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Transcatheter Closure of Perimembranous Ventricular Septal Defects Using an Occluder: 5-Year Outcomes

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Transcatheter Closure of Perimembranous Ventricular Septal D...

2019年浙江省医学会儿科学分会学术大会

作者： Hao Li youyang shi Songyue Zhang Yue Ren Xing Rong Zhenquan Wang Tianhe Xia Tingting Wu Haitang Xu Yaoyao Yan Yi Zhan Maoping Chu Rongzhou Wu The Second Affiliated Hospital of Wenzhou Medical University

Background Transcatheter closure of perimembranous ventricular septal defects is one of the greatest challenges in interventional cardiology. Long-term follow-up data are limited. This report presents our experience with transcatheter closure of perimembranous ventricular septal defects using an *** 253 patients included in the database of the Second Affiliated Hospital and Yuying Children’s Hospital from January 2011– December 2015 with transcatheter closure of perimembranous ventricular septal defects and discharged from follow-up. All patients were invited for clinical and transthoracic echocardiography, electrocardiogram, and thoracic radiography *** Device implantation was successful in 252 of 253 patients(99.6%). The median age was 42 months(range 27 months–18 years). The patients were followed for 6–60 months. The mean defect diameter was 3.5 ± 1.4 mm and the mean size of the ventricular septal defect rim below the aortic valve was 3.7 ± 1.8 mm. The mean diameter of the devices used was 4 mm. Thirty-seven patients developed arrhythmia after the procedure and recovered within 24 months;four patients had hemolysis and four had moderate tricuspid valve regurgitation. No other serious adverse event occurred during the follow-up *** Transcatheter closure of perimembranous ventricular septal defects using an occluder is safe and effective in most patients. Additional studies with larger cohorts and longer follow-up periods are needed to further evaluate the safety of this method. The use of a smaller occluder may shorten the operation time, decreasing the incidence of postoperative arrhythmia.

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从乳腺癌不同分子分型谈中医药研究策略

上海中医药大学学报 2023年第1期37卷 1-9页

作者：李斐斐史有阳刘胜上海中医药大学附属龙华医院上海200032 上海中医药大学研究生院上海201203

乳腺癌的发病率逐年增高,现已位居女性恶性肿瘤发病之首。近年来,中医药治疗乳腺癌的相关研究取得诸多进展,且中医外科辨病与辨证、整体与局部、内治与外治相结合的个体化治疗原则,与现代医学基于不同分子分型的精准治疗理念相符。针对... 详细信息

乳腺癌的发病率逐年增高,现已位居女性恶性肿瘤发病之首。近年来,中医药治疗乳腺癌的相关研究取得诸多进展,且中医外科辨病与辨证、整体与局部、内治与外治相结合的个体化治疗原则,与现代医学基于不同分子分型的精准治疗理念相符。针对乳腺癌的不同分子分型及治疗现状,从中医药抗三阴性乳腺癌(TNBC)复发转移、改善人表皮生长因子受体2(HER2)阳性乳腺癌靶向药物耐药、缓解激素受体(HR)阳性乳腺癌内分泌治疗耐药及其不良反应,归纳总结近年来中医药研究的重要成果,为乳腺癌的中医药治疗提供发展方向。

关键词：乳腺癌中医药分子分型研究策略

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刘胜运用“气血水”理论治疗乳腺囊性增生症

中医学报 2024年第8期39卷 1749-1753页

作者：蒋可心史有阳刘胜上海中医药大学附属龙华医院上海200032 浙江省中医院浙江杭州310006 上海中医药大学上海201203

乳腺囊性增生症属痰瘀互结型乳癖病,即气滞、血瘀、痰湿积聚乳房形成病理产物,根本病因为冲任失调、肝郁脾虚肾亏,主要病机为气不畅、血不利、水不行。治疗时应以调气为本,活血利水为标,气血水同治,活血利水必先要治气,才能打破气血水... 详细信息

乳腺囊性增生症属痰瘀互结型乳癖病,即气滞、血瘀、痰湿积聚乳房形成病理产物,根本病因为冲任失调、肝郁脾虚肾亏,主要病机为气不畅、血不利、水不行。治疗时应以调气为本,活血利水为标,气血水同治,活血利水必先要治气,才能打破气血水三方胶着的恶性循环局面,临证常用三子养亲汤。瘀血与痰水异流同源,瘀水交结,聚于乳络久生痰核,故活血则乳络通,治疗应活血与利水并举,水利则痰核散,临证常用桂枝茯苓丸。

关键词：乳腺囊性增生症 “气血水”理论痰瘀互结气血水同治三子养亲汤桂枝茯苓丸刘胜

Joint Feature Encoding and Task Alignment Mechanism for Emotion-Cause Pair Extraction

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Computers, Materials & Continua 2025年第1期82卷 1069-1086页

作者： shi Li Didi Sun College of Computer and Control Engineering Northeast Forestry UniversityHarbin150040China

With the rapid expansion of social media,analyzing emotions and their causes in texts has gained significant ***-cause pair extraction enables the identification of causal relationships between emotions and their triggers within a text,facilitating a deeper understanding of expressed sentiments and their underlying *** comprehension is crucial for making informed strategic decisions in various business and societal ***,recent research approaches employing multi-task learning frameworks for modeling often face challenges such as the inability to simultaneouslymodel extracted features and their interactions,or inconsistencies in label prediction between emotion-cause pair extraction and independent assistant tasks like emotion and cause *** address these issues,this study proposes an emotion-cause pair extraction methodology that incorporates joint feature encoding and task alignment *** model consists of two primary components:First,joint feature encoding simultaneously generates features for emotion-cause pairs and clauses,enhancing feature interactions between emotion clauses,cause clauses,and emotion-cause ***,the task alignment technique is applied to reduce the labeling distance between emotion-cause pair extraction and the two assistant tasks,capturing deep semantic information interactions among *** proposed method is evaluated on a Chinese benchmark corpus using 10-fold cross-validation,assessing key performance metrics such as precision,recall,and F1 *** results demonstrate that the model achieves an F1 score of 76.05%,surpassing the state-of-the-art by 1.03%.The proposed model exhibits significant improvements in emotion-cause pair extraction(ECPE)and cause extraction(CE)compared to existing methods,validating its *** research introduces a novel approach based on joint feature encoding and task alignment mechanisms,contributing to advancements in emotion-c

关键词： Emotion-cause pair extraction interactive information enhancement joint feature encoding label consistency task alignment mechanisms

Detection and Recognition of Spray Code Numbers on Can Surfaces Based on OCR

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Computers, Materials & Continua 2025年第1期82卷 1109-1128页

作者： Hailong Wang Junchao shi School of Computer Science Zhongyuan University of TechnologyZhengzhou450007China

A two-stage algorithm based on deep learning for the detection and recognition of can bottom spray codes and numbers is proposed to address the problems of small character areas and fast production line speeds in can bottom spray code number *** the coding number detection stage,Differentiable Binarization Network is used as the backbone network,combined with the Attention and Dilation Convolutions Path Aggregation Network feature fusion structure to enhance the model detection *** terms of text recognition,using the Scene Visual Text Recognition coding number recognition network for end-to-end training can alleviate the problem of coding recognition errors caused by image color distortion due to variations in lighting and background *** addition,model pruning and quantization are used to reduce the number ofmodel parameters to meet deployment requirements in resource-constrained environments.A comparative experiment was conducted using the dataset of tank bottom spray code numbers collected on-site,and a transfer experiment was conducted using the dataset of packaging box production *** experimental results show that the algorithm proposed in this study can effectively locate the coding of cans at different positions on the roller conveyor,and can accurately identify the coding numbers at high production line *** Hmean value of the coding number detection is 97.32%,and the accuracy of the coding number recognition is 98.21%.This verifies that the algorithm proposed in this paper has high accuracy in coding number detection and recognition.

关键词： Can coding recognition differentiable binarization network scene visual text recognition model pruning and quantification transport model

木犀草素对人AC16心肌细胞损伤治疗作用的转录组学研究

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世界科学技术-中医药现代化 2020年第5期22卷 1397-1404页

作者：史有阳陈力新秦悦农韩向晖孙霃平刘胜上海中医药大学附属龙华医院上海200032 上海中医药大学中医外科研究所上海200032

目的研究木犀草素(Luteolin,Lut)对阿霉素(Doxorubicin,Dox)诱导的人AC16心肌细胞损伤治疗作用转录组学的影响。方法采用MTT法检测AC16细胞活力,Hoechst33258染色法检测细胞凋亡水平。人AC16心肌细胞设置为正常组、Dox组、Dox加Lut组。... 详细信息

目的研究木犀草素(Luteolin,Lut)对阿霉素(Doxorubicin,Dox)诱导的人AC16心肌细胞损伤治疗作用转录组学的影响。方法采用MTT法检测AC16细胞活力,Hoechst33258染色法检测细胞凋亡水平。人AC16心肌细胞设置为正常组、Dox组、Dox加Lut组。正常组加入空白培养基,Dox组加入1μM的Dox,Dox加Lut组加入1μM的Dox及20μM的Lut。药物作用24 h后,提取各组细胞总RNA,进行转录组测序,并对差异表达基因(DEG)进行基因本体(GO)功能和基因组百科全书(KEGG)通路富集分析。结果Dox促进了AC16细胞的凋亡(P<0.05),Lut抑制了Dox诱导的AC16细胞凋亡(P<0.05)。Dox组与正常组进行比较得到3637个差异基因,其中上调基因1723个,下调基因1914个;Lut加Dox组与Dox组进行比较得到212个差异基因,其中上调基因52个,下调基因160个。选取交集基因,通过GO功能和KEGG富集分析,差异基因主要富集于细胞骨架、细胞囊泡、钙离子内流、内质网应激以及细胞衰老、细胞凋亡等信号通路。结论木犀草素可通过多靶点抑制阿霉素诱导的人AC16心肌细胞凋亡,其中调控心肌细胞骨架及细胞结构损伤可能是抑制细胞凋亡的关键机制。

关键词：木犀草素阿霉素转录组学差异基因凋亡

基于肠道菌群-免疫系统探讨乳腺癌从脾肾论治

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中华中医药杂志 2023年第12期38卷 6096-6099页

作者：杨小娟谢颖杨瑞史有阳张洋李斐斐刘胜上海中医药大学附属龙华医院上海200032

乳腺癌已成为全球最常见的恶性肿瘤,严重威胁女性生命健康。现代研究显示,肠道菌群可能通过其衍生的代谢产物调节免疫系统功能,参与乳腺癌发生发展的病理过程。中医多从脾肾论治乳腺癌,疗效明确,但其作用机制尚未阐明。而脾肾与肠道菌... 详细信息

乳腺癌已成为全球最常见的恶性肿瘤,严重威胁女性生命健康。现代研究显示,肠道菌群可能通过其衍生的代谢产物调节免疫系统功能,参与乳腺癌发生发展的病理过程。中医多从脾肾论治乳腺癌,疗效明确,但其作用机制尚未阐明。而脾肾与肠道菌群及免疫系统间存在相关性。脾主运化、统血,脾为之卫分别与肠道菌群对营养物质的消化吸收及免疫系统的发育和成熟功能相似,肾藏精、主骨生髓与肠道菌群及免疫系统的来源和功能发挥密切相关。故文章拟从“肠道菌群-免疫系统”角度,阐述乳腺癌从脾肾论治的现代科学内涵,以期为中医药治疗乳腺癌的研究提供新的思路和方法。

关键词：肠道菌群免疫系统乳腺癌脾肾辨证论治

仙苓莲夏方对三阴性乳腺癌小鼠肠道菌群及免疫功能的影响

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中华中医药杂志 2023年第11期38卷 5441-5446页

作者：杨小娟谢颖杨瑞马梅史有阳李斐斐张洋刘胜上海中医药大学附属龙华医院上海200032

目的:探讨仙苓莲夏方对三阴性乳腺癌小鼠的治疗作用及对肠道菌群和免疫功能的影响。方法:21只雌性BALB/c小鼠随机分为正常组、模型组和仙苓莲夏方组,每组7只,连续给药4周。治疗结束后剥离肿瘤,计算体积;采集外周血进行血常规检测,流式... 详细信息

目的:探讨仙苓莲夏方对三阴性乳腺癌小鼠的治疗作用及对肠道菌群和免疫功能的影响。方法:21只雌性BALB/c小鼠随机分为正常组、模型组和仙苓莲夏方组,每组7只,连续给药4周。治疗结束后剥离肿瘤,计算体积;采集外周血进行血常规检测,流式细胞术分析血液和骨髓中的免疫细胞;无菌条件下收集各组小鼠粪便,提取肠道菌群DNA,对V3-V4区进行双端测序及生物信息学分析。结果:与模型组比较,仙苓莲夏方显著减小肿瘤重量、体积及脾脏重量,降低外周血白细胞、血小板、单核细胞、淋巴细胞和中性粒细胞的数量,升高骨髓中短期造血干细胞(ST-HSC)和巨核系-红系祖细胞(MEP)及外周血中自然杀伤细胞(NK)的百分比,同时降低外周血中Treg、M-MDSC的百分比(P<0.05,P<0.01)。拟杆菌门、厚壁菌门和变形菌门是各组小鼠的主要菌群,且变形菌门的相对丰度在模型组中显著降低,仙苓莲夏方干预后显著升高(P<0.05)。结论:仙苓莲夏方可以有效抑制三阴性乳腺癌小鼠肿瘤生长,保护骨髓造血,降低外周血中抑制性细胞、升高NK细胞的百分比,调节肠道菌群紊乱。

关键词：三阴性乳腺癌仙苓莲夏方肠道菌群免疫细胞 16S rRNA基因测序流式细胞术

刘胜教授基于五脏相关理论治疗晚期乳腺癌经验

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西部中医药 2021年第5期34卷 39-41页

作者：史有阳杨瑞孙霃平(指导) 刘胜上海中医药大学附属龙华医院中西医结合乳腺科上海200032 上海中医药大学中医外科研究所

通过验案总结刘胜教授基于五脏相关理论治疗晚期乳腺癌的经验,刘胜教授认为正气亏虚、肝肾不足、冲任失调、痰毒瘀结为乳腺癌发病的根本病因;正虚毒留、余毒旁窜是晚期乳腺癌复发转移的关键因素;治疗应以宣肺、补心、疏肝、健脾、温肾... 详细信息

通过验案总结刘胜教授基于五脏相关理论治疗晚期乳腺癌的经验,刘胜教授认为正气亏虚、肝肾不足、冲任失调、痰毒瘀结为乳腺癌发病的根本病因;正虚毒留、余毒旁窜是晚期乳腺癌复发转移的关键因素;治疗应以宣肺、补心、疏肝、健脾、温肾等法进行辨证论治。

关键词：乳腺癌晚期五脏经验刘胜