one 11 and （-）-10β-hydroxy-4-muurolen-3-one C was accomplished. Through the total synthesis, the absolute configurations of the natural products A, B and C were established.

关键词： 10α-Hydroxy-4-muurolen-3-one 10β-Hydroxy-4-muurolen-3-one Allylic diazene rearrangement RCM reaction Total synthesis

First Asymmetry Synthesis and Stereochemistry of Glutinone

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Chinese Chemical Letters 2001年第10期12卷 881-882页

作者： Zhe ZHANG Zhao Ming XIONG yu Kun GUAN Guo Jun ZHENG yu lin li National Laboratory of Applied Organic Chemistry and Institute of Organic Chemistry Lanzhou UniversityLanzhou 730000

The first asymmetry synthesis of glutinone and its three diastereoisomers were carried out in 8 steps and the stereochemistry of this natural product was given out.

关键词： asymmetry synthesis asymmetry dihydroxylation sesquiterpenoid

The First Total Synthesis of Natural 6β-Cinnamoyloxy-1α- hydroxy-5, 10-bis-epi-eudesm-4-en-3-one

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Chinese Chemical Letters 2006年第10期17卷 1290-1292页

作者： Chen ZHANG Guo Jun ZHEN Jin Chun CHEN li Jing FANG yu lin li State Key Laboratory of Applied Organic Chemistry Lanzhou University Lanzhou 730000

The first total synthesis of natural 6β-cinnamoyloxy-1α-hydroxy-5, 10-bis-epi- eudesm-4-en-3-one （1）, a highly complex natural eudesmane, was described.

关键词： 6β-Cinnamoyloxy-1α-hydroxy-5,10-bis-epi-eudesm-4-en-3-one C- 1 oxygenated eudesmane total synthesis.

Role of 5-azacytidine in differentiation of human mesenchymal stem cell sinto cardiomyocytes in vitro

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Journal of Geriatric Cardiology 2009年第3期6卷 182-188页

作者： Fang-Ge Deng yu-lin li Xiu-Ying Zhang Key Laboratory of Pathobiology Jilin University Changchun 130021 China National Key Laboratory of Respiratory Diseases Guangzhou Institute of Respiratory Diseases First Affiliated Hospital of Guangzhou Medical College Guangzhou 510120 China

Objective 5-azacytidine could induce the differentiation of stem cells into cardiomyocytes （CMs）. The aim of this study was to screen the optimal condition for 5-azacytidine inducing differentiation of human mesenchumal stem cells （hMSCs） into CMs, and the effect of 5-azacytidine on adherence, cell vigor and chromosome karyotype of hMSCs. Methods hMSCs were isolated from human bone marrow and cultured in vitro. The phenotypes ofhMSCs were identified by flow cytometric analyses. MTT test was used to investigate the effect of different concentrations of 5-azacytidine on proliferation ofhMSCs. Four weeks after 5-azacytidine induction, semi-quantitative RT-PCR, transmission electron microscopy （TEM）, single-cell action potentials, detection of cardio-enzyme AST and LDH, cell adherence, cell viability and chromosome karyotype test were performed. Results The typical morphological features of hMSCs were fibroblast-like in shape, hMSCs expressed CD44 and CD105,and did not express CD34, CD45 and CD31. The optimal concentration of 5-azacytidine was 10μ mol/L. The shape of hMSCs treated with 5-Azacytidine changed from fusiform to polygon or astrocyte gradually, and passaged cells were evenly arranged as polarity structure. Indueed-hMSCs connected with neighbouring cells, fbrming myotube-like structures 4 weeks later. It was confirmed that induced hMSCs shaped myotubule-like structure and had some of micro-histologic structures of CMs by TEM. RT-PCR showed that induced hMSCs expressed cardiac specific product BNNP and early cardio-myogenesis specific transcription factor NKX2.5mRNA. Besides, induced-MSCs led to the weak action potential and secreted cardio-enzyme AST and LDH. There was no significant difference in cell adherence and viability before and after induction. Both hMSCs and induced-hNSCs kept stable normal diploid nucleus. Conclusion The optimal condition for inducing effect of 5-azacytidine is 10 la mol/L and 24-hour incubation; and under this condition, the adhere

关键词： Human mesenchymal stem cells 5-azacytidine differentiation cardiomyocytes

First Total Synthesis of 7-O-Geranyl-pseudobaptigenin

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Chinese Chemical Letters 2001年第5期12卷 409-410页

作者： Ya Ping WANG liang Xi li Jian Jun CHEN Qing lian WANG yu lin li National Laboratory of Applied Organic Chemistry and Institute of Organic Chemistry Lanzhou UniversityLanzhou 730000

Total synthesis of 7-O-geranyl-pseudobaptigenin is described, the key steps are Grignard reaction and cyclization reaction.

关键词： Synthesis 7-O-geranyl-pseudobaptigenin pseudobaptigenin O-geranylated isoflavone.

A simple and efficient synthesis of the valsartan

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Chinese Chemical Letters 2008年第7期19卷 759-761页

作者： Chen Xi Zhang Guo Jun Zheng Fu Qiang Bi yu lin li State Key Laboratory of Applied Organic Chemistry and Institute of Organic Chemistry Lanzhou University Lanzhou 730000 China

Valsartan 1, one of the most important agents used in antihypertensive therapy today, was synthesized starting from L-valin methyl ester hydrochloride 2 through four steps in an overall yield of 60%. The key step involves the palladium-catalyzed Suzuki coupling. This method overcomes many of the drawbacks associated with the previously reported syntheses and is more suitable for industrial production.

关键词： Valsartan Antihypertensive L-Valin methyl ester hydrochlofide Synthesis Suzuki coupling

Two New Xanthone Glycosides from Swertia Tetraptera

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Chinese Chemical Letters 2001年第5期12卷 433-434页

作者： Zhi Xin liAO yu lin li Ming Kui WANG li Sheng DING Yao Zu CHEN State Key Laboratory of Applied Organic Chemistry Lanzhou UniversityLanzhou 730000 Northwest Plateau Institute of Biology Chinese Academy of SciencesXining 810001 Chengdu Institute of Biology Chinese Academy of SciencesChengdu 610041

Two new xanthone glycosides, tetraswerosides A and B, were isolated from the whole plant of Swertia tertraptera. Their structures were determined as 3-O-beta -D-glucopyranosyl-1-hydroxy-4,7-dimethoxyxanthone and 3-O-[... 详细信息

关键词： Swertia tetrapetra xanthone glycoside tetraswerosides A and B.