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Case of inappropriate ADH syndrome:Hyponatremia due to polyethylene glycol bowel preparation

World Journal of Gastroenterology 2014年第34期20卷 12350-12354页

作者： Sun-Hye Ko Chul-Hyun lim Jae-young Kim Seung Hun Kang Myong Ki Baeg Hyun Jin Oh Division of Endocrinology and Metabolism Department of Internal MedicineCollege of MedicineThe Catholic UniversitySeoul 137-701South Korea Division of Gastroenterology Department of Internal MedicineCollege of MedicineThe Catholic University of KoreaSeoul 137-701South Korea

Colonoscopic screening has been reported to reduce deaths from colorectal *** bowel preparation is essential for this and safety is an important issue in choosing the *** glycol(PEG)is regarded as a safe method for cleansing,especially compared with oral sodium ***,we present a case of hyponatremia caused by the syndrome of inappropriate antidiuretic hormone(ADH)syndrome after PEG precolonoscopic cleansing resulting in generalized tonic-clonic seizures.A 62-year-old women had ingested PEG for precolonoscopic bowel *** waiting for the colonoscopy,she developed a stuporous mentality and generalized tonic-clonic seizures,which did not correlate with brain magnetic resonance *** serum sodium level was 113 mEq per liter and laboratory analyses were consistent with inappropriate ADH *** thyroid and adrenal functions were *** were no malignancies,infections,respiratory disorders or central nervous disorders and she had no history of taking either diuretics or other medications,which might have caused inappropriate ADH *** was treated with 3%hypertonic saline and showed a complete neurological recovery as her sodium levels ***-up visits showed the patient to have a normal sodium level without neurologic *** case shows that inappropriate ADH syndrome can be caused by PEG preparation,which implies that physicians have to be aware of the possible side effects of this colonic cleansing approach and mindful of the possible ensuing symptoms.

关键词： Inappropriate antidiuretic hormone syndrome Colonoscopy Polyethyelene glycol Hyponatremia Seizure

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Gut microbiota as a potential key to modulating humoral immunogenicity of new platform COVID-19 vaccines

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Signal Transduction and Targeted Therapy 2023年第6期8卷 2447-2450页

作者： Hye Seong Bo Kyu Choi young-Hee Han Jun Hyoung Kim Jeong-An Gim Sooyeon lim Ji Yun Noh Hee Jin Cheong Woo Joo Kim Joon young Song Department of Internal Medicine Korea University College of MedicineSeoulRepublic of Korea Asia Pacific Influenza Institute Korea University College of MedicineSeoulRepublic of Korea Vaccine Innovation Center Korea University College of MedicineSeoulRepublic of Korea Department of Biomedical Systems Informatics Yonsei University College of MedicineSeoulRepublic of Korea Department of Food and Nutrition Chungbuk National UniversityCheongjuRepublic of Korea Department of Internal Medicine Chungbuk National University HospitalCheongjuRepublic of Korea Medical Science Research Center Korea University College of MedicineSeoulRepublic of Korea

Dear Editor,Coronavirus disease 2019(COVID-19)is a novel respiratory infectious disease,caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),which led to a global *** vaccination is the best measure to overcome a pandemic,the immunogenicity of vaccines can be influenced by diverse factors,including intrinsic(age,sex,genetics,and comorbidities),extrinsic(diet,nutrition,and behavior),and vaccine-associated characteristics.

关键词： vaccines respiratory acute

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Fully implantable and battery-free wireless optoelectronic system for modulable cancer therapy and real-time monitoring

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npj Flexible Electronics 2023年第1期7卷 119-130页

作者： Kiho Kim In Sik Min Tae Hee Kim Do Hyeon Kim Seungwon Hwang Kyowon Kang Kyubeen Kim Sangun Park Jongmin Lee young Uk Cho Jung Woo Lee woon-Hong Yeo young Min Song youngmee Jung Ki Jun Yu Functional Bio-integrated Electronics and Energy Management Lab School of Electrical and Electronic EngineeringYonsei University50 Yonsei-roSeodaemun-guSeoul 03722Republic of Korea Center for Biomaterials Biomedical Research InstituteKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Department of Fusion Research and Collaboration Biomedical Research InstituteSeoul National University HospitalSeoul 03080Republic of Korea School of Electrical Engineering and Computer Science(EECS) Gwangju Institute of Science and Technology(GIST)Gwangju 61005Republic of Korea PA1 Foundry BusinessSamsung Electronics1 Samsungjeonja-roHwaseong-siGyeonggi-doRepublic of Korea R&D Center DNA Lab PharmaresearchSeongnam 13486Republic of Korea KU-KIST Graduate School of Converging Science and Technology Korea UniversitySeoul 136-705Republic of Korea School of Materials Science and Engineering Energy Materials for Soft Electronics LaboratoryPusan National UniversityBusan 46241Republic of Korea IEN Center for Human-Centric Interfaces and Engineering and George W.Woodruff School of Mechanical Engineering Georgia Institute of TechnologyAtlantaGA 30332USA Wallace H.Coulter Department of Biomedical Engineering Georgia Institute of Technology and Emory University School of MedicineAtlantaGA 30332USA Institute for Robotics and Intelligent Machines Parker H.Petit Institute for Bioengineering and BiosciencesInstitute for MaterialsNeural Engineering CenterGeorgia Institute of TechnologyAtlantaGA 30332USA School of Electrical and Electronic Engineering YU-Korea Institute of Science and Technology(KIST)InstituteYonsei University50Yonsei-roSeodaemun-guSeoul 03722Republic of Korea

Photodynamic therapy(PDT)is attracting attention as a next-generation cancer treatment that can selectively destroy malignant tissues,exhibit fewer side effects,and lack pain during *** PDT systems have recently been developed to resolve the issues of bulky and expensive conventional PDT systems and to implement continuous and repetitive *** implantable PDT systems,however,are not able to perform multiple functions simultaneously,such as modulating light intensity,measuring,and transmitting tumor-related data,resulting in the complexity of cancer ***,we introduce a flexible and fully implantable wireless optoelectronic system capable of continuous and effective cancer treatment by fusing PDT and hyperthermia and enabling tumor size monitoring in *** system exploits micro inorganic light-emitting diodes(μ-LED)that emit light with a wavelength of 624 nm,designed not to affect surrounding normal tissues by utilizing a fully programmable light intensity ofμ-LED and precisely monitoring the tumor size by Si phototransistor during a long-term implantation(2–3 weeks).The superiority of simultaneous cancer treatment and tumor size monitoring capabilities of our system operated by wireless power and data transmissions with a cell phone was confirmed through in vitro experiments,ray-tracing simulation results,and a tumor xenograft mouse model in *** all-in-one single system for cancer treatment offers opportunities to not only enable effective treatment of tumors located deep in the tissue but also enable precise and continuous monitoring of tumor size in real-time.

关键词： optoelectronic enable battery

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Giant choledocholithiasis treated by mechanical lithotripsy using a gastric bezoar basket

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World Journal of Gastroenterology 2012年第25期18卷 3327-3330页

作者： Hyun Jung Chung Seok Jeong Don Haeng Lee Jung Il Lee Jin-Woo Lee Byoung Wook Bang Kye Sook Kwon Hyung Kil Kim Yong woon Shin young Soo Kim Division of Gastroenterology Department of Internal MedicineInha University School of MedicineIncheon 400-711South Korea

Mechanical lithotripsy （ML） is usually considered as a standard treatment option for large bile duct stones. However, it is impossible to retrieve oversized stones because the conventional lithotripsy basket may not be able to grasp the stone. However, there is no es- tablished endoscopic extraction method for such gi- ant stone removal. We describe a case of successful extraction of a 4-cm large stone using a gastric bezoar basket. A 78-year-old woman had suffered from upper abdominal pain for 20 d. Contrast-enhanced computed tomogram revealed a 4-cm single stone in the distal common bile duct （CBD）. Endoscopic stone retraction was decided upon and endoscopic papillary balloon dilation was performed using a large balloon. An at- tempt to capture the stone using a standard lithotripsy basket failed due to the large stone size. Subsequently, we used a gastric bezoar basket to successfully capturethe stone. The stone was fragmented into small pieces and extracted. The stone was completely removed after two sessions of endoscopic retrograde cholangio- pancreatography; each of which took 30 rain. No com- plications occurred during or after the procedure. The patient was fully recovered and discharged on day 11 of hospitalization. ML using a gastric bezoar basket is a safe and effective retrieval method in select cases, and is considered as an alternative nonoperative option for the management of difficult CBD stones.

关键词： Giant choledocholithiasis Mechanical litho-tripsy Bezoar basket Common bile duct stone Endo-scopic papillary balloon dilatal^ion

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Steroids in Maxillofacial Space Infection: A Retrospective Cohort Study

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Open Journal of Stomatology 2017年第9期7卷 397-407页

作者： Li Fong Low Harshinie Audimulam Hui woon lim Kalpana Selvaraju Sathesh Balasundram Department of Oral and Maxillofacial Surgery Hospital Sultanah Nora Ismail Batu Pahat Johor Malaysia

Maxillofacial space infection (MSI) is one of the most common conditions encountered in oral and maxillofacial surgery clinics. Early recognition and proper management of MSI could prevent a life-threatening event. Objectives: To report a series of MSI managed with antibiotics, surgical intervention and exogenous steroids as an adjunct, highlighting functional improvement following steroid administration. Methods: A retrospective cohort study was carried out from December 2013 to September 2016, involving 30 patients (n = 30, 22 males, 8 females) diagnosed with MSI. All patients were initially managed with intravenous empirical antibiotics, analgesics and removal of potential source of infection. A course of 3 doses of IV Dexamethasone 8 mg at an interval of 8 hours was started during the first day of hospital admission. Results: This series reports 30 patients presenting with MSI, who received prompt antibiotics and 3 doses of steroids as inpatients. Significant clinical improvement was noted in the form of amelioration of pain, rapid reduction in edema, and improved trismus, shortening hospital stay to an average of 3.5 days, and omission of surgical intervention in 50% of our cases. No adverse effects or drug reaction was noted. Conclusion: In conclusion, the value of synergistic use of corticosteroids with antibiotics in management of MSI is significant. Despite these promising findings, there is scarce evidence in the literature to fully support the use of corticosteroids in abscess management. The role of corticosteroids in treatment of MSI should be explored further.

关键词： Maxillofacial Space Infections Abscess Odontogenic Infections Systemic Steroids Adjunctive Management

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Cost-effective screening using a two-antibody panel for detecting mismatch repair deficiency in sporadic colorectal cancer

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World Journal of Clinical Cases 2021年第24期9卷 6999-7008页

作者： Jong Beom Kim young Il Kim Yong Sik Yoon Jihun Kim Seo young Park Jong Lyul Lee Chan Wook Kim In Ja Park Seok-Byung lim Chang Sik Yu Jin Cheon Kim Division of Colon and Rectal Surgery University of Ulsan College of MedicineAsan Medical CenterSeoul 05505South Korea Department of Pathology University of Ulsan College of MedicineAsan Medical CenterSeoul 05505South Korea Department of Clinical Epidemiology and Biostatistics University of Ulsan College of MedicineAsan Medical CenterSeoul 05505South Korea

BACKGROUND The microsatellite instability(MSI)test and immunohistochemistry(IHC)are widely used to screen DNA mismatch repair(MMR)deficiency in sporadic colorectal cancer(CRC).For IHC,a two-antibody panel of MLH1 and MSH2 or four-antibody panel of MLH1,MSH2,PMS2,and MSH6 are *** general,MSI is known as a more accurate screening test than *** To compare two-and four-antibody panels of IHC in terms of accuracy and cost benefit on the basis of MSI testing for detecting MMR *** We retrospectively analyzed patients with CRC who underwent curative surgery between 2015 and 2017 at a tertiary referral *** IHC with four antibodies and MSI tests were routinely *** sensitivity and specificity of a fourand two types of two-antibody panels(PMS2/MSH6 and MLH1/MSH2)were compared on the basis of MSI testing for detecting MMR *** High-frequency MSI was found in 5.5%(n=193)of the patients(n=3486).The sensitivities of the four-and two types of two-antibody panels were 97.4%,92.2%,and 87.6%,*** specificities of the three types of panels did not differ significantly(99.6%for the four-antibody and PMS2/MSH6 panels,99.7%for the MLH1/MSH2 panel).Based on Cohen's kappa statistic(κ),four-and twoantibody panels were in almost perfect agreement with the MSI test(κ>0.9).The costs of the MSI test and the four-and two-antibody panels of IHC were approximately$200,$160,and$80,*** Considering the cost of the four-antibody panel IHC compared to that of the twoantibody panel IHC,a two-antibody panel of PMS2/MSH6 might be the best choice in terms of balancing cost-effectiveness and accuracy.

关键词： Adenocarcinoma DNA mismatch repair Immunochemistry Monoclonal antibody Microsatellite instability Cost-effectiveness

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Features of extrahepatic metastasis after radiofrequency ablation for hepatocellular carcinoma

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World Journal of Gastroenterology 2020年第32期26卷 4833-4845页

作者： Jae H Yoon young J Goo Chae-Jun lim Sung K Choi Sung B Cho Sang S Shin Chung H Jun Department of Gastroenterology Chonnam National University Hospital and Medical SchoolGwangju 61469South Korea Department of Gastroenterology Hwasun Chonnam National University Hospital and Medical SchoolHwasun 58128South Korea Department of Radiology Chonnam National University Hospital and Medical SchoolGwangju 61469South Korea Department of Internal Medicine Mokpo Hankook HospitalMokpo 58643South Korea

BACKGROUND Extrahepatic metastasis(EHM)of hepatocellular carcinoma(HCC)is associated with poor ***,the clinical features and risk factors of EHM of HCC after radiofrequency ablation(RFA)remain *** To elucidate the characteristics and risk factors of EHM after RFA for *** From January 2008 to December 2017,we retrospectively enrolled 661 patients who underwent RFA as first-line treatment for HCC at 2 tertiary *** inclusion criteria were age≥18 years,a diagnosis of HCC,and *** computed tomography(CT)or magnetic resonance imaging(MRI)and alpha-fetoprotein measurements were routinely performed at 1 mo after RFA and followed-up at intervals of 3-6 *** analyses were performed using the chi-squared test or Student’s t-test,and univariate and multivariate analyses were performed via logistic regression,as *** EHM was diagnosed in 44 patients(6.7%)during a median follow-up period of 1204 *** 10-year cumulative rate of HCC recurrence and EHM was 92.7%and 33.7%,*** recurrence was most often intrahepatic,and the rate of extrahepatic recurrence at initial recurrence was only 1.2%.The median time to the diagnosis of EHM was 2.68 years,and 68.2%of patients developed EHM within 2 years of the first recurrence,regardless of recurrence-free survival and 75.0%of patients developed EHM within 5 years after first *** was mostly diagnosed via abdominal CT/MRI in 33(75.0%)and 38 of 44 patients(86.4%)with EHM had either positive abdominal CT scan results or serum AFP level *** multivariate analysis,recurrence-free survival400 IU/mL were associated with a high EHM *** EHM occurs following multiple intrahepatic recurrences after RFA and combined contrast-enhanced abdominal CT and serum AFP were useful for *** especially with high-risk factors require close follow-up for

关键词： Hepatocellular carcinoma Metastasis Radiofrequency ablation Surveillance Risk factor

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Role of multidetector computed tomography in patients with acute infectious colitis

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World Journal of Clinical Cases 2022年第12期10卷 3686-3697页

作者： Seung Jung Yu Jae Hyuk Heo Eun Jeong Choi Jong Hyuk Kim Hong Sub Lee Sun young Kim Jae Hoon lim Department of Internal Medicine Inje University Busan Paik HospitalBusan 47392South Korea Department of Radiology Myongji HospitalHanyang University College of MedicineGoyang 10475South Korea Department of Cancer Control and Population Health National Cancer CenterGoyang 10408South Korea

BACKGROUND The role of multidetector computed tomography(MDCT)in patients with acute infectious colitis is still *** To examine the usefulness of MDCT in distinguishing the etiology of acute infectious *** Overall,244 patients who met the criteria for acute infectious colitis and visited the Hospital from February 2015 to 2018 were retrospectively enrolled and divided into two groups(bacterial:204,viral:40)according to causes of acute colitis,based on stool *** MDCT parameters,including wall thickening,submucosal edema,mucosal enhancement,serosa involvement,empty colon sign,small bowel involvement,comb sign,continuous distribution,accordion sign,mucosal thickening,and lymph node enlargement,were constructed in a blinded *** MDCT parameters of wall thickening(OR:13.60;95%CI:5.80–31.88;P<0.001),submucosal edema(OR:36.08;95%CI:13.54–96.13;P<0.001),mucosal enhancement(OR:22.55;95%CI:9.28–54.81;P<0.001),serosal involvement(OR:14.50;95%CI:3.33–63.23;P<0.001),empty colon sign(OR:6.68;95%CI: 2.44–18.32;P < 0.001), continuous distribution (OR: 24.09;95%CI: 9.38–61.90;P < 0.001), accordionsign (OR: 9.02;95%CI: 1.12–72.35;P = 0.038), mucosal thickening (OR: 46.41;95%CI: 10.38–207.51;P< 0.001), and lymph node enlargement (OR: 4.39;95%CI: 1.22–15.72;P = 0.023) were significantlyassociated with bacterial colitis. At least one positive finding in four CT outcomes (submucosaledema, mucosal enhancement, continuous distribution, mucosal thickening) in summer showed ahigh probability of bacterial colitis (sensitivity, 41.67;specificity, 92.50;OR: 24.95).CONCLUSIONMDCT provides many clues that can be useful in suggesting a specific etiology of acute infectiouscolitis.

关键词： Colitis Multidetector computed tomography Differential diagnosis Bacterial infections Viral infections

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Clinical course of subepithelial lesions detected on upper gastrointestinal endoscopy

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World Journal of Gastroenterology 2010年第4期16卷 439-444页

作者： Yeun Jung lim Hee Jung Son Jong-Soo Lee young Hye Byun Hyun Joo Suh Pool Lyul Rhee Jae J Kim Jong Chul Rhee Center for Health Promotion Department of MedicineSamsung Medical CenterSungkyunkwan University School of Medicine50Irwon-dongGangnam-guSeoul 135-710South Korea Division of Gastroenterology Department of MedicineSamsung Medical CenterSungkyunkwan University School of Medicine50Irwon-dongGangnam-guSeoul 135-710South Korea

AIM:To evaluate the natural history of subepithelial ***:We reviewed the medical records of 104 159 patients who underwent upper gastrointestinal endoscopy at the Center for Health Promotion of Samsung Medical Center between 1996 and *** lesions were detected in 795 patients(0.76%);252 patients were followed using upper gastrointestinal endoscopy for 82.5 ± 29.2 mo(range,12-160 mo;median,84 mo;1st quartile,60 mo;3rd quartile,105 mo).The median interval of follow-up endoscopy was 12 mo(range,6-105 mo;1st quartile,12 mo;3rd quartile,24 mo).RESULTS:The mean patient age was 53 years(range,22-80 years),and the male-to-female ratio was 2.36:1(177/75).The lesion size at initial measurement averaged 8.9 mm(range,2-25 mm;median,8 mm;1st quartile,5 mm;3rd quartile,10 mm).Of the 252 lesions,244(96.8%) were unchanged and 8(3.2%) were significantly increased in size(from 12.9 ± 6.0 to 21.2 ± 12.2 mm) after a mean interval of 59.1 ± 27.5 mo(range,12-86 mo).Surgical resection of lesions was performed when the lesions were ≥ 3 cm in *** lesions were diagnosed as gastrointestinal stromal tumors with an intermediate or high risk of malignancy and one lesion was classified as a ***:Most small subepithelial lesions do not change as shown by endoscopic examination,and regular follow-up with endoscopy may be considered in small,subepithelial lesions,especially lesions < 1 cm in size.

关键词： Subepithelial tumor Ultrasonography Gastrointestinal diseases Gastrointestinal endoscopy Time factors

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Discovery of highly immunogenic spleen-resident FCGR3^(+)CD103^(+)cDC1s differentiated by IL-33-primed ST2^(+)basophils

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Cellular & Molecular Immunology 2023年第7期20卷 820-834页

作者： Myeong-Ho Kang JungHyub Hong Jinjoo Lee Min-Suk Cha Sangho Lee Hye-young Kim Sang-Jun Ha Yong Taik lim Yong-Soo Bae Department of Biological Sciences Sungkyunkwan University2066 Seobu-roJangan-guSuwon-siGyeonggi-do 16419Republic of Korea Center for Immune Research on Non-Lymphoid Organs Sungkyunkwan University2066 Seobu-roJangan-guSuwon-siGyounggi-do 16419Republic of Korea Laboratory of Mucosal Immunology Department of Biomedical SciencesSeoul National University College of Medicine103 Daehak-roJongno-guSeoul 03080Republic of Korea Institute of Allergy and Clinical Immunology Seoul National University Medical Research CenterSeoulRepublic of Korea Department of Biochemistry College of Life Science and BiotechnologyYonsei UniversitySeoul 03722Republic of Korea Department of Nano Engineering and School of Chemical Engineering Sungkyunkwan University2066 Seobu-roJangan-guSuwon-siGyeonggi-do 16419Republic of Korea.

Recombinant interleukin-33(IL-33)inhibits tumor growth,but the detailed immunological mechanism is still ***-33-mediated tumor suppression did not occur in Batf3^(−/−)mice,indicating that conventional type 1 dendritic cells(cDC1s)play a key role in IL-33-mediated antitumor immunity.A population of CD103^(+)cDC1s,which were barely detectable in the spleens of normal mice,increased significantly in the spleens of IL-33-treated *** newly emerged splenic CD103^(+)cDC1s were distinct from conventional splenic cDC1s based on their spleen residency,robust effector T-cell priming ability,and surface expression of *** and DC precursors did not express Suppressor of Tumorigenicity 2(ST2).However,recombinant IL-33 induced spleen-resident FCGR3^(+)CD103^(+)cDC1s,which were found to be differentiated from DC precursors by bystander ST2+immune *** immune cell fractionation and depletion assays,we found that IL-33-primed ST2^(+)basophils play a crucial role in the development of FCGR3^(+)CD103^(+)cDC1s by secreting IL-33-driven extrinsic *** GM-CSF also induced the population of CD103^(+)cDC1s,but the population neither expressed FCGR3 nor induced any discernable antitumor *** population of FCGR3^(+)CD103^(+)cDC1s was also generated in vitro culture of Flt3L-mediated bone marrow-derived DCs(FL-BMDCs)when IL-33 was added in a pre-DC stage of ***-BMDCs generated in the presence of IL-33(FL-33-DCs)offered more potent tumor immunotherapy than control Flt3L-BMDCs(FL-DCs).Human monocyte-derived DCs were also more immunogenic when exposed to IL-33-induced *** findings suggest that recombinant IL-33 or an IL-33-mediated DC vaccine could be an attractive protocol for better tumor immunotherapy.

关键词： Recombinant interleukin-33(IL-33) Highly immunogenic Spleen residency FCGR3^(+)CD103^(+)cDC1s ST2^(+)basophils Antitumor immunity

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