Oxidative stress and inflammatory signaling in cerulein pancreatitis

作     者：Ji Hoon Yu Hyeyoung Kim 

作者机构：New Drug Development CenterDaegu-Gyeongbuk Medical Innovation FoundationDaegu 701-310South Korea Department of Food and NutritionBrain Korea 21 PLUS ProjectCollege of Human EcologyYonsei UniversitySeoul 120-749South Korea 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2014年第20卷第46期

页      面：17324-17329页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Supported by National Research Foundation of Korea grant funded by the Korea government No.2007-0056092 

主　　题：Reactive oxygen species Inflammatory signaling Cer 

摘      要：Oxidative stress is considered to be an important regulator of the pathogenesis of acute *** oxygen species(ROS)regulate the activation of inflammatory cascades,the recruitment of inflammatory cells and tissue damage in acute pancreatitis.A hallmark of the inflammatory response in pancreatitis is the induction of cytokine expression,which is regulated by a number of signaling molecules including oxidant-sensitive transcription factors such as nuclear factor-κB(NF-κB)and activator protein-1(AP-1),signal transducer and activator of transcription 3(STAT3),and mitogen-activated protein kinases(MAPKs).Cross-talk between ROS and pro-inflammatory cytokines is mediated by NF-κB,AP-1,STAT3,and MAPKs;this crosstalk amplifies the inflammatory cascade in acute *** studies have shown that antioxidants and natural compounds can have beneficial effects for patients with pancreatitis and can also influence the expression of proinflammatory cytokines in cerulein-induced *** oxidative stress may activate inflammatory signaling pathways and contribute to thedevelopment of pancreatitis,antioxidant therapy may alleviate the symptoms or prevent the development of *** chronic administration of high doses of antioxidants may have deleterious effects,dosage levels and duration of antioxidant treatment should be carefully determined.