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Interorgan communication in neurogenic heterotopic ossification: the role of brain-derived extracellular vesicles

Bone Research 2024年第1期12卷 137-152页

作者： Weicheng Lu Jianfei Yan Chenyu Wang Wenpin Qin Xiaoxiao han Zixuan Qin Yu Wei Haoqing Xu Jialu Gao Changhe Gao Tao Ye Franklin R.Tay Lina Niu Kai Jiao Department of Stomatology Tangdu Hospital&State Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration&School of StomatologyThe Fourth Military Medical UniversityXi’anShaanxiChina State Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration&National Clinical Research Center for Oral Diseases&Shaanxi Key Laboratory of Stomatology School of StomatologyThe Fourth Military Medical UniversityXi’anShaanxiChina The Dental College of Georgia Augusta UniversityAugustaGAUSA

Brain-derived extracellular vesicles participate in interorgan communication after traumatic brain injury by transporting pathogens to initiate secondary ***-related proteins encapsulated in brain-derived extracellular vesicles can cross the blood‒brain barrier to reach distal *** proteins initiate inflammatory dysfunction,such as neurogenic heterotopic *** recurrent condition is highly debilitating to patients because of its relatively unknown pathogenesis and the lack of effective prophylactic intervention ***,a rat model of neurogenic heterotopic ossification induced by combined traumatic brain injury and achillotenotomy was developed to address these two *** examination of the injured tendon revealed the coexistence of ectopic calcification and fibroblast *** relationships among brain-derived extracellular vesicles,fibroblast pyroptosis and ectopic calcification were further investigated in vitro and in *** injection of the pyroptosis inhibitor Ac-YVAD-cmk reversed the development of neurogenic heterotopic ossification in *** present work highlights the role of brain-derived extracellular vesicles in the pathogenesis of neurogenic heterotopic ossification and offers a potential strategy for preventing neurogenic heterotopic ossification after traumatic brain injury.

关键词： neurogenic ossification pathogenesis

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ZnS Nano-Spheres Formed by the Aggregation of Small Crys- tallites and Their Photocatalytic Degradation of Eosin B

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Chinese Journal of Chemistry 2017年第2期35卷 159-164页

作者： Sovann Khan joon Soo han SeungYong Lee So-Hye Cho Materials Architecturing Research Center Korea Institute of Science and Technology 02792 Republic of Korea Department of Nanomaterial Science and Engineering Korea University of Science and Technology Daejeon 34113 Republic of Korea

Monodispersed ZnS nano-spheres were synthesized by a simple precipitation. By adjusting the concentration of Zn and S sources, the particle size and morphology were easily controlled. Careful examination of the obtained par- ticles suggested porous structures composed of building blocks of small crystallites, ca. 4-- 13.4 nm in diameter. A higher [S]/[Zn]-precursor ratio resulted in a bigger crystallite size but a smaller particle size, and vice versa, for the lower precursor ratio. However, an extreme [S]/[Zn] ratio of 20 provided no spherical aggregation, but a formation of amorphous aggregates. We consider the rate to nucleation and the diffusion-controlled aggregation of crystallites to be important parameters in determining particle sizes and size distributions. Size homogeneity of the obtained ZnS nano-spheres, especially with a [S]/[Zn]-precursor ratio of 5, afforded a photonic crystal array that can poten- tially benefit the photocatalytic activity. When the photocatalytic activities of the ZnS nano-spheres obtained via different conditions were compared, it was found that spherical aggregation and high surface areas have a positive effect on catalytic activity. Although using a [S]/[Zn] ratio of 20 provided the highest surface area, the amorphous aggregation and overly excessive use of S caused a detrimental influence on the catalytic activity.

关键词： ZnS nano-spheres photocatalysis aggregation eosin B

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A 360-Degree Panoramic Image Inpainting Network Using a Cube Map

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Computers, Materials & Continua 2021年第1期66卷 213-228页

作者： Seo Woo han Doug young Suh Department of Electronic Engineering Kyung Hee UniversityYoungin17104South Korea

Inpainting has been continuously studied in the field of computer *** artificial intelligence technology developed,deep learning technology was introduced in inpainting research,helping to improve ***,the input target of an inpainting algorithm using deep learning has been studied from a single image to a ***,deep learning-based inpainting technology for panoramic images has not been actively *** propose a 360-degree panoramic image inpainting method using generative adversarial networks(GANs).The proposed network inputs a 360-degree equirectangular format panoramic image converts it into a cube map format,which has relatively little distortion and uses it as a training *** the cube map format is used,the correlation of the six sides of the cube map should be ***,all faces of the cube map are used as input for the whole discriminative network,and each face of the cube map is used as input for the slice discriminative network to determine the authenticity of the generated *** proposed network performed qualitatively better than existing single-image inpainting algorithms and baseline algorithms.

关键词： Panoramic image image inpainting cube map generative adversarial networks

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Atomically Precise Design of PtSn Catalyst for the Understanding of the Role of Sn in Propane Dehydrogenation

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Precision Chemistry 2024年第6期2卷 245-255页

作者： Hui Ye Lina Cao Minghui Gu han Nie Qingqing Gu Bing Yang Yunxing Bai Qinxue Nie Weixin Huang Junling Lu Institute of Advanced Technology Key Laboratory of Precision and Intelligent ChemistryDepartment of Chemical PhysicsHefei National Research Center for Physical Sciences at the MicroscaleKey Laboratory of Surface and Interface Chemistry and Energy Catalysis of Anhui Higher Education InstitutesUniversity of Science and Technology of ChinaHefei 230026P.R.China CAS Key Laboratory of Science and Technology on Applied Catalysis Dalian Institute of Chemical PhysicsThe Chinese Academy of SciencesDalian 116023P.R.China

Propane dehydrogenation(PDH),an atom-economic reaction to produce high-value-added propylene and hydrogen with high efficiency,has recently attracted extensive *** severe deactivation of Pt-based catalysts through sintering and coking remains a major challenge in this high-temperature *** introduction of Sn as a promoter has been widely applied to improve the stability and selectivity of the ***,the selectivity and stability of PtSn catalysts have been found to vary considerably with synthesis methods,and the role of Sn is still far from fully *** gain in-depth insights into this issue,we synthesized a series of PtSn/SiO_(2)and SnPt/SiO_(2)catalysts by varying the deposition sequence and Pt:Sn ratios using atomic layer deposition with precise *** found that PtSn/SiO_(2)catalysts fabricated by the deposition of SnO_(x)first and then Pt,exhibited much better propylene selectivity and stability than the SnPt/SiO_(2)catalysts synthesized the other way *** demonstrate that the presence of Sn species at the Pt-SiO_(2)interface is of essential importance for not only the stabilization of PtSn clusters against sintering under reaction conditions but also the promotion of charge transfers to Pt for high *** the above,the precise regulation of the Sn content is also pivotal for high performance,and the excess amount of Sn might generate additional acidic sites,which could decrease the propylene selectivity and lead to heavy coke *** findings provide deep insight into the design of highly selective and stable PDH catalysts.

关键词： Propane dehydrogenation PtSn catalysts sintering coke formation acidity

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Gate-field control of valley polarization in valleytronics

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Chinese Physics B 2024年第6期33卷 2-12页

作者：张婷婷韩依琳张闰午余智明 Institute of Physics Chinese Academy of SciencesBeijing 100190China Key Laboratory of Advanced Optoelectronic Quantum Architecture and Measurement Beijing Key Laboratory of Nanophotonics&Ultrafine Optoelectronic Systemsand School of PhysicsBeijing Institute of TechnologyBeijing 100081China

Valleytronics materials are a kind of special semiconductors which can host multiple symmetry-connected and wellseparated electron or hole pockets in the Brillouin zone when the system is slightly n or p doped. Since the low-energy particles residing in these pockets generally are not easily scattered to each other by small perturbations, they are endowed with an additional valley degree of freedom. Analogous to spin, the valley freedom can be used to process information,leading to the concept of valleytronics. The prerequisite for valleytronics is the generation of valley polarization. Thus,a focus in this field is achieving the electric generation of valley polarization, especially the static generation by the gate electric field alone. In this work, we briefly review the latest progress in this research direction, focusing on the concepts of the couplings between valley and layer, i.e., the valley–layer coupling which permits the gate-field control of the valley polarization, the couplings between valley, layer, and spin in magnetic systems, the physical properties, the novel designing schemes for electronic devices, and the material realizations of the gate-controlled valleytronics materials.

关键词： band structure electronic transport optical properties spintronics

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Id2 epigenetically controls CD8^(+)T-cell exhaustion by disrupting the assembly of the Tcf3-LSD1 complex

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Cellular & Molecular Immunology 2024年第3期21卷 292-308页

作者： Yiming Li Mingwei han Haolin Wei Wan Huang Zhinan Chen Tianjiao Zhang Meirui Qian Lin Jing Gang Nan Xiuxuan Sun Shuhui Dai Kun Wang Jianli Jiang Ping Zhu Liang Chen Department of Cell Biology of National Translational Science Center for Molecular Medicine and Department of Clinical Immunology of Xijing Hospital Fourth Military Medical UniversityXi’anShaanxi 710032China State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases GanzhouJiangxi341000Xi’anShaanxi 710032China School of Medicine Shanghai UniversityShanghai 200444China

CD8^(+)T-cell exhaustion is a state of dysfunction that promotes tumor progression and is marked by the generation of Slamf6^(+)progenitor exhausted(Tex^(prog))and Tim-^(3+)terminally exhausted(Tex^(term))*** of DNA binding protein 2(Id2)has been shown to play important roles in T-cell development and CD8^(+)T-cell ***,the role of Id2 in CD8^(+)T-cell exhaustion is ***,we found that Id2 transcriptionally and epigenetically regulates the generation of Texprog cells and their conversion to Texterm *** deletion of Id2 dampens CD8^(+)T-cell-mediated immune responses and the maintenance of stem-like CD8^(+)T-cell subpopulations,suppresses PD-1 blockade and increases tumor ***,through its HLH domain,Id2 binds and disrupts the assembly of the Tcf3-Tal1 transcriptional regulatory complex,and thus modulates chromatin accessibility at the Slamf6 promoter by preventing the interaction of Tcf3 with the histone lysine demethylase ***,Id2 increases the abundance of the permissive H3K4me2 mark on the Tcf3-occupied E-boxes in the Slamf6 promoter,modulates chromatin accessibility at the Slamf6 promoter and epigenetically regulates the generation of Slamf6+Texprog *** LSD1 inhibitor GSK2879552 can rescue the Id2 knockout phenotype in tumor-bearing *** of LSD1 increases the abundance of Slamf6^(+)Tim-3^(−)Tex^(prog) cells in tumors and the expression level of Tcf1 in Id2-deleted CD8+T *** study demonstrates that Id2-mediated transcriptional and epigenetic modification drives hierarchical CD8^(+)T-cell exhaustion,and the mechanistic insights gained may have implications for therapeutic intervention with tumor immune evasion.

关键词： Id2 T-cell exhaustion Epigenetic modification Immune evasion

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The effect of secondary phase on corrosion behaviors of the titanium–zirconium–molybdenum alloy

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Tungsten 2024年第2期6卷 342-354页

作者： Song-Wei Ge Ping Hu Jie Deng Shi-Lei Li Hai-Rui Xing Jia-Yu han Xing-Jiang Hua Li Wang Jun-Zhou Yang Bo Jin Wen Zhang Kuai-She Wang School of Metallurgy Engineering Xi’an University of Architecture and TechnologyXi’an 710055China National and Local Joint Engineering Research Center for Functional Materials Processing Xi’an University of Architecture and TechnologyXi’an 710055China Western Xinxing Rare and Precious Metals Co. Ltd.Shangluo 726000China Northwest Institute for Non-Ferrous Metal Research Xi’an 710016China

As the range of applications for molybdenum and its alloys has expanded,the corrosive environment for molybdenum alloys has become more *** the past,the content of doping elements has been studied to investigate their infl uence on the corrosion performance of titanium–zirconium–molybdenum(TZM)*** this paper,it is considered that the second phase in the alloy is the main factor aff ecting the corrosion performance of TZM *** comparing the corrosion behavior of molybdenum metal and TZM alloy,the eff ect of the secondary phase on corrosion behaviors of TZM alloy has been *** results show that the second phase reduces the corrosion resistance of the TZM *** potential of the second phase is 73.7 mV higher than that of the Mo matrix,which contributes to the formation of microscopic electric *** the action of microscopic electric couples,pitting corrosion is preferentially formed at the interface between the second phase and the matrix,which accelerates the corrosion of the *** paper provides a theoretical basis for the application of TZM alloys in corrosive environments.

关键词： Secondary phase Electrochemical corrosion Titanium–zirconium–molybdenum(TZM) Galvanic corrosion Corrosion resistance

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A Case of Acute HIV-1 and Monkeypox Coinfection After Condomless Insertive Anal Sex in the Previous 69 Days—Beijing Municipality,China,August-October,2023

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China CDC weekly 2024年第7期6卷 126-130页

作者： Lin Jia han Jia Yuan Fang Benyong Yan Mei Zhang Yang Zhang Wen Wang Caiping Guo Xiaojie Huang Tong Zhang Taiyi Jiang Clinical and Research Center for Infectious Diseases Beijing Youan HospitalCapital Medical UniversityBeijingChina

Summary What is already known about this topic?The prevalence of monkeypox(mpox)infections is primarily observed among young men who engage in sexual activities with other men,and there is a possibility of sexual ***-occurring sexually transmitted infections have also been *** is added by this report?In this report,we present a case of a patient in China who was simultaneously diagnosed with mpox,and acute human immunodeficiency virus(HIV)infection.

关键词： acute Acute prevalence

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An Ellipsoidal Set-Membership Approach to Distributed Joint State and Sensor Fault Estimation of Autonomous Ground Vehicles

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IEEE/CAA Journal of Automatica Sinica 2021年第6期8卷 1107-1118页

作者： Eman Mousavinejad Xiaohua Ge Senior Member Qing-Long han Teng joon Lim Ljubo Vlacic School of Electrical and Information Engineering The University of SydneySydneyNSW 2006Australia School of Engineering and Built Environment Griffith UniversityGold CoastQLD 4222Australia chool of Software and Electrical Engineering Swinburne University of TechnologyMelbourneVIC 3122Australia

This paper is concerned with the problem of distributed joint state and sensor fault estimation for autonomous ground vehicles subject to unknown-but-bounded(UBB)external disturbance and measurement *** order to improve the estimation reliability and performance in cases of poor data collection and potential communication interruption,a multisensor network configuration is presented to cooperatively measure the vehicular yaw rate,and further compute local state and fault *** this aim,an augmented descriptor vehicle model is first established,where the unknown sensor fault is modeled as an auxiliary state of the system ***,a new distributed ellipsoidal set-membership estimation approach is developed so as to construct an optimized bounding ellipsoidal set which guarantees to contain the vehicle’s true state and the sensor fault at each time step despite the existence of UBB disturbance and measurement ***,a convex optimization algorithm is put forward such that the gain matrix of each distributed estimator can be recursively ***,simulation results are provided to validate the effectiveness of the proposed approach.

关键词： Autonomous ground vehicle(AGV) distributed setmembership estimation fault estimation sensor networks vehicle lateral dynamics

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Negative enthalpy alloys and local chemical ordering:a concept and route leading to synergy of strength and ductility

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National Science Review 2024年第4期11卷 172-184页

作者： Zibing An Tao Yang Caijuan Shi Shengcheng Mao Lihua Wang Ang Li Wei Li Xianmeng Xue Ming Sun Yifan Bai Yapeng He Fuzeng Ren Zhouguang Lu Ming Yan Yang Ren Chain-Tsuan Liu Ze Zhang Xiaodong han Beijing Key Lab of Microstructure and Property of Advanced Materials College of Materials Science &Engineering Beijing University of Technology Department of Materials Science and Engineering City University of Hong Kong Key Laboratory of Partial Acceleration Physics& Technology Institute of High Energy PhysicsChinese Academy of Sciences Department of Materials Science &Engineering Southern University of Science and Technology Department of Physics City University of Hong Kong State Key Laboratory of Silicon Materials Department of Materials Science and Engineering Zhejiang University

Solid solutions are ubiquitous in metals and alloys. Local chemical ordering(LCO) is a fundamental sub-nano/nanoscale process that occurs in many solid solutions and can be used as a microstructure to optimize strength and ductility. However, the formation of LCO has not been fully elucidated, let alone how to provide efficient routes for designing LCO to achieve synergistic effects on both superb strength and ductility. Herein, we propose the formation and control of LCO in negative enthalpy alloys. With engineering negative enthalpy in solid solutions, genetic LCO components are formed in negative enthalpy refractory high-entropy alloys(RHEAs). In contrast to conventional ‘trial-and-error' approaches, the control of LCO by using engineering negative enthalpy in RHEAs is instructive and results in superior strength(1160 MPa) and uniform ductility(24.5%) under tension at ambient temperature, which are among the best reported so far. LCO can promote dislocation cross-slip, enhancing the interaction between dislocations and their accumulation at large tensile strains; sustainable strain hardening can thereby be attained to ensure high ductility of the alloy. This work paves the way for new research fields on negative enthalpy solid solutions and alloys for the synergy of strength and ductility as well as new functions.

关键词： negative enthalpy alloys local chemical ordering strength ductility dislocation

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