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Relationship between insulin resistance, obesity and serum prostate-specific antigen levels in healthy men

Asian Journal of Andrology 2010年第3期12卷 400-404,I0011页

作者： June Hyun Han Yong Taec Lee Kyung Won Kwak Seung Hyun Ahn In Ho Chang Soon Chul Myung Seung young Oh Yong-Seong Lee Wonyong Kim young-woo jin Tae-In Choi Sook Hee Sung Department of Urology KEPCO Medical Foundation Hanil General Hospital Seou1132-703 Korea Department of Urology Chung-Ang University Hospital Seoul 140-757 Korea Department of Urology Hyundae General Hospital Namyangju 472-865 Korea Department of Urology Hallym University Hangang Sacred Heart Hospital Seoul 150-719 Korea Department of Microbiology College of Medicine Chung-Ang University Seoul 156- 756 Korea Radiation Health Research Institute Korea Hydro ＆ Nuclear Power Co. LTD Seoul 132-703 Korea

The purpose of this study was to determine the relationship between insulin resistance, obesity and serum prostate-specific antigen （PSA） levels in healthy men with serum PSA level below 4 ng mL-1. The men included in the study cohort were 11 827 healthy male employees of the Korea Hydro and Nuclear Power Co., LTD who had undergone medical checkups including fasting glucose, fasting insulin and serum PSA between January 2003 and December 2008. Insulin resistance was calculated by homeostasis model assessment （HOMA [fasting glucose × fasting insulin]/22.5） and quantitative insulin sensitivity check index （QUICK/; 1/[log （fasting insulin）＋ log （fasting glucose）]）. Age-adjusted body mass index （BMI） was significantly increased according to increasing quartile of insulin resistance as determined by HOMA and QUICKI, respectively, in analysis of variance （ANOVA） test and Duncan＇s multiple comparison test （P 〈 0.001）, but age-adjusted serum PSA concentration was significantly decreased according to increasing quartile of insulin resistance as determined by HOMA and QUICK/（P 〈 0.001）. Age, BMI, insulin resistance by HOMA or QUICK/were significantly independent variables to serum PSA level in a multivariate linear regression analysis （P 〈 0.001）. Insulin resistance was a significant independent variable to serum PSA level along with BMI. Insulin resistance and BMI were negatively correlated with serum PSA level in healthy men. Insulin resistance was positively correlated with BMI.

关键词： body mass index insulin resistance metabolic syndrome X obesity prostate-specific antigen

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Long-term culture-induced phenotypic difference and efficient cryopreservation of small intestinal organoids by treatment timing of Rho kinase inhibitor

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World Journal of Gastroenterology 2017年第6期23卷 964-975页

作者： Sung-Hoon Han Sehwan Shim Min-Jung Kim Hye-Yun Shin Won-Suk Jang Sun-Joo Lee young-woo jin Seung-Sook Lee Seung Bum Lee Sunhoo Park Laboratory of Radiation Exposure and Therapeutics National Radiation Emergency Medical CenterKorea Institute of Radiological and Medical ScienceSeoul 01812South Korea

To investigate a suitable long-term culture system and optimal cryopreservation of intestinal organoid to improve organoid-based therapy by acquiring large numbers of *** were isolated from jejunum of C57BL/6 mouse. Two hundred crypts were cultured in organoid medium with either epidermal growth factor/Noggin/R-spondin1 (ENR) or ENR/CHIR99021/VPA (ENR-CV). For subculture, organoids cultured on day 7 were passaged using enzyme-free cell dissociation buffer (STEMCELL Technologies). The passage was performed once per week until indicated passage. For cryopreservation, undissociated and dissociated organoids were resuspended in freezing medium with or without Rho kinase inhibitor subjected to different treatment times. The characteristics of intestinal organoids upon extended passage and freeze-thaw were analyzed using EdU staining, methyl thiazolyl tetrazolium assay, qPCR and time-lapse live cell *** established a three-dimensional culture system for murine small intestinal organoids using ENR and ENR-CV media. Both conditions yielded organoids with a crypt-villus architecture exhibiting Lgr5+ cells and differentiated intestinal epithelial cells as shown by morphological and biochemical analysis. However, during extended passage (more than 3 mo), a comparative analysis revealed that continuous passaging under ENR-CV conditions, but not ENR conditions induced phenotypic changes as observed by morphological transition, reduced numbers of Lgr5+ cells and inconsistent expression of markers for differentiated intestinal epithelial cell types. We also found that recovery of long-term cryopreserved organoids was significantly affected by the organoid state, i.e., whether dissociation was applied, and the timing of treatment with the Rho-kinase inhibitor Y-27632. Furthermore, the retention of typical morphological characteristics of intestinal organoids such as the crypt-villus structure from freeze-thawed cells was observed

关键词： intestinal organoid Rho kinase inhibitor three-dimensional culture cryopreservation long-term culture

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Analysis of Cancer Incidence among Korean Nuclear Power Plant Workers

Analysis of Cancer Incidence among Korean Nuclear Power Plan...

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The Second Asian and Oceanic Congress for Radiation Protection

作者： Meeseon JEONG young-woo jin young Khi LIM Soo Keun KIM Byoung-Il LEE Youn Koun JANG Sook Hee SUNG Ill Keun PARK Yeon Joo LEE Chong-Soon KIM Radiation Health Research Institute KHNPSeoulKorea Radiation Health Research Institute KHNPSeoulKorea Radiation Health Research Institute KHNPSeoulKorea Radiation Health Research Institute KHNPSeoulKorea Radiation Health Research Institute KHNPSeoulKorea Radiation Health Research Institute KHNPSeoulKorea Radiation Health Research Institute KHNPSeoulKorea Radiation Health Research Institute KHNPSeoulKorea Radiation Health Research Institute KHNPSeoulKorea Radiation Health Research Institute KHNPSeoulKorea

Epidemiological studies of nuclear industry workers have important role to examine the health effect of low dose and low dose-rate radiation *** this study we analyzed the cohort of Korean nuclear power plants *** cohort consists of 7,459 male workers exposed to ionizing radiation and 6,508 controls without exposure *** paper presents the results of analysis on their cancer incidence between 1993 and 2002.A total of 58 cancers were ascertained for radiation workers and 50 for non-radiation ***-standardized rate ratio for two groups was 1.09（95% CI:0.74,1.62）.Trend test showed that cancer incidence rate in individual dose group was not significantly increased with increasing cumulative dose（p=0.2506）.Excess relative risk for all cancers combined was 6.77（95% CI:-4.02,27.54）per sievert,suggesting no statistically significant association between radiation dose and cancer *** of this study are not conclusive because of considerable *** size of the cohort,small cases of cancer incidence,and young ages of subjects limit the power of the *** we need further follow-up and the expansion of cohort to increase the power and to obtain stable risk estimate.

关键词： radiation workers cohort standardized incidence ratio rate ratio excess relative risk

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High mobility group box 1 in the central nervous system:regeneration hidden beneath inflammation

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Neural Regeneration Research 2025年第1期20卷 107-115页

作者： Hanki Kim Bum Jun Kim Seungyon Koh Hyo jin Cho Xuelian jin Byung Gon Kim Jun young Choi Department of Brain Science Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Ajou University Graduate School of MedicineSuwonSouth Korea Department of Neurology Ajou University School of MedicineSuwonSouth Korea Department of Geriatrics The Affiliated Suqian First People’s Hospital of Nanjing Medical UniversitySuqianJiangsu ProvinceChina

High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and ***-mobility group box 1 in the extracellular space functions as a pro-inflammatory damage-associated molecular pattern,which has been proven to play an important role in a wide variety of central nervous system disorders such as ischemic stroke,Alzheimer’s disease,frontotemporal dementia,Parkinson’s disease,multiple sclerosis,epilepsy,and traumatic brain *** drugs that inhibit high-mobility group box 1 as a damage-associated molecular pattern,such as glycyrrhizin,ethyl pyruvate,and neutralizing anti-high-mobility group box 1 antibodies,are commonly used to target high-mobility group box 1 activity in central nervous system *** it is commonly known for its detrimental inflammatory effect,high-mobility group box 1 has also been shown to have beneficial pro-regenerative roles in central nervous system *** this narrative review,we provide a brief summary of the history of high-mobility group box 1 research and its characterization as a damage-associated molecular pattern,its downstream receptors,and intracellular signaling pathways,how high-mobility group box 1 exerts the repair-favoring roles in general and in the central nervous system,and clues on how to differentiate the pro-regenerative from the pro-inflammatory *** targeting high-mobility group box 1 in the central nervous system may benefit from differentiating between the two functions rather than overall suppression of high-mobility group box 1.

关键词： central nervous system damage-associated molecular pattern ethyl pyruvate glycyrhizzin high mobility group box 1 inflammation neural stem cells neurodevelopment oligodendrocyte progenitor cells redox status regeneration

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Semi-crystalline photovoltaic polymers with siloxane-terminated hybrid side-chains

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Science China Chemistry 2017年第4期60卷 528-536页

作者： Yuxiang Li Seyeong Song Song Yi Park jin young Kim Han young woo Department of Cogno-Mechatronics Engineering Pusan National University Miryang 627-706 Republic of Korea Department of Energy and Chemical Engineering Ulsan National Institute of Science and Technology Ulsan 689-798 Republic of Korea Department of Chemistry Korea University Seoul 136-713 Republic of Korea

Three types of semi-cry stalline photovoltaic polymers were synthesized by incorporating a siloxane-terminated organic/inorganic hybrid side-chain and changing the number of fluorine substituents.A branch point away from a polymer main backbone in the siloxane-containing side-chains and the intra-and/or interchain noncovalent coulombic interactions enhance a chain planarity and facile interchain *** resulting polymers formed strongly agglomerated films with high roughness,suggesting strong intermolecular *** optical band gap of ca.1.7 eV was measured for all polymers with a pronounced shoulder peak due to tight π-π *** increasing the fluorine substituents,the frontier energy levels decreased and preferential face-on orientation was *** siloxane-terminated side-chains and fluorine substitution promoted the intermolecular packing,showing well resolved lamellar scatterings up to(300) for this series of polymers in the grazing incidence wide angle X-ray scattering *** PPsiDTBT,PPsiDTFBT and PPsiDT2 FBT devices showed a power conversion efficiency of 3.16%,4.40%and 5.65%,respectively,by blending with PC_(71)***-type bimolecular charge recombination was similar for three polymeric solar *** main loss in the photocurrent generation for PPsiDTBT:PC_(71)BM was interpreted to originate from the trap assisted charge recombination by measuring light-intensity dependent short-circuit current density(J_(SC)) and open-circuit voltage(V_(Oc)).Our results provide a new insight into the rational selection of solubilizing substituents for optimizing crystalline interchain packing with appropriate miscibility with PC71 BM for further optimizing polymer solar cells.

关键词： siloxane side-chain fluorine substitution semi-crystalline charge transport

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Malignant sweat gland tumor of breast arising in pre-existing benign tumor: A case report

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World Journal of Clinical Cases 2019年第19期7卷 3033-3038页

作者： jin Kyung An Jeong Joo woo young Ok Hong Department of Radiology Nowon Eulji Medical CenterEulji UniversitySeoul 01830South Korea Department of Pathology Nowon Eulji Medical CenterEulji UniversitySeoul 01830South Korea

BACKGROUND Sweat glands belong to skin *** gland tumors are uncommon,especially when they occur as malignant tumors in the *** report a case of malignant sweat gland tumor of the breast,including imaging and pathological *** SUMMARY A 47-year-old woman visited our hospital with a non-tender palpable lesion in her left *** lesion had not shown changes for 10 ***,it recently increased in *** showed a well circumscribed cystic lesion with internal debris and fluid-fluid *** resonance imaging showed a well circumscribed oval mass with T1 hyper-intensity compared to muscle and T2 high signal *** was a small enhancing mural component in the inner wall of the *** tumor was *** pathologic result was a malignant transformation of benign sweat gland tumor such as *** lesion was treated with excision and radiation *** 1-year follow up,there was no local recurrence or metastasis in the *** In the case of a rapid growing cystic mass in the nipple and subareola,it is necessary to distinguish it from a malignant sweat gland tumor.

关键词： Sweat gland neoplasm Breast Ultrasonography Magnetic resonance imaging

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Super-resolution localization photoacoustic microscopy using intrinsic red blood cells as contrast absorbers

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Light(Science & Applications) 2019年第1期8卷 212-222页

作者： Jongbeom Kim jin young Kim Seungwan Jeon jin woo BAIK Seong Hee Cho Chulhong Kim Departments of Creative IT Engineering Electrical EngineeringMechanical Engineeringand Interdisciplinary Bioscience and BioengineeringPohang University of Science and Technology(POSTECH)77 Cheongam-roNam-guPohangGyeongbuk 37673Republic of Korea

Photoacoustic microscopy(PAM)has become a premier microscopy tool that can provide the anatomical,functional,and molecular information of animals and humans in ***,conventional PAM systems suffer from limited temporal and/or spatial ***,we present a fast PAM system and an agent-free localization method based on a stable and commercial galvanometer scanner with a custom-made scanning mirror(L-PAM-GS).This novel hardware implementation enhances the temporal resolution significantly while maintaining a high signal-to-noise ratio(SNR).These improvements allow us to photoacoustically and noninvasively observe the microvasculatures of small animals and humans in ***,the functional hemodynamics,namely,the blood flow rate in the microvasculature,is successfully monitored and quantified in *** importantly,thanks to the high SNR and fast B-mode rate(500 Hz),by localizing photoacoustic signals from captured red blood cells without any contrast agent,unresolved microvessels are clearly distinguished,and the spatial resolution is improved by a factor of 2.5 in ***-GS has great potential in various fields,such as neurology,oncology,and pathology.

关键词： resolution absorber scanner

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Comparison Study and Forensic Analysis between Experiment and Coupled Dynamics Simulation for Submerged Floating Tunnel Segment with Free Ends under Wave Excitations

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Computer Modeling in Engineering & Sciences 2023年第10期137卷 155-174页

作者： woo Chul Chung Chungkuk jin Moo Hyun Kim Ju-young Hwang Division of Mechanical Engineering Korea Maritime&Ocean UniversityBusanSouth Korea Department of Ocean Engineering and Marine Sciences Florida Institute of TechnologyMelbourneFLUSA Department of Ocean Engineering Texas A&M UniversityCollege StationTXUSA Department of Civil Engineering Dong-Eui UniversityBusanSouth Korea

This paper presents dynamic-behavior comparisons and related forensic analyses of a submerged floating tunnel(SFT)between numerical simulation and physical experiment under regular and irregular *** experiments are conducted in the 3Dwave tank with 1:33.3 scale,and the corresponding coupled time-domain simulation tool is devised for *** entire SFT systemconsists of a long concrete tunnel and 12 tubular aluminummooring *** numerical simulation models,the Cummins equation with 3D potential theory including second-order wave-body interaction effects and the much simpler Morison-equation-based formula with the lumped-massbased line model,are designed and *** analyses for mooring-line adjustments in the simulation are carried out in view of the best representation of the physical *** that,the measured pre-tension distribution and systemstiffness of twelvemooring lines arewell reproduced in the ***,the dynamic responses and mooring tensions of the SFT are compared under regular and irregular *** measured and simulated results coincide reasonably well for both regular-and irregular-wave conditions.

关键词： Submerged floating tunnel comparative study forensic analysis mooring-line modeling dynamic response mooring tension

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Production of high-purity Mg metal from dolomite through novel molten salt electrolysis and vacuum distillation

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Journal of Magnesium and Alloys 2023年第4期11卷 1308-1320页

作者： Hyeong-Jun Jeoung Tae-Hyuk Lee jin-young Lee Kyung-woo Yi Jungshin Kang Korea Institute of Geoscience and Mineral Resources 124 Gwahak-ro Yuseong-guDaejeon 34132Republic of Korea Department of Materials Science and Engineering Seoul National University1 Gwanak-roGwanak-guSeoul 08826Republic of Korea Department of Resources Engineering University of Science and Technology217 Gajeong-ro Yuseong-guDaejeon 34113Republic of Korea School of Materials Science and Engineering Pusan National University2 Busandaehak-roGeumjeong-guBusan 46241Republic of Korea

In this study,a novel Mg production process for producing high-purity Mg metal from dolomite was *** the electrolysis of calcined dolomite was conducted using Cu cathode and C anode in MgF_(2)–LiF molten salt at 1083–1173 K by applying an average current of 1.42–1.46 A for 9.50–21.0 h,the current efficiency of 66.4–88.6%was *** produced Mg alloys consisted of MgCu_(2)and Cu(Mg)or MgCu_(2)and CuMg_(2)phases,depending on the Mg concentration in the Mg *** the electrolysis of calcined dolomite was conducted in MgF_(2)–LiF–CaF_(2)molten salt at 1083 K,the current efficiency was 40.9–71.4%,owing to undesired reactions such as electroreduction of Ca^(2+)or/and CO_(3)^(2−)***,the current efficiency increased from 40.9%to 63.2%by utilizing a Pt anode,because the occurrence of CO_(3)^(2−)ions in the molten salt was *** vacuum distillation of the obtained Mg alloys at 1300 K for 10 h,Mg metal with a purity of 99.9996–99.9998%was ***,the feasibility of this novel process for the production of high-purity Mg metal from dolomite was demonstrated.

关键词： High-purity magnesium Dolomite Magnesium oxide Electrolytic process Copper metal cathode Vacuum distillation

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High-index-contrast photonic structures:a versatile platform for photon manipulation

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Light(Science & Applications) 2022年第11期11卷 2617-2632页

作者： young-Bin Kim jin-woo Cho Yun-Jo Lee Dukkyu Bae Sun-Kyung Kim Department of Applied Physics Kyung Hee UniversityYonginGyeonggido 17104Republic of Korea Hexa Solution Co. LtdSuwonGyeonggi-do 16229Republic of Korea

In optics,the refractive index of a material and its spatial distribution determine the characteristics of light ***,exploring both low-and high-index materials/structures is an important consideration in this *** cavities,which are defined as low-index bases,exhibit a variety of unusual or even unexplored optical characteristics and are used in numerous functionalities including diffraction gratings,localised optical antennas and low-loss *** this report,we discuss the fabrication of hollow cavities of various sizes(O.2-5μm in diameter)that are supported by conformal dielectric/metal shells,as well as their specific applications in the ultraviolet(photodetectors),visible(light-emitting diodes,solar cells and metalenses),near-infrared(thermophotovoltaics)and mid-infrared(radiative coolers)*** findings demonstrate that hollow cavities tailored to specific spectra and applications can serve as versatile optical platforms to address the limitations of current optoelectronic ***,hollow cavity embedded structures are highly elastic and can minimise the thermal stress caused by high *** such,future applications will likely include high-temperature devices such as thermophotovoltaics and concentrator photovoltaics.

关键词： versatile index ultraviolet

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