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miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong Jing-Jing Hu yan yu Xiao-Li Li Xiao-Ting Sun Li-Ting Wang Xia Wu Ling-Jie Zhu Xiao-Jia yang Qian-Ru He Fei Ding Hai-yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

Analysis of Micromechanical Properties at the Interface of Pre-wet SBS Modified Asphalt Mixture Based on Molecular Simulation Technology

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 103-113页

作者： CHEN Wuxing CHEN Shuang yu yan ZHANG Jiangyi XU Haiyang GUO Wei School of Mines China University of Mining and TechnologyXuzhou 221000China College of Construction Engineering Jilin Uni-versityChangchun 130026China

The pre-wetting of aggregate surface is a means to improve the interface performance of SBS modified asphalt and *** effect of pre-wetting technology on the interaction between SBS modified asphalt and aggregate was analyzed by molecular dynamics *** diffusion coefficient and concentration distribution of SBS modified asphalt on aggregate surface are *** simulation results show that the diffusion coefficient of the aggregate surface of SBS modified asphalt is increased by 47.6%and 70.5%respectively after 110#asphalt and 130#asphalt are *** concentration distribution of SBS modified asphalt on the aggregate surface after pre-wetting is more *** to the results of interface energy calculation,the interface energy of SBS modified bitumen and aggregate can be increased by about 5%after *** to the results of molecular dynamics simulation,the pre-wetting technology can effectively improve the interface workability of SBS modified bitumen and aggregate,so as to improve the interface performance.

关键词： pre-wet oil-stone interface interface interaction interface mechanics molecular dynamics simulation

大语言模型对批评隐喻分析中隐喻识别的应用性研究

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外语学刊 2025年第1期 47-56页

作者：于艳春黑龙江大学外文学院哈尔滨150080 哈尔滨学院外国语学院哈尔滨150080

批评隐喻分析(critical metaphor analysis,CMA)作为一种语篇的隐喻分析方法,意在揭示语言使用者的潜在意图,不但可深化我们对语言隐喻的理解,还能揭示隐喻在人类思维和交流中的重要作用。隐喻识别作为CMA分析框架中的一个关键步骤,为... 详细信息

批评隐喻分析(critical metaphor analysis,CMA)作为一种语篇的隐喻分析方法,意在揭示语言使用者的潜在意图,不但可深化我们对语言隐喻的理解,还能揭示隐喻在人类思维和交流中的重要作用。隐喻识别作为CMA分析框架中的一个关键步骤,为隐喻阐释和隐喻说明等后续研究工作提供了坚实基础,是CMA中极其重要且不可或缺的一部分。本研究首先对CMA中隐喻识别的融合性和枢纽性进行深入讨论,探究CMA中隐喻识别的发展特性,熟悉CMA的整个分析框架。同时,针对CMA在隐喻识别中存在的客观性不足问题,提出尝试结合大语言模型(ChatGPT)进行隐喻识别的方法,并基于真实研究案例了解该方法的具体实践操作。通过案例,本研究也对使用大语言模型(ChatGPT)进行隐喻识别过程中遇到的问题进行分析和总结,希望通过合理、恰当地应用技术手段,探索人机协作的最佳方式,以提升隐喻识别的客观性,完善CMA的分析框架,更深入地进行语篇的隐喻研究。

关键词：大语言模型 ChatGPT 批评隐喻分析隐喻识别隐喻阐释隐喻说明

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反垄断干预、地区知识产权保护与企业专利创新——基于《反垄断法》准自然实验的经验

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经济问题 2025年第2期 31-39页

作者：于明言郑惠中天津市中国特色社会主义理论体系研究中心天津300191 中国人民大学应用经济学院北京100872

基于2006—2022年A股上市公司样本,以《反垄断法》的实施作为准自然实验,运用双重差分模型考察了我国调整市场竞争关系的具体部门法规范实施对企业专利创新的影响。结果发现,相比竞争性企业,《反垄断法》的实施显著抑制了垄断性企业的... 详细信息

基于2006—2022年A股上市公司样本,以《反垄断法》的实施作为准自然实验,运用双重差分模型考察了我国调整市场竞争关系的具体部门法规范实施对企业专利创新的影响。结果发现,相比竞争性企业,《反垄断法》的实施显著抑制了垄断性企业的专利创新活动,抑制效应通过降低企业研发费用进行传导,地区知识产权保护的增强可以显著削弱政策的抑制效应。进一步异质性分析结果表明,《反垄断法》的实施并不存在选择性执法现象,且对抑制国有企业创新激励有更显著的作用;《反垄断法》的实施在政府干预程度高的地区、高新技术产业抑制效果更强。研究发现丰富了反垄断规制对企业创新能力影响的相关研究,为政府干预中性提供了证据。

关键词：《反垄断法》企业创新专利质量知识产权保护

隐匿的法定裁量情节——基于《行政处罚法》第33条的展开

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甘肃政法大学学报 2025年第1期 122-137页

作者：严于南京大学法学院

行政处罚实践中广泛存在行政机关因法定裁量情节不足而无法减罚的困境.由于酌定裁量的法律依据、权力性质与法律效力具有特殊性,被续造的酌定裁量情节无法发挥与法定裁量情节同等的作用,多数执法者不敢据此减罚.《行政处罚法》(2021年修... 详细信息

行政处罚实践中广泛存在行政机关因法定裁量情节不足而无法减罚的困境.由于酌定裁量的法律依据、权力性质与法律效力具有特殊性,被续造的酌定裁量情节无法发挥与法定裁量情节同等的作用,多数执法者不敢据此减罚.《行政处罚法》(2021年修订)第33条是对多个从宽处罚情节叠加导致行政处罚裁量权收缩为不予行政处罚结果的规定,具有行政处罚裁量一般条款的性质.据此,“违法行为轻微”“没有造成危害后果或危害后果轻微”“及时改正”“初次违法”等不予处罚的个别要件,均为法定从宽处罚情节.反向解释则能得出“违法行为严重”“危害后果严重”“责令改正而拒不改正”“屡次违法”等为法定从严处罚情节.当出现三个或三个以上法定从宽处罚情节,又不存在从严处罚情节时,行政机关可以援引《行政处罚法》第32条和第33条的规定作出不予处罚决定.

关键词：法定裁量情节酌定裁量从宽处罚从严处罚

Refractive status and histological changes after posterior scleral reinforcement in guinea pig

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International Journal of Ophthalmology(English edition) 2025年第3期18卷 375-382页

作者： yu-yan Huang Li-yang Zhou Guo-Fu Chen Duo Peng Miao-Zhen Pan Ji-Bo Zhou Jia Qu National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina Hefei Aier Eye Hospital Hefei 230000Anhui ProvinceChina The Affiliated Suzhou Hospital of Nanjing Medical University Suzhou Municipal HospitalSuzhou 215000Jiangsu ProvinceChina Department of Ophthalmology Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China

AIM:To investigate the refractive and the histological changes in guinea pig eyes after posterior scleral reinforcement with scleral ***:Four-week-old guinea pigs were implanted with scleral allografts,and the changes of refraction,corneal curvature and axis length were monitored for *** effects of methylprednisolone(MPS)on refraction parameters were also *** the microstructure and ultra-microstructure of eyes were observed on the 9d and 51d after ***-measures analysis of variance and one-way analysis of variance were ***:The refraction outcome of the implanted eye decreased after operation,and the refraction change of the 3 mm scleral allografts group was significantly different with control group(P=0.005)and the sham surgical group(P=0.004).After the application of MPS solution,the reduction of refraction outcome was statistically suppressed(P=0.008).The inflammatory encapsulation appeared 9d after *** 51d after operation,the loose implanted materials were absorbed,while the adherent implanted materials with MPS group were still tightly attached to the recipient’s ***:After implantation of scleral allografts,the refraction of guinea pig eyes fluctuated from a decrease to an *** outcome of the scleral allografts is affected by implantation methods and the inflammatory *** of the material can be improved by MPS.

关键词： posterior scleral reinforcement methylprednisolone inflammation myopia guinea pig

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基于关键词语义功能的领域主题演化分析

情报杂志 2025年第1期44卷 187-197页

作者：俞琰郑斯煜葛萌南京工业大学图书馆南京210009

[研究目的]领域主题演化分析利用领域科技文献,识别领域主题构成,揭示领域主题变化和演化脉络,具有十分重要的研究意义。[研究方法]使用提示学习模型识别关键词的语义功能,通过识别的关键词的不同语义功能,为领域主题演化分析添加不同... 详细信息

[研究目的]领域主题演化分析利用领域科技文献,识别领域主题构成,揭示领域主题变化和演化脉络,具有十分重要的研究意义。[研究方法]使用提示学习模型识别关键词的语义功能,通过识别的关键词的不同语义功能,为领域主题演化分析添加不同的语义功能维度。[研究结果/结论]相较于传统的机器学习模型,提示学习模型可以使用更少的训练数据更精准地划分关键词的语义功能,而基于不同关键词语义功能进行的主题演化分析能够保留特定的语义信息,为领域主题演化分析提供更细致的分析视角。

关键词：关键词语义功能识别提示学习领域主题主题演化分析 Bootstrapping

β-Pb3P2S8: A new optical crystal with exceptional birefringence effect

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Chinese Chemical Letters 2025年第02期36卷 514-517页

作者： Weiping Guo Ying Zhu Hong-Hua Cui Lingyun Li yan yu Zhong-Zhen Luo Zhigang Zou Key Laboratory of Eco-materials Advanced Technology Key Laboratory of Advanced Materials Technologies International (HongKong Macao and Taiwan) Joint Laboratory on Advanced Materials Technologies College of Materials Science and Engineering Fuzhou University Fujian Science & Technology Innovation Laboratory for Optoelectronic Information of China Mechanical and Electrical Engineering Practice Center Fuzhou University Eco-materials and Renewable Energy Research Center College of Engineering and Applied Sciences Nanjing University

Birefringent crystals play an irreplaceable role in optical systems by adjusting the polarization state of light in optical *** work successfully synthesized a new thiophosphate phase of β-Pb3P2S8through the high-temperature solid-state spontaneous crystallization *** from the cubicα-Pb3P2S8,the β-Pb3P2S8crystallizes in the orthorhombic Pbcn space ***,β-Pb3P2S8shows a large band gap of 2.37 e V in lead-based chalcogenides,wide infrared transparent window （2.5-15μm）,and excellent thermal ***,the experimental birefringence shows the largest value of0.26@550 nm in chalcogenides,even larger than the commercialized oxide *** Barder charge analysis result indicates that the exceptional birefringence effect is mainly from the Pb2+and S2-in the[Pb S_n]***,the parallelly arranged polyhedral layers could improve the structural ***,this work supports a new method for designing chalcogenides with exceptional birefringence effect in the infrared region.

关键词： Birefringent crystals Chalcogenides Optical properties Structural anisotropic β-Pb3P2S8

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儿童与自然的联系:向度、发展与建立

教育理论与实践 2025年第4期45卷 3-9页

作者：於金滟顾荣芳南京师范大学教育科学学院江苏南京210024

儿童与自然的联系是一种身体、情感和认知的联系,情感联系的发展优先于认知联系,身体联系是心理联系的基础和归宿,三种联系随时间以螺旋上升、逐渐扩大的方式发展。建立儿童与自然的联系,需提供有真实复杂感的自然环境,归还儿童充分的... 详细信息

儿童与自然的联系是一种身体、情感和认知的联系,情感联系的发展优先于认知联系,身体联系是心理联系的基础和归宿,三种联系随时间以螺旋上升、逐渐扩大的方式发展。建立儿童与自然的联系,需提供有真实复杂感的自然环境,归还儿童充分的户外活动时间,发挥成人的榜样和引导作用,遵循儿童的内部自然,支持儿童在自然中的感受、体验、理解和思考。

关键词：儿童自然自然环境情感联系认知联系身体联系