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Xianling Lianxia formula improves the efficacy of trastuzumab by enhancing NK cell-mediated ADCC in HER2-positive BC

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Journal of Pharmaceutical Analysis 2024年第10期14卷 1450-1467页

作者： Feifei Li youyang shi Mei Ma Xiaojuan Yang Xiaosong Chen Ying Xie Sheng Liu Department of Breast Surgery Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai200030China Institute of Chinese Traditional Surgery Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai200030China Institute of Toxicology School of Public HealthLanzhou UniversityLanzhou730000China Department of General Surgery Comprehensive Breast Health CenterRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai200001China

Trastuzumab has improved survival rates in human epidermal growth factor receptor 2(HER2)-positive breast cancer(BC),but drug resistance leads to treatment *** killer(NK)cell-mediated antibody-dependent cell cytotoxicity(ADCC)represents an essential antitumor immune mechanism of *** Chinese medicine(TCM)has been used for centuries to treat diseases because of its capacity to improve immune *** Lianxia formula(XLLXF),based on the principle of“strengthening body and eliminating toxin”,exhibits a synergistic effect in the trastuzumab treatment of patients with HER2-positive ***,this synergistic effect of XLLXF was executed by enhancing NK cells and ADCC,as demonstrated through in vitro co-culture of NK cells and BC cells and in vivo intervention ***,the augmented impact of XLLXF on NK cells is linked to a decrease in cytokine inducible Src homology 2(SH2)containing protein(CISH)expression,which in turn activates the Janus kinase 1(JAK1)/signal transducer and activator of transcription 5(STAT5)***,these findings suggested that XLLXF holds promise for enhancing NK cell function and sensitizing patients with HER2-positive BC to trastuzumab.

关键词： HER2-positive breast cancer Traditional chinese medicine Trastuzumab NK cell ADCC effect

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Investigating the Immunogenic Cell Death‑Dependent Subtypes and Prognostic Signature of Triple‑Negative Breast Cancer

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Phenomics 2024年第1期4卷 34-45页

作者： youyang shi Yuanyuan Wu Feifei Li Kexin Jiang Xiaofang Fang Yu Wang Xiaoyun Song Rui Wang Lixin Chen Jinzhou Zheng Chunyu Wu Yuenong Qin Xiaofei Liu Sheng Liu Breast Surgery Longhua HospitalShanghai University of Traditional Chinese MedicineWanping South Road725Shanghai 200033China First Clinical College Shandong University of Traditional Chinese MedicineNo.16369Jingshi RoadLixia DistrictJinan 250011ShandongChina

Recently,immunotherapy has emerged as a promising and efective method for treating triple-negative breast cancer(TNBC).However,challenges still *** cell death(ICD)is considered a prospective treatment and potential combinational treatment strategy as it induces an anti-tumor immune response by presenting the antigenic epitopes of dead ***,the ICD process in TNBC and its impact on disease progression and the response to immunotherapy are not well *** this study,we observed dysregulation of the ICD process and verifed the altered expression of prognostic ICD genes in TNBC through quantitative real-time polymerase chain reaction(qRT-PCR)*** investigate the potential role of the ICD process in TNBC progression,we determined the ICD-dependent subtypes,and two were *** of their distinct tumor immune microenvironment(TIME)and cancer hallmark features revealed that Cluster 1 and 2 corresponded to the immune“cold”and“hot”phenotypes,*** addition,we constructed the prognostic signature ICD score of TNBC patients and demonstrated its clinical independence and *** ICD score could also serve as a potential biomarker for immune checkpoint blockade and may aid in the identifcation of targeted efective agents for individualized clinical strategies.

关键词： Immunogenic cell death Triple-negative breast cancer Tumor immune microenvironment Prognostic signature

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Comprehensive Metabolomic Characterization in Coronary Artery Lesions of Kawasaki Disease

Comprehensive Metabolomic Characterization in Coronary Arter...

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2018年浙江省医学会儿科学分会学术年会

作者： Xuliang Wang Ping Li Yaoyao Yan youyang shi yi Zhan Rongzhou Wu jingzhou Chen Children's Heart Center The Second Affiliated Hospital and Yuying Children's HospitalInstitute of Cardiovascular Development and Translational MedicineWenzhou Medical University State Key Laboratory of Cardiovascular Disease FuWai HospitalNational Center for Cardiovascular DiseasesPeking Union Medical College & Chinese Academy of Medical Sciences

Background:Coronary artery lesion(CAL) was a serious complication of Kawasaki Disease(KD) which will result in stenosis and *** uncleared pathogenesis and lacking of the effective diagnostic biomarks according to CAL of KD was necessary for clinical *** and diagnostic biomarks could be discovered by metabolomic profiling of ***:40 of CAL and 39 of non-coronary artery lesion(NCAL) patients of KD after drug treatment enrolled and the plasma were collected for metabolomic *** metabolites were detected by ultra high performance liquid tandem chromatography quadrupole time of flight mass spectrometry and analyzed by multivariate statistics between ***:The metabolic profiles could clearly distinguish CAL and NCAL patients of KD at acture *** bile acid biosynthesis,phenylalanine metabolism and fatty acid biosynthesis were disorded in coronary artery *** 14 significantly different expressed metabolites were found,and palmitic acid had the biggest fold chang at 9.879 among them.A panel of 4 metabolites,1-stearoyl-sn-glycerol,palmitic acid,heptadecanoic acid and phenylethylamine had a well power to diagnosis CAL in KD patients accroding to ROC curve,the areas under the curve,sensitivity,and specificity at 0.978,95%,100%.Concluions:Plasma metabolomics had a powerful ability to discover biomarks and potential pathogenesis in KD.A panel of 4 metabolites could be biomarks to identify CAL in KD *** palmitic acid could be a new insight in furture research of KD with CAL.

关键词： Kawasaki disease Mucocutaneous Lymph Node Syndrome Coronary disease Metabolomics

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基于HER-2阳性乳腺癌治疗难点探讨中医药治疗特色及研究进展

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中国实验方剂学杂志 2023年第7期29卷 237-243页

作者：李斐斐史有阳张洋杨小娟刘胜上海中医药大学附属龙华医院上海200030

人表皮生长因子受体-2(HER-2)阳性乳腺癌因HER-2的过表达而具有高侵袭转移潜能,导致患者的不良预后。靶向HER-2治疗药物如曲妥珠单抗、帕妥珠单抗、恩美曲妥珠单抗的上市显著延长了患者的无病生存期(DFS)。然而,频发的多药耐药、肿瘤的... 详细信息

人表皮生长因子受体-2(HER-2)阳性乳腺癌因HER-2的过表达而具有高侵袭转移潜能,导致患者的不良预后。靶向HER-2治疗药物如曲妥珠单抗、帕妥珠单抗、恩美曲妥珠单抗的上市显著延长了患者的无病生存期(DFS)。然而,频发的多药耐药、肿瘤的复发转移及辅助治疗带来的心脏损伤、胃肠道不适等不良反应,仍然是HER-2阳性乳腺癌的治疗挑战。中医药对于乳腺癌的认识源远流长,在几千年的传承与创新发展中,已逐步形成具有中医药特色的规范化治疗体系,在乳腺癌治疗中表现出独特优势及显著疗效。中医药理论指导下的“辨证施治”“分期分型论治”“因人制宜”“根据癌毒邪气从化的不同分脏腑论治”等治疗原则,与现代个体化精准治疗的理念不谋而合。该文基于HER-2阳性乳腺癌中存在的“多药耐药、肿瘤复发转移、心脏毒性、胃肠道不适”等治疗难点,从中医学对乳腺癌术后“扶正兼以祛邪、辨证施治”的基本治疗理念出发,梳理归纳中医药在“逆转HER-2阳性乳腺癌靶向药物的多药耐药、协同增效、抑制乳腺癌复发转移、延长患者无病生存期、改善患者预后、减轻辅助治疗所带来的不良反应、提高患者生活质量”等方面的治疗特色及研究进展,旨在为HER-2阳性乳腺癌的中医药治疗提供参考。

关键词：中医药人表皮生长因子-2(HER-2)阳性乳腺癌耐药复发转移不良反应

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The new SHSMA Patent Ductus Arteriosus Occluder: Single Center Experience

The new SHSMA Patent Ductus Arteriosus Occluder: Single Cent...

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2019年浙江省医学会儿科学分会学术大会

作者： youyang shi Jing Huang Tingting Wu Songyue Zhang Hao Li Qiaoyu Wang Ping Li Rongzhou Wu Children’s Heart Center The Second Affiliated Hospital and Yuying Children’s Hospital Institute of Cardiovascular Development and Translational Medicine Wenzhou Medical University

Objectives: To evaluate the feasibility, safety, and efficacy of the SHSMA patent ductus arteriosus(PDA) occluder for closure of ***: The new type SHSMA patent ductus arteriosus(PDA) occluder is novel, self-shaping Nitinol wire device with nano fabric patches integrated into the shank of the device to assure a better obturation of the ductus. The SHSMA PDA occluder has undergone animal ***: A prospective, randomized pilot study was started in August 2014.13 patients were included until June 2017. Patients weighing less than 6 kg or those with associated cardiac anomalies that required surgery were excluded. All patients were followed up by transthoracic echocardiography, electrocardiogram, and chest radiographs at 24 hours, 30, 90, 180, 360 and 720 days after implantation. All occluders were delivered via 7-9 F long sheaths and PDA closures were performed following standard ***: Thirteen patients(6 nano-film single-rivet, 7 double-rivet), were included. All the 13 patients were closed successfully using SHSMA ductal occluder, 5 patients(83.3%) in nano fabric patches singlerivet group, and 7 patients(100%) in double-rivet group had immediate and complete closure on angiography. Within 24 hours, color Doppler revealed complete closure in all 13 patients, 100% at 30 days, and in 100% of patients at 2 years. There was no device embolization, hemolysis, or obstruction to the pulmonary artery or descending ***: The new type SHSMA PDA occluder is feasible, safe and effective.

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Interventional treatment of patent ductus arteriosus combined with congenital bronchial artery pulmonary arteriovenous fistula: clinical outcomes and follow-up

Interventional treatment of patent ductus arteriosus combine...

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2019年浙江省医学会儿科学分会学术大会

作者： Ping Li Songyue Zhang Yaoyao Yan Bo Cheng Yue Ren Xing Rong Zhenquan Wang Huixian Qiu youyang shi Rongzhou Wu The Second Affiliated Hospital of Wenzhou Medical University

Background Congenital bronchial artery to pulmonary artery or vein fistula(BA-PAVF) is a rare abnormality which may induce recurrent pulmonary infection, fatal hemoptysis, and respiratory failure and it is even scarcely reported that BA-PAVF coexisted with patent ductus arteriosus(PDA).Therefore, BA-PAVF can be easily neglected or misdiagnosed in clinic without being treated *** and results In our study, 22 children were diagnosed with congenital BA-PAVF and PDA by cardiac catheterization and selective bronchial *** BAPAVF which was greater than the horizontal adjacent bronchial artery, vascular plug, MicroNester embolization coils, and interlock fibered IDC occlusion system were respectively used to close BA-PAVF after the transcatheter closure of PDA. And the size, shape, number, tortuosity degree of the fistula, the location of the lesions, the specific complications and family economic status were seriously considered before the procedure. 2 of the patients respectively existed small atrial septal defect(ASD) and small ventricular septal defect(VSD). Finally, 9 of them accepted transcatheter embolization(TCE) according to the size of the fistula. After intermediate to long-term followup, all patients have no abnormal ***-stage interventional closure of BA-PAVF and PDA can be used safely and effectively in children coexisted with BA-PAV and PDAand selective bronchial arteriography is an optimal examination to precisely localize BA-PAVF, but the establishment of specific therapy criteria needs more clinical data and summary.

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primary carnitine deficiency case report

primary carnitine deficiency case report

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2019年浙江省医学会儿科学分会学术大会

作者： Yaoyao Yan Rongzhou Wu Zhenquan Wang Ping Li Yi Zhan youyang shi Tingting Wu Hao Li Qiaofang Ye Qiaoyu Wang The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical Universuty

Objective:To explore primary carnitine deficiency(PCD)-induced cardiomyopathy patients’ clinical features,gene mutation and prognosis. To analyze the therapeutic dose of L-carnitine and myocardial recovery. To improve the understanding of cardiomyopathy caused by heterozygous mutation of PCD so as to promote the timely diagnosis and the accurate *** Analyzing the clinical data of PCD hospitalized in The Second Affiliated Hospital of Wenzhou Medical University in 2016, summarized and analyzed the results of gene test and patient’s clinical feature,electrocardiogram, echocardiography, plasma free carnitine level before and after *** involvement is one of the most common clinical features of PCD, which occurs on average in children aged 2-4 years. In this case, the female, who was 5 years old at the time of diagnosis, was admitted to hospital due to *** was hepatomegaly and blood ammonia increased to 110 umol/L(normally 9-30μmol/L) on admission;echocardiography showed left ventricular hypertrophy: left ventricular posterior wall during diastole(LVPWd) was 8.0 mm(normally 5-7 mm);left ventricular enlargement: Left ventricular internal diameter at end-diastolic(LVIDd) is 38 mm(normal value is less than 34 mm) and left ventricular ejection fraction(LVEF) is 58%(normal value is greater than 55%);chest radiographs suggest an increase in cardiothoracic ratio with 57.8%;electrocardiogram showed high T waves;first screen plasma free carnitine concentration was decreased to 1.19μmol/L(normal value 10-60μmol/L) and with other kinds of acylcarnitine decreased. Finally,the heterozygous mutation in exon 4 of the SLC22 A5 gene was found by the second generation DNA sequencing technique and further diagnosed as PCD. At the early stage of diagnosis, 100 mg/(kg·day) L-carnitine was given intravenously to supplement carnitine, after two weeks,the serum carnitine level returned to normal, and then changed to L-carnitine oral solution(D

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Survivin protects neonatal mouse cardiomyocytes from CVB3-induced apoptosis in a caspase-dependent manner

Survivin protects neonatal mouse cardiomyocytes from CVB3-in...

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2019年浙江省医学会儿科学分会学术大会

作者： Tingting Wu Ping Li Hao Li Yi Zhan Songyue Zhang youyang shi Yaoyao Yan Tianhe Xia Zhenquan Wang Rongzhou Wu The Second Affiliated Hospital of Wenzhou Medical University

Background Viral myocarditis(VMC) is a kind of inflammatory cardiomyopathy mainly affecting children and young adults and resulting in heart failure due to dilated cardiomyopathy or cardiac arrest. Cardiomyocyte apoptosis has been shown to play a critical role in the pathogenesis of coxsackievirus B3(CVB3) induced VMC and blocking of this process may contribute to the therapeutic effect towards VMC. Therefore, the aim of this study was to examine whether survivin, one of the strongest antiapoptotic proteins, participates in the apoptotic activity after CVB3 infection and further reveal its related *** and results Herethe cultured neonatal mouse cardiomyocytes(NMCs) were exposed to CVB3 to establish the cell model of VMC and we found a time-dependent manner of survivin expression after CVB3 infection by Western Blot. Lentivirus was next used to mediate survivin expression thereby examine the function of survivin in CVB3-infected NMCs. TUNEL assay demonstrated that survivin overexpression interrupted CVB3-induced apoptosis and significantly decreased the apoptotic rate at 36 h and 60 h after CVB3 infection. It was next examined whether caspase-3 and-9 were involved in the antiapoptotic pathway initiated by survivin via Western Blot. The results showed a reverse relationship between survivin expression and cleaved caspase-3 and-9 expression, suggesting that survivin may inhibit apoptosis by restraining the activity of caspase-3 and-9. Moreover, the supernatant from cultured NMCs was extracted to detect the quantitation of released LDH and a sharp decrease was shown in survivin overexpressed group compared to CVB3 infected group, indicating a protective role of survivin in CVB3-induced cell *** In the present study, we demonstrated that survivin was triggered by CVB3 infection in NMCs in a time-dependent manner and executed its antiapoptotic effects via caspase-3-and caspase-9-dependent signaling pathway.

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Prophylactic Transcatheter Bronchial Arterial Embolization in Treatment of Congenital Bronchial Artery to Pulmonary Artery or Vein Fistula

Prophylactic Transcatheter Bronchial Arterial Embolization i...

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2018年浙江省医学会儿科学分会学术年会

作者： Songyue Zhang Ping Li youyang shi Bo Cheng Yue Ren Xing Rong Zhenquan Wang Huixian Qiu Rongzhou Wu Maoping Chu Children’s Heart Center the Second Affiliated Hospital and Yuying Children’s HospitalInstitute of Cardiovascular Development and Translational MedicineWenzhou Medical University

Objective:This study sought to demonstrate that prophylactic transcatheter embolization(TCE) can be used safely and effectively for the treatment of congenital bronchial artery to pulmonary artery or vein(BA-PAV) fistula and selective bronchial arteriography is an optimal examination to precisely localize these abnormal ***:BA-PAV fistula is a rare abnormality and may induce recurrent pulmonary infection,fatal hemoptysis and respiratory ***,there is no recommended treatment experience or protocol in the pediatric population.

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乳腺癌类器官研究进展及中医药应用展望

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世界科学技术-中医药现代化 2024年第5期26卷 1118-1124页

作者：高阳刘胜周细秋史有阳上海中医药大学附属龙华医院乳腺外科上海200030 上海中医药大学研究生院上海201203 上海中医药大学中医外科研究所上海200030

乳腺癌是一种高度异质性的恶性肿瘤,其包括多种不同的亚型,这些亚型在遗传、病理、临床治疗及预后上各不相同。传统的乳腺癌细胞系研究模型不能完全符合临床肿瘤发病的实际病理过程及其肿瘤异质性的特征。乳腺癌类器官(Organoids)是一... 详细信息

乳腺癌是一种高度异质性的恶性肿瘤,其包括多种不同的亚型,这些亚型在遗传、病理、临床治疗及预后上各不相同。传统的乳腺癌细胞系研究模型不能完全符合临床肿瘤发病的实际病理过程及其肿瘤异质性的特征。乳腺癌类器官(Organoids)是一种基于3D细胞培养(Three-dimensional cells culture)系统建立的模型,在保留患者肿瘤的分子表型和基因型变化的同时,再现原发肿瘤的异质性,因此被应用于肿瘤发病机制和抗肿瘤药物筛选的研究中。目前,乳腺癌的中医药研究大多以细胞系和人源性肿瘤异种移植为主,类器官的相关研究则相对缺乏。该综述简要介绍乳腺癌类器官培养体系的发展,以及其在生命科学研究中的应用,以期为中医药乳腺癌相关研究提供思路。

关键词：乳腺癌类器官研究进展中医药展望

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