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Laparoscopic hepatectomy by curettage and aspiration:a new technique

国家级“乳腺癌诊治新进展”学习班暨学术年会

作者： Shao xy Cai JF Xu XH Cai JW Zheng YB Cao WM Qin jing Ye WW Zhang YM yu xy Ling ZQ Feng JG Han MX Wang XJ Zhejiang Cancer Research Institute Zhejiang Cancer Hospital

Background:The human epidermal growth factor(HER2/neu) oncoprotein is composed of an intracellular tyrosine kinase portion,a short transmembrane section,and an extracellular ligand-binding domain(ECD). The latter is frequently cleaved from the surface of breast cancer cells and the serum HER2 ECD levels can be detected by enzyme-linked immunosorbent assay(ELISA).Consistent with majority of reports,our prior study showed that high circulating levels of the HER2 ECD indicates poor prognosis in 207 patients with metastatic breast *** the present study,we aimed to elucidate whether serum HER2 ECD levels would predict the clinical outcome of metastatic breast cancer patients.

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Chinese Medical Journal 2007年第20期120卷 1773-1776页

作者： CAI Xiu-jun LIANG Xiao WANG Yi-fan yu Hong ZHENG Xue-yong HUANG Di-yu PENG Shu-you Department of General Surgery,Sir Run Run Shaw Hospital,College of Medicine Institute of Minimally Invasive Surgery of Zhejiang University,Hangzhou 310016,China (Cai XJ,Liang X,Wang YF,yu H,Zheng xy,Huang DY and Peng SY) Department of General Surgery Sir Run Run Shaw HospitalCollege of MedicineInstitute of Minimally Invasive Surgery of Zhejiang University Hangzhou 310016 China）

Background Laparoscopic surgery is advantageous for minimal invasiveness and rapid postoperative recovery. Since the use of laparoscopic hepatectomy in liver resection in the 1990s, it has been performed in a few institutions worldwide, Lack of efficient and safe techniques for liver transaction is the major obstacle preventing from its further development, We developed a new technique for laparoscopic hepatectomy by curettage and aspiration in 1998. In this paper we analyze the clinical outcomes of this technique after 7 years of practice.Methods Altogether 59 consecutive patients underwent laparoscopic hepatectomy by curettage and aspiration from August 1998 to January 2005 at our institution. These patients included 33 males and 26 females, with a mean age of 47 years. For liver transecsion laparoscopic Peng＇s multifunctional operative dissector （LPMOD） was used. Lesions included malignant liver tumors in 19 patients, benign liver tumors in 17, intrahepatic calculus in 18, and other liver lesions in 5. Procedures included local resections in 30 patients, left lateral segmentectomy in 28, and right hemihepatectomy in 1.Results Laparoscopic operation was completed in 57 patients. Two patients （3.4%） had the operation converted to laparotomy. The mean operating time was 143 minutes and the mean intraoperative blood loss was 456 ml. The mean length of postoperative hospital stay was 7 days. Complications occurred in 2 patients （3.4%）, and there was no pedoperative death.Conclusion Laparoscopic hepatectomy by curettage and aspiration is efficient and safe for liver resection.

关键词： laparoscopic liver resection hepatectomy Peng's multifunctional operative dissector curettage and aspiration

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胰腺星状细胞活化相关因子研究进展

世界华人消化杂志 2006年第20期14卷 2009-2013页

作者：余晓云陈婕侯晓华华中科技大学同济医学院附属协和医院消化科湖北省武汉市430022

胰腺纤维化是慢性胰腺炎主要的病理学变化,而活化的胰腺星状细胞(PSC)是纤维化过程的主要效应细胞.多种细胞因子,如转化生长因子-β1(TGF-β1)、结缔组织生长因子(CTGF)、血小板衍化生长因子(PDGF)、白细胞介素-10(IL-10)等及氧自由基,... 详细信息

胰腺纤维化是慢性胰腺炎主要的病理学变化,而活化的胰腺星状细胞(PSC)是纤维化过程的主要效应细胞.多种细胞因子,如转化生长因子-β1(TGF-β1)、结缔组织生长因子(CTGF)、血小板衍化生长因子(PDGF)、白细胞介素-10(IL-10)等及氧自由基,细胞内压力等因素,通过各自的作用来影响PSC的活性.最终通过有丝分裂原活化蛋白激酶途径(MAPK)、Smad信号转导蛋白、过氧化物酶体增生物激活受体-γ(PPAR-γ)等细胞内信号调节PSC的活化及胰腺炎症和纤维化过程.

关键词：胰腺星状细胞胰腺纤维化

Circulating HER2 extracellular domain(ECD) levels are associated with progression-free survival in metastatic breast cancer patients

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Circulating HER2 extracellular domain(ECD) levels are associ...

AN ANALYSIS OF AXISYMMETRIC BUCKLING AND GROWTH OF CIRCULAR-SHAPED DELAMINATION

2012年全国肿瘤分子标志学术大会与国际肿瘤转化医学论坛暨第七届中国中青年肿瘤专家论坛

作者： Shao xy,Chen ZH,Cai JF,Ye WW,Xu XH,Qin jing,Zhang YM,Zheng YB,yu xy,Lei L, Ling ZQ,Feng JG,Han MX,Wang XJ Zhejiang Cancer Research Institute,Zhejiang Cancer Hospital,No.38 Guangji Rd., Banshanqiao District,Hangzhou 310022,P.R.China.

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Acta Mechanica Solida Sinica 1996年第3期9卷 201-209页

作者： Zhang, xy yu, SW TSING HUA UNIV DEPT ENGN MECHBEIJING 100084PEOPLES R CHINA

The buckling and post-buckling of clamped circular plate subjected to distributed radial compressed load is presented by using the high-order perturbation analysis and shooting method. The sixth-order solution shows good agreement with the FEM results in [11]. The results in this paper are applied to investigate the buckling and growth of pressed thin film delamination in the film/substrate system. Under a certain residual pressure in the thin film, two characteristic blister radii R(c) and R(g), the critical radius and growing radius respectively, are obtained. The numerical result shows that the growth criterion of delamination in [9,10] is not perfect. In variant residual stress or interface toughness, the conditions of no growth, stable growth and unstable growth of the delamination are obtained by comparing the driving force at the interface crack tip with the interface toughness.

关键词： circular delamination axisymmetric buckling interface crack

Synthesis and structural characterization of a new trimetallic thiocubane cluster

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Chinese Journal of Chemistry 1997年第2期15卷 114-122页

作者： yu, RM Lu, SF Huang, xy Huang, JQ CHINESE ACAD SCI FUJIAN INST RES STRUCT MATTERFUZHOU 350002FUJIANPEOPLES R CHINA

The trimetallic cluster W2CuAgS4(TDT)(2)(PPh3)(2) . CH2Cl2 (TDT=[S-2(C6H3)CH3](2-)) (2) has been prepared from the reaction of the well-defined molecule building block [W2S4(TDT)(2)](2-) (1) with AgNO3, CuBr and PPh3. The structure contains a [W2CuAgS4](4+) distorted cubane-like core, Two types of metal-metal bonds exist in the core, One is W-W bond of which length is 0.2871(1) nm, the other is W-M' (M'=Cu or Ag) bends, whose mean distance is 0.2980 nm. The details of synthesis, structure, IR, UV-Vis and P-31 NMR spectra are reported. The crystallographic data are: space group P2(1)/n, with a=1.6987(4), b=1.7763(6), c=1.8918(5) nm, beta=98.54(2)degrees, V=5.645(3) nm(3), Z=4, and final R=0.043 for 6437 observed reflections.

关键词： W-Cu-Ag-S cubane-like cluster structure synthesis

Targeting TrkB–PSD-95 coupling to mitigate neurological disorders

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Neural Regeneration Research 2025年第3期20卷 715-724页

作者： Xin Yang yu-Wen Alvin Huang John Marshall Department of Molecular Biology Cell Biology and BiochemistryBrown UniversityProvidenceRIUSA Department of Neurology Warren Alpert Medical School of Brown UniversityProvidenceRIUSA Center for Translational Neuroscience Robert J.and Nancy D.Carney Institute for Brain Science and Brown Institute for Translational ScienceBrown UniversityProvidenceRIUSA

Tropomyosin receptor kinase B(TrkB)signaling plays a pivotal role in dendritic growth and dendritic spine formation to promote learning and *** activity-dependent release of brain-derived neurotrophic factor at synapses binds to pre-or postsynaptic TrkB resulting in the strengthening of synapses,reflected by long-term ***,the association of postsynaptic density protein-95 with TrkB enhances phospholipase Cγ-Ca^(2+)/calmodulin-dependent protein kinaseⅡand phosphatidylinositol 3-kinase-mechanistic target of rapamycin signaling required for long-term *** this review,we discuss TrkB-postsynaptic density protein-95 coupling as a promising strategy to magnify brain-derived neurotrophic factor signaling towards the development of novel therapeutics for specific neurological disorders.A reduction of TrkB signaling has been observed in neurodegenerative disorders,such as Alzheimer's disease and Huntington's disease,and enhancement of postsynaptic density protein-95 association with TrkB signaling could mitigate the observed deficiency of neuronal connectivity in schizophrenia and *** with brain-derived neurotrophic factor is problematic,due to poor pharmacokinetics,low brain penetration,and side effects resulting from activation of the p75 neurotrophin receptor or the truncated TrkB.T1 *** TrkB agonists and antibodies that activate TrkB are being intensively investigated,they cannot distinguish the multiple human TrkB splicing isoforms or cell type-specific *** TrkB–postsynaptic density protein-95 coupling provides an alternative approach to specifically boost TrkB signaling at localized synaptic sites versus global stimulation that risks many adverse side effects.

关键词： Angelman syndrome autism brain-derived neurotrophic factor depression neurodegenerative disorder neurodevelopmental disorder postsynaptic density protein-95 synaptic plasticity TrkB

A new horizon for neuroscience:terahertz biotechnology in brain research

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Neural Regeneration Research 2025年第2期20卷 309-325页

作者： Zhengping Pu yu Wu Zhongjie Zhu Hongwei Zhao Donghong Cui Shanghai Key Laboratory of Psychotic Disorders Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Department of Psychiatry Kangci Hospital of JiaxingTongxiangZhejiang ProvinceChina Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghaiChina Key Laboratory of Interfacial Physics and Technology Shanghai Institute of Applied PhysicsChinese Academy of ScienceShanghaiChina National Facility for Protein Science in Shanghai Shanghai Advanced Research InstituteChinese Academy of SciencesShanghaiChina

Terahertz biotechnology has been increasingly applied in various biomedical fields and has especially shown great potential for application in brain *** this article,we review the development of terahertz biotechnology and its applications in the field of *** evidence indicates promising prospects for the use of terahertz spectroscopy and terahertz imaging techniques in the diagnosis of amyloid disease,cerebrovascular disease,glioma,psychiatric disease,traumatic brain injury,and myelin *** vitro and animal experiments have also demonstrated the potential therapeutic value of terahertz technology in some neuropsychiatric *** the precise underlying mechanism of the interactions between terahertz electromagnetic waves and the biosystem is not yet fully understood,the research progress in this field shows great potential for biomedical noninvasive diagnostic and therapeutic ***,the biosafety of terahertz radiation requires further exploration regarding its two-sided efficacy in practical *** review demonstrates that terahertz biotechnology has the potential to be a promising method in the field of neuropsychiatry based on its unique advantages.

关键词： biological effect brain neuron neuropsychiatry neuroscience non-thermal effect terahertz imaging terahertz radiation terahertz spectroscopy terahertz technology

A clinical evaluation of serological diagnosis for pancreatic cancer

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World Journal of Gastroenterology 1998年第2期4卷 55-57页

作者： Zhao, xy yu, SY Da, SP Bai, L Guo, XZ Dai, XJ Wang, YM Third Mil Med Univ Xinqiao Hosp Dept Gastroenterol Chongqing 400037 Peoples R China

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关键词： pancreatic neoplasms/diagnosis tumor markers, biological antigens, neoplasm/analysis CA 19 9 antigen/analysis pancreatopeptidase/analysis carcinoembryonic antigen/analysis alpha 1 antitrypsin/analysis enzyme linked immunosorbent assay radioim