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Osteoblastic and anti-osteoclastic activities of strontium-substituted silicocarnotite ceramics: In vitro and in vivo studies

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Bioactive Materials 2020年第3期5卷 435-446页

作者： Junkai Zeng Jingshu Guo Zhenyu Sun Fanyan Deng Congqin Ning youzhuan xie Shanghai Key Laboratory of Orthopaedic Implants Department of Orthopaedic SurgeryShanghai Ninth People's HospitalShanghai Jiaotong University School of MedicineShanghaiChina State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai200050China

Osteoporosis bone defect is a refractory orthopaedic disease which characterized by impaired bone quality and bone regeneration *** therapies,including antiosteoporosis drugs and artificial bone grafts,are not always ***,a strontium-substituted calcium phosphate silicate bioactive ceramic(Sr-CPS)was *** the present study,the extracts of Sr-CPS were prepared for in vitro study and Sr-CPS scaffolds were used for in vivo *** cytocompatibility,osteogenic and osteoclastogenic properties of Sr-CPS extracts were characterized in comparison to *** mechanisms were also evaluated by Western ***-CPS extracts were found to promote osteogenesis by upregulating Wnt/β-catenin signal pathways and inhibit osteoclastogenesis through downregulating NF-κB signal *** vivo,micro-CT,histological and histomorphometric observation were conducted after 8 weeks of implantation to evaluate the bone formation using calvarial defects model in ovariectomized *** with CPS,Sr-CPS significantly promoted critical sized ovariectomy(OVX)calvarial defects *** all the samples,Sr-10 showed the best performance due to a perfect match of bone formation and scaffold degradation ***,the present study demonstrated that Sr-CPS ceramic can dually modulate both bone formation and resorption,which might be a promising candidate for the reconstruction of osteoporotic bone defect.

关键词： Strontium Bioceramics Osteoblastic Osteoclastic Silicocarnotite

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Mass extinctions, their causes and consequences: an interview with Douglas *** and Shuzhong Shen

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National Science Review 2024年第1期11卷 66-70页

作者： Shucheng xie State Key Laboratory of Biogeology and Environmental Geology China University of Geosciences at Wuhan

‘Mass extinctions’ have been a hot topic for several decades. What triggers a mass extinction? How does a mass extinction impact the evolution of life? How does our ecosystem recover after a mass extinction? These questions attracted the interest of both scientists and the public *** spoke to two renowned researchers in the field of mass extinctions: Prof. Douglas H. Erwin from the National Museum of Natural History of the USA, and Prof. Shuzhong Shen from Nanjing University, China.

关键词： Stratigraphy

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腰椎术后手术部位深部感染的诊断与治疗

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中国脊柱脊髓杂志 2018年第8期28卷 720-725页

作者：曾俊凯谢幼专赵鑫管捷何雨舟赵杰上海交通大学附属第九人民医院骨科上海市200001

目的 :探讨腰椎术后手术部位深部感染的诊断与治疗方法。方法 :回顾性分析2012年1月~2017年7月我院骨科收治的14例腰椎术后深部感染患者的临床资料、诊疗方法、随访结果。其中男性9例,女性5例,平均年龄53.0±13.1岁(19~73岁);早期感染(<... 详细信息

目的 :探讨腰椎术后手术部位深部感染的诊断与治疗方法。方法 :回顾性分析2012年1月~2017年7月我院骨科收治的14例腰椎术后深部感染患者的临床资料、诊疗方法、随访结果。其中男性9例,女性5例,平均年龄53.0±13.1岁(19~73岁);早期感染(<30d)13例,迟发感染(≥30d)1例;应用内固定物13例,未应用内固定物1例。患者出现感染征象后,立即留取标本送检并经验性静脉应用抗生素,随后根据细菌培养结果与病情变化调整抗生素种类,待主要炎症指标正常后改为口服抗生素。12例单纯抗生素治疗后病情未见改善者,予全麻下彻底清创;其中4例清创术后采用对口持续灌洗引流,另8例清创术后采用VSD负压引流,随访观察治疗效果。结果:本组共7例患者细菌培养结果阳性,其中单一细菌感染6例,混合感染1例。所有患者均应用抗生素治疗;静脉抗生素使用时间平均39.7±13.2d(24~77d),口服抗生素使用时间平均32.9±3.1d(28~38d)。13例内固定置入术后感染患者中11例内固定物得以保留,2例因多次清创无效后移除部分内固定物。14例患者均逐渐好转、最终治愈出院,平均住院时间51.4±13.1d。所有患者经平均32.4±18.6个月(4~67个月)随访,至末次随访时未见感染复发,且均主诉满意。结论:抗生素治疗、外科彻底清创是腰椎术后深部感染的有效治疗手段;对于有内固定物者,早期感染获得积极治疗后可保留内固定。

关键词：腰椎深部手术部位感染诊断治疗

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载纳米银磷酸三钙的体外细胞毒性及兔体内毒性

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中国组织工程研究 2019年第6期23卷 917-923页

作者：程坚张军管捷曾俊凯赵鑫谢幼专上海交通大学医学院附属第九人民医院骨科上海市内植物重点实验室上海市200011 余姚市人民医院外五科浙江省余姚市315400 上海青浦区中心医院骨科上海市200011

背景:课题组前期研究发现,负载5%纳米银颗粒β-磷酸三钙材料具有抗菌性和良好的生物相容性。目的:10%纳米银颗粒β-磷酸三钙材料的体内外毒性。方法:(1)体外细胞毒性:分别采用含质量分数10%纳米银颗粒β-磷酸三钙材料浸提液、多孔β-磷... 详细信息

背景:课题组前期研究发现,负载5%纳米银颗粒β-磷酸三钙材料具有抗菌性和良好的生物相容性。目的:10%纳米银颗粒β-磷酸三钙材料的体内外毒性。方法:(1)体外细胞毒性:分别采用含质量分数10%纳米银颗粒β-磷酸三钙材料浸提液、多孔β-磷酸三钙材料浸提液、正常组织培养液培养SD大鼠(上海西普尔-必凯实验动物有限公司提供)骨髓间充质干细胞,培养1,3,5,7 d,CCK-8法检测细胞增殖;(2)动物体内毒性:取20只新西兰大白兔(上海市甲干生物科技有限公司提供),在左侧股骨外髁制作直径6 mm、深度13 mm的骨缺损,随机分2组,实验组缺损处植入含质量分数10%纳米银颗粒的β-磷酸三钙材料,对照组植入β-磷酸三钙材料。植入后12周,采用电感耦合等离子体质谱法检测血液和各组织器官内银离子浓度;苏木精-伊红染色切片观察各组织器官病理状态;Van Gieson染色切片观察材料植入区组织生长情况。结果与结论:(1)β-磷酸三钙浸提液组、正常组织培养液组、含纳米银颗β-磷酸三钙材料浸提液组培养不同时间点的细胞增殖比较无差异(P <0.05);(2)实验组和对照组兔血液、心、肝、脾、肺、肾各脏器中的银离子浓度均小于0.1×10^(-6),小于WHO规定的人体内银离子的最高浓度0.5×10^(-6);(3)实验组与对照组兔心、肝、脾、肺、肾组织切片均未见明显病理性改变;(4)实验组与对照组材料轮廓可分辨,材料周围可见被染成红色的新骨组织,材料内部多孔结构内可见大量红染的新骨组织,两组材料多孔结构内的新骨组织分布未见明显差异;(5)结果表明,含质量分数10%纳米银颗粒的β-磷酸三钙材料无明显细胞毒性与动物体内毒性,具有良好的生物相容性。

关键词：纳米银颗粒 β-磷酸三钙生物毒性骨缺损载纳米银磷酸三钙银磷酸钙类毒性试验组织工程

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Turbulence Statistics of Thermo-Buoyancy Supercritical Fuel Flow in a Regenerative Cooling Channel

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Journal of Thermal Science 2024年第1期33卷 126-137页

作者： SUN Feng xie Gongnan School of Marine Science and Technology Northwestern Polytechnical UniversityXi'an 710072China Department of Thermal Engineering Tsinghua UniversityBeijing 100084China

Active regenerative cooling with supercritical hydrocarbon fuel is considered as the most promising thermal protection *** existence of buoyancy force would lead to strongly anisotropic flow and thermal transport *** is closely related to the cooling performance of the *** elucidate the mechanisms of turbulent transport,the large eddy simulation(LES) was performed to assess turbulence statistics within different turbulence *** results indicated that the buoyancy and inertial force together dominated the change of turbulent ***,the spatial thermal buoyancy effect significantly suppressed the vertical velocity *** is due to the laminar motion caused by the buoyancy force,thereby weakening the thermal *** the statistics of velocity fluctuation,it was found that the buoyancy force and inertial force greatly weaken the vertical and streamwise velocity fluctuation,*** the statistics of thermal transport,the results pointed out that the near-wall heat transport characteristics need to be paid more *** thickness of the temperature mixing boundary layer led to the attenuation of vertical heat flux,which inhibited vertical temperature diffusion and predisposed to extreme conditions of heat transfer *** results can enhance the academic understanding of the heat transfer mechanism of supercritical fluids,and give guidance for further applications of thermal protection.

关键词： active regenerative cooling large eddy simulation(LES) buoyancy force turbulence statistics

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尿石素A抑制BMMs向破骨细胞分化

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医学研究杂志 2023年第7期52卷 97-101页

作者：周贤豪谢幼专上海市骨科内植物重点实验室、上海交通大学医学院附属第九人民医院骨科 200011

目的探究尿石素A对小鼠骨髓来源巨噬细胞(bone marrow derived macrophages,BMMs)向破骨细胞分化的影响。方法提取小鼠骨髓腔BMMs,通过CCK-8法检测尿石素A对BMMs的增殖毒性,使用核因子-κB受体活化因子配体(receptor activator of nucle... 详细信息

目的探究尿石素A对小鼠骨髓来源巨噬细胞(bone marrow derived macrophages,BMMs)向破骨细胞分化的影响。方法提取小鼠骨髓腔BMMs,通过CCK-8法检测尿石素A对BMMs的增殖毒性,使用核因子-κB受体活化因子配体(receptor activator of nuclear factor-κB ligand,RANKL)诱导BMMs向破骨细胞分化并与浓度梯度尿石素A共培养,抗酒石酸酸性磷酸酶(tartrate resistant acid phosphatase,TRAP)染色检测破骨细胞数量和面积大小,实时荧光定量聚合酶链反应(real-time quantitative polymerase chain reaction,RT-qPCR)法检测破骨分化相关基因水平表达,2′,7′-二氯二氢荧光素二乙酸酯(2′,7′-Dichlorofluorescin diacetate,DCFH-DA)检测细胞活性氧(reactive oxygen species,ROS)水平。结果CCK-8法检测结果显示,尿石素A在16μmol/L范围内对BMMs无明显毒性;TRAP染色结果表明,尿石素A显著抑制了BMMs向破骨细胞分化,成熟破骨细胞数目和面积减少(P<0.01);RT-qPCR检测结果显示,尿石素A明显抑制了破骨分化相关基因(C-FOS、CTSK、MMP9、ACP5)的相对表达水平(P<0.01);DCFH-DA检测结果显示,尿石素A明显降低了RANKL诱导的高ROS水平。结论尿石素A能抑制RANKL诱导的BMMs向破骨细胞分化,并降低分化过程中的ROS,有望作为骨质疏松治疗的潜在药物。

关键词：尿石素A 破骨分化活性氧

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Output feedback stabilization of stochastic high-order planar nonlinear systems with stochastic inverse dynamics and output-constraint

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Science China(Information Sciences) 2024年第3期67卷 182-196页

作者： Ruiming xie Shengyuan XU Nanjing University of Science and Technology School of Automation

In this paper, we solve the output feedback control problem of stochastic high-order planar nonlinear systems with output constraint and stochastic integral input-to-state stability(SiISS) inverse dynamics. By employing a key coordinate transformation, a stochastic nonlinear system with output constraint and SiISS inverse dynamics is converted into an unconstrained system. By skillfully constructing an observer and adopting SiISS small-gain conditions, we develop a new output feedback control design and analysis method, and prove that all the closed-system signals are bounded almost surely, the output constraint is not violated almost surely, and the equilibrium point of the closed-loop system is stochastically asymptotically stable.

关键词： stochastic high-order planar nonlinear system outputconstraint stochastic inverse dynamics output feedbackstabilization stochastic integral input-to-state stability(SiISS)

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Fixed-time stabilization of output-constrained stochastic high-order nonlinear systems

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Science China(Information Sciences) 2024年第4期67卷 5-20页

作者： Ruiming xie Shengyuan XU Nanjing University of Science and Technology School of Automation

In this study, the fixed-time stabilization problem of stochastic high-order nonlinear systems with output constraint and high-order and low-order nonlinearities is addressed. A new coordinate transformation is employed to directly convert output-constrained stochastic systems into an equivalent unconstrained *** fully extracting the characteristics of system nonlinearities and using the stochastic fixed-time stability theorem, a new design and analysis method is constructed to guarantee that the trivial solution of the closed-loop system is stochastically fixed-time stable while fulfilling the output constraint.

关键词： stochastic high-order nonlinear system outputconstraint high-order and low-order nonlinearity fixed-timestabilization finite-time stabilization

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Review of the research on the development and utilization of clay-type lithium resources

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Particuology 2024年第4期87卷 46-53页

作者： Ruiqi xie Zhihui Zhao Xiong Tong Xian xie Qiang Song Peiqiang Fan Faculty of Land Resource Engineering Kunming University of Science and TechnologyKunming650093China Yunnan Engineering Research Center for Metal Tailings Resource Utilization Kunming650093China

Since the demands for lithium have been in explosive growth recently and several great clay lithium resources were founded in China,the development and utilization of clay-type lithium resources become a hot *** order to provide a guidance for the concentration and extracting lithium of clay-type lithium resources,this review systematically summarized the main types and characteristics of clay-type lithium resources and the research status of lithium extraction from clay lithium ***,the flotation research status of the main mineral of clay lithium ore was also ***,we discussed the difficulties in the development and utilization of clay-type lithium ore and put forward the subsequent research *** paper can provide a guidance for the con-centration and extracting lithium of clay-type lithium resources in the future.

关键词： Clay lithium Clay mineral flotation Lithium extraction Leaching

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Conductive and stable polyphenylene/CNT composite membrane for electrically enhanced membrane fouling mitigation

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Frontiers of Environmental Science & Engineering 2024年第1期18卷 35-47页

作者： Huijuan xie Haiguang Zhang Xu Wang Gaoliang Wei Shuo Chen xie Quan Key Laboratory of Industrial Ecology and Environmental Engineering(Ministry of Education) School of Environmental Science and TechnologyDalian University of TechnologyDalian 116024China

Nanocarbon-based conductive membranes, especially carbon nanotube (CNT)-based membranes, have tremendous potential for wastewater treatment and water purification because of their excellent water permeability and selectivity, as well as their electrochemically enhanced performance (e.g., improved antifouling ability). However, it remains challenging to prepare CNT membranes with high structural stability and high electrical conductivity. In this study, a highly electroconductive and structurally stable polyphenylene/CNT (PP/CNT) composite membrane was prepared by electropolymerizing biphenyl on a CNT hollow fiber membrane. The PP/CNT membrane showed 3.4 and 5.0 times higher electrical conductivity than pure CNT and poly(vinyl alcohol)/CNT (PVA/CNT) membranes, respectively. The structural stability of the membrane was superior to that of the pure CNT membrane and comparable to that of the PVA/CNT membrane. The membrane fouling was significantly alleviated under an electrical assistance of −2.0 V, with a flux loss of only 11.7% after 5 h filtration of humic acid, which is significantly lower than those of PP/CNT membranes without electro-assistance (56.8%) and commercial polyvinylidene fluoride (PVDF) membranes (64.1%). Additionally, the rejection of negatively charged pollutants (humic acid and sodium alginate) was improved by the enhanced electrostatic repulsion. After four consecutive filtration-cleaning cycle tests, the flux recovery rate after backwashing reached 97.2%, which was much higher than those of electricity-free PP/CNT membranes (67.0%) and commercial PVDF membranes (61.1%). This study offers insights into the preparation of stable conductive membranes for membrane fouling control in potential water treatment applications.

关键词： Polyphenylene CNTs Membrane Electro-assistance Membrane fouling mitigation

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