Molecular mechanisms of chemoresistance in gastric cancer

作     者：Wen-Jia Shi Jin-Bo Gao 

作者机构：Department of Pediatric SurgeryUnion HospitalTongji Medical CollegeHuazhong University of Science and Technology Department of Gastrointestinal SurgeryUnion HospitalTongji Medical CollegeHuazhong University of Science and Technology 

出 版 物：《World Journal of Gastrointestinal Oncology》 (世界胃肠肿瘤学杂志（英文版）（电子版）)

年 卷 期：2016年第8卷第9期

页      面：673-681页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported by National Natural Science Foundation of China No.81572411 

主　　题：Drug resistance Gastric cancer Chemotherapy 

摘      要：Gastric cancer is the fourth most common cancer and the second leading cause of cancer deaths *** is one of the major treatments for gastric cancer,but drug resistance limits the effectiveness of chemotherapy,which results in treatment *** to chemotherapy can be present intrinsically before the administration of chemotherapy or it can develop during *** mechanisms of chemotherapy resistance in gastric cancer are complex and multifactorial.A variety of factors have been demonstrated to be involved in chemoresistance,including the reduced intracellular concentrations of drugs,alterations in drug targets,the dysregulation of cell survival and death signaling pathways,and interactions between cancer cells and the tumor *** review focuses on the molecular mechanisms of chemoresistance in gastric cancer and on recent studies that have sought to overcome the underlying mechanisms of chemoresistance.