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Correlation between cerebral neurotransmitters levels by proton magnetic resonance spectroscopy and HbA1c in patients with type 2 diabetes

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World Journal of Diabetes 2024年第6期15卷 1263-1271页

作者： Xiang-yu Gao Chen-Xia Zhou Hong-Mei Li Min Cheng Da Chen Zi-Yi Li Bo Feng Jun Song Department of Endocrinology East HospitalTongji University School of MedicineShanghai 200120China Department of Endocrinology Qilu Hospital(Qingdao)Cheeloo College of MedicineShandong UniversityQingdao 266000Shandong ProvinceChina Department of Immunization Program Huangdao District Center for Disease Prevention and ControlQingdao 266400Shandong ProvinceChina

BACKGROUND Cognitive dysfunction is the main manifestation of central *** cognitive impairments tend to be overlooked in patients with diabetes mellitus(DM),there is a growing body of evidence linking DM to cognitive *** is closely related to neurological abnormalities,while often disregarded in clinical *** in cerebral neurotransmitter levels are associated with a variety of neurological abnormalities and may be closely related to blood glucose control in patients with type 2 DM(T2DM).AIM To evaluate the concentrations of cerebral neurotransmitters in T2DM patients exhibiting different hemoglobin A1c(HbA1c)*** A total of 130 T2DM patients were enrolled at the Department of Endocrinology of Shanghai East *** participants were divided into four groups according to their HbA1c levels using the interquartile method,namely Q1(cholesterol(LDL-C),homeostasis model assessment of insulin resistance(HOMA-IR),and beta cell function(HOMA-β),N-acetylaspartate/creatine(NAA/Cr),and NAA/choline(NAA/cho).Spearman correlation analysis showed that mALB,LDL-C,HOMA-IR and NAA/Cr in the left brainstem area were positively correlated with the level of HbA1c(Pcho[Odds ratio(OR):1.608,95%confidence interval(95%CI):1.004-2.578,P<0.05],LDL-C(OR:1.627,95%CI:1.119-2.370,P<0.05),and HOMA-IR(OR:1.107,95%CI:1.031-

关键词： Type 2 diabetes mellitus Hemoglobin A1c Proton magnetic resonance spectroscopy Neurotransmitters Central neuropathy

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In vitro antibacterial activity and major bioactive components of Cinnamomum verum essential oils against cariogenic bacteria,Streptococcus mutans and Streptococcus sobrinus

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Asian Pacific Journal of Tropical Biomedicine 2016年第4期6卷 308-314页

作者： Okhee choi Su kyung cho Junheon Kim Chung Gyoo Park Jinwoo Kim Division of Applied Life Science (BK21 Plus) Gyeongsang National University Institute of Agriculture & Life Science Gyeongsang National University

Objective:To evaluate the antibacterial activity of Cinnamomum verum(***) from32 different essential oils against cariogenic bacteria,Streptococcus mutans(***)and Streptococcus sobrinus(***).Methods:The antibacterial activities of each essential oil were individually investigated against *** and *** essential oil of *** was selected for further evaluation against *** and *** chromatography mass spectrometry was used to determine the major constituents of *** essential *** addition,the minimum inhibitory concentration(MIC) and minimum bactericidal concentration of the most effective constituent was ***:The essential oil from *** exhibited the greatest antibacterial *** chromatography mass spectrometry analysis revealed that the major components of *** essential oil were cinnamaldehyde(56.3%),cinnamyl acetate(7.1%) and bphellandrene(6.3%).The MIC of cinnamaldehyde was measured using broth dilution *** MIC of cinnamaldehyde was 0.02%(v/v) against both bacterial strains *** minimum bactericidal concentration of cinnamaldehyde against *** and *** were 0.2% and 0.1%(v/v),***:The essential oil of *** and its major component cinnamaldehyde possessed considerable in vitro antibacterial activities against cariogenic bacteria,*** and *** *** results showed that the essential oil of *** and its bioactive component,cinnamaldehyde,have potential for application as natural agents for the prevention and treatment of dental caries.

关键词： Streptococcus mutans Streptococcus sobrinus Cariogenic bacteria Essential oil Antibacterial activity Cinnamaldehyde

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Thoracic pyogenic infectious spondylitis presented as pneumothorax:A case report

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World Journal of Clinical Cases 2021年第6期9卷 1402-1407页

作者： Mi-kyung cho Byeong-Ju Lee Jae-Hyeok Chang Young-Mo Kim Department of Rehabilitation Medicine Pusan National University HospitalBusan 49241South Korea

BACKGROUND Pyogenic infectious spondylitis(PIS)is a rare condition,with an incidence between 0.2 and 2 cases per 100000 per ***’s most common symptom-back or neck pain-occurs in more than 90%of ***,we reported a case of thoracic PIS accompanied by pneumothorax in a 65-year-old male *** SUMMARY A 65-year-old man presented with right chest pain and *** initial erect posteroanterior chest radiography revealed pneumothorax,which was further evaluated by chest computed tomography,revealing pleural effusion in the right lung and a paravertebral abscess with bony destruction of vertebral *** on magnetic resonance imaging,the patient was diagnosed with thoracic infectious spondylitis with an anterior paravertebral *** was prescribed antibiotics and underwent neurosurgery due to aggravated symptoms and neurologic *** examination revealed that the cause of pleural effusion and pneumothorax was Staphylococcus aureus infection contiguously spread to lung *** several surgical treatments with intravenous antibiotic therapy for two months and transition to oral antibiotics(rifampin 600 mg qd and ciprofloxacin 500 mg bid),the patient received physical therapy to recover *** month after discharge,the patient had no chest pain or dyspnea,and exhibited no elevation in inflammatory markers or new thoracic *** To our knowledge,this is the very first report of a case of thoracic PIS with pneumothorax.

关键词： Chest pain Pneumothorax Pleural effusion Neurologic deficits Spondylitis Case report

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Structurally engineered colloidal quantum dot phosphor using TiO_(2) photonic crystal backbone

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Light(Science & Applications) 2022年第11期11卷 2782-2789页

作者： Hansol Lee Tae-yun Lee Yeonsang Park kyung-Sang cho Young-Geun Rho Hyuck choo Heonsu Jeon Department of Physics and Astronomy Seoul National UniversitySeoul 08826Republic of Korea Inter-university Semiconductor Research Center Seoul National UniversitySeoul 08826Republic of Korea Department of Physics Chungnam National UniversityDaejeon 34134Republic of Korea Institute of Quantum Systems Chungnam National UniversityDaejeon 34134Republic of Korea Samsung Advanced Institute of Technology Suwon 16678Republic of Korea Institute of Applied Physics Seoul National UniversitySeoul 08826Republic of Korea

Photonic crystal(PhC)phosphor,in which the phosphor material is periodically modulated for an enhancement in color-conversion efficiency via resonant absorption of excitation photons,is a paradigm-shifting structural phosphor ***-dimensional(2D)square-lattice PhC phosphor is currently considered the most advanced platform because of not only its high efficiency,but also its immunity to excitation *** the present study,two major modifications are made to further improve the performance of the 2D PhC phosphor:increasing the refractive index contrast and planarizing the *** index contrast is improved by replacing the PhC backbone material with TiO_(2)whereas the surface planarization is achieved by removing excessive colloidal quantum dots from the *** comparison with the reference phosphor,the upgraded PhC phosphor exhibits~59 times enhanced absorption(in simulations)and~7 times enhanced emission(in experiments),both of which are unprecedentedly *** results not only brighten the viability and applicability of the PhC phosphor but also spur the phosphor development through structural engineering of phosphor materials.

关键词： immunity phosphor backbone

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Analysis of Quenching Resistor Effect to Improve Stability of TIA Circuit for APD-A Secondary Publication

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Journal of Electronic Research and Application 2024年第2期8卷 54-61页

作者： Dong-Han Ki yu-Rin Jin Sung-Mi Kim Seong-Ik cho Department of Electronics Engineering Jeonbuk National UniversityJeollabuk-doRepublic of Korea

In this paper,since the Avalanche Photo Diode(APD)for Light-to-Voltage LTV conversion uses a high voltage in the operating range unlike other Photo Diodes(PD),the quenching resistor must be connected in series to prevent overcurrent when using the Transimpedance Amplifier(TIA).In such a case,quenching resistance may affect the transfer function of the TIA circuit,resulting in serious ***,in this paper,by analyzing the effect of APD quenching resistance on the voltage and current loop transfer function of TIA,we proposed a loop analysis and a method for determining the quenching resistance value to improve stability.A TIA circuit with quenching resistance was designed by the proposed method and its operational stability was verified through simulation and chip fabrication.

关键词： APD TIA Quenching resistor Stability Transfer function

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FET-based nanobiosensors for the detection of smell and taste

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Science China(Life Sciences) 2020年第8期63卷 1159-1167页

作者： Dongseok Moon Yeon kyung Cha So-ong Kim Seongyeon cho Hwi Jin Ko Tai Hyun Park School of Chemical and Biological Engineering Institute of Chemical ProcessesSeoul National UniversitySeoul 08826Republic of Korea Interdisciplinary Program for Bioengineering Seoul National UniversitySeoul 08826Republic of Korea

Various nanobiosensors composed of biomaterials and nanomaterials have been developed,due to their demonstrated advantage of showing high *** various biomaterials for biological recognition elements of the nanobiosensor,sensory receptors,such as olfactory and taste receptors,are promising biomaterials for developing nanobiosensors,because of their high selectivity to target ***-effect transistors(FET)with nanomaterials such as carbon nanotube(CNT),graphene,and conducting polymer nanotube(CPNT),can be combined with the biomaterials to enhance the sensitivity of ***,many efforts have been made to develop nanobiosensors using biomaterials,such as olfactory receptors and taste receptors for detecting various smells and *** review focuses on the biomaterials and nanomaterials used in nanobiosensor systems and studies of various types of nanobiosensor platforms that utilize olfactory receptors and taste receptors which could be applied to a wide range of industrial fields,including the food and beverage industry,environmental monitoring,the biomedical field,and anti-terrorism.

关键词： nanobiosensor olfactory receptor taste receptor field-effect transistor(FET)

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The Impacts of Simulated Microgravity on Rat Brain Depended on Durations and Regions

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Biomedical and Environmental Sciences 2019年第7期32卷 496-507页

作者： CHEN Bo ZHANG yu Shi LI George cho Jun-Lae DENG yu Lin LI yu Juan School of Life Science Beijing Institute of Technology Beijing 100081 China Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences Beijing 100700 China Faculty of Pharmacy The University of Sydney Sydney 2006 NSW Australia

Objective To explore the dynamic impacts of simulated microgravity(SM) on different vital brain regions of rats. Methods Microgravity was simulated for 7 and 21 days, respectively, using the tail-suspension rat model. Histomorphology, oxidative stress, inflammatory cytokines and the expression of some key proteins were determined in hippocampus, cerebral cortex and striatum. Results 21-day SM decreased brain derived neurotrophic factor and induced neuron atrophy in the cerebral cortex. Strong oxidative stress was triggered at day 7 and the oxidative status returned to physiological level at day 21. Inflammatory cytokines were gradually suppressed and in striatum, the suppression was regulated partially through c-Jun/c-Fos. Conclusion The results revealed that the significant impacts of SM on rat brain tissue depended on durations and regions, which might help to understand the health risk and to prevent brain damage for astronauts in space travel.

关键词： Microgravity Brain Neuron atrophy Oxidative stress Inflammatory cytokines

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Fish bone migration to the urinary bladder after rectosigmoid colon perforation

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World Journal of Gastroenterology 2014年第22期20卷 7075-7078页

作者： Min-kyung cho Moon-Soo Lee Hyun-Young Han Seung Hyo Woo Department of Surgery Eulji University HospitalDaejeon 302-799South Korea Department of Radiology Eulji University HospitalDaejeon 302-799South Korea Department of Urology Eulji University HospitalDaejeon 302-799South Korea

Fish bones are the most common foreign objects leading to bowel *** cases are confined to the extraluminal space without penetration of an adjacent ***,abscess formation due to the perforation of the rectosigmoid colon by a fish bone can lead to the penetration of the urinary bladder and may subsequently cause the fish bone to migrate into the urinary *** the presented case,a 42-yearold female was admitted for lower abdominal *** computed tomography(CT)demonstrated a 5cm pelvic abscess containing a thin and curvilinear foreign *** conservative management,the patient was *** 1 mo,the subject developed a mechanical *** had to be delayed due to her *** of the foreign body to the urinary bladder was shown on additional CT.A Yellowish fish bone 3.5 cm in size was removed through intraoperative *** patient was discharged 8 d after the operation without any unexpected event.

关键词： Fish bone Rectosigmoid colon perforation Urinary bladder Foreign body ingestion Foreign body induced bowel perforation

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Turbulent vortex trains in narrow square arrayed rod bundles of a dual-cooled nuclear reactor

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Science China(Technological Sciences) 2013年第9期56卷 2143-2149页

作者： KIM Taehwan KIM kyung Min BAE Ji-Yeul SHIN Chang Hwan IN Wang-Kee cho Hyung Hee School of Mechanical Engineering Yonsei University Korea Atomic Energy Research Institute

The dual-cooled nuclear reactor is currently considered for improving the designs of current/future nuclear reactors. Investigation of the thermal-hydraulic characteristics of the nuclear reactor via experiments is essential for commercializing the dual-cooled nuclear reactor. In this paper, the turbulent flow in square arrayed six-rod bundles in the form of magnified copies of the dual-cooled and current OPR-1000 nuclear reactor is experimentally investigated by means of hot-wire anemometry and smoke-wire generation methods. Vortex trains which do not exist in an ordinary reactor subchannel are presented in the subchannel of the dual-cooled reactor. The vortices are induced by a span-wise velocity gradient. This flow pulsation phenomenon increases the inter-channel mixing of the subchannel. To understand the periodic feature of the pulsation, axial/cross velocities are measured and the periodic characteristic frequencies are obtained by a Fast Fourier Transform (FFT) analysis. The peak frequency that represents the quasi-periodic pulsation of the flow is increased with an increase in the axial velocity while the wavelength of the pulsation remains constant within a tested range of the Reynolds number (9000 51000). The vortex trains are highly synchronized with each other, as confirmed by means of visualization.

关键词： dual-cooled nuclear reactor vortex train flow pulsation turbulent mixing rod bundles

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Effect of two different doses of intravitreal bevacizumab with temporal retina-sparing laser photocoagulation for retinopathy of prematurity

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International Journal of Ophthalmology(English edition) 2018年第1期11卷 166-169页

作者： A Young choi Hochan cho yu Cheol Kim Department of Ophthalmology Keimyung University School of Medicine Dongsan Medical Center Department of Internal Medicine Keimyung University School of Medicine Dongsan Medical Center

This study aims to compare the efficacy and safety between two different doses of intravitreal bevacizumab（IVB） injection with temporal retina-sparing laser（TRSL） photocoagulation for retinopathy of prematurity（ROP）. We retrospectively evaluated 22 eyes of ROP infants who underwent IVB combined with partial TRSL for stage 3＋ zone I or posterior zone II ROP. Laser photocoagulation was applied on the avascular retina, sparing two-discdiameter width temporal avascular area anterior to ridge. A half dose（0.625 mg） or minimal dose（0.25 mg） of IVB was conducted. Four eyes in minimal dose group were retreated with IVB and laser photocoagulation on the spared retina. Of those 4 retreated eyes, three developed preretinal hemorrhage around the ridge after the first treatment, resulting in fibrotic macular dragging. A half dose of IVB may be more effective than a minimal dose with partial TRSL for ROP. Preretinal hemorrhage may be a harbinger of poor prognosis.

关键词： bevacizumab laser photocoagulation retinopathy of prematurity

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