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Fully implantable and battery-free wireless optoelectronic system for modulable cancer therapy and real-time monitoring

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npj Flexible Electronics 2023年第1期7卷 119-130页

作者： Kiho Kim In Sik Min Tae Hee Kim Do Hyeon Kim Seungwon Hwang Kyowon Kang Kyubeen Kim Sangun Park Jongmin Lee Young Uk Cho jung Woo Lee Woon-Hong Yeo Young Min Song youngmee jung Ki Jun Yu Functional Bio-integrated Electronics and Energy Management Lab School of Electrical and Electronic EngineeringYonsei University50 Yonsei-roSeodaemun-guSeoul 03722Republic of Korea Center for Biomaterials Biomedical Research InstituteKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Department of Fusion Research and Collaboration Biomedical Research InstituteSeoul National University HospitalSeoul 03080Republic of Korea School of Electrical Engineering and Computer Science(EECS) Gwangju Institute of Science and Technology(GIST)Gwangju 61005Republic of Korea PA1 Foundry BusinessSamsung Electronics1 Samsungjeonja-roHwaseong-siGyeonggi-doRepublic of Korea R&D Center DNA Lab PharmaresearchSeongnam 13486Republic of Korea KU-KIST Graduate School of Converging Science and Technology Korea UniversitySeoul 136-705Republic of Korea School of Materials Science and Engineering Energy Materials for Soft Electronics LaboratoryPusan National UniversityBusan 46241Republic of Korea IEN Center for Human-Centric Interfaces and Engineering and George W.Woodruff School of Mechanical Engineering Georgia Institute of TechnologyAtlantaGA 30332USA Wallace H.Coulter Department of Biomedical Engineering Georgia Institute of Technology and Emory University School of MedicineAtlantaGA 30332USA Institute for Robotics and Intelligent Machines Parker H.Petit Institute for Bioengineering and BiosciencesInstitute for MaterialsNeural Engineering CenterGeorgia Institute of TechnologyAtlantaGA 30332USA School of Electrical and Electronic Engineering YU-Korea Institute of Science and Technology(KIST)InstituteYonsei University50Yonsei-roSeodaemun-guSeoul 03722Republic of Korea

Photodynamic therapy(PDT)is attracting attention as a next-generation cancer treatment that can selectively destroy malignant tissues,exhibit fewer side effects,and lack pain during *** PDT systems have recently been developed to resolve the issues of bulky and expensive conventional PDT systems and to implement continuous and repetitive *** implantable PDT systems,however,are not able to perform multiple functions simultaneously,such as modulating light intensity,measuring,and transmitting tumor-related data,resulting in the complexity of cancer ***,we introduce a flexible and fully implantable wireless optoelectronic system capable of continuous and effective cancer treatment by fusing PDT and hyperthermia and enabling tumor size monitoring in *** system exploits micro inorganic light-emitting diodes(μ-LED)that emit light with a wavelength of 624 nm,designed not to affect surrounding normal tissues by utilizing a fully programmable light intensity ofμ-LED and precisely monitoring the tumor size by Si phototransistor during a long-term implantation(2–3 weeks).The superiority of simultaneous cancer treatment and tumor size monitoring capabilities of our system operated by wireless power and data transmissions with a cell phone was confirmed through in vitro experiments,ray-tracing simulation results,and a tumor xenograft mouse model in *** all-in-one single system for cancer treatment offers opportunities to not only enable effective treatment of tumors located deep in the tissue but also enable precise and continuous monitoring of tumor size in real-time.

关键词： optoelectronic enable battery

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Facile Surface Functionalization of Electrospun Elastic Nanofibers Via Initiated Chemical Vapor Deposition for Enhanced Neural Cell Adhesion and Alignment

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Advanced Fiber Materials 2024年第5期6卷 1583-1595页

作者： Yerim Jang Soonjong Roh Younghak Cho youngmee jung Kangwon Lee Nakwon Choi Jin Yoo Hyejeong Seong Brain Science Institute Korea Institutes of Science and Technology(KIST)Seoul 02792Republic of Korea KU-KIST Graduate School of Converging Science and Technology Korea UniversitySeoul 02841Republic of Korea Biomaterials Research Center Korea Institutes of Science and Technology(KIST)Seoul 02792Republic of Korea Department of Applied Bioengineering Graduate School of Convergence Science and TechnologySeoul National UniversitySeoul 08826Republic of Korea Research Institute for Convergence Science Seoul National UniversitySuwon-siGyeonggi-do 16229Republic of Korea Division of Bio-Medical Science and Technology KIST SchoolKorea University of Science and Technology(UST)Seoul 02792Republic of Korea School of Electrical Electronic Engineering YU-KIST InstituteYonsei UniversitySeoul 03722Republic of Korea

An advanced approach for functionalizing the surfaces of electrospun poly(l-lactide-co-ε-caprolactone)(PLCL)nanofibers for biomedical applications is presented *** initiated chemical vapor deposition(iCVD),a coating of the copolymer p(PFMA-co-DVB)containing poly(pentafluorophenyl methacrylate)(PFMA)and divinylbenzene(DVB)was applied to the PLCL *** coating facilitated efficient immobilization of the biomolecules on the PLCL nanofiber surfaces,allowing precise adjustments to the polymer composition through modulation of the monomer flow *** resulting copolymer exhibited superior efficiency for immobilizing IgG,as confirmed by immunofluorescence intensity *** vitro studies conducted with different neural cell types demonstrated that the laminin-coated iCVD-functionalized PLCL nanofibers maintained their inherent biocompatibility while significantly enhancing cell *** exploiting the elastic nature of the PLCL nanofibers,cell elongation could be successfully manipulated by controlling the nanofiber alignment,as demonstrated by scanning electron microscopy and quantification of the immunofluorescence image *** findings highlight the potential of iCVD-modified PLCL nanofibers as versatile platforms for neural tissue engineering and various biomedical applications,allowing valuable biomaterial surface modifications for enhanced cellular interactions.

关键词： Electrospun nanofiber Initiated chemical vapor deposition Poly(l-lactide-co-ε-caprolactone) Post-surface modification Neural cells

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Foldable three dimensional neural electrode arrays for simultaneous brain interfacing of cortical surface and intracortical multilayers

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npj Flexible Electronics 2022年第1期6卷 840-853页

作者： Ju Young Lee Sang Hoon Park Yujin Kim Young Uk Cho Jaejin Park jung-Hoon Hong Kyubeen Kim Jongwoon Shin Jeong Eun Ju In Sik Min Mingyu Sang Hyogeun Shin Ui-Jin Jeong Yuyan Gao Bowen Li Aizhan Zhumbayeva Kyung Yeun Kim Eun-Bin Hong Min-Ho Nam Hojeong Jeon youngmee jung Huanyu Cheng Il-Joo Cho Ki Jun Yu School of Electrical and Electronic Engineering Yonsei University50 Yonsei-roSeodaemunguSeoul 03722Republic of Korea Department of Biomedical Sciences College of MedicineKorea UniversitySeoul 02841Republic of Korea Brain Science Institute Korea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea School of Electrical Engineering Korea UniversitySeoul 02841Republic of Korea Department of Engineering Science and Mechanics The Pennsylvania State UniversityUniversity ParkPA 16802USA Center for Biomaterials Biomedical Research InstituteKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Biomaterials Research Center Biomedical Research DivisionKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Department of Mechanical Engineering Seoul National UniversitySeoul 08826Republic of Korea Department of Biotechnology College of Life Science and BiotechnologyYonsei UniversitySeoul 03722Republic of Korea Department of KHU-KIST Convergence Science and Technology Kyung Hee UniversitySeoul 02447Republic of Korea KU-KIST Graduate School of Converging Science and Technology Korea UniversitySeoul 02841Republic of Korea School of Electrical and Electronic Engineering YU-KIST InstituteYonsei UniversitySeoul 03722Republic of Korea Department of Materials Science and Engineering The Pennsylvania State UniversityUniversity ParkPA 16802USA Materials Research Institute The Pennsylvania State UniversityUniversity ParkPA 16802USA Department of Anatomy College of MedicineKorea UniversitySeoul 02841Republic of Korea Department of Electrical and Electronic Engineering YU-Korea Institute of Science and Technology(KIST)InstituteYonsei University50Yonsei-roSeodaemun-guSeoul 03722Korea

Challenges in the understanding of three-dimensional(3D)brain networks by simultaneously recording both surface and intracortical areas of brain signals remain due to the difficulties of constructing mechanical design and spatial limitations of the implanted ***,we present a foldable and flexible 3D neural prosthetic that facilitates the 3D mapping of complex neural circuits with high spatiotemporal dynamics from the intracortical to cortical *** device is the tool to map the 3D neural transmission through sophisticatedly designed four flexible penetrating shanks and surface electrode arrays in one integrated *** demonstrate the potential possibilities of identifying correlations of neural activities from the intracortical area to cortical regions through continuous monitoring of electrophysiological *** also exploited the structural properties of the device to record synchronized signals of single spikes evoked by unidirectional total whisker *** platform offers opportunities to clarify unpredictable 3D neural pathways and provides a next-generation neural interface.

关键词： neural electrode simultaneous

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The H∞ Robust Stability and Performance Conditions for Uncertain Robot Manipulators

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IEEE/CAA Journal of Automatica Sinica 2025年第1期 270-272页

作者： Geun Il Song Hae Yeon Park jung Hoon Kim the Department of Electrical Engineering Pohang University of Science and Technology (POSTECH) the Department of Electrical Engineering Pohang University of Science and Technology (POSTECH) the Institute for Convergence Research and Education in Advanced Technology Yonsei University

Dear Editor,H∞This letter develops a new framework for the robust stability and performance conditions as well as the relevant controller synthesis with respect to uncertain robot *** often exist model uncertainties between the nominal model and the real robot manipulator and disturbances. Hence, dealing with their effects plays a crucial role in leading to high tracking performances, as discussed in [1]–[5].

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Study on durability of Pt supported on graphitized carbon under simulated start-up/shut-down conditions for polymer electrolyte membrane fuel cells

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Journal of Energy Chemistry 2018年第1期27卷 326-334页

作者： Won Suk jung Department of Chemical Engineering University of South CarolinaColumbiaSC 29208USA

The primary issue for the commercialization of proton exchange membrane fuel cell（PEMFC） is the carbon corrosion of support under start-up/shut-down conditions. In this study, we employ the nanostructured graphitized carbon induced by heat-treatment. The degree of graphitization starts to increase between 900 and 1300 ℃ as evidenced by the change of specific surface area, interlayer spacing, and ID/IG value. Pt nanoparticles are deposited on fresh carbon black（Pt/CB） and carbon heat-treated at 1700 ℃（Pt/HCB17） with similar particle size and distribution. Electrochemical characterization demonstrates that the Pt/HCB17 shows higher activity than the Pt/CB due to the inefficient microporous structure of amorphous carbon for the oxygen reduction reaction. An accelerating potential cycle between 1.0 and 1.5 V for the carbon corrosion is applied to examine durability at a single cell under the practical start-up/shutdown conditions. The Pt/HCB17 catalyst shows remarkable durability after 3000 potential cycles. The Pt/HCB17 catalyst exhibits a peak power density gain of 3%, while the Pt/CB catalyst shows 65% loss of the initial peak power density. As well, electrochemical surface area and mass activity of Pt/HCB17 catalyst are even more stable than those of the Pt/CB catalyst. Consequently, the high degree of graphitization is essential for the durability of fuel cells in practical start-up/shut-down conditions due to enhancing the strong interaction of Pt and π-bonds in graphitized carbon.

关键词： Polymer electrolyte membrane fuel ceils Membrane electrolyte assembly Carbon corrosion Start-up/shut-down Durability

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Tolerating Permanent State Transition Faults in Asynchronous Sequential Machines

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Journal of Computer Science & Technology 2016年第5期31卷 1028-1037页

作者： jung-Min Yang School of Electronics Engineering Kyungpook National University Daegu 41566 Korea

Corrective control theory lays a novel foundation for the fault-tolerant control of asynchronous sequential machines. In this paper, we present a corrective control scheme for tolerating permanent state transition faults in the dynamics of asynchronous sequential machines. By a fault occurrence, the asynchronous machine may be stuck at a faulty state, not responding to the external input. We analyze the detectability of the considered faults and present the necessary and sufficient condition for the existence of a controller that overcomes any permanent transition faults. Fault tolerance is realized by using potential reachability and asynchronous mechanisms in the machine. A case study on an asynchronous counter is provided to illustrate the proposed fault detection and tolerance scheme.

关键词： asynchronous sequential machine corrective control permanent fault fault tolerance

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Next High Performance and Low Power Flash Memory Package Structure

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Journal of Computer Science & Technology 2007年第4期22卷 515-520页

作者： jung-Hoon Lee ERI Control Instrumentation EngineeringGyeongSang National UniversityJinju660-701Korea

In general, NAND flash memory has advantages in low power consumption, storage capacity, and fast erase/write performance in contrast to NOR flash. But, main drawback of the NAND flash memory is the slow access time for random read operations. Therefore, we proposed the new NAND flash memory package for overcoming this major drawback. We present a high performance and low power NAND flash memory system with a dual cache memory. The proposed NAND flash package consists of two parts, i.e., an NAND flash memory module, and a dual cache module. The new NAND flash memory system can achieve dramatically higher performance and lower power consumption compared with any conventionM NAND-type flash memory module. Our results show that the proposed system can reduce about 78% of write operations into the flash memory cell and about 70% of read operations from the flash memory cell by using only additional 3KB cache space. This value represents high potential to achieve low power consumption and high performance gain.

关键词： flash memory NAND-type NOR-type memory localities buffer or cache memory

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Plant-pollinator metanetworks in fragmented landscapes:a simulation study

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Ecological Processes 2023年第1期12卷 415-424页

作者： Ehsan Rahimi Chuleui jung Agricultural Science and Technology Institute Andong National UniversityAndong City 36729Republic of Korea Department of Plant Medicals Andong National UniversityAndong CityRepublic of Korea

Background The topology of the plant-pollinator network can be explained by the species’abundance and their random ***-pollinator networks can be studied in the context of a landscape,because each patch can accommodate a certain local *** populations of pollinators in the landscape can be connected through migration and then constitute a metanetwork that is known as a combination of spatial and ecological *** this regard,habitat fragmentation can affect the topology of plant-pollinator metanetworks through changes in the species abundance and limiting their ***,it is not clear what pattern(fragmented or aggregated)of the landscape structure can accommodate networks with a higher degree of *** we created simulated landscapes with different forest proportions scenarios(from 5%to 50%of the total landscape)and degrees of ***,for each landscape,we limited the proportion of pollinators to the forest *** assumed that plants and pollinators are randomly distributed around the landscape and interact *** used landscape metrics to measure different aspects of landscape structure and bipartite metrics for calculating the degree of specialization in plant-pollinator *** The statistical relationship between bipartite and landscape metrics showed that the relationship between the topology of plant-pollinator networks and the landscape structure is affected by the forest amount in the landscape and the degree of forest *** also found that according to the nestedness and H2(a measure of specialization)metrics,fragmented landscapes contain more general plant-pollinator *** Our findings suggest that fragmented landscapes,characterized by scattered forest patches,can promote higher levels of interaction between limited pollinators and diverse flowers,leading to more general plant-pollinator networks.

关键词： Plant–pollinator metanetwork Habitat fragmentation Simulated landscape Landscape metrics Bipartite metrics

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Asymptotic T_u-Toeplitzness of weighted composition operators on H^2

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Science China Mathematics 2018年第5期61卷 881-896页

作者： Sungeun jung Department of Mathematics Hankuk University of Foreign Studies

Given a unilateral forward shift S acting on a complex,separable,infinite dimensional Hilbert space H,an asymptotically S-Toeplitz operator is a bounded linear operator T on H satisfying that{S^(*n)T S^n}is convergent with respect to one of the topologies commonly used in the algebra of bounded linear operators on *** this paper,we study the asymptotic T_u-Toeplitzness of weighted composition operators on the Hardy space H^2,where u is a nonconstant inner function.

关键词： Toeplitz operator asymptotically S-Toeplitz operator weighted composition operator inner function

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Calcium-and sulfate-functionalized artificial cathode–electrolyte interphases of Ni-rich cathode materials

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Rare Metals 2021年第10期40卷 2793-2801页

作者： Kwangeun jung Taeeun Yim Department of Chemistry Incheon National UniversityIncheon 22012Republic of Korea

Ni-rich lithium nickel–cobalt-manganese oxides(NCM) are considered the most promising cathode materials for lithium-ion batteries(LIBs);however, relatively poor cycling performance is a bottleneck preventing their widespread use in energy systems. In this work, we propose the use of a dually functionalized surface modifier, calcium sulfate(CaSO_(4), CSO), in an efficient one step method to increase the cycling performance of Ni-rich NCM cathode materials. Thermal treatment of LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2)(NCM811) cathode materials with a CSO precursor allows the formation of an artificial Ca-and SO_(x)-functionalized cathode–electrolyte interphase(CEI) layer on the surface of Ni-rich NCM cathode materials. The CEI layer then inhibits electrolyte decomposition at the interface between the Ni-rich NCM cathode and the electrolyte. Successful formation of the CSO-modified CEI layer is confirmed by scanning electron microscopy(SEM) and Fourier transform infrared(FTIR) spectroscopy analyses, and the process does not affect the bulk structure of the Ni-rich NCM cathode material. During cycling, the CSO-modified CEI layer remarkably decreases electrolyte decomposition upon cycling at both room temperature and 45 ℃, leading to a substantial increase in cycling retention of the cells. A cell cycled with a 0.1 CSO-modified(modified with 0.1% CSO)NCM811 cathode exhibits a specific capacity retention of90.0%, while the cell cycled with non-modified NCM811 cathode suffers from continuous fading of cycling retention(74.0%) after 100 cycles. SEM, electrochemical impedance spectroscopy(EIS), X-ray photoelectron spectroscopy(XPS), and inductively coupled plasma mass spectrometry(ICP-MS) results of the recovered electrodes demonstrate that undesired surface reactions such as electrolyte decomposition and metal dissolution are well controlled in the cell because of the artificial CSO-modified CEI layer present on the surface of Ni-rich NCM811 cathodes.

关键词： Lithium-ion battery Cathode Cathode–electrolyte interphase Calcium sulfate Electrochemical performance

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