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The Relationship between Thyroid Hormone Levels and Corrected QT Interval and QT Dispersion in Non-Diabetic Hemodialysis Patients

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Open Journal of Nephrology 2014年第1期4卷 13-19页

作者： Heo-Yeong Kim Ji Soo Kim Seung Eun Suh yu kyung hyun Kyeong Mi Park hyung-Jong Kim Department of Internal Medicine Bundang CHA Medical Center CHA University Seongnam South Korea

Background: Cardiovascular disease and sudden cardiac death are common in hemodialysis patients. These cardiac complications are often associated with prolonged QTc interval (QTc) and QTc dispersion (QTcd). Subclinical hypothyroidism (SH) can alter autonomic modulation of heart rate and cause increased inhomogeneity of ventricular recovery time. We aimed to evaluate the relationship between thyroid hormone levels and QTc and QTcd in non-diabetic hemodialysis patients. Methods: We enrolled 29 non-diabetic hemodialysis patients without thyroid disease. After each hemodialysis session, a 12-lead ECG was recorded. Before each hemodialysis session, routine laboratory tests and measurement of thyroid hormone levels were performed. Patients were divided into 2 groups according to QTc (group 1 QTc ms, group 2 QTc ≥ 430 ms). We examined the relationship between QTc or QTcd and thyroid hormone in the respective groups and then compared the results from the 2 groups. Results: The mean age was 54.06 ± 14.72 years and the means of QTc and QTcd were 433.82 ± 22.03 ms, 59.10 ± 28.29 ms, respectively. Homocysteine levels were significant higher in group 2 than group 1 (p 0.05) and QTcd was comparable between groups. In group 1, QTc and QTcd were not significant correlated with TSH, T3, fT4 and biochemical parameters. In group 2, QTc was significant positively correlated with TSH (p 0.05) and QTcd was not significant correlated with thyroid hormone levels. Conclusion: The results of this study showed that TSH is associated with prolonged QTc interval and hyperhomocysteinemia in non-diabetic hemodialysis patients. Moreover, we suggest that SH may be associated with prolonged QTc in non-diabetic hemodialysis patients. However, further studies are required to elucidate the role of the L-thyroxine doses and TSH target levels in hemodialysis patients.

关键词： Thyroid Hormone Hemodialysis Cardiovascular Disease

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Grain size dependence of flow stress in ECAPed Ti with constant texture

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中国有色金属学会会刊：英文版 2012年第S3期22卷 673-677页

作者： Chang-Young hyun Ho-kyung KIM Department of Materials Science and Engineering Seoul National University of Science and Technology Department of Automotive Engineering Seoul National University of Science and Technology

The effect of grain size on the flow stress in an ECAPed Ti with a constant texture was investigated,assuming that 2,4,5 and 6 passes microstructures have a similar *** average size of recrystallized grains decreased to 0.5 μm,0.4 μm,and 0.3 μm with respect to the ECAP pass number of 2,4,and 6,*** ultimate tensile strength (UTS) and yield strength (YS) increase with an increase in the number of *** UTS and YS of the 6 passes ECAPed sample were found to be 740.2 MPa and 580.3 MPa,*** equation for the flow stress of an ECAPed Ti with a constant texture as a function of the strain and grain size was derived for the ECAPed *** following equation was finally obtained:σ(ε)=103.9+1825ε-9.6ε1/2·d-1/2+8.3d-1/2.

关键词： Ti mechanical properties grain size flow stress equal channel angular pressing

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In situ synthesis of chemically bonded NaTi2（PO4）3/rGO 2D nanocomposite for high-rate sodium-ion batteries

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Nano Research 2016年第6期9卷 1844-1855页

作者： Ha-kyung Roh hyun-kyung Kim Myeong-Seong Kim Dong-hyun Kim kyung Yoon Chung Kwang Chul Roh Kwang-Bum Kim Department of Material Science & Engineering Yonsei University 50 Yonsei-ro Seodaemun-gu Seou103722 Republic of Korea Department of Materials Science and Metallurgy University of Cambridge 27 Charles Babbage Road Cambridge CB30FS UK Center for Energy Convergence Korea Institute of Science and Technology 5 Hwarang-ro 14-gil Seongbuk-gu Seou102792 Republic of Korea Energy & Environmental Division Korea Institute of Ceramic Engineering & Technology 101 Soho-ro Jinju-si Gyeongsangnam-do 52851 Republic of Korea

A phase-pure NaTi2（PO4）3/reduced graphene oxide （rGO） nanocomposite was prepared using a microwave-assisted one-pot method and subsequent heat treatment. The well-crystallized NaTi2（PO4）3 nanoparticles （30-40 nm） were uniformly precipitated on rGO templates through Ti-O-C bonds. The chemical interactions between the NaTi2（PO4）3 nanoparticles and rGO could immobilize the NaTi2（PO4）3 nanoparticles on the rGO sheets, which might be responsible for the excellent electrochemical performance of the nanocomposite. The NaTi2（PO4）B/rGO nanocomposite exhibited a specific capacity of 128.6 mA-h.g-1 approaching the theoretical value at a 0.1 C-rate with an excellent rate capability （72.9% capacity retention at 50 C-rate） and cycling performance （only 4.5% capacity loss after 1,000 cycles at a high rate of 10 C）. These properties were maintained even when the electrodes were prepared without the use of an additional conducting agent. The excellent sodium storage properties of the NaTi2（PO4）B/rGO nanocomposite could be attributed to the nano-sized NaTi2（PO4）3 particles, which significantly reduced the transport lengths for Na＋ ions, and an intimate contact between the NaTi2（PO4）3 particles and rGO due to chemical bonding.

关键词： NaTi2(PO4)dreducedgraphene oxide (rGO)nanocomposite chemical bonding energy-efficiency in situ synthesis high-rate sodium-ion batteries

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Three-dimensional label-free morphology of CD8+T cells as a sepsis biomarker

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Light(Science & Applications) 2023年第12期12卷 2565-2576页

作者： MinDong Sung Jong hyun Kim hyun-Seok Min Sooyoung Jang JaeSeong Hong Bo Kyu Choi JuHye Shin kyung Soo Chung yu Rang Park Division of Pulmonary and Critical Care Medicine Department of Internal MedicineYonsei University College of MedicineSeoulRepublic of Korea Department of Biomedical Systems Informatics Yonsei University College of MedicineSeoulRepublic of Korea Tomocube Inc155 Sinseong-roShinsung-dongYuseong-guDaejeonRepublic of Korea

Sepsis is a dysregulated immune response to infection that leads to organ dysfunction and is associated with a high incidence and mortality *** lack of reliable biomarkers for diagnosing and prognosis of sepsis is a major challenge in its *** aimed to investigate the potential of three-dimensional label-free CD8+T cell morphology as a biomarker for *** study included three-time points in the sepsis recovery cohort(N=8)and healthy controls(N=20).Morphological features and spatial distribution within cells were compared among the patients'*** developed a deep learning model to predict the diagnosis and prognosis of sepsis using the internal cell *** between the morphological features and clinical indices were *** morphological features and spatial distribution differed significantly between patients with sepsis and healthy controls and between the survival and non-survival *** model for predicting the diagnosis and prognosis of sepsis showed an area under the receiver operating characteristic curve of nearly 100%with only a few cells,and a strong correlation between the morphological features and clinical indices was *** study highlights the potential of three-dimensional label-free CD8+T cell morphology as a promising biomarker for *** approach is rapid,requires a minimum amount of blood samples,and has the potential to provide valuable information for the early diagnosis and prognosis of sepsis.

关键词： sepsis diagnosis Morphological

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A Miniaturized Tadpole Robot Using an Electromagnetic Oscillatory Actuator

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Journal of Bionic Engineering 2015年第1期12卷 29-36页

作者： Bu hyun Shin kyung-Min Lee Seung-Yop Lee Department of Mechanical Engineering Hanbat National University Daejeon 305-719 Korea Convergence Technology Examination Division Korean Intellectual Property Office Daejeon 302-701 Korea Department of Mechanical Engineering Sogang University Seoul 121-742 Korea

In this paper, we propose a miniaturized tadpole-like robot using an electromagnetic oscillatory actuator. The electro- magnetic actuator has a simple structure with a moving-magnet type and the body size is 13 mm （length） × 11 mm （height） ×10 mm （width）. A tail has the thickness of 100 μm and the length of 20 mm which is twice of the body-length （BL）. The tail attached to the oscillatory actuator generates undulatory propulsion for the forward swimming. Moreover, the tadpole robot enables the change of the direction by controlling input signal pattems applied to the oscillatory actuator. Prototypes of the tadpole robot have been manufactured and the thrust force and swimming speed are measured to evaluate the performance of the biomimetic robot in water at various tail-beat frequencies. The maximum thrust force is 42 mN at the tail-beat frequency of 30 Hz with voltage of 3 V, enabling the tadpole robot to swim at the speed of 210 mm·s^-1 （6 BL·s^-1）. The tadpole robot can also change its moving direction with the angular velocity of 21 deg·s^-1 at the half pulse pattem of 30 Hz.

关键词： fish robot biomimetics tadpole robot electromagnetic actuator

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Small RNA- and DNA-based gene therapy for the treatment of liver cirrhosis, where we are?

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World Journal of Gastroenterology 2014年第40期20卷 14696-14705页

作者： kyung-hyun Kim Kwan-Kyu Park Department of Pathology College of Medicine Catholic University of Daegu Daegu 705-718 South Korea

Chronic liver diseases with different aetiologies rely on the chronic activation of liver injuries which result in a fibrogenesis progression to the end stage of cirrhosis and liver *** on the underlying cellular and molecular mechanisms of a liver fibrosis,there has been proposed several kinds of approaches for the treatment of liver ***,liver gene therapy has been developed as an alternative way to liver transplantation,which is the only effective therapy for chronic liver *** activation of hepatic stellate cells,a subsequent release of inflammatory cytokines and an accumulation of extracellular matrix during the liver fibrogenesis are the major obstacles to the treatment of liver *** targeted strategies have been developed,such as antisense oligodeoxynucleotides,RNA interference and decoy oligodeoxynucleotides to overcome this *** this report an overview will be provided of targeted strategies for the treatment of liver cirrhosis,and particularly,of the targeted gene therapy using short RNA and DNA segments.

关键词： Liver cirrhosis Gene therapy Oligodeoxynucleotides Antisense Small interfering RNA Micro RNA Decoy

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Transcriptomic Responses of Garlic(Allium sativum L.)to Heat and Drought Stresses

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Phyton-International Journal of Experimental Botany 2023年第11期92卷 3077-3090页

作者： Seung Hee Eom Tae kyung hyun Department of Industrial Plant Science and Technology Chungbuk National UniversityCheongju28644Korea

Heat and drought are prominent abiotic stressors that limit crop productivity and yield,particularly concerning climate change;therefore,understanding the molecular mechanisms underlying plant stress responses is crucial for stress-tolerant crop *** study conducted a transcriptomic analysis to elucidate how garlic(Allium sativum L.)responds to drought and heat stress *** libraries were generated to identify differentially expressed genes(DEGs)induced by drought and heat *** classification and clustering analysis of DEGs revealed stress-specific gene expression ***,cell wall-related genes were implicated in the drought response,whereas heat stress was associated with heat stress transcription factors and heat shock *** results provide essential information for future studies on stress tolerances in garlic.

关键词： Differentially expressed gene drought heat garlic transcriptome

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Relationship between early structural changes at cornea incision sites and surgical outcomes after phacoemulsification

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International Journal of Ophthalmology(English edition) 2019年第7期12卷 1139-1145页

作者： kyung hyun Jin Tae Gi Kim Department of Ophthalmology Kyung Hee University Medical Center Kyung Hee University Seoul 02447 Korea Department of Ophthalmology Kyung Hee University Hospital at Gangdong Kyung Hee University Seoul 05278 Korea

AIM: To assess the early structural changes at clear corneal cataract incision sites and surgical outcomes using anterior segment optical coherence tomography(AS-OCT).METHODS: We evaluated 80 eyes of 59 patients who underwent phacoemulsification with a clear corneal incision. All incisions were evaluated 1 wk, 1, and 3 mo postoperatively using AS-OCT and analyzed regarding angle, length of the incision, maximal corneal thickness at the incision, and if present, corneal endothelial gap length and incision gap area. The patients were divided into two groups according to whether or not an endothelial gap was present at 1 wk postoperatively(endothelial gap, group 1;no endothelial gap, group 2). We analyzed the difference in patient and surgical factors between the two groups, and compared the surgical outcome and the refractive ***: An endothelial gap was observed in 56(70.0%) of 80 eyes at 1 wk postoperatively but not at 3 mo postoperatively. The mean patient age was significantly higher in group 1 than in group 2. The longer the length of the corneal incision and the steeper the incision angle, the greater the length and area of the endothelial gap. In group 1, the mean change in mean keratometry of the anterior cornea was significantly greater than in group 2, and the spherical equivalent(SE) and mean numerical error indicated significant myopic changes at 1 wk postoperatively. CONCLUSION: The risk of an endothelial gap increases with patient age and a long corneal incision and steep incision angle. The presence of an endothelial gap aftersurgery may affect the early postoperative corneal curvature and SE.

关键词： corneal incision structure phacoemulsification corneal curvature corneal endothelial gap anterior segment optical coherence tomography

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Stability of PAC(Psy-2A-Crt I) gene and agronomic traits in the F_(2:3) of IR36/PAC transgenic plants

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Journal of Integrative Agriculture 2015年第6期14卷 1163-1170页

作者： hyun Suk Lee Gihwan Yi kyung Min Kim Division of Plant Biosciences School of Applied Biosciences College of Agriculture and Life Science Kyungpook National University Department of Farm Management College of Agriculture and Life Science Kyungpook National University

This study was carried out to evaluate the expression of yellow endosperm color in the progeny of Psy-2A-Crt I（β-carotene gene, PAC） transgenic plants crossed with IR36. The selected 25 lines of F2 progeny exhibited stable expression of yellow endosperm color and high agronomic characteristics. IR36 and PAC transgenic plant of the grain length, width and ratio showed the same tendency of normal distribution. For progeny selection, colorimeters were as employed to distinguish differing visible colors. Correlation analysis was conducted to investigate the relationship between b＊ value and the expression of specific genes. b＊ value was associated with the relative expression of the PAC-Rev and MAR product by real-time PCR and t-test revealed significant difference. Based on this study, correlation between colorimetric values and real-time PCR was effective to detect gene expression. Yellow endosperm progenies represent a new genetic pool that might be useful to increase the genetic diversity of yellow endosperm rice.

关键词： transgenic agronomic crossed yellow breeding panicle length distinguish phenotype Correlation

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Effective parameters on diameter of carbon nanotubes by plasma enhanced chemical vapor deposition

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中国有色金属学会会刊：英文版 2012年第S3期22卷 712-716页

作者： Kang Young JEONG hyun kyung JUNG hyung Woo LEE National Core Research Center for Hybrid Materials Solution Hybrid Graduate SchoolPusan National University Department of Diagnostic Radiology Inje University College of MedicineHaeundae Paik Hospital

The effective parameters on the diameter of carbon nanotubes (CNTs) by plasma enhanced chemical vapor deposition (PECVD) were *** lots of influential parameters,the effects of the catalytic film thickness and the pretreatment plasma power on the growth of CNTs were *** results show that the size of catalytic islands increases by increasing the thickness of catalytic layer,but the density of CNTs *** pretreatment duration time of 30 s is the optimal condition for growing CNTs with about 50 nm in *** increasing the pretreatment plasma power,the diameter of CNTs decreases ***,the diameter of CNTs does not change drastically from 80 to 120 *** uniformly grown CNTs with the diameter of 50 nm are obtained at the pretreatment plasma power of 100 W.

关键词： carbon nanotubes catalytic film thickness pretreatment plasma power plasma enhanced chemical vapor deposition

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