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1.45 GPa ultrastrong cryogenic strength with superior impact toughness in the in-situ nano oxide reinforced CrMnFeCoNi high-entropy alloy matrix nanocomposite manufactured by laser powder bed fusion

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Journal of Materials Science & Technology 2022年第2期97卷 10-19页

作者： young-Kyun kim Min-Chul kim Kee-Ahn Lee Department of Materials Science and Engineering Inha UniversityIncheon 22212Republic of Korea Korea Atomic Energy Research Institute(KAERI) Daejeon 34057Republic of Korea

CrMnFeCoNi high-entropy alloys(HEAs)exhibit an excellent combination of tensile strength and ductility at cryogenic *** study led to the introduction of a new method for the development of high-performance CrMnFeCoNi HEAs at cryogenic temperatures by jointly utilizing additive manufacturing(AM)and the addition of interstitial *** interstitial oxygen present in the powder feedstock was transformed into beneficial nano-sized oxides during AM *** HEA nanocomposite fabricated using laser powder bed fusion(L-PBF)not only contains heterogeneous grains and substructures but also a high number density of nano-sized *** tensile results revealed that the L-PBF HEA nanocomposite has superior yield strengths of 0.77 GPa and 1.15 GPa,and tensile strengths of 0.92 GPa and 1.45 GPa at 298 K and 77 K,*** addition,the Charpy impact energies of the samples tested at 298 K and 77 K were measured as 176.2 J and 103.7 J,*** results indicate that the L-PBF HEA nanocomposite successfully overcomes the well-known strength-toughness *** tensile deformation microstructure contained a relatively large number of deformation twins(DTs)at cryogenic temperature,a possible consequence of the decrease in the stacking fault energy with decreasing *** the other hand,cracks were found to propagate along the grain boundaries at room temperature,whereas a transgranular crack was observed at cryogenic temperature in the specimens fractured as a result of the Charpy impact.

关键词： Laser powder bed fusion High-entropy alloy matrix nanocomposite Nano-oxide:cryogenic Tensile Impact toughness

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Identification of Aristolactam Derivatives That Act as Inhibitors of Human Immunodeficiency Virus Type 1 Infection and Replication by Targeting Tat-Mediated Viral Transcription

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Virologica Sinica 2021年第2期36卷 254-263页

作者： young Hyun Shin Chul Min Park Hong Gi kim Dong-Eun kim Min Suk Choi Jeong-ah kim Byeong-Sun Choi Cheol-hee Yoon Division of Viral Disease Research Center for Infectious Disease ResearchKorea National Institute of HealthHeungdeok-guCheongju-siShungbuk 28159Republic of Korea Center for Convergent Research of Emerging Virus Infection Korea Research Institute of Chemical TechnologyYuseong-guDaejeon 34114Republic of Korea

Despite the success of antiretroviral therapy(ART),efforts to develop new classes of antiviral agents have been hampered by the emergence of drug ***-indole-bearing aristolactams are compounds that have been isolated from various plants species and which show several clinically relevant effects,including anti-inflammatory,antiplatelet,and antimycobacterial ***,the effect of these compounds on human immunodeficiency virus type 1(HIV-1)infection has not yet been *** this study,we discovered an aristolactam derivative bearing dibenzo[cd,f]indol-4(5 H)-one that had a potent anti-HIV-1 effect.A structure-activity relationship(SAR)study using nine synthetic derivatives of aristolactam identified the differing effects of residue substitutions on the inhibition of HIV-1 infection and cell *** the compounds tested,1,2,8,9-tetramethoxy-5-(2-(piperidin-1-yl)ethyl)-dibenzo[cd,f]indol-4(5 H)-one(Compound 2)exhibited the most potent activity by inhibiting HIV-1 infection with a half-maximal inhibitory concentration(IC50)of 1.03 lmol/L and a half-maximal cytotoxic concentration(CC50)of 16.91 lmol/L(selectivity index,16.45).The inhibitory effect of the compounds on HIV-1 infection was linked to inhibition of the viral replication ***-of-action studies showed that the aristolactam derivatives did not affect reverse transcription or integration;instead,they specifically inhibited Tat-mediated viral *** together,these findings show that several aristolactam derivatives impaired HIV-1 infection by inhibiting the activity of Tat-mediated viral transcription,and suggest that these derivatives could be antiviral drug candidates.

关键词： Human immunodeficiency virus type 1(HIV-1) Aristolactam Antiviral activity HIV-1 transcription

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Evaluation the Properties of Titanium Matrix Composites by Melting Route Synthesis

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Journal of Materials Science & Technology 2008年第1期24卷 105-109页

作者： Bong-Jae Choi Si-young Sung Myoung-Gyun kim young-Jig kim Department of Advanced Materials Engineering Sungkyunkwan University SuwonKorea Department of Advanced Materials Engineering Sungkyunkwan University SuwonKorea Materials & Processing Engineering CenterR&D DivisionKorea Automotive Technology InstituteChonanChungnamKorea Research Institute of Industrial Science and Technology Pohang Korea

The main purpose of this study is an in-situ synthesis of （TiB＋TiC） hybrid titanium matrix composites （TMCs） by vacuum induction melting method and to verify its mechanical *** melting route was adopted to synthesize the commercial pure titanium （cp Ti） and granular boron carbide （B-4C）.The reinforcements,the fraction of 10 ***,were formed by adding 1.88 wt pct B-4C to cp *** in-situ synthesis of TMCs,electron probe micro-analysis elemental mapping was carried out to confirm the distribution and shape of *** cone-on-disk type sliding wear test was also done for the identification of *** is concluded that （TiB＋TiC） hybrid TMCs can be in-situ synthesized and has better wear properties than H13.

关键词： Titanium matrix composites H13 In-situ Wear

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Prospective comparison of prophylactic antibiotic use between intravenous moxifloxacin and ceftriaxone for high-risk patients with post-ERCP cholangitis

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Hepatobiliary & Pancreatic Diseases International 2017年第5期16卷 512-518页

作者： Nam hee kim Hong Joo kim Ki Bae Bang Department of Internal Medicine Sungkyunkwan University Kangbuk Samsung Hospital Department of Internal Medicine Dankook University Hospital

BACKGROUND: The use of prophylactic antibiotics before endoscopic retrograde cholangiopancreatography(ERCP) is recommended by all major international gastroenterological societies, especially in the presence of an obstructed biliary system. This study compared the occurrence rate of post-procedural complications, including cholangitis and septicemia between prophylactic intravenous moxifloxacin and ceftriaxone in patients with bile duct obstruction scheduled for therapeutic ***: From November 2013 to July 2015, 86 consecutive patients with biliary obstruction with one or more factors predicting benefits of antibiotic prophylaxis prior to ERCP were included in the current randomized open-label non-inferiority trial(Clinical *** identifier NCT02098486). Intravenous moxifloxacin(400 mg/day) or ceftriaxone(2 g/day)were given 90 minutes before ERCP, and were administered for more than 3 days if the patient developed symptoms and signs of cholangitis or septicemia. Recalcitrant cholangitis was defined as persistence of cholangitis for more than 5 days after ERCP or recurrence of cholangitis within 30 days after ***: Recalcitrant cholangitis occurred in 1(2.3%) and 2(4.8%) patients receiving intravenous moxifloxacin and ceftriaxone group, respectively(P=0.612). Septicemia was noted in1(2.3%) and 1(2.4%) patient in intravenous moxifloxacin and ceftriaxone group, respectively(P=1.0). The mean hospital stay was also not significantly different between the moxifloxacin and ceftriaxone groups(8.8±7.2 vs 9.1±9.4 days, P=0.867). Antibiotic resistance of the isolated pathogens by in vitro activity assay was noted in 1(2.3%) and 2(4.8%) patients in the moxifloxacin and ceftriaxone group, respectively(P=0.612). CONCLUSION: Intravenous moxifloxacin is not inferior to intravenous ceftriaxone for the prophylactic treatment of post-ERCP cholangitis and cholangitis-associated morbidity.

关键词： endoscopic retrograde cholangiopancreatography cholangitis moxifloxacin ceftriaxone recalcitrant cholangitis

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Determining node duty cycle using Q-learning and linear regression for WSN

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Frontiers of Computer Science 2021年第1期15卷 17-23页

作者： Han Yao HUANG Kyung Tae kim hee Yong YOUN College of Software Sungkyunkwan UniversitySuwon 440-746Korea

Wireless sensor network(WSN)is effective for monitoring the target environment,which consists of a large number of sensor nodes of limited *** efficient medium access control(MAC)protocol is thus imperative to maximize the energy efficiency and performance of *** most existing MAC protocols are based on the scheduling of sleep and active period of the nodes,and do not consider the relationship between the load condition and *** this paper a novel scheme is proposed to properly determine the duty cycle of the WSN nodes according to the load,which employs the Q-leaming technique and function approximation with linear *** allows low-latency energy-efficient scheduling for a wide range of traffic conditions,and effectively overcomes the limitation of Q-learning with the problem of continuous state-action ***3 simulation reveals that the proposed scheme significantly improves the throughput,latency,and energy efficiency compared to the existing fully active scheme and S-MAC.

关键词： wireless sensor network media access control duty-cycle scheduling Q-leaming linear regression

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Scalp electroacupuncture at the Baihui acupoint (DU 20) improves functional recovery in rats with cerebral ischemia Association with increased expression of vascular endothelial growth factors

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Neural Regeneration Research 2011年第36期6卷 2822-2828页

作者： Min-Wook kim You Chul Chung hee Chan Jung Moon-Seo Park young-Min Han Yong-An Chung Lee-So Maeng Sang-In Park Jiyeon Lim Seung Chan kim Woo-Seok Im Jin young Chung Minky kim Manho kim Institute of Catholic Integrative Medicine (ICIM) Incheon St. Mary’s Hospital Catholic University of Korea Incheon Korea Department of Rehabilitation Medicine Catholic University of Korea Seoul Korea Department of Neurology Seoul National University Hospital SNUMRC Seoul Korea Department of Biotechnology Yonsei University Seoul Korea Department of Neurology Seoul Medical Center Seoul Korea

In this study, we induced cerebral infarction in rats by occluding the right middle cerebral artery, and tested the effects of electroacupuncture at the Baihui acupoint （DU 20）. Motor and sensory function was tested using Garcia’s scale and motor weakness grading, and the expression of vascular endothelial growth factor in the brain was quantified using immunoblotting and immunohistochemistry. We found that scalp electroacupuncture at DU 20 significantly improved motor performance and sensory function in rats with stroke, and this was accompanied by an increased expression of vascular endothelial growth factor in the ischemic brain tissue and peri-ischemic area. In addition, Pearson correlation analysis showed that the improvements in functional recovery were correlated with the increased expression of vascular endothelial growth factor.

关键词： electroacupuncture cerebrovascular disorder vascular endothelial growth factor Baihui acupoint functional improvement

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Sigmoidorectal intussusception of adenoma of sigmoid colon treated by laparoscopic anterior resection after sponge-on-the-stick-assisted manual reduction

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World Journal of Gastroenterology 2006年第1期12卷 146-149页

作者： Ki-Jae Park Hong-Jo Choi Sung-Heun kim Sang-young Han Sook-hee Hong Jin-Han Cho Hyung-Ho kim Department of Surgery Dong-A University College of MedicinePusanSouth Korea Department of Internal Medicine Dong-A University College of Medicine.PusanSouth Korea Department of Pathology Dong-A University College of MedicinePusanSouth Korea Department of Radiology Dong-A University College of MedicinePusanSouth Korea Department of Surgery Seoul National University Bundang HospitalBundangKyunggi-DoSouth Korea

We present herein a case report of sigmoidorectal intussusception as an unusual case of sigmoid adenomatous polyp. The patient was a 56-year-old man who suffered from rectal bleeding for one day. He initially visited his general practitioner and was diagnosed as having an intraluminal mass of 15 cm from the anal verge. Several hours after admission to our coloproctology clinic, he suddenly presented with lower abdominal cramping pain with rectal bleeding during his bowel preparation using polyethylene glycol electrolyte solution. An emergency colonoscopy revealed that the invaginated colon with polypoid mass was protruded to the lower rectum. Gastrograffin enema showed that the invaginated bowel segment was 3 cm from the anal verge. CT scan showed the typical finding of intussusception. We performed laparoscopic anterior resection and anastomosis after the sponge-on-the-stickassisted manual reduction. The permanent pathologic finding showed villotubular adenoma of the sigmoid colon.

关键词： Sigmoidorectal intussusception Adenomatouspolyp Laparoscopic resection

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Rice pollen-specific OsRALF17 and OsRALF19 are essential for pollen tube growth

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Journal of Integrative Plant Biology 2023年第9期65卷 2218-2236页

作者： Eui‐Jung kim Ji‐Hyun kim Woo‐Jong Hong Eun young kim Myung‐hee kim Su Kyoung Lee Cheol Woo Min Sun Tae kim Soon Ki Park Ki‐Hong Jung Yu‐Jin kim Graduate School of Green Bio‐Science&Crop Biotech Institute Kyung Hee UniversityYongin 17104Republic of Korea Department of Life Science and Environmental Biochemistry Life and Industry Convergence Research InstitutePusan National UniversityMiryang 50463Republic of Korea Department of Smart Farm Science Kyung Hee UniversityYongin 17104Republic of Korea School of Applied Biosciences Kyungpook National UniversityDaegu 41566Republic of Korea Genomics Division Department of Agricultural Bio‐ResourcesNational Institute of Agricultural SciencesRural Development AdministrationJeonju 54874Republic of Korea Department of Plant Bioscience Pusan National UniversityMiryang 50463Republic of Korea Research Center for Plant Plasticity Seoul National UniversitySeoul 08826Republic of Korea

Pollen tube growth is essential for successful double fertilization, which is critical for grain yield in crop plants. Rapid alkalinization factors(RALFs) function as ligands for signal transduction during fertilization. However, functional studies on RALF in monocot plants are ***, we functionally characterized two pollen-specific RALFs in rice(Oryza sativa) using multiple clustered regularly interspaced palindromic repeats(CRISPR)/CRISPR-associated protein 9-induced loss-of-function mutants,peptide treatment, expression analyses, and tag reporter lines. Among the 41 RALF members in rice, OsRALF17 was specifically expressed at the highest level in pollen and pollen *** applied OsRALF17 or OsRALF19peptide inhibited pollen tube germination and elongation at high concentrations but enhanced tube elongation at low concentrations, indicating growth regulation. Double mutants of OsRALF17 and OsRALF19(ralf17/19) exhibited almost full male sterility with defects in pollen hydration, germination, and tube elongation,which was partially recovered by exogenous treatment with OsRALF17 peptide. This study revealed that two partially functionally redundant OsRALF17 and OsRALF19 bind to Oryza sativa male-gene transfer defective 2(OsMTD2) and transmit reactive oxygen species signals for pollen tube germination and integrity maintenance in rice. Transcriptomic analysis confirmed their common downstream genes, in osmtd2 and ralf17/19. This study provides new insights into the role of RALF, expanding our knowledge of the biological role of RALF in regulating rice fertilization.

关键词： CRISPR-Cas9 CrRLK1L monocot Oryza sativa pollen tube growth rapid alkalinization factor(RALF)

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Model development to estimate site index values for six major tree species in North Korea

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Journal of Forestry Research 2023年第2期34卷 387-400页

作者： Sohee Park A-Ram Yang Eun-hee kim Joongbin Lim Division of Global Forestry Department of Future Forest StrategyNational Institute of Forest ScienceSeoul 02455Republic of Korea Forest ICT Research Center National Institute of Forest ScienceSeoul 02455Republic of Korea

Due to considerable deforestation in North Korea,there is a need to plan forest restoration programs based on scientific forest *** this study,a methodology was developed for estimating the site index values of six major tree species and the forest productivity *** site index values of these tree species were derived in South Korea using the Chapman-Richards *** values were used with data from the 6th National Forest Inventory,which included 20 types of edaphic,topographic,and climatic factors,and random forest analysis—a widely used machine learning technique for spatial prediction—to develop a new model for estimating the site index values of these species across South *** prediction accuracy of this model was evaluated using the root mean square *** results show that the prediction accuracy was high,with a root mean square error of~***,the importance of the variables related to climate and geography was generally *** proposed site index estimation model for six tree species was applied across North Korea,and its effectiveness tested by comparing the estimated values with those reported in literature from North *** differences between the model outputs and recorded data in the northern alpine regions were presumably due to the lack of data for high-altitude regions in South *** model is based on the determination of the suitability of tree species in restoration ***,it can contribute to the evaluation of forest productivity in North Korea and may help plan efficient forest restoration programs.

关键词： Environmental factors Forest productivity Machine learning North Korea Random forest Site index

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Cutaneous ciliated cyst on the anterior neck in young women: A case report

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World Journal of Clinical Cases 2020年第19期8卷 4481-4487页

作者： Yon hee kim Jihyoun Lee Department of Pathology Soonchunhyang University Seoul HospitalSeoul 04401South Korea Department of Surgery Soonchunhyang University Seoul HospitalSeoul 04401South Korea

BACKGROUND A cutaneous ciliated cyst(CCC)is a rare,benign tumor in young female adults,which is usually found on the lower *** SUMMARY We found an uncommon location of CCC in the anterolateral cervical area and reviewed the literature.A 20-year-old female complained of a well-defined,painless,palpable mass that started several years *** mass was tense and movable and located at the anterolateral aspect of the *** showed a non-enhancing round *** excision biopsy was performed,and the cystic mass was revealed to be a *** The rare location of CCC can be found in anterior neck area,which should be another diagnostic option for mass on anterior neck.

关键词： Head and neck neoplasms Female young adult Subcutaneous mass Mixed tumor Mullerian Case report

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