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Effect of epidermal growth factor on follicle-stimulating hormone-induced proliferation of granulosa cells from chicken prehierarchical follicles

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第11期12卷 875-883页

作者： Jin-xing LIN yu-dong JIA Cai-qiao ZHANG Key Laboratory of Animal Epidemic Etiology ＆ Immunological Prevention of the Ministry of Agriculture Department of Veterinary Medicine College of Animal Sciences Zhejiang University Hangzhou 310058 China

The development of ovarian follicular cells is controlled by multiple circulating and local hormones and factors, including follicle-stimulating hormone （FSH） and epidermal growth factor （EGF）. In this study, the stagespecific effect of EGF on FSH-induced proliferation of granulosa cells was evaluated in the ovarian follicles of egg-laying chickens. Results showed that EGF and its receptor （EGFR） mRNAs displayed a high expression in granulosa cells from the prehierarchical follicles, including the large white follicle （LWF） and small yellow follicle （SYF）, and thereafter the expression decreased markedly to the stage of the largest preovulatory follicle. SYF represents a turning point of EGF/EGFR mRNA expression during follicle selection. Subsequently the granulosa cells from SYF were cultured to reveal the mediation of EGF in FSH action. Cell proliferation was remarkably increased by treatment with either EGF or FSH （0.1-100 ng/ml）. This result was confirmed by elevated proliferating cell nuclear antigen （PCNA） expression and decreased cell apoptosis. Furthermore, EGF-induced cell proliferation was accompanied by increased mRNA expressions of EGFR, FSH receptor, and the cell cycle-regulating genes （cyclins D1 and El, cyclin-dependent kinases 2 and 6） as well as decreased expression of luteinizing hormone receptor mRNA. However, the EGF or FSH-elicited effect was reversed by simultaneous treatment with an EGFR inhibitor AG1478. In conclusion, EGF and EGFR expressions manifested stage-specific changes during follicular development and EGF mediated FSH-induced cell proliferation and retarded cell differentiation in the prehierarchical follicles. These expressions thus stimulated follicular growth before selection in the egg-laying chicken.

关键词： Epidermal growth factor Follicle-stimulating hormone Granulosa cell Proliferation Chicken

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VISPNN:VGG-Inspired Stochastic Pooling Neural Network

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Computers, Materials & Continua 2022年第2期70卷 3081-3097页

作者： Shui-Hua Wang Muhammad Attique Khan yu-dong Zhang School of Mathematics and Actuarial Science University of LeicesterLeicesterLE17RHUnited Kingdom Department of Computer Science HITEC University TaxilaTaxila47080Pakistan School of Informatics University of LeicesterLeicesterLE17RHUnited Kingdom

Aim Alcoholism is a disease that a patient becomes dependent or addicted to *** paper aims to design a novel artificial intelligence model that can recognize alcoholism more *** We propose the VGG-Inspired stochastic pooling neural network(VISPNN)model based on three components:(i)a VGG-inspired mainstay network,(ii)the stochastic pooling technique,which aims to outperform traditional max pooling and average pooling,and(iii)an improved 20-way data augmentation(Gaussian noise,salt-and-pepper noise,speckle noise,Poisson noise,horizontal shear,vertical shear,rotation,Gamma correction,random translation,and scaling on both raw image and its horizontally mirrored image).In addition,two networks(Net-I and Net-II)are proposed in ablation ***-I is based on VISPNN by replacing stochastic pooling with ordinary max ***-II removes the 20-way data *** The results by ten runs of 10-fold cross-validation show that our VISPNN model gains a sensitivity of 97.98±1.32,a specificity of 97.80±1.35,a precision of 97.78±1.35,an accuracy of 97.89±1.11,an F1 score of 97.87±1.12,an MCC of 95.79±2.22,an FMI of 97.88±1.12,and an AUC of 0.9849,*** The performance of our VISPNN model is better than two internal networks(Net-I and Net-II)and ten state-of-the-art alcoholism recognition methods.

关键词： Deep learning alcoholism multiple-way data augmentation VGG convolutional neural network stochastic pooling

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Exogenous Nitric Oxide Involved in Subcellular Distribution and Chemical Forms of Cu^(2+) Under Copper Stress in Tomato Seedlings

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Journal of Integrative Agriculture 2013年第10期12卷 1783-1790页

作者： dong yu-xiu WANG Xiu-feng CUI Xiu-min Key Laboratory of Crop Biology Shandong Agricultural University College of Resources and Environment Shandong Agricultural University

Nitric oxide（NO）,a bioactive signaling molecule,serves as an antioxidant and anti-stress agent under abiotic stress.A hydroponics experiment was conducted to investigate the effects of sodium nitroprusside（SNP）,a NO donor,on tomato seedlings exposed to 50 μmol L-1CuCl *** results show that copper is primarily stored in the soluble cell sap fraction in the roots,especially after treatment with Cu＋SNP treatment,which accounted for 66.2% of the total copper *** copper concentration gradually decreased from the roots to the *** the leaves,exogenous NO induces the storage of excess copper in the cell *** stress decreases the proportion of copper integrated with pectates and proteins,but exogenous NO remarkably reverses this *** alleviating effect of NO is blocked by ***,exogenous NO is likely involved in the regulation of the subcellular copper concentrations and its chemical forms under copper *** exogenous NO inhibited the absorption and transport of excess copper to some extent,the copper accumulation in tomato seedlings significantly increased under copper *** use of exogenous NO to enhance copper tolerance in some plants is a promising method for copper remediation.

关键词： tomato seedlings nitric oxide copper stress subcellular distribution chemical form

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Composition and distribution of ground-dwelling beetles among oak fragments and surrounding pine plantations in a temperate forest of North China

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Insect Science 2014年第1期21卷 114-124页

作者： Xiao-dong yu Tian-Hong Luo Hong-Zhang Zhou Key Laboratory of Zoological Systematics and Evolution Institute of Zoology Chinese Academy of Sciences Beijing China

In this study, we compared ground-dwelling beetle assemblages （Coleoptera） from a range of different oak fragments and surrounding conifer plantations to evaluate effects of forest size and surrounding matrix habitat in a temperate forest of north China. During 2000, beetles were sampled via pitfall traps within two large oak fragments （ca. 2.0-4.0 ha）, two small oak fragments （ca. 0.2-0.4 ha） and two surrounding matrices dom- inated by pine plantations （〉4 ha） in two sites of different aspects. Overall, no significantly negative effects from forest patch size and the surrounding matrix habitat were detected in total species number and abundance of ground-dwelling beetles. However, compared with small oak patches or pine plantations, more species were associated with an affinity for at least one large oak patch of the two aspects. Multivariate regression trees showed that the habitat type better determined the beetle assemblage structure than patch size and aspect, indicating a strong impact of the surrounding matrix. Linear mixed models indicated that species richness and abundance of all ground-dwelling beetles or beetle families showed different responses to the selected environmental variables. Our results suggest that more disturbed sites are significantly poorer in oak forest specialists, which are usually more abundant in large oak fragments and decrease in abundance or disappear in small fragments and surrounding matrix habitats. Thus, it is necessary to preserve a minimum size of forest patch to create conditions characteristic for forest interior, rather than the more difficult task of increasing habitat connectivity.

关键词： forest patch size fragmentation ground-dwelling beetles North China,surrounding matrix habitat temperate forest

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In-vivo retinal imaging by optical coherence tomography using an RSOD-based phase modulator

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第4期10卷 607-612页

作者： Ling WANG Zhi-hua DING Guo-hua SHI yu-dong ZHANG State Key Laboratory of Modern Optical Instrumentation Zhejiang University Hangzhou 310027 China Institute of Optics and Electronies Chinese Academy of Sciences Chengdu 610209 China

Fourier-domain rapid scanning optical delay line (RSOD) was introduced for phase modulation and depth scanning in a time-domain optical coherence tomography (TD-OCT) system. Investigation of parameter optimization of RSOD was conducted. Experiments for RSOD characterization at different parameters of the groove pitch, focal length, galvomirror size, etc. were performed. By implementing the optimized RSOD in our established TD-OCT system with a broadband light source centered at 840 nm with 50 nm bandwidth, in vivo retina imaging of a rabbit was presented, demonstrating the feasibility of high-quality TD-OCT imaging using an RSOD-based phase modulator.

关键词： Optical coherence tomography (OCT) Phase modulation Retina imaging

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A hybrid trade-old-for-new and trade-old-for-remanufactured supply chain with carbon tax

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中国科学技术大学学报 2024年第8期54卷 39-52,38,I0002,I0003页

作者： yu dong Wuqing Liao School of Management University of Science and Technology of ChinaHefei 230026China

Facing serious environmental problems,governments and manufacturers are taking action to reduce carbon *** these endeavors,carbon tax policy are widely adopted by governments,and trade-old-for-new(TON)and trade-old-for-remanufactured(TOR)are offered by manufacturers and subsidized by *** explore the effects of remanufacturer competition and carbon tax on the manufacturer’s TON and TOR decisions and the environment,we formulate three profit maximization models and present some theoretical and numerical *** results show that,under the remanufacturer competition and carbon tax,the manufacturer’s optimal price and production decisions mainly depend on consumer willingness and carbon tax rate.A higher consumer willingness to manufacturer’s remanufactured products will decrease the demand for the manufacturer’s TON,but it always increases the demand for the manufacturer’s TOR.A higher consumer willingness to remanufacturer’s products will not affect the demand for the manufacturer’s TON;however,it will reduce the demand for manufacturer’s *** addition,we find that a higher carbon tax rate always reduces total carbon emission reduction,and that it may increase the manufacturer’s profit due to the increase in TOR demand.

关键词： trade-old-for-new trade-old-for-remanufactured remanufacturer competition carbon tax consumer willingness

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Microcracks repairing technique for gun barrel

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中国有色金属学会会刊：英文版 2004年第Z1期14卷 219-221页

作者： yu Xu-dong WU Bin SU Bing WANG Cheng-tao Military Engineering Department Artillery Academy Hefei 230031 China Military Engineering Department Artillery Academy Hefei 230031 China School of Mechanical Engineering Shanghai Jiaotong University Shanghai 200030China School of Mechanical Engineering Shanghai Jiaotong University Shanghai 200030China

When a gun fires the diffusion of chemical species from the propellant gas, such as CO, CO2, H2, H2O and N2, into the hot surface through the microcracks forms reaction products and speeds up the erosion ***, crack repairing and healing can be a possible measure for protecting against erosion of gun bore. The present study develops a novel nanocomposite with the size of 30 - 150 nm to repair and heal the microcracks so that the propellant gas can be prevented from reacting with the steel. Sample of gun steel 40CrNiMoV plate (10 mm× 10 mm × 2 mm) is prepared and a fishtail crack is generated through a repeated plastic deformation process. The crackrepairing results show that the fishtail crack become shorter and narrower. A new phase is formed, which is found to have the elements, such as Ca, La, from the raw materials of nanocomposite by energy spectrum analysis.

关键词： nanocomposite microcrack repair

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Surface and interface analysis of HAP/TiO2 composite films on Ti6Al4V

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中国有色金属学会会刊：英文版 2004年第Z1期14卷 193-198页

作者： SU Bing ZHANG Weng-guang yu Xu-dong WANG Cheng-tao School of Mechanical and Power Engineering Shanghai Jiaotong University Shanghai 200030 China School of Mechanical and Power Engineering Shanghai Jiaotong University Shanghai 200030 China 1st Department Artillery Academy of PLA of China Hefei 230031 China School of Mechanical and Power Engineering Shanghai Jiaotong University Shanghai 200030 China

The composite films constituted of hydroxyapatite (HAP) submicron particles embedded in the gel composed of the titania nanoparticles were prepared on commercial Ti6Al4V plates with titania buffer layer obtained by a spin-coating technique. The films were annealed in air at 450 ℃, 550 ℃ and 650 ℃, respectively. The phase formation, surface morphology, andinterfacial microstructure of the films were investigated by X-ray diffraction(XRD),Fourier transform infrared spectroscopy (FT-IR), field emission-scanning electron microscopy(FE-SEM) and energy dispersive X-ray (EDS) analysis. The results show that the as-prepared films are all well-crystallized, dense,homogeneous, and there was a close interfacial bond between the film and the substrate. The results of adhesion test indicate that there is a good bonding strength between the film and the substrate. The bone-like apatite formation on the surface of the films after immersion in acellular simulatedbody fluid(SBF) validated their bioactivities.

关键词： titanium dioxide hydroxyapatite composite film spin-coating technique

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Understanding the structure of d~*(2380) in chiral quark model

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Science China(Physics,Mechanics & Astronomy) 2016年第2期59卷 40-48页

作者： Fei Huang Peng Nian Shen yu Bing dong Zong Ye Zhang School of Physical Sciences University of Chinese Academy of Sciences Institute of High Energy Physics Chinese Academy of Sciences Theoretical Physics Center for Science Facilities Chinese Academy of Sciences College of Physics and Technology Guangxi Normal University

The structure and decay properties of d＊ have been detailedly investigated in both the chiral SU（3） quark model and the extended chiral SU（3） quark model that describe the energies of baryon ground states and the nucleon-nucleon （NN） scattering data satisfactorily. By performing a dynamical coupled-channels study of the system of △△ and hidden-color channel （CC） with quantum numbers l（JP） = 0（3^＋） in the framework of the resonating group method （RGM）, we find that the d＊ has a mass of about 2.38-2.42 GeV and a root-mean-square radius （RMS） of about 0.76-0.88 fm. The channel wave function is extracted by a projection of the RGM wave function onto the physical basis, and the fraction of CC component in the d＊ is found to be about 66%-68%, which indicates that the d＊ is a hexaquark-dominated exotic state. Based on this scenario the partial decay widths of d＊ → dπ^0π^0 and d＊ → dn^＋n^- are further explicitly evaluated and the total width is then obtained by use of the branching ratios extracted from the measured cross sections of other possible decay channels. Both the mass and the decay width of d＊ calculated in this work are compatible with the data （M ≈ 2380 MeV, F ≈ 70 MeV） reported by WASA-at-COSY Collaboration.

关键词： hexaquark state d*(2380) quark model hidden-color channel

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Suppression of Vortex-Induced Vibration Caused by A Terebridae-Inspired Cylinder with Different Helical Angles

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China Ocean Engineering 2024年第5期38卷 739-754页

作者： yu Qi-dong MAO Zhao-yong TIAN Wen-long WANG Wei Unmanned System Research Institute Northwestern Polytechnical UniversityXi’an 710072China School of Marine Science and Technology Northwestern Polytechnical UniversityXi’an 710072China Department of Civil and Environmental Engineering The Hong Kong Polytechnic UniversityKowloonHong KongChina

Biomimetic design has recently received widespread *** by the Terebridae structure,this paper provides a structural form for suppressing vortex-induced vibration(VIV)*** different structural forms are shown,including the traditional smooth cylinder(P0),and the Terebridae-inspired cylinder with the helical angle of 30°(P_(30)),60°(P_(60)),and 90°(P_(90)).Computational fluid dynamics(CFD)method is adopted to solve the flow pass the Terebridae-inspired structures,and the vibration equation is solved using the Newmark-β*** results show that for P_(30),P_(60) and P_(90),the VIV responses are effectively suppressed in the lock-in region,and P_(60) showed the best VIV suppression *** transverse amplitude and the downstream amplitude can be reduced by 82.67%and 91.43%respectively for P_(60) compared with that for P0,and the peak of the mean-drag coefficient is suppressed by 53.33%.The Q-criterion vortices of P_(30),P_(60),and P_(90) are destroyed,with irregular vortices *** is also found that the boundary layer separation is located on the Terebridae-inspired *** twisted ribs cause the separation point to constantly change along the spanwise direction,resulting in the development of the boundary layer separation being completely *** strength of the wake flow is significantly weakened for the Terebridae-inspired cylinder.

关键词： vortex-induced vibration(VIV) Terebridae cylinder suppression helical angle

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