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Fabrication of high-strength duplex nanoporous Cu by dealloying a dual-phase Mg-Cu precursor alloy

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Journal of Magnesium and Alloys 2020年第3期8卷 910-916页

作者： Si-young Lee Soo-Min Baek Eun-Ji Gwak Na-Ri Kang ju-young kim Su-Hyeon kim jung Gu Lee Sung Soo Park School of Materials Science and Engineering Ulsan National Institute of Science and TechnologyUlsan 44919Republic of Korea Korea Institute of Materials Science Changwon 51508Republic of Korea School of Materials Science and Engineering University of UlsanUlsan 44610Republic of Korea

Duplex nanoporous Cu was successfully fabricated by dealloying a dual-phase Mg-Cu precursor alloy consisting of intermetallic Mg2Cu and *** duplex nanoporous Cu with embedded nanoporous struts exhibited highly enhanced strength compared to the typical monolithic nanoporous Cu under both compressive and flexural test conditions at room temperature;the duplex np-Cu sample exhibited a 12 times higher compressive strength and a 40 times greater flexural strength than the monolithic np-Cu *** responsible for the strength enhancement in the duplex nanoporous Cu are discussed.

关键词： Mg-Cu alloy Nanoporous Cu Dealloying Duplex structure Strength

Highly impermeable and flexible silica encapsulation films synthesized by sol-gel process

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Nano Research 2022年第8期15卷 7476-7483页

作者： Si-Hoon kim Gyeong-Seok Hwang Donghwan Koo Dong-Hyun Seo Ye-Pil Kwon Hansuek Lee Hyesung Park Eun-chae Jeon ju-young kim School of Materials Science and Engineering University of UlsanTechno saneop-ro 55beon-gil 12Ulsan 44776Republic of Korea Department of Materials Science and Engineering Ulsan National Institute of Science and Technology(UNIST)UNIST-gil 50Ulsan 44919Republic of Korea Department of Physics Korea Advanced Institute of Science and Technology(KAIST)Daehak-ro 291Deajeon 34141Republic of Korea Graduate School of Semiconductor Materials and Devices Ulsan National Institute of Science and Technology(UNIST)UNIST-gil 50Ulsan 44919Republic of Korea

Silica thin films synthesized sol–gel process are proposed as flexible encapsulation materials.A sol–gel process provides a dense and stable amorphous silica structure,yielding an extremely high elastic deformation limit of 4.9%and extremely low water vapor transmission rate(WVTR)of 2.90×10^(−4)g/(m^(2)∙day)at 60℃and relative humidity of 85%.The WVTR is not degraded by cyclic bending deformations for the bending radius corresponding to a tensile strain of 3.3%in the silica encapsulation film,implying that the silica thin film is robust against the formation of pinhole-type defects by cyclic bending *** organic solar cells encapsulated with the silica films operate without degradation in power conversion efficiency for 50,000 bending cycles for a bending radius of 6 mm.

关键词： silica thin film sol-gel flexible encapsulation mechanical reliability flexible organic solar cell

A population-based case-crossover study of polyethylene glycol use and acute renal failure risk in the elderly

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World Journal of Gastroenterology 2011年第5期17卷 651-656页

作者： Nam-Kyong Choi Yoosoo Chang Sun-young jung Yu-Kyong Choi Joongyub Lee Jin-Ho Lee ju-young kim Byung-Joo Park Department of Preventive Medicine Seoul National University College of MedicineSeoul 110-799South Korea Medical Research Center Seoul National UniversitySeoul 110-799South Korea Department of Occupational Medicine Health Screening CenterKangbuk Samsung HospitalSungkyunkwan University College of MedicineSeoul 110-746South Korea National Evidence-Based Healthcare Collaborating Agency Seoul 110-450South Korea Department of Internal Medicine Gumi HospitalGumi 730-909South Korea Medical Research Collaborating Center Seoul National University Hospital Seoul National University College of Medicine Seoul 110-799South Korea Department of Internal Medicine Dongguk University Ilsan HospitalSchool of MedicineDongguk UniversityGoyang 410-733South Korea Department of Family Medicine Health Promotion CenterSeoul National University Bundang HospitalBundang 463-707South Korea

AIM:To evaluate the possibility of an association between polyethylene glycol(PEG) and acute renal failure(ARF) in elderly patients using a health insurance claims ***:We conducted a population-based casecrossover study using information obtained from Korean Health Insurance Review and Assessment Service(HIRA) claims from January 1,2005 to December 31,2005(Seoul,Korea).The study population consisted of elderly patients who received PEG prior to experiencing their first ARF-related hospitalization from April 1,2005 to December 31,*** each patient,one case and two control periods were *** use in a 2-or 4-wk window period prior to hospitalization for ARF was compared with PEG use in two earlier 2-or 4-wk control window *** logistic regression analysis was used to estimate odds ratios(ORs) and 95% CI,adjusting for concomitant uses of diuretics,angiotensin converting enzyme inhibitors,non-steroidal anti-inflammatory drugs,antibiotics,anti-cancer drugs,and contrast ***:Within the HIRA database which contained 1 093 262 elderly patients,1156 hospitalized ARF cases were *** these cases,PEG was prescribed to 17(1.5%) patients before *** adjusted ORs when applying the 2-and 4-wk window periods were 0.4(95% CI:0.03-5.24) and 2.1(95% CI:0.16-27.78),***:No increased risk of ARF was found in elderly PEG ***,based on the limited number of study subjects,further analysis should be performed to confirm these results.

关键词： Polyethylene glycol Acute renal failure Adverse drug reaction Health insurance claims data-base Case-crossover

Corrosion characteristics of single-phase Mg-3Zn alloy thin film for biodegradable electronics

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Journal of Magnesium and Alloys 2023年第9期11卷 3241-3254页

作者： Ji-Woo Gu Jae-young Bae Guangzhe Li Hae Won Hwang So-Hyeon Lee Sung-Geun Choi ju-young kim Myoung-Ryul Ok Yu-Chan kim Seung-Kyun Kang Department of Materials Science and Engineering Seoul National University(SNU)Seoul 08826Republic of Korea Research Institute of Advanced Materials(RIAM) Seoul National UniversitySeoul 08826Republic of Korea Soft Foundry Nano Systems Institute(NSI) Seoul National UniversitySeoul 08826Republic of Korea Biomaterials Research Center Biomedical Research DivisionKorea Institute of Science and Technology(KIST)Seoul 34141Republic of Korea Division of Bio-Medical Science and Technology KIST SchoolKorea University of Science and TechnologySeoul 02792Republic of Korea Department of Materials Science and Engineering Ulsan National Institute of Science and Technology(UNIST)Ulsan 44919Republic of Korea

Biodegradable metals as electrodes, interconnectors, and device conductors are essential components in the emergence of transient electronics, either for passive implants or active electronic devices, especially in the fields of biomedical electronics. Magnesium and its alloys are strong candidates for biodegradable and implantable conducting materials because of their high conductivity and biocompatibility, in addition to their well-understood dissolution behavior. One critical drawback of Mg and its alloys is their considerably high dissolution rates originating from their low anodic potential, which disturbs the compatibility to biomedical applications. Herein, we introduce a single-phase thin film of a Mg-Zn binary alloy formed by sputtering, which enhances the corrosion resistance of the device electrode, and verify its applicability in biodegradable electronics. The formation of a homogeneous solid solution of single-phase Mg-3Zn was confirmed through X-ray diffraction and transmission electron microscopy. In addition, the dissolution behavior and chemistry was also investigated in various biological fluids by considering the effect of different ion species. Micro-tensile tests showed that the Mg-3Zn alloy electrode exhibited an enhanced yield strain and elongation in relation to a pure Mg electrode. Cell viability test revealed the high biocompatibility rate of the Mg-3Zn binary alloy thin film. Finally, the fabrication of a wireless heater demonstrated the integrability of biodegradable electrodes and highlighted the ability to prolong the lifecycle of thermotherapy-relevant electronics by enhancing the dissolution resistance of the Mg alloy.

关键词： Biodegradable alloy Mg-3Zn binary alloy Solid-solution thin film electrode Biodegradable conductor Transient electronics

Design and evaluation of nicorandil extended-release tablet

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Asian Journal of Pharmaceutical Sciences 2015年第2期10卷 108-113页

作者： ju-young kim Chun-Woong Park Beom-Jin Lee Eun-Seok Park Yun-Seok Rhee College of Pharmacy Woosuk UniversityWanju-gun 565-701Republic of Korea College of Pharmacy Chungbuk National UniversityCheongju 361-763Republic of Korea College of Pharmacy Ajou UniversitySuwon 443-749Republic of Korea School of Pharmacy Sungkyunkwan UniversitySuwon 440-746Republic of Korea College of Pharmacy and Research Institute of Pharmaceutical Sciences Gyeongsang National UniversityJinju 660-701Republic of Korea

The aim of this study was to design and evaluate extended-release formulations of a model drug,nicorandil,in order to achieve the desired steady-state plasma concentration of drug in *** was employed to estimate optimum dissolution and absorption rate of *** dissolution test was employed using pH 1.2,4.0,6.8 buffer solution,or water,to measure the in vitro release behaviors of nicorandil formulations.A single dose(15 mg)of each formulation was orally administered to four beagle dogs under fasted conditions,and the pharmacokinetic parameters were *** in vitro/in vivo relationship of the extended-release formulation was confirmed using in vitro dissolution profiles and plasma concentrations of drug in beagle *** was released completely within 30 min from the immediate-release tablets and released for 24 h from the extended-release *** nicorandil plasma concentration could be modified by adjusting the drug release rate from the extended-release *** release rate of nicorandil was the rate-limiting step in the overall absorption of drug from the extendedrelease *** results highlight the potential of a nicorandil extended-release formulation in the treatment of angina pectoris.

关键词： Nicorandil In vitro In vivo Pharmacokinetic Extended-release

Korean red ginseng alleviates benign prostatic hyperplasia by dysregulating androgen receptor signaling and inhibiting DRP1-mediated mitochondrial fission

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Chinese Journal of Natural Medicines 2024年第7期22卷 599-607页

作者： HONG Geum-Lan kim Kyung-Hyun CHO Sung-Pil LEE Hui-ju kim Yae-Ji juNG ju-young Department of Veterinary Medicine&Institute of Veterinary Science Chungnam National UniversityDaejeon 34134Korea Department of Anatomy College of MedicineKonyang UniversityDaejeon 35365Korea

Panax ginseng(***.)has been traditionally employed in Korea and China to alleviate fatigue and digestive *** particular,Korean red ginseng(KRG),derived from streamed and dried ***,is known for its anti-aging and anti-inflammatory ***,its effects on benign prostatic hyperplasia(BPH),a representative aging-related disease,and the underlying mechanisms remain *** study aims to elucidate the therapeutic effects of KRG on BPH,with a particular focus on mitochondrial dynamics,including fission and fusion *** effects of KRG on cell proliferation,apoptosis,and mitochondrial dynamics and morphology were evaluated in a rat model of testosterone propionate(TP)-induced BPH and TP-treated LNCaP cells,with mdivi-1 as a *** results revealed that KRG treatment reduced the levels of androgen receptors(AR)and prostate-specific antigens in the BPH *** inhibited cell proliferation by downregulating cyclin D and proliferating cell nuclear antigen(PCNA)levels,and it promoted apoptosis by increasing the ratio of B-cell lymphoma protein 2(Bcl-2)-associated X protein(Bax)to Bcl-2 ***,KRG treatment enhanced the phosphorylation of dynamin-related protein 1(DRP-1,serine 637)compared with that in the BPH group,which inhibited mitochondrial fission and led to mitochondrial *** modulation of mitochondrial dynamics was associated with decreased cell proliferation and increased *** dysregulating AR signaling and inhibiting mitochondrial fission through enhanced DRP-1(ser637)phosphorylation,KRG effectively reduced cell proliferation and induced *** findings suggest that KRG’s regulation of mitochondrial dynamics offers a promising clinical approach for the treatment of BPH.

关键词： Androgen Benign prostatic hyperplasia Fission Korean red ginseng Mitochondria

High tibial osteotomy with human umbilical cord blood-derived mesenchymal stem cells implantation for knee cartilage regeneration

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World Journal of Stem Cells 2020年第6期12卷 514-526页

作者： jun-Seob Song Ki-Taek Hong Chae-Gwan Kong Na-Min kim Jae-Yub jung Han-Soo Park young ju kim Ki Bong Chang Seok jung kim Department of Orthopedic Surgery Gangnam JS HospitalSeoul 06053South Korea Department of Orthopedic Surgery College of MedicineThe Catholic University of KoreaUijeongbu-si 11765South Korea Department of Nursing Education&Administration Uijeongbu St.Mary’s HospitalThe Catholic University of KoreaUijeongbu-si 11765South Korea

BACKGROUND High tibial osteotomy(HTO)is a well-established method for the treatment of medial compartment osteoarthritis of the knee with varus ***,HTO alone cannot adequately repair the arthritic joint,necessitating cartilage regeneration *** regeneration procedures with concomitant HTO are used to improve the clinical outcome in patients with varus *** To evaluate cartilage regeneration after implantation of allogenic human umbilical cord blood-derived mesenchymal stem cells(hUCB-MSCs)with concomitant *** Data for patients who underwent implantation of hUCB-MSCs with concomitant HTO were *** patients included in this study were over 40 years old,had a varus deformity of more than 5°,and a full-thickness International Cartilage Repair Society(ICRS)grade IV articular cartilage lesion of more than 4 cm2 in the medial compartment of the *** patients underwent second-look arthroscopy during hardware *** regeneration was evaluated macroscopically using the ICRS grading system in second-look *** also assessed the effects of patient characteristics,such as trochlear lesions,age,and lesion size,using patient medical *** A total of 125 patients were included in the study,with an average age of 58.3±6.8 years(range:43-74 years old);95(76%)were female and 30(24%)were *** average hip-knee-ankle(HKA)angle for measuring varus deformity was 7.6°±2.4°(range:5.0-14.2°).In second-look arthroscopy,the status of medial femoral condyle(MFC)cartilage was as follows:73(58.4%)patients with ICRS grade I,37(29.6%)with ICRS grade II,and 15(12%)with ICRS grade *** patients were staged with ICRS grade ***,the scores[except International Knee Documentation Committee(IKDC)at 1 year]of the ICRS grade I group improved more significantly than those of the ICRS grade II and III *** Implantation of hUCB-MSCs with concomitant HTO is an effective treatment for patients wit

关键词： Allogeneic Human umbilical cord blood-derived mesenchymal stem cells Cartilage regeneration High tibial osteotomy Osteoarthritic knees Arthroscopy

Machine Learning-Assisted Fabrication of PCBM-Perovskite Solar Cells with Nanopatterned TiO2 Layer

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Energy & Environmental Materials 2024年第4期7卷 223-230页

作者： Siti Norhasanah Sanimu Hwa-young Yang Jeevan Kandel Ye-Chong Moon Gangasagar Sharma Gaudel Seung-ju Yu Yong ju kim Sejung kim Bong-Hyun jun Won-Yeop Rho Graduate School of Integrated Energy-AI Jeonbuk National University School of Energy and Chemical Engineering Ulsan National Institute of Science and Technology (UNIST) Department of Herbal Medicine Resources College of Environmental and Bioresource Sciences Jeonbuk National University School of Chemical Engineering Jeonbuk National University Department of Bioscience and Biotechnology Konkuk University School of International Engineering and Science Jeonbuk National University

To unlock the full potential of PSCs,machine learning （ML） was implemented in this research to predict the optimal combination of mesoporous-titanium dioxide （mp-TiO2） and weight percentage （wt%） of phenyl-C61-butyric acid methyl ester （PCBM）,along with the current density(Jsc),open-circuit voltage (Voc),fill factor （ff）,and energy conversion efficiency （ECE）.

关键词： machine learning nanopatterning PCBM perovskite solar cells prediction

Research on flexible display at Ulsan National Institute of Science and Technology

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npj Flexible Electronics 2017年第1期1卷 47-59页

作者： Jihun Park Sanghyun Heo Kibog Park Myoung Hoon Song ju-young kim Gyouhyung Kyung Rodney Scott Ruoff Jang-Ung Park Franklin Bien School of Materials Science and Engineering Ulsan National Institute of Science and Technology(UNIST)Ulsan Metropolitan City 44919Republic of Korea School of Electrical and Computer Engineering Ulsan National Institute of Science and Technology(UNIST)Ulsan Metropolitan City 44919Republic of Korea Department of Physics Ulsan National Institute of Science and Technology(UNIST)Ulsan Metropolitan City 44919Republic of Korea School of Design and Human Engineering Ulsan National Institute of Science and Technology(UNIST)Ulsan Metropolitan City 44919Republic of Korea Center for Multidimensional Carbon Materials Institute for Basic Science(IBS)Ulsan 44919Republic of Korea Department of Chemistry Ulsan National Institute of Science and Technology(UNIST)Ulsan 44919Republic of Korea

Displays represent information visually,so they have become the fundamental building block to visualize the data of current electronics including ***,electronics have been advanced toward flexible and wearable electronics that can be bent,folded,or stretched while maintaining their performance under various ***,recent advances in research to demonstrate flexible and wearable displays are *** introduce these results by dividing them into several categories according to the components of the display:active-matrix backplane,touch screen panel,light sources,integrated circuit for fingerprint touch screen panel,and characterization tests;and we also present mechanical tests in nano-meter scale and visual ergonomics research.

关键词： dividing electronics panel