Osteoblastic and anti-osteoclastic activities of strontium-substituted silicocarnotite ceramics: In vitro and in vivo studies

作     者：Junkai Zeng Jingshu Guo Zhenyu Sun Fanyan Deng Congqin Ning Youzhuan Xie 

作者机构：Shanghai Key Laboratory of Orthopaedic ImplantsDepartment of Orthopaedic SurgeryShanghai Ninth People's HospitalShanghai Jiaotong University School of MedicineShanghaiChina State Key Laboratory of High Performance Ceramics and Superfine MicrostructureShanghai Institute of CeramicsChinese Academy of SciencesShanghai200050China 

出 版 物：《Bioactive Materials》 (生物活性材料（英文）)

年 卷 期：2020年第5卷第3期

页      面：435-446页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 0836[工学-生物工程] 

基　　金：financial support from National Key Research and Development Program of China(Grant No.2018YFC2002303) National Natural Science Foundation of China(Grant No.51672304) International Partnership Program of Chinese Academy of Science(Grant No.GJHZ1760) 

主　　题：Strontium Bioceramics Osteoblastic Osteoclastic Silicocarnotite 

摘      要：Osteoporosis bone defect is a refractory orthopaedic disease which characterized by impaired bone quality and bone regeneration *** therapies,including antiosteoporosis drugs and artificial bone grafts,are not always ***,a strontium-substituted calcium phosphate silicate bioactive ceramic(Sr-CPS)was *** the present study,the extracts of Sr-CPS were prepared for in vitro study and Sr-CPS scaffolds were used for in vivo *** cytocompatibility,osteogenic and osteoclastogenic properties of Sr-CPS extracts were characterized in comparison to *** mechanisms were also evaluated by Western ***-CPS extracts were found to promote osteogenesis by upregulating Wnt/β-catenin signal pathways and inhibit osteoclastogenesis through downregulating NF-κB signal *** vivo,micro-CT,histological and histomorphometric observation were conducted after 8 weeks of implantation to evaluate the bone formation using calvarial defects model in ovariectomized *** with CPS,Sr-CPS significantly promoted critical sized ovariectomy(OVX)calvarial defects *** all the samples,Sr-10 showed the best performance due to a perfect match of bone formation and scaffold degradation ***,the present study demonstrated that Sr-CPS ceramic can dually modulate both bone formation and resorption,which might be a promising candidate for the reconstruction of osteoporotic bone defect.