Comprehensive Metabolomic Characterization in Coronary Artery Lesions of Kawasaki Disease
作者单位：Children's Heart CenterThe Second Affiliated Hospital and Yuying Children's HospitalInstitute of Cardiovascular Development and Translational MedicineWenzhou Medical University State Key Laboratory of Cardiovascular DiseaseFuWai HospitalNational Center for Cardiovascular DiseasesPeking Union Medical College & Chinese Academy of Medical Sciences
会议名称：《2018年浙江省医学会儿科学分会学术年会》
会议日期：2018年
学科分类：1002[医学-临床医学] 100202[医学-儿科学] 10[医学]
关 键 词：Kawasaki disease Mucocutaneous Lymph Node Syndrome Coronary disease Metabolomics
摘 要：Background:Coronary artery lesion(CAL) was a serious complication of Kawasaki Disease(KD) which will result in stenosis and *** uncleared pathogenesis and lacking of the effective diagnostic biomarks according to CAL of KD was necessary for clinical *** and diagnostic biomarks could be discovered by metabolomic profiling of ***:40 of CAL and 39 of non-coronary artery lesion(NCAL) patients of KD after drug treatment enrolled and the plasma were collected for metabolomic *** metabolites were detected by ultra high performance liquid tandem chromatography quadrupole time of flight mass spectrometry and analyzed by multivariate statistics between ***:The metabolic profiles could clearly distinguish CAL and NCAL patients of KD at acture *** bile acid biosynthesis,phenylalanine metabolism and fatty acid biosynthesis were disorded in coronary artery *** 14 significantly different expressed metabolites were found,and palmitic acid had the biggest fold chang at 9.879 among them.A panel of 4 metabolites,1-stearoyl-sn-glycerol,palmitic acid,heptadecanoic acid and phenylethylamine had a well power to diagnosis CAL in KD patients accroding to ROC curve,the areas under the curve,sensitivity,and specificity at 0.978,95%,100%.Concluions:Plasma metabolomics had a powerful ability to discover biomarks and potential pathogenesis in KD.A panel of 4 metabolites could be biomarks to identify CAL in KD *** palmitic acid could be a new insight in furture research of KD with CAL.