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Cost-effective screening using a two-antibody panel for detecting mismatch repair deficiency in sporadic colorectal cancer

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World Journal of Clinical Cases 2021年第24期9卷 6999-7008页

作者： Jong Beom kim Young Il kim Yong Sik Yoon Jihun kim Seo Young Park Jong Lyul Lee Chan Wook kim In Ja Park Seok-Byung Lim Chang Sik yu jin Cheon kim Division of Colon and Rectal Surgery University of Ulsan College of MedicineAsan Medical CenterSeoul 05505South Korea Department of Pathology University of Ulsan College of MedicineAsan Medical CenterSeoul 05505South Korea Department of Clinical Epidemiology and Biostatistics University of Ulsan College of MedicineAsan Medical CenterSeoul 05505South Korea

BACKGROUND The microsatellite instability(MSI)test and immunohistochemistry(IHC)are widely used to screen DNA mismatch repair(MMR)deficiency in sporadic colorectal cancer(CRC).For IHC,a two-antibody panel of MLH1 and MSH2 or four-antibody panel of MLH1,MSH2,PMS2,and MSH6 are *** general,MSI is known as a more accurate screening test than *** To compare two-and four-antibody panels of IHC in terms of accuracy and cost benefit on the basis of MSI testing for detecting MMR *** We retrospectively analyzed patients with CRC who underwent curative surgery between 2015 and 2017 at a tertiary referral *** IHC with four antibodies and MSI tests were routinely *** sensitivity and specificity of a fourand two types of two-antibody panels(PMS2/MSH6 and MLH1/MSH2)were compared on the basis of MSI testing for detecting MMR *** High-frequency MSI was found in 5.5%(n=193)of the patients(n=3486).The sensitivities of the four-and two types of two-antibody panels were 97.4%,92.2%,and 87.6%,*** specificities of the three types of panels did not differ significantly(99.6%for the four-antibody and PMS2/MSH6 panels,99.7%for the MLH1/MSH2 panel).Based on Cohen's kappa statistic(κ),four-and twoantibody panels were in almost perfect agreement with the MSI test(κ>0.9).The costs of the MSI test and the four-and two-antibody panels of IHC were approximately$200,$160,and$80,*** Considering the cost of the four-antibody panel IHC compared to that of the twoantibody panel IHC,a two-antibody panel of PMS2/MSH6 might be the best choice in terms of balancing cost-effectiveness and accuracy.

关键词： Adenocarcinoma DNA mismatch repair Immunochemistry Monoclonal antibody Microsatellite instability Cost-effectiveness

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Triboelectric nanogenerators with gold-thin-film-coated conductive textile as floating electrode for scavenging wind energy

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Nano Research 2018年第1期11卷 101-113页

作者： Bhaskar Dudem Dong Hyun kim Jae Su yu Department of Electronic Engineering Kyung Hee University 1732 Deogyeong-daero Giheung-gu Yongin-si Gyeonggi-do 446-701Republic of Korea

We report triboelectric nanogenerators （TENGs） composed of a flexible and cost-effective gold-coated conductive textile （CT） to convert wind energy into electricity. The Au-coated CT is employed because of its high surface roughness resulting from Au nanodots distributed on microsized fibers. Thus, the Au-coated CT with nano/microarchitecture plays an important role in enhancing the effective contact area as well as the output performance of the TENG. Moreover, the surface roughness of the Au-coated CT is controlled by adjusting the Au thermal deposition time or tailoring the diameter of the Au nanodots. At an applied wind speed of 10 m.s-1, a wind-based TENG （W-TENG） with dimensions of 75 mm × 12 mm ×25 mm produces an open-circuit voltage （Voc） of - 39 V and a short-circuit current （Isc） of - 3 A by using the airflow-induced vibrations of an optimized Au-coated CT between two flat polydimethylsiloxane （PDMS） layers. To further specify the device performance, the electric output of the W-TENG is analyzed by varying several parameters such as the distance between the PDMS layer and Au-coated CT, applied wind speed, external load resistance, and surface roughness of the PDMS layers. Introducing an inverse micropyramid architecture on the PDMS layers further improves the output performance of the W-TENG, which exhibits the highest Voc （- 49 V） and Isc （- 5μA） values at an applied wind speed of 6.8 m.s-1. Additionally, the reliability of the W-TENG is also tested by measuring its output current during long-term cyclic operation. Furthermore, the rectified output signals observed by the W-TENG device are used as a direct power source to light 45 green commercial light-emitting diodes connected in series and also to charge capacitors （100 and 4.7μF）. Finally, the output performance of the W-TENG device in an actual windy situation is also investigated.

关键词： triboelectric nanogenerators Au-coated conductivetextile polydimethylsiloxanelayer wind energy

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Impression of prognosis regarding pathologic stage after preoperative chemoradiotherapy in rectal cancer

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World Journal of Gastroenterology 2015年第2期21卷 563-570页

作者： Kyungyeon Hwang In Ja Park Chang Sik yu Seok-Byung Lim Jong Lyul Lee Yong Sik Yoon Chan Wook kim jin Cheon kim Department of Colon and Rectal Surgery University of Ulsan College of Medicine and Asan Medical CenterSeoul 138-736South Korea

AIM: To ascertain pathologic stage as a prognostic indicator for rectal cancer patients receiving preoperative chemoradiotherapy(PCRT).METHODS: Patients with mid- and low rectal carcinoma(magnetic resonance imaging- based clinical stage Ⅱ or Ⅲ) between 2000 and 2009 and treated with curative radical resection were identified. Patients were divided into two groups: PCRT and No-PCRT. Recurrence-free survival(RFS) was examined according to pathologic stage and addition of adjuvant ***: Overall, 894 patients were identified. Of these, 500 patients received PCRT. Adjuvant chemotherapy was delivered to 81.5% of the No-PCRT and 94.8% of the PCRT patients. Adjuvant radiotherapy was given to 29.4% of the patients in the No PCRT group. The 5-year RFS for the No-PCRT group was 92.6% for StageⅠ, 83.3% for Stage Ⅱ, and 72.9% for Stage Ⅲ. The 5-year RFS for the PCRT group was 95.2% for yp Stage 0, 91.7% for yp StageⅠ, 73.9% for yp Stage Ⅱ, and 50.7% for yp Stage Ⅲ.CONCLUSION: Pathologic stage can predict prognosis in PCRT patients. Five-year RFS is significantly lower among PCRT patients than No-PCRT patients in pathologic stage Ⅱ and Ⅲ. These results should be taken into account when considering adjuvant treatment for patients treated with PCRT.

关键词： Preoperative Chemoradiotherapy Rectal cancer Patho

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Nanoparticle-Mediated Lipid Metabolic Reprogramming of T Cells in Tumor Microenvironments for Immunometabolic Therapy

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Nano-Micro Letters 2021年第2期13卷 180-206页

作者： Dongyoon kim Yina Wu Qiaoyun Li yu-Kyoung Oh College of Pharmacy and Research Institute of Pharmaceutical Sciences Seoul National UniversitySeoul 08826Republic of Korea

We report the activation of anticancer effector functions of T cells through nanoparticle-induced lipid metabolic *** was encapsulated in amphiphilic polygamma glutamic acid-based nanoparticles(F/ANs),and the surfaces of F/ANs were modified with an anti-CD3e f(ab′)2 fragment,yielding aCD3/F/*** in vitro study reveals enhanced delivery of aCD3/F/ANs to T cells compared with plain F/***3/F/AN-treated T cells exhibited clear mitochondrial cristae,a higher membrane potential,and a greater mitochondrial oxygen consumption rate under glucose-deficient conditions compared with T cells treated with other nanoparticle *** proliferatoractivated receptor-αand downstream fatty acid metabolismrelated genes are expressed to a greater extent in aCD3/F/AN-treated T *** of fatty acid metabolism by aCD3/F/ANs supports the proliferation of T cells in a glucose-deficient environment mimicking the tumor ***-time video recordings show that aCD3/F/AN-treated T cells exerted an effector killing effect against B16F10 melanoma *** vivo administration of aCD3/F/ANs can increase infiltration of T cells into tumor *** treatment of tumor-bearing mice with aCD3/F/ANs enhances production of various cytokines in tumor tissues and prevented tumor *** findings suggest the potential of nanotechnology-enabled reprogramming of lipid metabolism in T cells as a new modality of immunometabolic therapy.

关键词： Metabolic reprogramming T cells Fatty acid metabolism Immunometabolic therapy Mitochondrial function

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Recent developments of emerging inorganic, metal and carbon- based nanomaterials for pressure sensors and their healthcare monitoring applications

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Nano Research 2021年第9期14卷 3096-3111页

作者： Kyowon Kang Jaejin Park Kiho kim Ki Jun yu School of Electrical and Electronic Engineering YU-KIST InstituteYonsei UniversitySeoul 03722Republic of Korea

Recently,flexible pressure sensors have gained substantial research interest in bioelectronics because they can monitor the conditions of various organs,enable early diagnosis of diseases,and provide precise medical treatment by applying them to various parts of the *** particular,inorganic materials,metal and carbon-based materials are broadly used in novel structured pressure sensors from wearable devices to implantable *** the excellent electronic properties,distinctive morphologies,and remarkable mechanical and chemical stability of these materials,it is expected that these flexible pressure sensors can be the basis for new methods for human *** article covers an extensive review of the inorganic,metal and carbon-based flexible pressure sensor design strategies and sensing mechanisms studied in recent years for diverse applications such as tactile sensors,arterial pulse sensors,intracranial pressure sensors,intraocular pressure sensors,and bladder pressure *** section provides an overview by introducing the recent progress in flexible pressure sensors.

关键词： nanomaterial inorganic carbon pressure sensor wearable device implantable device

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Progress in developing self-consolidating concrete(SCC)constituting recycled concrete aggregates:A review

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International Journal of Minerals,Metallurgy and Materials 2021年第4期28卷 522-537页

作者： yu-Xuan Liu Tung-Chai Ling kim-Hung Mo Key Laboratory for Green&Advanced Civil Engineering Materials and Application Technology of Hunan Province College of Civil EngineeringHunan UniversityChangsha 410082China Department of Civil Engineering Faculty of EngineeringUniversity of MalayaMalaysia

Recycled concrete aggregate(RCA)derived from demolition waste has been widely explored for use in civil engineering *** of the promising strategies globally is to incorporate RCA into concrete ***,the use of RCA in high-performance concrete,such as self-consolidating concrete(SCC),has only been studied in the past *** paper summarizes recent publications on the use of coarse and/or fine RCA in *** expected,the high-water absorption and porous structure of RCA have posed challenges in producing a high-fluidity *** to an analysis of published data,a lower strength reduction(within 23%regardless of coarse RCA content)is observed in SCC compared with vibrated concrete,possibly due to the higher paste content in the SCC matrix,which enhances the weak surface layer of RCA and interfacial transition ***,SCC tends to become less durable with RCA substitution although the deterioration can be minimized by using treated RCA through removing or strengthening the adhered *** date,the information reported on the role of RCA in the long-term performance of SCC is still limited;thus,a wide range of research is needed to demonstrate the feasibility of RCA–SCC in field applications.

关键词： self-consolidating concrete construction and demolition waste recycled concrete aggregate(RCA) durability property enhancement

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Cumulative incidence and risk factors for pouch adenomas associated with familial adenomatous polyposis following restorative proctocolectomy

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World Journal of Gastroenterology 2022年第30期28卷 4152-4162页

作者： Hyo Seon Ryu Chang Sik yu Young Il kim Jong Lyul Lee Chan Wook kim Yong Sik Yoon In Ja Park Seok-Byung Lim jin Cheon kim Division of Colon and Rectal Surgery Department of SurgeryUniversity of Ulsan College of MedicineAsan Medical CenterSeoul 05505South Korea

BACKGROUND The emergence of restorative total proctocolectomy has significantly reduced the lifetime colorectal cancer risk associated with familial adenomatous polyposis(FAP).However,adenomas may develop in the ileal pouch over time and may even progress to *** evaluated the cumulative incidence,time to development,and risk factors associated with ileal pouch *** To evaluate the cumulative incidence,time to development,and risk factors associated with pouch *** In this retrospective,observational study conducted at a tertiary center,95 patients with FAP who underwent restorative proctocolectomy at our center between 1989 and 2018 were consecutively *** mean follow-up period was 88 *** Pouch adenomas were found in 24(25.3%)patients,with a median time of 52 mo to their first *** adenomas were detected in most patients(95.9%).There were no high-grade dysplasia or *** the 24 patients with pouch adenomas,13 had all detected adenomas *** the 13 patients who underwent complete adenoma removal,four(38.5%)developed *** 11(45.8%)patients with numerous polyps within the pouch,seven(63.6%)exhibited progression of pouch *** cumulative risks of pouch adenoma development at 5,10,and 15 years after pouch surgery were 15.2%,29.6%,and 44.1%,*** colorectal polyposis(with more than 1000 polyps)was a significant risk factor for pouch adenoma development(hazard ratio,2.49;95% confidence interval:1.04-5.96;P=0.041).CONCLUSION Pouch adenomas occur at a fairly high rate in association with FAP after restorative proctocolectomy,and a high colorectal polyp count is associated with pouch adenoma development.

关键词： Adenomatous polyposis coli Familial adenomatous polyposis Adenoma Intestinal polyps Proctocolectomy,restorative Ileal pouch anal anastomosis

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Oxidative stress and inflammatory signaling in cerulein pancreatitis

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World Journal of Gastroenterology 2014年第46期20卷 17324-17329页

作者： Ji Hoon yu Hyeyoung kim New Drug Development Center Daegu-Gyeongbuk Medical Innovation FoundationDaegu 701-310South Korea Department of Food and Nutrition Brain Korea 21 PLUS ProjectCollege of Human EcologyYonsei UniversitySeoul 120-749South Korea

Oxidative stress is considered to be an important regulator of the pathogenesis of acute pancreatitis. Reactive oxygen species (ROS) regulate the activation of inflammatory cascades, the recruitment of inflammatory cells and tissue damage in acute pancreatitis. A hallmark of the inflammatory response in pancreatitis is the induction of cytokine expression, which is regulated by a number of signaling molecules including oxidant-sensitive transcription factors such as nuclear factor-κB (NF-κB) and activator protein-1 (AP-1), signal transducer and activator of transcription 3 (STAT3), and mitogen-activated protein kinases (MAPKs). Cross-talk between ROS and pro-inflammatory cytokines is mediated by NF-κB, AP-1, STAT3, and MAPKs; this crosstalk amplifies the inflammatory cascade in acute pancreatitis. Therapeutic studies have shown that antioxidants and natural compounds can have beneficial effects for patients with pancreatitis and can also influence the expression of proinflammatory cytokines in cerulein-induced pancreatitis. Since oxidative stress may activate inflammatory signaling pathways and contribute to the development of pancreatitis, antioxidant therapy may alleviate the symptoms or prevent the development of pancreatitis. Since chronic administration of high doses of antioxidants may have deleterious effects, dosage levels and duration of antioxidant treatment should be carefully determined.

关键词： Reactive oxygen species Inflammatory signaling Cerulein pancreatitis

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Tp53 gene mediates distinct dopaminergic neuronal damage in different dopaminergic neurotoxicant models

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Neural Regeneration Research 2017年第9期12卷 1413-1417页

作者： Tao Lu Paul kim yu Luo Department of Neurological Surgery Case Western Reserve University Medical Faculty Kunming University of Science and Technology

Tp53, a stress response gene, is involved in diverse cell death pathways and its activation is implicated in the pathogenesis of Parkinson＇s disease. However, whether the neuronal Tp53 protein plays a direct role in regulating dopaminergic （DA） neuronal cell death or neuronal terminal damage in different neurotoxicant models is unknown. In our recent studies, in contrast to the global inhibition of Tp53 function by phar- macological inhibitors and in traditional Tp53 knock-out mice, we examined the effects of DA-specific Tp53 gene deletion after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and methamphetamine exposure. Our data suggests that the Tp53 gene might be involved in both neuronal apoptosis and neuronal termi- nal damage caused by different neurotoxicants. Additional results from other studies also suggest that as a master regulator of many pathways that regulate apoptosis and synaptic terminal damage, it is possible that Tp53 may function as a signaling hub to integrate different signaling pathways to mediate distinctive target pathways. Tp53 protein as a signaling hub might be able to evaluate the microenvironment of neurons, assess the forms and severities of injury incurred, and determine whether apoptotic cell death or neuro- nal terminal degeneration occurs. Identification of the precise mechanisms activated in distinct neuronal damage caused by different forms and severities of injuries might allow for development of specific Tp53 inhibitors or ways to modulate distinct downstream target pathways involved.

关键词： Parkinson's disease Tp53 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity apoptosis methamphetamine

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Postoperative changes of manometry after restorative proctocolectomy in Korean ulcerative colitis patients

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World Journal of Gastroenterology 2017年第31期23卷 5780-5786页

作者： se heon oh yong sik yoon jong lyul lee chan wook kim in ja park seok-byung lim chang sik yu jin cheon kim department of surgery division of colon and rectal surgery university of ulsan college of medicine asan medical center

To investigate the changes of postoperative anal sphincter function and bowel frequency in Korean patients with ulcerative colitis (UC). METHODSA total of 127 patients with UC who underwent restorative proctocolectomy (RPC) during 20 years were retrospectively analyzed. The parameters of anal manometry and bowel frequency were compared according to the 6-mo intervals until 24 mo postoperatively. Manometry was used to measure the maximal squeezing pressure (MSP) and maximal resting pressure (MRP). RESULTSMSP decreased after surgery until 6 mo (157 to 142 mmHg); thereafter, it improved and was recovered to and maintained at the preoperative value at 12 mo postoperatively (142-170 mmHg, P < 0.001). Although the decreased MRP (65 to 56 mmHg) improved after 18 mo (62 mmHg), it did not completely recover to the preoperative value. The decreased rectal capacity after surgery (90 to 82 mL) gradually increased up to 150 mL at 24 mo. Although bowel frequency showed significant gradual decreases at each interval, it was stabilized after 12 mo postoperatively (6.5 times/d). CONCLUSIONPostoperative changes of manometry and bowel frequency after restorative proctocolectomy in Korean patients with UC were not different from those in Western patients with UC.

关键词： Ulcerative colitis Surgery Treatment outcome Manometry Bowel frequency Restorative proctocolectomy

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