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SYNCRIP controls miR-137 and striatal learning in animal models of methamphetamine abstinence

Acta Pharmaceutica Sinica B 2022年第8期12卷 3281-3297页

作者： Baeksun Kim sung Hyun Tag Eunjoo Nam suji Ham sujin Ahn Juhwan Kim Doo-Wan Cho Sangjoon Lee young-su yang Seung Eun Lee Yong Sik Kim Il-Joo Cho Kwang Pyo Kim su-Cheol Han Heh-In Im Convergence Research Center for Diagnosis Treatment and Care System of Dementia(DTC)Korea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Division of Bio-Medical Science&Technology KIST SchoolKorea University of Science and Technology(UST)Seoul 02792Republic of Korea Center for Neuroscience KISTSeoul 02792Republic of Korea Animal Model Research Center Jeonbuk Department of Inhalation ResearchKorea Institute of Toxicology(KIT)Korea Research Institute of Chemical Technology(KRICT)Jeongeup 56212Republic of Korea Research Animal Resource Center KISTSeoul 02792Republic of Korea Department of Pharmacology Seoul National University College of MedicineSeoul 03080Republic of Korea Center for BioMicrosystems KISTSeoul 02792Republic of Korea Department of Applied Chemistry Kyung Hee UniversityGyeonggi-do 17104Republic of Korea

Abstinence from prolonged psychostimulant use prompts stimulant withdrawal *** adaptations within the dorsal striatum have been considered the main hallmark of stimulant abstinence. Here we explored striatal miRNA-target interaction and its impact on circulating miRNA marker as well as behavioral dysfunctions in methamphetamine(MA) abstinence. We conducted miRNA sequencing and profiling in the nonhuman primate model of MA abstinence, followed by miRNA qPCR,LC-MS/MS proteomics, immunoassays, and behavior tests in mice. In nonhuman primates, MA abstinence triggered a lasting upregulation of miR-137 in the dorsal striatum but a simultaneous downregulation of circulating miR-137. In mice, aberrant increase in striatal miR-137-dependent inhibition of SYNCRIP essentially mediated the MA abstinence-induced reduction of circulating miR-137. Pathway modeling through experimental deduction illustrated that the MA abstinence-mediated downregulation of circulating miR-137 was caused by reduction of SYNCRIP-dependent miRNA sorting into the exosomes in the dorsal striatum. Furthermore, diminished SYNCRIP in the dorsal striatum was necessary for MA abstinence-induced behavioral bias towards egocentric spatial learning. Taken together, our data revealed circulating miR-137 as a potential blood-based marker that could reflect MA abstinence-dependent changes in striatal miR-137/SYNCRIP axis, and striatal SYNCRIP as a potential therapeutic target for striatum-associated cognitive dysfunction by MA withdrawal syndrome.

关键词： Methamphetamine Abstinence Withdrawal Striatum miR-137 SYNCRIP Biomarker Behavior

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Spatio-temporal Evolution Characteristics and Driving Forces of Winter Urban Heat Island:A Case Study of Rapid Urbanization Area of Fuzhou City,China

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Chinese Geographical Science 2024年第1期34卷 135-148页

作者： WANG Zili LU Chunyan su Yanlin su Yue YU Qianru LI Wenzhe yang Nuocheng College of Computer and Information Sciences Fujian Agriculture and Forestry UniversityFuzhou350002China Key Laboratory of Smart Agriculture and Forestry(Fujian Agriculture and Forestry University) Fujian Province UniversityFuzhou350002China College of Forestry Fujian Agriculture and Forestry UniversityFuzhou350002China

Under the influence of anthropogenic and climate change,the problems caused by urban heat island(UHI)has become increasingly *** order to promote urban sustainable development and improve the quality of human settlements,it is significant for exploring the evolution characteristics of urban thermal environment and analyzing its driving *** the Landsat series images as the basic data sources,the winter land surface temperature(LST)of the rapid urbanization area of Fuzhou City in China was quantitatively retrieved from 2001 to *** comprehensively the standard deviation ellipse model,profile analysis and GeoDetector model,the spatio-temporal evolution characteristics and influencing factors of the winter urban thermal environment were systematically *** results showed that the winter LST presented an increasing trend in the study area during 2001–2021,and the winter LST of the central urban regions was significantly higher than the *** was a strong UHI effect from 2001 to 2021with an expansion trend from the central urban regions to the suburbs and coastal areas in space *** LST of green lands and wetlands are significantly lower than croplands,artificial surface and unvegetated *** and water bodies had a significant mitigation effect on UHI,especially in the *** winter UHI had been jointly driven by the underlying surface and socio-economic factors in a nonlinear or two-factor interactive enhancement mode,and socio-economic factors had played a leading *** research could provide data support and decision-making references for rationally planning urban layout and promoting sustainable urban development.

关键词： winter urban heat island(UHI) rapid urbanization area land surface temperature(LST)retrieval profile analysis GeoDetector model Fuzhou City,China

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Effect of reduction pretreatment on the structure and catalytic performance of Ir-In_(2)O_(3)catalysts for CO_(2) hydrogenation to methanol

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Journal of Environmental Sciences 2024年第6期140卷 2-11页

作者： Changyu Ding Feifei yang Xue Ye Chongya yang Xiaoyan Liu Yuanlong Tan Zheng Shen Hongmin Duan Xiong su Yanqiang Huang CAS Key Laboratory of Science and Technology on Applied Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China University of Chinese Academy of Sciences Beijing 100049China

In_(2)O_(3)has been found a promising application in CO_(2)hydrogenation to methanol,which is beneficial to the utilization of CO_(2).The oxygen vacancy(O_(v))site is identified as the catalytic active center of this ***,there remains a great challenge to understand the relations between the state of oxygen species in In_(2)O_(3)and the catalytic performance for CO_(2)hydrogenation to *** the present work,we compare the properties of multiple In_(2)O_(3)and Ir-promoted In_(2)O_(3)(Ir-In_(2)O_(3))catalysts with different Ir loadings and after being pretreated under different reduction *** CO_(2)conversion rate of Ir-In_(2)O_(3)is more promoted than that of pure In_(2)O_(3).With only a small amount of Ir loading,the highly dispersed Ir species on In_(2)O_(3)increase the concentration of O_(v)sites and enhance the *** finely tuning the catalyst structure,Ir-In_(2)O_(3)with an Ir loading of 0.16 wt.%and pre-reduction treatment under 300℃exhibits the highest methanol yield of 146 mgCH_(3)OH/(gcat·hr).Characterizations of Raman,electron paramagnetic resonance,X-ray photoelectron spectroscopy,CO_(2)-temperature programmed desorption and CO_(2)-pulse adsorption for the catalysts confirm that more O_(v)sites can be generated under higher reduction temperature,which will induce a facile CO_(2)adsorption and desorption *** performance for methanol production requires an adequate dynamic balance among the surface oxygen atoms and vacancies,which guides us to find more suitable conditions for catalyst pretreatment and reaction.

关键词： Carbon dioxide Hydrogenation Methanol In_(2)O_(3) Fixed-bed Reduction temperature

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Robustness of Pullback Attractors for 2D Incompressible Navier-Stokes Equations with Delay

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Journal of Partial Differential Equations 2024年第1期37卷 25-46页

作者： su Keqin yang Xinguang College of Information and Management Science Henan Agricultural UniversityZhengzhou 450046China. Department of Mathematics and Information Science Henan Normal UniversityXinxiang 453007China

This paper is concerned with the pullback dynamics and robustness for the 2D incompressible Navier-Stokes equations with delay on the convective term in bounded *** appropriate assumption on the delay term,we establish the existence of pullback attractors for the fluid flow model,which is dependent on the past *** by the idea in Zelati and Gal’s paper(JMFM,2015),the robustness of pullback attractors has been proved via upper semi-continuity in last section.

关键词： Navier-Stokes equations pullback attractors delay upper semi-continuity

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A manual acupuncture treatment attenuates common cold and its symptoms: a case series report from South Korea

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Journal of Traditional Chinese Medicine 2016年第6期36卷 724-729页

作者： Je-Sin Heo su-young yang sung-Ah Lim Jong-Moo Lee Ji-young Kang Seung-Ho sun Hyeong-Geug Kim Weechang Kang Jung-Hyo Cho Department of Acupuncture Therapy Association of Sang Su Medicine Department of Beauty and Health Care College of Sports and Health Public Daejeon University Department of Internal Immune Center Daejeon Oriental Hospital of Daejeon University Department of Internal Medicine Sangji University Korean Medicine Hospital Department of Business Information Statistics College of Business Administration Daejeon University

OBJECTIVE: To investigate beneficial effects of manual acupuncture on common cold periods and its symptoms depended on the difference onset time of common cold, within 36 h or over than that. To prove effects of manual acupuncture on common cold, a retrospective chart review was ***: Chart data for patients with commoncold who were treated with only manual acupuncture with fulfilling Jackson scales and satisfaction at the end of each treatment were collected via multi-centers of Oriental hospitals,Oriental medicine clinics and covalent hospital in South Korea. Totally 187 patients were divided into two groups, Group Ⅰ(115 patients, within 36 h)and Group Ⅱ(72 patients, onset time of cold over than 36 h). Finally 120 patients were observed until entire resolution of cold ***: GroupⅠ showed significant decreases themediandurationsofcompletelyrecovery(3 days;95% CI 3.0-4.0) as compared with Group Ⅱ(6 days;95% CI 4.0-7.0, P susceptibility on the early time of onset cold.

关键词： Common cold Hand acupuncture Traditional Chinese Medicine therapy Case reports

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Heterogeneous integration of 2D materials on Si charge-coupled devices as optical memory

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Science China(Information Sciences) 2024年第6期67卷 190-197页

作者： Zheng BIAN Feng TIAN Zongwen LI Xiangwei su Tianjiao ZHANG Jialei MIAO Bin YU yang XU Yuda ZHAO College of Integrated Circuits Hangzhou Global Scientific and Technological Innovation CentreZhejiang University

Optical memory integrates the function of optical sensing in memory devices, remarkably promoting the interconnection between sensory and memory terminals. Silicon charge-coupled photodetectors and floating gate memory have been widely used in imaging and storage technologies, respectively. However,the heterogeneous integration of the two devices requires technological innovation and complex electrical connections. In this work, we adopt a three-dimensional layer stacking method to design a novel optical memory device. On the top of Si charge-coupled photodetectors, we successively deposit two-dimensional graphene,hexagonal boron nitride, and molybdenum disulfide as a floating gate layer, a tunneling layer, and a readout layer, respectively. By applying a gate bias on lightly doped Si, a deep depletion layer is formed with a high voltage potential drop. Under dark conditions, the depletion layer cannot be filled, and the electric field across the h-BN tunnel barrier is relatively small. Under light irradiation, the deep depletion layer is gradually filled, and the h-BN tunneling layer withstands the increasing electric field, resulting in charge storage in the floating gate layer. Based on this mechanism, the device exhibits a gate voltage-dependent operation mode, including an integrated optical sensing-memory mode and an electrically driven storage mode. Under moderate gate voltage, the device can effectively detect the optical information with varied intensity and store the optical information in the floating gate, displaying optically controlled memory characteristics. Our work demonstrates a compact device structure for optical memory and displays excellent optically controlled memory performance, which can be applied in artificial vision systems.

关键词： heterogeneous integration charge-coupled device floating gate optical memory molybdenum disulfide lightly doped silicon

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Associations between the use of red yeast rice preparations and adverse health outcomes:An umbrella review of meta-analyses of randomized controlled trials

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Journal of Integrative Medicine 2024年第2期22卷 126-136页

作者： Zhen-yu Ma Shu-ping yang Ying Li Tian-tian Xu Ya-lin yang Hui-yong yang Heng-bing Li Le-jin Zhou Yong Diao su-yun Li School of Medicine Huaqiao UniversityQuanzhou 362021Fujian ProvinceChina College of Traditional Chinese Medicine Shandong University of Traditional Chinese MedicineJinan 250355Shandong ProvinceChina Second Clinical Medical College Nanjing Medical UniversityNanjing 211166Jiangsu ProvinceChina

Background:Red yeast rice(RYR),a natural lipid-lowering agent,is widely used in clinical ***,the existing meta-analyses concerning the safety of RYR preparations have yielded inconsistent results,and the credibility of the evidence has not been ***:This study was designed to evaluate the existing evidence and offer a comprehensive understanding of the associations between the use of RYR preparations and various adverse health *** strategy:Seven literature databases were searched from inception to May 5,2023,using medical subject headings and free-text terms(e.g.,“red yeast rice,”“Xuezhikang,”and“Zhibitai”).Inclusion criteria:Meta-analyses that investigated and quantitatively estimated associations between the use of RYR preparations and adverse health outcomes were included in this *** extraction and analysis:Two researchers independently extracted data using a standardized data collection table;any disagreements were resolved by consulting a third *** on the participant,intervention,comparator and outcome(PICO)framework in each eligible meta-analysis,a series of unique associations between the use of RYR preparations and adverse health outcomes were *** associations’effect estimates were re-evaluated using random-effect ***:Fifteen meta-analyses,comprising 186(164 unique)randomized controlled trials,were *** on A Mea surement Tool to Assess Systematic Reviews version 2,3(20%)and 12(80%)of these meta-analyses had low and critically low confidence,respectively.A total of 61 unique associations between the use of RYR preparations and adverse health outcomes were extracted from eligible *** on the random-effect models,10(16.4%)associations indicated a significant protective effect of RYR preparations against adverse health outcomes,while 5(8.2%)indicated an increased risk of adverse health outcomes related to uric acid,alanine transaminase and aspartate trans

关键词： Red yeast rice Safety Adverse health outcomes Umbrella review Meta-analysis Systematic review

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METTL3 regulates glucose transporter expression in placenta exposed to hyperglycemia through the mTOR signaling pathway

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Chinese Medical Journal 2024年第13期137卷 1563-1575页

作者： Jie Ning Jing Huai Shuxian Wang Jie Yan Rina su Muqiu Zhang Mengtong Liu Huixia yang Department of Obstetrics and Gynaecology Peking University First HospitalBeijing 100034China Beijing Key Laboratory of Maternal Foetal Medicine of Gestational Diabetes Mellitus Beijing 100034China Peking University Beijing 100034China

Background:Alterations in the placental expression of glucose transporters(GLUTs),the crucial maternal-fetal nutrient transporters,have been found in women with hyperglycemia in pregnancy(HIP).However,there is still uncertainty about the underlying effect of the high-glucose environment on placental GLUTs expression in ***:We quantitatively evaluated the activity of mammalian target of rapamycin(mTOR)and expression of GLUTs(GLUT1,GLUT3,and GLUT4)in the placenta of women with normal pregnancies(CTRL,n=12)and pregnant women complicated with poorly controlled type 2 diabetes mellitus(T2DM,n=12)by *** addition,BeWo cells were treated with different glucose concentrations to verify the regulation of ***,changes in the expression of GLUTs following the activation or suppression of the mTOR pathway were also assessed using MHY1485/rapamycin(RAPA)treatment or small interfering RNA(siRNA)-mediated silencing ***,we further explored the alteration and potential upstream regulatory role of methyltransferase-like 3(METTL3)when exposed to ***:mTOR,phosphorylated mTOR(p-mTOR),and GLUT1 protein levels were upregulated in the placenta of women with T2DM compared with those *** BeWo cells,mTOR activity increased with increasing glucose concentration,and the expression of GLUT1,GLUT3,and GLUT4 as well as GLUT1 cell membrane translocation were upregulated by hyperglycemia to varying *** the drug-mediated and genetic depletion of mTOR signaling in BeWo cells suppressed GLUTs expression,whereas MHY1485-induced mTOR activation upregulated GLUTs ***,high glucose levels upregulated METTL3 expression and nuclear translocation,and decreasing METTL3 levels suppressed GLUTs expression and mTOR activity and vice ***,in METTL3 knockdown BeWo cells,the inhibitory effect on GLUTs expression was eliminated by activating the mTOR signaling pathway using ***:High-g

关键词： Glucose transporters Hyperglycemia Type 2 diabetes mellitus Pregnancy Mammalian target of rapamycin Methyltransferase-like 3

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High performance and stable pure-blue quasi-2D perovskite light-emitting diodes by multifunctional zwitterionic passivation engineering

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Advanced Photonics 2024年第2期6卷 32-40页

作者： Chao Shen Shuyan Fang Jibin Zhang Xiangfei Liang Chenhui su Jian Qing Wanzhu Cai Yunhan Luo Renqiang yang Lintao Hou Jinan University College of Physics and Optical Engineering Guangdong Provincial Engineering Technology Research Center of Vacuum Coating Technologies and New Energy Materials Guangzhou Key Laboratory of Vacuum Coating Technologies and New Energy Materials Jinan University College of Physics and Optical Engineering Guangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications Zhengzhou University School of Physics and Microelectronics Key Laboratory of Materials Physics of Ministry of Education Jinan University Key Laboratory of Optoelectronic Information and Sensing Technologies of Guangdong Higher Education Institutes Jianghan University School of Optoelectronic Materials and Technology Key Laboratory of Optoelectronic Chemical Materials and Devices of Ministry of Education

Despite the rapid advances of red and green perovskite light-emitting diodes（Pe LEDs）, achieving high brightness with high external quantum efficiency（EQE） remains a challenge for the pure-blue Pe LEDs,which greatly hinders their practical applications, such as white-light illumination and in optical communication as a high-speed and low-loss light source. Herein, we report a high-performance pure-blue Pe LED based on mixed-halide quasi-2D perovskites incorporated with a zwitterionic molecule of 3-（benzyldimethylammonio）propanesulfonate（3-BAS）. Experimental and density functional theory analysis reveals that 3-BAS can simultaneously eliminate non-radiative recombination loss, suppress halide migration, and regulate phase distribution for smoothing energy transfer in the mixed-halide quasi-2D perovskites, leading to the final perovskites with high photoluminescence quantum yield and robust spectrum stability. Thus, the highperformance pure-blue Pe LED with a recorded brightness with 1806 cd m;-2;and a relative higher EQE of 9.25% is achieved, which is successfully demonstrated in a visible light communication system for voice signal transmission. We pave the way for achieving highly efficient pure-blue Pe LEDs with great application potential in future optical communication networks.

关键词： pure-blue PeLEDs quasi-2D perovskite zwitterionic additive visible light communication

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Numerical simulation of microwave-induced cracking and melting of granite based on mineral microscopic models

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International Journal of Minerals,Metallurgy and Materials 2024年第7期31卷 1512-1524页

作者： Xiaoli su Diyuan Li Junjie Zhao Mimi Wang Xing su Aohui Zhou School of Resources and Safety Engineering Central South UniversityChangsha 410083China

This study introduces a coupled electromagnetic–thermal–mechanical model to reveal the mechanisms of microcracking and mineral melting of polymineralic rocks under microwave *** tests validate the rationality of the proposed *** microscopic mineral sections into the granite model for simulation shows that uneven temperature gradients create distinct molten,porous,and nonmolten zones on the fracture ***,the varying thermal expansion coefficients and young's moduli among the minerals induce significant thermal stress at the mineral *** and biotite with higher thermal expansion coefficients are subjected to compression,whereas plagioclase with smaller coefficients experiences tensile *** the molten zone,quartz undergoes transgranular cracking due to theα–βphase *** local high temperatures also induce melting phase transitions in biotite and *** numerical study provides new insights into the distribution of thermal stress and mineral phase changes in rocks under microwave irradiation.

关键词： microwave numerical modeling microcracking phase change granite

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