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Disruption of Charged Dust Grains in Cometary Plasma Environments

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Chinese Physics Letters 1998年第2期15卷 155-156页

作者： shi Zhi-dong LI Zhong-yuan CHEN Yao Department of Earth and Space Science University of Science and Technology of ChinaHefei 230026 Advanced Center for Earth Science and Astronomy Third World Academy of Science

The equilibrium potential and dust fragmentation criterion of fluffy dust grains in plasma are calculated for comet P/*** is found that the dust grain acquires its largest negative potential and disruptive probability... 详细信息

关键词： change. comet criterion

CBP/p300： intramolecular and intermolecular regulations

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Frontiers in Biology 2018年第3期13卷 168-179页

作者： Yongming Xue Hong Wen Xiaobing shi Department of Epigenetics and Molecular Carcinogenesis Center for Cancer Epigenetics The University of Texas MD Anderson CancerCenter Houston TX 77030 USA Genetics and Epigenetics Graduate Program The University of Texas MD Anderson Cancer Center UTHealth Graduate School ofBiomedical Sciences Houston TX 77030 USA Center for Epigenetics Van Andel Research Institute Grand Rapids MI 49503 USA

CREB binding protein (CBP) and its close paralogue p300 are transcriptional coactivators with intrinsic acetyltransferase activity. Both CBP/p300 play critical roles in development and diseases. The enzymatic and biological functions of CBP/p300 are tightly regulated by themselves and by external factors. However, a comprehensive up-to-date review of the intramolecular and intermolecular regulations is lacking. To summarize the molecular mechanisms regulating CBP/p300s functions. A systematic literature search was conducted using the PubMed ( https://***/***/pubmed/ ) for literatures published during 1985–2018. Keywords “CBP regulation” or “p300 regulation” were used for the search. The functions of CBP/p300, especially their acetyltransferase activity and chromatin association, are regulated both intramolecularly by their autoinhibitory loop (AIL), bromodomain, and PHD-RING region and intermolecularly by their interacting partners. The intramolecular mechanisms equip CBP/p300 with the capability of self-regulation while the intermolecular mechanisms allow them to respond to various cell signaling pathways. Investigations into those regulation mechanisms are crucial to our understanding of CBP/p300s role in development and pathogenesis. Pharmacological interventions targeting these regulatory mechanisms have therapeutic potentials.

关键词： p300, CBP, histone acetylation, autoacetylation, HAT

The Belt and Road Initiative and International Law:Viewed from the Perspective of the Supply of International Public Goods

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Social Sciences in China 2021年第4期42卷 20-37页

作者： shi Jingxia Shao Ya’nan Law School Renmin University of China the School of Foreign Languages at Tianjin Chengjian University

The international community is facing the dilemma of an insufficient supply of public goods due to the conjunction of various forces and factors including the profound impact of the economic crisis,increased trade protectionism,changes in the global governance system and the impact of the Covid-19 *** Belt and Road Initiative(BRI)is a non-rivalrous and non-excludable public good provided to the international community by China as a responsible major country in the new era of historical *** law has an important role in promoting and guaranteeing the supply of international public goods(IPGs).Since the implementation of the Belt and Road Initiative,the international governance environment has changed dramatically,with the rule of law being the basic premise and important guarantee of the long-term and smooth implementation of the *** pursuing the BRI,buttressed as it is by the rule of law,China should pay attention to diversified governance based on a combination of international soft and hard law and make judicious use of existing bilateral,regional and multilateral international legal *** addition,China must also pay close attention to the latest developments in international economic and trade rules and must innovate and improve its ability to supply rules for investment,trade liberalization,*** by international law,the BRI should focus not only on recent concrete initiatives in trade and investment liberalization,but also on the long-term planning and sustainable development of institutional supply,so as to realize the vision and goals of the BRI.

关键词： BRI international public goods BRI buttressed by the rule of law international governance international law

UNIFIED MODEL FOR SPLASH DROPLETS AND SUSPENDED MIST OF ATOMIZED FLOW

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Journal of Hydrodynamics 2008年第1期20卷 125-130页

作者： LIU shi-he SUN Xiao-fei LUO Jing State Key Laboratory of Water Resources and Hydropower Engineering Science Wuhan University Wuhan 430072 China

In this article, the unified mathematical model for splash droplets and suspended mist of atomized flow was established, which classifies the atomized sources into the splash source and the suspended source. For the splash source, the Lagrangian method was used to simulate the random motion of splash water droplets, and for the suspended source the theory of air-water two-phase flow was used to simulate the mist flow moving in particle clouds. The rainfall intensity of the atomized flow was obtained by summarizing the rainfall intensities relative to the above two types of atomized sources. Both experimental data and prototype observation data were used for the verification of the mathematical model. For both the distribution of rainfall intensity, and the outer edge of the atomized flow, the simulation results are in agreement with the experimental data or prototype observation data.

关键词： two phase flow atomized flow splash water drop suspended mist

Molecular mechanisms of chemoresistance in gastric cancer

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World Journal of Gastrointestinal Oncology 2016年第9期8卷 673-681页

作者： Wen-Jia shi Jin-Bo Gao Department of Pediatric Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and Technology Department of Gastrointestinal Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and Technology

Gastric cancer is the fourth most common cancer and the second leading cause of cancer deaths *** is one of the major treatments for gastric cancer,but drug resistance limits the effectiveness of chemotherapy,which results in treatment *** to chemotherapy can be present intrinsically before the administration of chemotherapy or it can develop during *** mechanisms of chemotherapy resistance in gastric cancer are complex and multifactorial.A variety of factors have been demonstrated to be involved in chemoresistance,including the reduced intracellular concentrations of drugs,alterations in drug targets,the dysregulation of cell survival and death signaling pathways,and interactions between cancer cells and the tumor *** review focuses on the molecular mechanisms of chemoresistance in gastric cancer and on recent studies that have sought to overcome the underlying mechanisms of chemoresistance.

关键词： Drug resistance Gastric cancer Chemotherapy

The Cycloaddition Reactions Catalyzed by Some Rare Earth Chlorides

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Chemical Research in Chinese Universities 1999年第4期15卷 381-384页

作者： shi Lei SUN Ren-an YANG Ren-wu YU Shu-wen LIAO shi-jian YU Dao-rong Department of Chemistry Liaoning Normal UniversityDalian116029 Dalian Institute of Chemical Physics Chinese Academy of SciencesDalian116023

Optimizing order policy and credit term for items with inventory-level-dependent demand under trade credit limit

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Journal of Management Science and Engineering 2023年第4期8卷 413-429页

作者： Feng Lin Yongyan shi Xingxuan Zhuo School of Economics and Management Fuzhou UniversityFuzhou350108China

Under the combined effects of inventory-level-dependent demand(ILDD)and trade credit,the retailer is able to order more quantities to stimulate market ***,from the supplier's perspective,two important issues are lacking sufficient ***,during the credit period,the retailer's higher order quantities imply increases in both the retailer's account payable and the supplier's opportunity cost of ***,given the supplier's fixed production rate,the increased market demand may drive the capacity utilization to be ***,by formulating a supplier-dominated system,this paper incorporates trade credit limit(TCL)to address its effects on optimal policies vis-a-vis the item with ***,three indicators can be proposed to reveal which type of financing policy the retailer should ***,based on TCL,the supplier can effectively manage the retailer's order quantity and the corresponding account ***,the retailer's maximum allowable order quantity is developed to ensure that the supplier can supply the retailer's order quantity on ***,when the effects of ILDD become more significant,the manufacturer will reduce the maximum allowable order quantity to control the retailer's order incentive.

关键词： Trade credit limit Inventory-level-dependentdemand Order policy Delay in payments Supplier-dominated channel

Water-saving Technologies,Solar Green House and Ecological Rehabilitation in Minqin Oasis of Gansu Province,China

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Chinese Journal of Population,Resources and Environment 2008年第3期6卷 73-82页

作者： Tao Weichun shi Minjun Zhao Xuetao Graduate University of Chinese Academy of Sciences CAS Beijing 100049 China Research Center on Fictitious Economy and Data Science CAS Beijing 100080 China

Land degradation and desertification have become severe environmental problems in arid areas due to excessive use of water resources. It is urgent to reduce agricultural water use for ecological rehabilitation, which may result in a decrease in agricultural production and farmer＇s welfare. This paper focused on the impacts of some main measures including extensions of watersaving irrigation, expanding solar green house and increasing off-farm employment, which are generally recognized to be important to alleviate water shortage and poverty. A bioconomic model is applied taking Minqin Oasis in Gansu Province as a case study site. Simulation results showed that the effect of expanding solar greenhouse was more positive than other ones so it drew more attention. On the view of the different effects between each irrigation zone, mixed policy patterns suitable for them are suggested. In Baqu, expanding solar greenhouse should be the most important, auxiliary with encouraging pipe irrigation. Inversely, with regard to Quanshan, the major attention should be paid to subsidy for pipe irrigation and it would be better to supply the off-farm employment opportunities to the households in Huqu, where the expanding of solar greenhouse should also be summoned. Finally, it should be noted that farmer＇s income would only resume to 90% of the current level in the short run by putting more effort into local policies. Thus, the ecological compensation is needed to ensure farmer＇s welfare.

关键词： water-saving technologies solar green house Minqin Oasis ecological rehabilitation

Bounding of near-fault ground motion based on radiated seismic energy with a consideration of fault frictional mechanisms

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Earthquake Science 2010年第4期23卷 357-368页

作者： Baoping shi Boyan Liu Lingyuan Meng Earth Science Colleg the Graduate School Chinese Academy of Seiences Beijing 100049 China

The energy radiated as seismic waves strongly depends on the fault rupture process associated with rupture speed and dynamic frictional mechanisms involved in the fault slip motion. Following McGarr and Fletcher approach, we derived a physics-based relationship of the weighted average fault slip velocity vs apparent stress, rupture speed and static stress drop based on a dynamic circular fault model. The resultant function can be approximately used to bound near-fault ground motion and seismic energy associated with near-fault coseismic deformation. Fault frictional overshoot and under- shoot mechanisms governed by a simple slip-weakening constitutive relation are included in our consideration by using dy- namic rupture models named as M- and D-models and proposed by Madariaga （1976） and Boatwright. We applied the above function to the 2008 great Wenchuan earthquake and the 1999 Jiji （Chi-Chi） earthquake to infer the near-fault ground motion called slip weighted average particle velocity and obtained that such model-dependent prediction of weighted average ground velocities is consistent to the results derived from the near-fault strong motion observations. Moreover, we compared our re- sults with the results by McGarr and Fletcher approach, and we found that the values of the weighted average particle veloci- ties we obtained for these two earthquakes are generally smaller and closer to the values by direct integration of strong mo- tion recordings of the near-fault particle velocity waveform data. In other words, if this result comes to be true, it would be a straightforward way used to constrain the near-fault ground motion or to estimate source parameters such as rupture speed, static and dynamic stress drops.

关键词： stress drop radiated energy apparent stress circular-fault-model rupture speed