检索结果-南通市图书馆

Lanthanum promoting bone formation by regulating osteogenesis,osteoclastogenesis and angiogenesis

Journal of Rare Earths 2024年第3期42卷 621-628,I0007页

作者： Dandan Zou Runlian Lin yu han Juan Jia Guoqiang Zhou Haisong Zhang Kun Ge Hebei Key Laboratory of Chronic Kidney Diseases and Bone Metabolism Affiliated Hospital of Hebei UniversityBaoding071000China Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education Key Laboratory of Chemical Biology of Hebei ProvinceCollege of Chemistry and Environmental ScienceHebei UniversityBaoding071002China

With lanthanum(La) in agriculture, medicine, and the chemical industry, La shows accumulation in the body, especially in the bone, because of its similar structure to calcium. Moreover, La has a direct role in bone formation regulating osteoblasts and osteoclasts. Nevertheless, bone formation is complex under the regulation of osteogenesis, osteoclastogenesis, and angiogenesis in the bone microenvironment. It is difficult to comprehensively understand the regulation of bone homeostasis from a single kind of cell.Herein, some bone microenvironment-related cells and mouse calvaria culture models were used to study the regulatory effect of La-based compound-lanthanum nitrate(La(NO_(3))_(3)) on bone formation.La(NO_(3))_(3) has good biological safety, and the osteogenic differentiation is significantly increased under La(NO_(3))_(3) treatment for bone marrow mesenchymal stem cells(BMMSC). In contrast, the differentiation,maturation, and bone erosion ability of osteoclasts are significantly decreased. Meanwhile, the angiogenesis ability of human umbilical vein endothelial cells(HUVEC) is significantly promoted when treated with La(NO_(3))_(3). Furthermore, bone metabolism and angiogenesis are improved under La(NO_(3))_(3) treatment in the calvaria ex vivo culture model and BMMSC-HUVEC co-culture system. These results suggest that La has the beneficial effect of promoting bone metabolism and improving bone formation in the bone microenvironment.

关键词： Lanthanum Bone microenvironment Osteogenic differentiation Angiogenesis Rare earths

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Optimization of Gas Production from Hydrate-Bearing Sediments with Fluctuation Characteristics

引用

Journal of Ocean University of China 2024年第3期23卷 618-632页

作者： LI Yaobin XU Tianfu XIN Xin yu han yuAN Yilong ZHU Huixing Key Laboratory of Groundwater Resources and Environment Ministry of EducationJilin UniversityChangchun 130021China Jilin Provincial Key Laboratory of Water Resources and Environment Jilin UniversityChangchun 130021China

As an important source of low-carbon,clean fossil energy,natural gas hydrate plays an important role in improving the global energy consumption structure.Developing the hydrate industry in the South China Sea is important to achieving‘carbon peak and carbon neutrality’goals as soon as possible.Deep-water areas subjected to the action of long-term stress and tectonic movement have developed complex and volatile terrains,and as such,the morphologies of hydrate-bearing sediments(HBSs)fluctuate correspondingly.The key to numerically simulating HBS morphologies is the establishment of the conceptual model,which represents the objective and real description of the actual geological body.However,current numerical simulation models have characterized HBSs into horizontal strata without considering the fluctuation characteristics.Simply representing the HBS as a horizontal element reduces simulation accuracy.Therefore,the commonly used horizontal HBS model and a model considering the HBS’s fluctuation characteristics with the data of the SH2 site in the Shenhu Sea area were first constructed in this paper.Then,their production behaviors were compared,and the huge impact of the fluctuation characteristics on HBS production was determined.On this basis,the key parameters affecting the depressurization production of the fluctuating HBSs were studied and optimized.The research results show that the fluctuation characteristics have an obvious influence on the hydrate production of HBSs by affecting their temperatures and pressure distributions,as well as the transmission of the pressure drop and methane gas discharge.Furthermore,the results show that the gas productivity of fluctuating HBSs was about 5%less than that of horizontal HBSs.By optimizing the depressurization amplitude,well length,and layout location of vertical wells,the productivity of fluctuating HBSs increased by about 56.6%.

关键词： natural gas hydrate numerical simulation fluctuation characteristics depressurization production production well optimization

来源：

维普期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Recent advances in visible light-mediated chemical transformations of enaminones

引用

Chinese Chemical Letters 2024年第2期35卷 4-15页

作者： yu han Liyun Zhou Chengyu Wang Shangti Feng Rong Ma Jie-Ping Wan College of Chemistry and Chemical Engineering Jiangxi Normal UniversityNanchang 330022China School of Chemistry and Chemical Engineering Linyi UniversityLinyi 276000China Linyi Sanfeng Chemical Co. Ltd.Linyi 276000China

Enaminones,which possesses both the nucleophilic enamine as well as electrophilic enone structures,are well known versatile building blocks in organic synthesis.Meanwhile,visible light-mediated reactions have emerged as useful synthetic strategy with enhanced sustainability.Around the last decade,various photochemical transformations of enaminones have been developed to construct cyclic or acyclic compounds.In this review,we describe the recent advances in visible light-mediated chemical transformations of enaminones.Detailed discussion on the reaction mechanism of the related reactions is given to provide guide to the reader.Finally,a summary on the existing challenges and the future outlook towards the development of practical photocatalytic reactions of enaminones is also presented.

关键词： Enaminone Visible light C-H functionalization C=C bond cleavage Cyclization Multicomponent reactions

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Performance analysis of the tight combination of GPS, BDS, GALILEO,and QZSS mixed frequencies signals

引用

Geodesy and Geodynamics 2024年第4期15卷 366-378页

作者： yu han Fangjun Qin Xugang Lian Shengliang Wang Leiyuan Qian Wenhua Huang College of Electrical Engineering Naval University of Engineering College of Mining Engineering Taiyuan University of Technology State Key Laboratory of Satellite Navigation System and Equipment Technology State Key Laboratory of Geodesy and Earth's Dynamics Innovation Academy for Precision Measurement Science and Technology Chinese Academy of Sciences China Energy Engineering Group Shanxi Electric Power Engineering CO.LTD.

With the gradual development and modernization of satellite navigation systems, using observation information from multi-GNSS has become one of the hot-spot issues in recent years. Multi-system loose combinations form double-difference observation equations within their respective systems, and the positioning effect is improved. However, the interchangeability and compatible interoperability between global navigation satellite systems(GNSS) cannot be truly realized. At the same time, when the number of visible satellites decreases abruptly, the positioning performance deteriorates sharply. This paper focuses on the GNSS multi-system tight combination relative positioning technique, gives a mathematical model of multi-system tight combination relative positioning considering differential intersystem bias(DISB), and analyzes the time-varying characteristics of DISB at overlapping and nonoverlapping frequencies among GPS/Galileo, GPS/BDS, and GPS/QZSS in terms of receiver brand, temperature, and receiver restart. The GNSS tight combination relative positioning performance is verified by static data from Curtin University and dynamic data measured at Taiyuan University of Technology. The results show that compared with loose combination, the ambiguity-fixed rate increases from 62.18% to 97.60% for static data and from 74.97% to 99.53% for dynamic data when the elevation mask angle is 50°,resulting in a significant improvement in positioning performance.

关键词： GNSS Mix frequencies Redundancy Tight combination Differential inter-system bias

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Status and progress of metal-supported solid oxide fuel cell: Towards large-scale manufactory and practical applications

引用

Energy Reviews 2024年第1期3卷 1-23页

作者： Haoran Xu yu han Jing Zhu Meng Ni Zhen Yao State Key Laboratory of Clean Energy Utilization Zhejiang University38 Zheda RoadHangzhou310027China Department of Building and Real Estate Research Institute for Sustainable Urban Development(RISUD)&Research Institute for Smart Energy(RISE)Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina Fakultät für Physik Universität BielefeldUniversitätsstr.2533615BielefeldGermany

Metal-supported solid oxide fuel cells(MS-SOFCs)own advantages of high performance,fast start-up,thermal cycle stability,easy sealing,and reduced material cost.In recent years,significant progress has been made in the development of MS-SOFCs,particularly with respect to improved electrochemical performance,long-term stability,and industrial production.Previous studies have mainly focused on stainless steel-based MS-SOFCs,with an emphasis on the development of low-temperature preparation processes,antioxidant coatings,stable electrodes,and the direct utilization of hydrocarbon fuels.Notably,Ceres Power and GE have successfully commercialized MS-SOFCs and have constant cooperated with several institutions and companies,such as Jülich Research Center,Weichai and Cummins,to promote the performance and expand the market of MS-SOFC.Looking ahead,this review paper provides an outlook on future research directions in this rapidly evolving field.

关键词： Metal support Solid oxide fuel cell High performance Long-term stability

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Analytical Channel Modeling: From MIMO to Extra Large-Scale MIMO

引用

Chinese Journal of Electronics 2024年

作者： Jiachen TIAN yu han Shi JIN Jun ZhanG Jue WANG National Mobile Communication Research Laboratory Southeast University Jiangsu Key Laboratory of Wireless Communications Nanjing University of Posts and Telecommunications School of Information Science and Technology Nantong University

Multiple antenna technologies, from traditional multiple-input multiple-output(MIMO) to massive MIMO and the emerging extra large-scale MIMO, have consistently played a pivotal role in enhancing transmission rates by increasing the number of antennas. To guide the design of transmission strategies, channel models, especially analytical ones, are always significant tools, which can also reveal the performance improvements brought about by multiple antenna technologies. Analytical channel models have enjoyed significant success in traditional MIMO and massive MIMO systems. Nevertheless, due to the extended size of the array in an extra large-scale MIMO system, the distance between the receiver and the transmitter decreases and new channel properties, which did not manifest in massive MIMO systems, begin to kick in. To model the channel tailored for extra large-scale MIMO systems analytically, it is crucial to conduct a comprehensive review of traditional analytical MIMO channel models, which serves as a foundational step in understanding the fundamental characteristics of multi-antenna channels. In this paper, we first provide a survey on the state-of-the-art analytical MIMO channel models from the perspective of spatial correlation and signal propagation. Subsequently, we summarize the new properties of extra large-scale MIMO systems, i.e.,near-field properties and spatial non-stationarities, and their influences on analytical channel modeling. Our objective is to elucidate how these novel properties affect the analytical MIMO channel models, and ultimately facilitate the development of precise analytical channel models well-suited to the extra large-scale MIMO systems.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

ACBP4-WRKY70-RAP2.12 module positively regulates submergence-induced hypoxia response in Arabidopsis thaliana

引用

Journal of Integrative Plant Biology 2024年第6期66卷 1052-1067页

作者： Mengyun Guo Yingjun Yao Kangqun Yin Luna Tan Meng Liu Jing Hou han Zhang Ruyun Liang Xinran Zhang Heng Yang Xiaoxiao Chen Jinrui Tan Yan Song Shangling Lou Liyang Chen Xuejing Liu Si Tang Yongqi Hu Jin Yan Wensen Fu Kai Yang Ruijia Zhang Xuerui Li Yao Liu Zhen Yan Wei Liu yu han Jianquan Liu Kangshan Mao Huanhuan Liu Key Laboratory for Bio-resources and Eco-environment & State Key Lab of Hydraulics & Mountain River Engineering Sichuan Zoige Alpine Wetland Ecosystem National Observation and Research Station Key Laboratory for Bio-resource and Eco-environment of Ministry of Education College of Life Sciences Sichuan University

ACYL-CoA-BINDING PROTEINs(ACBPs) play crucial regulatory roles during plant response to hypoxia, but their molecular mechanisms remain poorly understood. Our study reveals that ACBP4 serves as a positive regulator of the plant hypoxia response by interacting with WRKY70,influencing its nucleocytoplasmic shuttling in Arabidopsis thaliana. Furthermore, we demonstrate the direct binding of WRKY70 to the ACBP4 promoter, resulting in its upregulation and suggesting a positive feedback loop. Additionally, we pinpointed a phosphorylation site at Ser638 of ACBP4, which enhances submergence tolerance, potentially by facilitating WRKY70's nuclear shuttling. Surprisingly, a natural variation in this phosphorylation site of ACBP4 allowed A.thaliana to adapt to humid conditions during its historical demographic expansion. We further observed that both phosphorylated ACBP4 and oleoyl-Co A can impede the interaction between ACBP4 and WRKY70, thus promoting WRKY70's nuclear translocation. Finally, we found that the overexpression of orthologous Bna C5.ACBP4and Bna A7.WRKY70 in Brassica napus increases submergence tolerance, indicating their functional similarity across genera. In summary, our research not only sheds light on the functional significance of the ACBP4 gene in hypoxia response, but also underscores its potential utility in breeding flooding-tolerant oilseed rape varieties.

关键词： ACBP4 Arabidopsis thaliana humid adaptation natural variation RAP2.12 WRKY70

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

The p38/MAPK pathway as a therapeutic target to prevent therapeutic escape of breast cancer stem cells

引用

Science China Life Sciences 2024年

作者： Weixiao Yan Xiaotong Wang Wenjing Wang Qi Guo Na Huang Hao Chen Xingjie Liang yu han Dandan Liu Jinchao Zhang State Key Laboratory of New Pharmaceutical Preparations and Excipients Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of EducationCollege of Chemistry and Materials Science Chemical Biology Key Laboratory of Hebei Province Hebei University CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety National Center for Nanoscience and Technology

Cancer stem cells(CSCs) play an important role in metastasis development, tumor recurrence, and treatment resistance, and are essential for the eradication of cancer. Currently, therapies fail to eradicate CSCs due to their therapeutic stress-induced cellular escape, which leads to enhanced aggressive behaviors compared with CSCs that have never been treated. However, the underlying mechanisms regulating the therapeutic escape remain unknown. To this end, we established a model to isolate the therapeutic escaped CSCs(TSCSCs) from breast CSCs and performed the transcription profile to reveal the mechanism. Mechanistically, we demonstrated that the behavior of therapeutic escape was regulated through the p38/MAPK signaling pathway, resulting in TSCSCs exhibiting enhanced motility and metastasis. Notably,blocking the p38/MAPK signaling pathway effectively reduced motility and metastasis ability both in vitro and in vivo, which were further supported by downregulated motility-related genes and epithelial-mesenchymal transition(EMT)-related proteins vimentin and N-cadherin.The obtained findings reveal the p38/MAPK pathway as a potential therapeutic target for TSCSCs and would provide profound implications for cancer therapy.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Macroporous Directed and Interconnected Carbon Architectures Endow Amorphous Silicon Nanodots as Low‑Strain and Fast‑Charging Anode for Lithium‑Ion Batteries

引用

Nano-Micro Letters 2024年第5期16卷 333-351页

作者： Zhenwei Li Meisheng han Peilun yu Junsheng Lin Jie yu Guangdong Provincial Key Laboratory of Semiconductor Optoelectronic Materials and Intelligent Photonic Systems Shenzhen Engineering Lab for Supercapacitor MaterialsSchool of Material Science and EngineeringHarbin Institute of TechnologyShenzhenUniversity TownShenzhen 518055People’s Republic of China Songshan Lake Materials Laboratory Dongguan Dongguan 523808GuangdongPeople’s Republic of China Department of Mechanical and Energy Engineering Southern University of Science and TechnologyShenzhen 518055People’s Republic of China

Fabricating low-strain and fast-charging silicon-carbon composite anodes is highly desired but remains a huge challenge for lithium-ion batteries.Herein,we report a unique silicon-carbon composite fabricated by uniformly dis-persing amorphous Si nanodots(SiNDs)in carbon nanospheres(SiNDs/C)that are welded on the wall of the macroporous carbon framework(MPCF)by vertical graphene(VG),labeled as MPCF@VG@SiNDs/C.The high dispersity and amor-phous features of ultrasmall SiNDs(~0.7 nm),the flexible and directed electron/Li+transport channels of VG,and the MPCF impart the MPCF@VG@SiNDs/C more lithium storage sites,rapid Li+transport path,and unique low-strain property during Li+storage.Consequently,the MPCF@VG@SiNDs/C exhibits high cycle stability(1301.4 mAh g^(-1) at 1 A g^(-1) after 1000 cycles without apparent decay)and high rate capacity(910.3 mAh g^(-1),20 A g^(-1))in half cells based on industrial electrode standards.The assembled pouch full cell delivers a high energy density(1694.0 Wh L^(-1);602.8 Wh kg^(-1))and an excellent fast-charging capability(498.5 Wh kg^(-1),charging for 16.8 min at 3 C).This study opens new possibilities for preparing advanced silicon-carbon com-posite anodes for practical applications.

关键词： Amorphous Si nanodots Low-strain Fast-charging Lithium-ion batteries

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Adsorption Effect of Phosphate Modified Grape Branch Biochar on Cd²

引用

Journal of Geoscience and Environment Protection 2024年第4期12卷 59-77页

作者： yu han yuming Yin Hao Zhang Sijing Sun Zuzhi Huang Yishu Deng Li Bao College of Resources and Environment Yunnan Agricultural University Kunming China yunnan Soil Fertilization and Pollution Remediation Laboratory Kunming China College of Building Engineering Yunnan Agricultural University Kunming China

Two major problems facing agriculture at present are soil pollution and the disposal of solid wastes generated during plant growth. The method of preparing biochar from solid wastes produced by plants is a means of maximizing the use of resources to combat the problem of soil pollution. In this study, we did not choose straw in the traditional sense but the waste branches from grape pruning, which has higher lignin cellulose, as the raw material. The biochar derived from grape branches pyrolyzed at 300˚C for two hours was utilized as a raw material to prepare modified biochar with varying concentrations of phosphoric acid. The adsorption performance and mechanism of Cd2 were explored through experiments involving different concentrations, addition amounts, reaction times, kinetic analyses, and isothermal adsorption tests. The findings indicated that the optimal adsorption of Cd2 occurred with a 20% phosphoric acid concentration, achieving the highest adsorption rate of 84.62%. At a dosage of 10 g/L, the maximum adsorption capacity reached 7.02 mg/g. The adsorption kinetics and isothermal adsorption of Cd2 on biochar modified with 0.2% phosphoric acid (0.2 PB) closely followed the pseudo-first-order kinetics model (R2 > 0.98) and the Freundlich model (R2 > 0.97), respectively. This suggests that the adsorption process involves both physical and chemical mechanisms. SEM and FTIR analyses revealed that phosphoric acid modification primarily increased the biochar’s specific surface area and enhanced certain original functional groups. The adsorption process predominantly involved rapid ion diffusion and chemical adsorption, as confirmed by kinetic analysis and isothermal adsorption model analysis. In summary, the adsorption efficiency of 0.2 PB significantly improved, showing potential and feasibility for heavy metal remediation in soil. This supports the environmentally friendly concept of “treating waste with waste”.

关键词： Phosphate Modified Grape Branch Biochar Adsorbs Cd

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：