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Performance of the EDACS-ADP incorporating high-sensitivity troponin assay:Do components of major adverse cardiac events matter?

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World Journal of Emergency Medicine 2024年第3期15卷 175-180页

作者： Yedalm Yoo Shin Ahn Bora chae Won young Kim Department of Emergency Medicine Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505Republic of Korea

BACKGROUND:the accelerated diagnostic protocol(ADP)using the Emergency Department Assessment of Chest pain Score(EDACS-ADP),a tool to identify patients at low risk of a major adverse cardiac event(MACE)among patients presenting with chest pain to the emergency department,was developed using a contemporary troponin *** study was performed to validate and compare the performance of the EDACS-ADP incorporating high-sensitivity cardiac troponin I between patients who had a 30-day MACE with and without unstable angina(MACE I and II,respectively).MEtHODS:A single-center prospective observational study of adult patients presenting with chest pain suggestive of acute coronary syndrome was *** performance of EDACS-ADP in predicting MACE was assessed by calculating the sensitivity and negative predictive ***:Of the 1,304 patients prospectively enrolled,399(30.6%;95%confidence interval[95%CI]:27.7%–33.8%)were considered low-risk using the *** them,the rates of MACE I and II were 1.3%(5/399)and 1.0%(4/399),*** EDACS-ADP showed sensitivities and negative predictive values of 98.8%(95%CI:97.2%–99.6%)and 98.7%(95%CI:97.0%–99.5%)for MACE I and 98.7%(95%CI:96.8%–99.7%)and 99.0%(95%CI:97.4%–99.6%)for MACE II,***:EDACS-ADP could help identify patients as safe for early ***,when unstable angina was added to the outcome,the 30-day MACE rate among the designated lowrisk patients remained above the level acceptable for early discharge without further evaluation.

关键词： Chest pain Major adverse cardiac event Acute coronary syndrome Emergency department

Survival benefit of concurrent chemoradiotherapy for advanced ampulla of Vater cancer

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World Journal of Clinical Cases 2024年第2期12卷 267-275页

作者： chae Hwa Kwon Hyung Il Seo Dong Uk Kim Sung Yong Han Suk Kim Nam Kyung Lee Seung Baek Hong Ji Hyun Ahn young Mok Park Byeong Gwan Noh BioMedical Research Institute Pusan National University HospitalBusan 49241South Korea Department of Surgery Pusan National University School of Medicine and Biomedical Research InstitutePusan National University HospitalBusan 49241South Korea Department of Internal Medicine Pusan National University School of Medicine and Biomedical Research InstitutePusan National University HospitalBusan 49241South Korea Department of Radiology Pusan National University School of Medicine and Biomedical Research InstitutePusan National University HospitalBusan 49241South Korea Department of Pathology and Biomedical Research Institute Pusan National University HospitalBusan 49241South Korea

BACKGROUND Currently,there is no standard adjuvant therapy for patients with resected ampulla of Vater(AoV)*** to evaluate the effectiveness of adjuvant concurrent chemoradiotherapy(CCRt)in patients with advanced AoV cancer who underwent curative *** this single-centered,retrospective study included 29 patients with advanced AoV cancer who underwent pancreaticoduodenectomy between 2006 and *** impact of CCRt on advanced AoV cancer was *** the 1-,3-,and 5-yr recurrence-free survival(RFS)rates for patients with advanced AoV cancer were 82.8%,48.3%,and 40.8%,respectively,and the overall survival(OS)rates were 89.7%,62.1%,and 51.7%,***-cular invasion was found to be a significant risk factor for RFS and OS in patients with advanced AoV cancer in the univariate analysis,whereas t stage and lymph node metastasis were significantly associated with OS in the multivariate *** to the patients who did not receive adjuvant CCRt,those who received adjuvant CCRt did not show statistically significant improvements in the RFS and OS,although they had a significantly lower average age and significantly higher platelet-to-lymphocyte *** Adjuvant CCRt did not improve survival outcomes in patients with advanced AoV *** findings contribute to existing knowledge on the effectiveness of CCRt in this patient population and provide important insights for clinical decision-making.

关键词： Advanced ampulla of Vater cancer Adjuvant concurrent chemoradiotherapy Recurrence Survival Vater cancer

Computed tomography coronary angiography after excluding myocardial infarction:high-sensitivity troponin versus risk score-guided approach

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World Journal of Emergency Medicine 2023年第6期14卷 428-433页

作者： Won Jae Yoo Shin Ahn Bora chae Won young Kim Department of Emergency Medicine Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505Republicof Korea

BACKGROUND:Patients with suspected acute coronary syndrome (ACS) in whom myocardial infarction has been ruled out are still at risk of having obstructive coronary artery disease (CAD).this rate is higher among patients with intermediate high-sensitivity troponin I (hstnI) concentrations (5 ng/L to 99th percentile) than low concentrations (therefore,an intermediate concentration has been suggested as a candidate for downstream investigation with computed tomography coronary angiography(CtCA).We tried to compare the HEARt score-guided ***-guided approach for identifying obstructive ***:From a prospective cohort study of patients presenting to the emergency department with suspected ACS,433 patients without elevated hstnI who also underwent CtCA were selected and *** performances of hstnI concentration and HEARt score were compared using sensitivity,specificity,positive predictive value (PPV),and negative predictive value (NPV).RESULtS:Overall,120 (27.7%) patients had obstructive *** with intermediate hstnI concentrations were more likely to have obstructive CAD than those with low hstnI concentrations(40.0%vs.18.1%);patients with non-low-risk HEARt scores (≥4 points) were also more likely to have obstructive CAD than those with low-risk scores (0 to 3 points)(41.0%vs.7.6%).the HEARt score had higher sensitivity and NPV for detecting obstructive CAD in each classification than hstnI concentration (sensitivity:89.2%vs.63.3%;NPV:92.4%vs.81.9%,respectively).CONCLUSION:After excluding myocardial infarction in patients with suspected ACS,adding the HEARt score for selecting candidates for CtCA could improve patient risk stratification more accurately than relying on hstnI concentration.

关键词： Chest pain Coronary artery disease Acute coronary syndrome troponin HEARt score

Effects of acupuncture stimulation on brain activation induced by cue-elicited alcohol craving

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Neural Regeneration Research 2022年第5期17卷 1059-1064页

作者： Hyeok Gyu Kwon Seong Hun Choi Joon Ho Seo chae Ha Yang Mi young Lee Department of Physical therapy College of Health ScienceEulji UniversityGyeonggiRepublic of Korea Department of Anatomy and Histology College of Oriental MedicineDaegu Haany UniversityGyeongsanRepublic of Korea Department of Rehabilitation Gyeongbuk Regional Rehabilitation HospitalGyeongsanRepublic of Korea Department of Physiology College of Korean MedicineDaegu Haany UniversityDaeguRepublic of Korea Department of Physical therapy College of Biomedical ScienceDaegu Haany UniversityGyeongsanRepublic of Korea

Acupuncture has been shown to be effective on alcohol use ***,the underlying mechanism remains poorly *** investigate the effects of Shenmen(Ht7)acupoint on brain activation induced by cue-elicited alcohol craving,30 right-handed healthy light to moderate alcohol drinkers were recruited from the *** were randomly assigned to undergo acupuncture either at Ht7(experimental acupoint,n=15)or Jingqu(LU8,control acupoint,n=15)*** randomized controlled study was performed in Daegu Haany University and Daegu-Gyeongbuk Medical Innovation Foundation,Republic of *** and data collection were conducted from December 2018 to May *** results showed that after acupuncture at Ht7 acupoint,the activation of orbitofrontal cortex and dorsolateral prefrontal cortex was greatly increased,while the activation of dorsolateral prefrontal cortex was obviously reduced,and subject's craving for alcohol was reduced when he/she seeing alcohol-related video clips involving various alcohols(beer,wine,or soju)or drinking *** at Ht7 more greatly reduced subject's alcohol cravings than acupuncture at LU8 *** findings suggest that acupuncture can improve the self-control of mild to moderate social drinkers through the activation of the orbitofrontal cortex and dorsolateral prefrontal cortex,thereby reducing the craving for *** study protocol was approved by the Institutional Review Board of Daegu Haany University Korean Medicine Hospital,Republic of Korea(approval ***-D-18026-PRO-02)on November 30,2018.

关键词： acupuncture addiction alcohol brain activation craving cue functional MRI Shenmen(Ht7)acupoint

Highly impermeable and flexible silica encapsulation films synthesized by sol-gel process

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Nano Research 2022年第8期15卷 7476-7483页

作者： Si-Hoon Kim Gyeong-Seok Hwang Donghwan Koo Dong-Hyun Seo Ye-Pil Kwon Hansuek Lee Hyesung Park Eun-chae Jeon Ju-young Kim School of Materials Science and Engineering University of UlsanTechno saneop-ro 55beon-gil 12Ulsan 44776Republic of Korea Department of Materials Science and Engineering Ulsan National Institute of Science and Technology(UNIST)UNIST-gil 50Ulsan 44919Republic of Korea Department of Physics Korea Advanced Institute of Science and Technology(KAIST)Daehak-ro 291Deajeon 34141Republic of Korea Graduate School of Semiconductor Materials and Devices Ulsan National Institute of Science and Technology(UNIST)UNIST-gil 50Ulsan 44919Republic of Korea

Silica thin films synthesized sol–gel process are proposed as flexible encapsulation materials.A sol–gel process provides a dense and stable amorphous silica structure,yielding an extremely high elastic deformation limit of 4.9%and extremely low water vapor transmission rate(WVtR)of 2.90×10^(−4)g/(m^(2)∙day)at 60℃and relative humidity of 85%.the WVtR is not degraded by cyclic bending deformations for the bending radius corresponding to a tensile strain of 3.3%in the silica encapsulation film,implying that the silica thin film is robust against the formation of pinhole-type defects by cyclic bending *** organic solar cells encapsulated with the silica films operate without degradation in power conversion efficiency for 50,000 bending cycles for a bending radius of 6 mm.

关键词： silica thin film sol-gel flexible encapsulation mechanical reliability flexible organic solar cell

Application of extracellular vesicles from mesenchymal stem cells promotes hair growth by regulating human dermal cells and follicles

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World Journal of Stem Cells 2022年第7期14卷 527-538页

作者： Ramya Lakshmi Rajendran Prakash Gangadaran Mi Hee Kwack Ji Min Oh chae Moon Hong young KwanSung Jaetae Lee Byeong-Cheol Ahn Department of Nuclear Medicine School of MedicineKyungpook National UniversityDaegu 41944South Korea BK21 FOUR KNU Convergence Educational Program of Biomedical Sciences for Creative Future talents Department of Biomedical SciencesSchool of MedicineKyungpook National UniversityDaegu 41944South Korea Department of Immunology School of MedicineKyungpook National UniversityDaegu 41944South Korea Department of Nuclear Medicine Kyungpook National University HospitalDaegu 41944South Korea

BACKGROUND Dermal papillae(DP)and outer root sheath(ORS)cells play important roles in hair growth and regeneration by regulating the activity of hair follicle(HF)*** to investigate the effects of human mesenchymal stem cell-derived extracellular vesicles(hMSC-EVs)on DP and ORS cells as well as *** are known to regulate various cellular ***,the effects of hMSC-EVs on hair growth,particularly on human-derived HF cells(DP and ORS cells),and the possible mechanisms underlying these effects are *** hMSC-EVs were isolated and characterized using transmission electron microscopy,nanoparticle tracking analysis,western blotting,and flow *** activation of DP and ORS cells was analyzed using cellular proliferation,migration,western blotting,and real-time polymerase chain *** growth was evaluated ex vivo using human *** Wnt3a is present in a class of hMSC-EVs and associated with the EV ***-EVs promote the proliferation of DP and ORS ***,they translocateβ-catenin into the nucleus of DP cells by increasing the expression ofβ-catenin target transcription factors(Axin2,EP2 and LEF1)in DP *** with hMSC-EVs also promoted the migration of ORS cells and enhanced the expression of keratin(K)differentiation markers(K6,K16,K17,and K75)in ORS ***,treatment with hMSC-EVs increases hair shaft elongation in cultured human *** these findings suggest that hMSC-EVs are potential candidates for further preclinical and clinical studies on hair loss treatment.

关键词： Mesenchymal stem cells Extracellular vesicles Hair growth Dermal papillae Outer root sheath cells

Online Approach for Spatio-temporal trajectory Data Reduction for Portable Devices

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Journal of Computer Science & technology 2013年第4期28卷 597-604页

作者： Heemin Park young-Jun Lee Jinseok chae Wonik Choi Department of Computer Software Engineering Sangmyung University Department of Computer Science and Engineering Incheon National University School of Information and Communication Engineering Inha University

As location data are widely available to portable devices, trajectory tracking of moving objects has become an essential technology for most location-based services. to maintain such streaming data of location updates from mobile clients, conventional approaches such as time-based regular location updating and distance-based location updating have been used. However, these methods suffer from the large amount of data, redundant location updates, and large trajectory estimation errors due to the varying speed of moving objects. In this paper, we propose a simple but efficient online trajectory data reduction method for portable devices. to solve the problems of redundancy and large estimation errors, the proposed algorithm computes trajectory errors and finds a recent location update that should be sent to the server to satisfy the user requirements. We evaluate the proposed algorithm with real GPS trajectory data consisting of 17 201 trajectories. the intensive simulation results prove that the proposed algorithm always meets the given user requirements and exhibits a data reduction ratio of greater than 87% when the acceptable trajectory error is greater than or equal to 10 meters.

关键词： online trajectory sampling moving object tracking data reduction location-based service

Sliding Wear Behavior of Plasma Sprayed Zirconia Coating on Cast Aluminum against Silicon Carbide Ceramic

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Journal of Materials Science & technology 2005年第5期21卷 666-670页

作者： thuong-Hien LE young-Hun chae Seock-Sam KIM School of Mechanical Engineering Graduate School Kyungpook National University Daegu 702-701 KoreaEngineering Tribology Research Institute Kyungpook National University Daegu 702-701 KoreaSchool of Mechanical Engineering Kyungpook National University Daegu 702-701 Korea

the sliding wear behaviors of ZrO2-22 wt pct MgO （MZ） and ZrO2-8 wt pct Y2O3（YZ） coatings deposited on a cast aluminum alloy with bond layer （NiCrCoAlY） by plasma spray were investigated under dry test conditions at room temperature. Under all load conditions, the wear mechanisms of the MZ and YZ coatings were almost the same. the material transfer and pullout were involved in the wear process of the studied coatings under the test conditions. the wear rate of the MZ coating was less than that of the YZ coating. While increasing the normal load, the wear rates of the MZ and YZ coatings increased. SEM was used to examine the worn surfaces and to elucidate likely wear mechanisms. Energy dispersive X-ray spectroscopy （EDX） analysis of the worn surfaces indicated that material transfer occurred in the direction from the SiC ball to the disk. Fracture toughness had a significant influence on the wear performance of the coatings. It was suggested that the material transfer played an important role in the wear behavior.

关键词： Plasma spray Zirconia coating Wear mechanism Fracture toughness

Interaction of Streamwise and Wall-Normal Velocities in Combined Wave-Current Motion

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China Ocean Engineering 2005年第4期19卷 557-570页

作者： In-Soo KIM Daniel S.KOH young-chae SONG Division of Construction and Environmental Engineering College of EngineeringKorea Maritime University Busan606791Korea

the aim of this paper is to present an analytical expression for the streamwise velocity distribution in a non-uniform flow in the presence of waves; the correlation between the horizontal and vertical velocity components has been compreheusively examined. Different from previous researches which attributed the deviation of velocity from the classical log-law to the wave Reynolds stress, i.e. - ρ uv^- only, this study demonstrates that the momentum flux caused by mean velocities, i.e., u^- and v^-, is also responsible for the velocity deviation, and it is found that the streamwise velocity for a flow in the presence of non-zero wall-normal velocity does not follow the classical log-law, but the modified log-law proposed in this study based on simplified mixing-length theorem. the validity of the modified log-law has been verified by use of available experimental data from published sources for combined wave-current flows, and good agreement between the predicted and observed velocity profiles has been achieved.

关键词： streamwise velocity distribution wave-current flow Reynolds shear stress non-zero wall-normal velocity