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Conditioned secretome of adipose-derived stem cells improves dextran sulfate sodium-induced colitis in mice

World Journal of Gastroenterology 2021年第23期27卷 3342-3356页

作者： Seunghun Lee Jeonghoon Heo Eun-kyung Ahn Jae hyun Kim Young-Ho Kim Hee-kyung Chang Sang-Joon Lee Jongsik Kim Seun-Ja Park Department of Colorectal Surgery Kosin University College of MedicineBusan 49267South Korea Department of Molecular Biology and Immunology Kosin University College of MedicineBusan 49267South Korea Department of Gastroenterology Kosin University College of MedicineBusan 49267South Korea Department of Pathology Kosin University College of MedicineBusan 49267South Korea Department of Ophthalmology Kosin University College of MedicineBusan 49267South Korea Department of Anatomy Kosin University College of MedicineBusan 49267South Korea

BACKGROUND Inflammatory bowel diseases(IBD)is related to uncontrolled immune ***,there is no successful treatment for significant improvement in *** cells display their therapeutic effects through their repopulating capacity or secreting *** To investigate the effects of conditioned mouse adipose-derived stem cells(mADSCs)secretome on colitis-induced *** mADSCs were isolated from adipose tissue of C57BL/6 *** mADSCs secrectome was obtained by culturing of mADSCs with lipopolysaccharides(LPS,1μg/mL)for 24 *** colitis was induced by 2%dextran sulfate sodium(DSS)drinking water for 7 d and then normal drinking water for 4 *** mice were treated with normal culture medium(NM group),conditioned mADSCs secretome(CM group)or mADSCs(SC group).The length of colon and histopatholgy of colon tissues were *** mRNA expression levels of inflammatory cytokines in colon tissue and the serum interleukin(IL)-6 levels were *** The isolated mADSCs maintained the mADSCs specific gene expression profiles during *** conditioned mADSCs secretome released by the treatment of mADSCs with LPS contained mainly inflammatory chemokines,colony-stimulating factors and inflammatory *** loss of body weight and reduction in colon length were ameliorated in the CM *** conditioned mADSCs secretome reduced the histological score in colon *** expression of IL-1b and IL-6 mRNAs in colon tissues significantly inhibited in the CM group compared to SC group and NM group,*** elevation of serum IL-6 levels was also ameliorated in the CM *** results indicate that the conditioned mADSCs secretome suppressed the synthesis of inflammatory cytokines in damaged colon tissue and the elevation of serum IL-6 concentration in DSS-induced mice CONCLUSION Conditioned mADSCs secretome might play regenerative roles by the suppression of IL-6 in serum and tissue during acute colitis,and may be

关键词： Adipose-derived stem cells Conditioned secretome Cytokines Interleukin-6 Colitis Regeneration

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Machining characteristics of complex prism pattern on electroplated roll by copper

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中国有色金属学会会刊：英文版 2009年第B09期19卷 288-294页

作者： Tae-Jin JE Sang-Cheon PARK Kang-Won LEE Yeong-Eun YOO Doo-Sun CHOI kyung-hyun WHANG Myung-Chang KANG Nano-Machining Laboratory Division of Nano-Mechanical Systems Korea Institute of Machinery and Materials Nano-Mechatronics Department University of Science and TechnologySinseongnoYouseong-GuDaejeonKorea National Core Research Center for Hybrid Materials Solution Pusan National University

The BLU (back light unit) is the core component of the LCD for notebook, mobile-phone, navigation, as well as large sized TV, PID (public information display), etc. In order to enhance optical efficiency of LCD, optical films with the uniform prism patterns have been used for BLU by stacking two films up orthogonally. In this case, light interference-phenomenon occurred such as Morie, wet-out, u-turning, etc. It caused several problems such as low brightness, spots and stripes in LCD. Recently, the high-luminance micro complex prism patterns are actively studied to avoid the light interference-phenomenon and enhance the optical efficiency. In this study, the roll master to manufacture complex micro prism pattern film was machined by using the high precision lathe. The machined patterns on the roll master were 50, 45, 40, 35, 30, 25, 20, 15, 10 and 5 μm in the pitch with 25.0, 22.5, 20.0, 17.5, 15.0, 12.5, 10.0, 7.5, 5.0 and 2.5 μm in the peak height, respectively. The roll was 2 000 mm in length and 320 mm in diameter. The electroplated roll by copper and the natural single crystal diamond tool was used for machining the patterns. The cutting force was measured and analyzed for each cutting condition by using the dynamometer. The chips and the surfaces after being machined were analyzed by SEM and microscope.

关键词：车床加工微棱镜铜电镀特征光学效率光学薄膜笔记本电脑金刚石工具

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Influence of tool deflection on micro channel pattern of 6:4 brass with rectangular tool

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中国有色金属学会会刊：英文版 2009年第B09期19卷 164-170页

作者： Tae-Jin JE Kang-Won LEE Sang-Cheon PARK Jae-Gu KIM Doo-Sun CHOI Kyoung-Taik PARK kyung-hyun WHANG Nano Mechanical Systems Research Division Korea Institute of Machinery & Materials (KIMM)

Machining experiment of micro channel structure with 6:4 brass was carried out by shaping process using a single crystal diamond tool. FEM simulation using solid cantilever beam model was analyzed. In result of experiment, tool deflection is observed as machining characteristics through result of experiments such as surface roughness, cutting force and burr formations. And the influence of tool deflection is experimentally proved.

关键词：金刚石工具挠度通道模式黄铜矩形实验证明加工特性有限元模拟

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Sharkskin-Inspired Magnetoactive Reconfigurable Acoustic Metamaterials

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Research 2020年第1期2020卷 799-811页

作者： kyung Hoon Lee Kunhao yu Hasan Al Ba’ba’a An Xin Zhangzhengrong Feng Qiming Wang Sonny Astani Department of Civil and Environmental Engineering University of Southern CaliforniaLos AngelesCA 90089USA

Most of the existing acoustic metamaterials rely on architected structures with fixed configurations,and thus,their properties cannot be modulated once the structures are *** active acoustic metamaterials highlight a promising opportunity to on-demand switch property states;however,they typically require tethered loads,such as mechanical compression or pneumatic *** untethered physical stimuli to actively switch property states of acoustic metamaterials remains largely ***,inspired by the sharkskin denticles,we present a class of active acoustic metamaterials whose configurations can be on-demand switched via untethered magnetic fields,thus enabling active switching of acoustic transmission,wave guiding,logic operation,and *** key mechanism relies on magnetically deformable Mie resonator pillar(MRP)arrays that can be tuned between vertical and bent states corresponding to the acoustic forbidding and conducting,*** MRPs are made of a magnetoactive elastomer and feature wavy air channels to enable an artificial Mie resonance within a designed frequency *** Mie resonance induces an acoustic bandgap,which is closed when pillars are selectively bent by a sufficiently large magnetic *** magnetoactive MRPs are further harnessed to design stimuli-controlled reconfigurable acoustic switches,logic gates,and *** of creating the first generation of untethered-stimuli-induced active acoustic metadevices,the present paradigm may find broad engineering applications,ranging from noise control and audio modulation to sonic camouflage.

关键词： typically conducting artificial

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Correlation of Microstructure and Hydrogen Delayed Fracture for 1GPa Steels

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Journal of Iron and Steel Research International 2011年第S1期18卷 252-254页

作者： Hee Jae Kang Ji Tae Park Soon Tae Ahn kyung Mox Cho Nam hyun Kang Department of Materials Science and Engineering Pusan National UniversityBusan 609-735Korea Samhwa Steel 339-4 Samrak-dongSasang-guBusan 617-825Korea

Automobile industry tries to reduce the weight of automobile using high-strength ***,the high-strength steels are highly susceptible to delayed-fracture caused by hydrogen *** increasing the strength,hydrogen embrittlement is more sensitive to diffusible *** mechanism of delayed-fracture and the relationship with the microstructure and alloying elements are still *** study analyzed the effect of the size and the spheroidization rate for the carbides on hydrogen-induced delayed fracture for 1GPa TS steel.

关键词： hydrogen delayed fracture microstructure spheroidization

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Effect of Isothermal Annealing on Nano Ti-Carbides Precipitation

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Journal of Iron and Steel Research International 2011年第S1期18卷 287-289页

作者： Cheol-ho Park Woo-jin Kim Nam-hyun Kang hyung-hyup Do kyung-Mox Cho Department of Materials Science and Engineering Pusan National UniversityBusan 609-735Korea Technical Research Laboratories Hyundai steelsDangjinChungnam 343-711Korea

Transmission electron microscopy was used to investigate the effect of isothermal holding temperature and time on the nano Ti-precipitates.A holding temperature was varied systematically from 400℃ to 1200℃.The isothermal holding was continued for 30s,300s and 900s,*** carbides of (Ti,Nb)C were precipitated significantly at 900℃.The size of carbides was approximately 10nm at 30s holding and increased to 20～30nm at 900s *** holding at 1000℃ showed the increased amount of carbides larger than *** 800℃,nano (Ti,Nb)C was not observed at 30s and it was examined at *** size of nano (Ti,Nb)C was smaller than that of 900℃.As the isothermal temperature decreased to 700 ℃,the nano (Ti,Nb)C was only seen at 900s holding and the size of carbides was smaller than *** (Ti,Nb)C was disappeared at isothermal holding below 600℃.The kinetics of nano (Ti,Nb)C precipitation were studied as a function of isothermal holding temperature and time,respectively,using the precipitate growth equations.

关键词： Ti carbide hot rolled steel hole expansion ratio isothermal holding nano precipitates

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Electrochemical Performance and ex situ Analysis of ZnMn2O4 Nanowires as Anode Materials for Lithium Rechargeable Batteries

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Nano Research 2011年第5期4卷 505-510页

作者： Sung-Wook Kim hyun-Wook Lee Pandurangan Muralidharan Dong-Hwa Seo Won-Sub Yoon Do kyung Kim Kisuk Kang Research Institute of Advanced Materials Seoul National University 599 Kwanak-ro Kwanak-gu Seoul 151-742 Republic of Korea Department of Materials Science and Engineering Korea Advanced Institute of Science and Technology 335 Gwahangno Yuseong-gu Daejeon 305-701 Republic of Korea Department of Materials Science and Engineering Korea Advanced Institute of Science and Technology 335 Gwahangno Yuseong-gu Daejeon 305-701 Republic of Korea Department of Materials Science and Engineering Seoul National University 599 Kwanak-ro Kwanak-gu Seoul 151-742 Republic of Korea

One-dimensional ZnMn2O4 nanowires have been prepared and investigated as anode materials in Li rechargeable batteries. The highly crystalline ZnMn2O4 nanowires about 15 nm in width and 500 nm in length showed a high specific capacity of about 650 mAh.g-1 at a current rate of 100 mA.g-1 after 40 cycles. They also exhibited high power capability at elevated current rates, i.e., 450 and 350 mAh.g 1 at current rates of 500 and 1000 mA.g 1, respectively. Formation of Mn3O4 and ZnO phases was identified by ex situ X-ray diffraction （XRD） and transmission electron microscopy （TEM） studies after the initial discharge-charge cycle, which indicates that the ZnMn2O4 phase was converted to a nanocomposite of Mn3O4 and ZnO phases immediately after the electrochemical conversion reaction.

关键词： Energy storage lithium rechargeable battery anode ZnMn204 nanowire

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Long-term pretreatment with proton pump inhibitor and Helicobacter pylori eradication rates

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World Journal of Gastroenterology 2014年第4期20卷 1061-1066页

作者： Seung Bae Yoon Jae Myung Park Jong-yul Lee Myong Ki Baeg Chul-hyun Lim Jin Soo Kim yu kyung Cho In Seok Lee Sang Woo Kim Myung-Gyu Choi Division of Gastroenterology Department of Internal Medicine College of Medicine The Catholic University of Korea

AIM: To investigate whether proton pump inhibitor (PPI) pretreatment influences Helicobacter pylori eradication rate.

关键词： Proton pump inhibitor Helicobacter pylori Urea breath test Antibiotics Drug resistance

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Two-Terminal Lithium-Mediated Artificial Synapses with Enhanced Weight Modulation for Feasible Hardware Neural Networks

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Nano-Micro Letters 2023年第5期15卷 236-253页

作者： Ji hyun Baek kyung Ju Kwak Seung Ju Kim Jaehyun Kim Jae Young Kim In Hyuk Im Sunyoung Lee Kisuk Kang Ho Won Jang Department of Materials Science and Engineering Research Institute of Advanced MaterialsSeoul National UniversitySeoul 08826Republic of Korea Advanced Institute of Convergence Technology Seoul National UniversitySuwon 16229Korea

Recently,artificial synapses involving an electrochemical reaction of Li-ion have been attributed to have remarkable synaptic ***-terminal synaptic transistors utilizing Li-ion intercalation exhibits reliable synaptic characteristics by exploiting the advantage of nondistributed weight updates owing to stable ion ***,the three-terminal configurations with large and complex structures impede the crossbar array implementation required for hardware neuromorphic ***,achieving adequate synaptic performances through effective Li-ion intercalation in vertical two-terminal synaptic devices for array integration remains ***,two-terminal Au/LixCoO_(2)/Pt artificial synapses are proposed with the potential for practical implementation of hardware neural *** Au/LixCoO_(2)/Pt devices demonstrated extraordinary neuromorphic behaviors based on a progressive dearth of Li in LixCoO_(2)*** intercalation and deintercalation of Li-ion inside the films are precisely controlled over the weight control spike,resulting in improved weight control *** types of synaptic plasticity were imitated and assessed in terms of key factors such as nonlinearity,symmetricity,and dynamic ***,the LixCoO_(2)-based neuromorphic system outperformed three-terminal synaptic transistors in simulations of convolutional neural networks and multilayer perceptrons due to the high linearity and low programming *** impressive performances suggest the vertical two-terminal Au/LixCoO_(2)/Pt artificial synapses as promising candidates for hardware neural networks.

关键词： Artificial synapse Neuromorphic Li-based Two-terminal Synaptic plasticity

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Transverse myelitis caused by herpes zoster following COVID-19 vaccination:A case report

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World Journal of Clinical Cases 2023年第6期11卷 1419-1425页

作者： Su-Yeon Cho Bo-hyun Jang Jun-Won Seo Suk-Whee Kim kyung-Joon Lim hyun-Young Lee Dong-Joon Kim Department of Anesthesiology and Pain Medicine Chosun University HospitalGwangju 61453South Korea Department of Internal Medicine Chosun UniversityCollege of MedicineGwangju 61453South Korea Department of Anesthesiology and Pain Medicine Chosun UniversityCollege of MedicineGwangju 61453South Korea

BACKGROUND Transverse myelitis(TM)is characterized by sudden lower extremity progressive weakness and sensory impairment,and most patients have a history of advanced viral infection symptoms.A variety of disorders can cause TM in association with viral or nonviral infection,vascular,neoplasia,collagen vascular,and iatrogenic,such as *** has become common through the global implementation against coronavirus disease 2019(COVID-19)and reported complications like herpes zoster(HZ)activation has *** SUMMARY This is a 68-year-old woman who developed multiple pustules and scabs at the T6-T9 dermatome site 1 wk after vaccination with the COVID-19 vaccine(Oxford/AstraZeneca([ChAdOx1S{recombinant}]).The patient had a paraplegia aggravation 3 wk after HZ symptoms *** magnetic resonance imaging(MRI)showed transverse myelitis at the T6–T9 *** was acyclovir with steroids combined with physical *** neurological function was slowly restored by Day *** HZ developed after COVID-19 vaccination,which may lead to more severe ***,HZ treatment itself should not be *** neurological complications worsen after appropriate management,an immediate diagnostic procedure,such as magnetic resonance imaging and laboratory tests,will start and should treat the neurological complications.

关键词： Herpes zoster Transverse myelitis Paraplegia COVID-19 Vaccination Case report

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