Circulating HER2 extracellular domain(ECD) levels are associated with progression-free survival in metastatic breast cancer patients
作者单位：Zhejiang Cancer Research InstituteZhejiang Cancer Hospital
会议名称：《国家级“乳腺癌诊治新进展”学习班暨学术年会》
会议日期：2013年
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
摘 要：Background:The human epidermal growth factor(HER2/neu) oncoprotein is composed of an intracellular tyrosine kinase portion,a short transmembrane section,and an extracellular ligand-binding domain(ECD). The latter is frequently cleaved from the surface of breast cancer cells and the serum HER2 ECD levels can be detected by enzyme-linked immunosorbent assay(ELISA).Consistent with majority of reports,our prior study showed that high circulating levels of the HER2 ECD indicates poor prognosis in 207 patients with metastatic breast *** the present study,we aimed to elucidate whether serum HER2 ECD levels would predict the clinical outcome of metastatic breast cancer patients.