检索结果-南通市图书馆

In vitro fungistatic activity of 36 traditional oriental medicines and their synergistic effect against Trichophyton rubrume

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Medicine 2018年第2期11卷 109-115页

作者： young soo Kim Jin Yeul Ma Korean Medicine Application Center Korea Institute of Oriental Medicine

Objective: To investigate the fungistatic activity and synergistic effects of natural products and their constituents, including traditional oriental medicines(TOMs).Methods: Fungistatic activities of TOMs prepared by hot-water(115 ℃) or ethanol(70%; 40 ℃) extraction were determined by their minimum inhibitory *** assess possible synergistic effects, minimum inhibitory concentrations of various combinations were ***: By evaluating antifungal susceptibility of Trichophyton rubrum, which is a major causative fungus for several types of dermatophytosis, we confirmed that ethanol extracts were more active than hot-water extracts in 25 of the 36 TOMs, suggesting that the constituents with high hydrophobicity tend to contribute significantly to fungistatic *** selected four TOMs with high fungistatic activity, including Aucklandiae radix, Gentianae macrophyllae radix, Scutellariae radix, and Galla rhois, and their synergistic effects were investigated through the combination studies between TOMs or TOM-conventional drug *** combinations between four TOMs, partial synergistic effects were observed in Aucklandiae radix–Galla rhois and Gentianae macrophyllae radix–Galla rhois combinations, as supported by the lowest fractional inhibitory concentration index value of 0.66 for both ***, Galla rhois showed the strongest synergistic effect on growth inhibition of Trichophyton rubrumwith a fractional inhibitory concentration index value of 0.50 in combination with ***: Our findings indicate that the combination of TOMs and TOM-terbinafine may be effective on treatment for chronic and recurrent dermatophytosis by improving fungistatic activity and led to decrease systemic toxicity in clinical practice.

关键词： Fungistatic activity Hot-water and ethanol extracts Traditional oriental medicine Tinea Trichophyton rubrum Synergistic effect

Kale Juice Improves Coronary Artery Disease Risk Factors in Hypercholesterolemic Men

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2008年第2期21卷 91-97页

作者： soo YEON KIM SUN yoon soo MI KWON KYE sooK PARK YANG CHA LEE-KIM Graduate School of Human Environmental Science Department of Food and Nutrition College of Human Ecology Yonsei Health Center Yonsei University 134 Shinchon-dong Sudaemun-ku 120-749 Seoul Korea

Objective To evaluate the effect of 3-month kale （Brassica oleracea acephala） juice supplementation on coronary artery disease risk factors among hypercholesterolemic men. Methods Thirty-two men with hypercholesterolemia （〉 200 mg/dL） were recruited after annual health examinations among the faculty and staff at university. The subjects consumed 150 mL of kale juice per day for a 12-week intervention period. Dietary and anthropometric assessments were performed and blood samples were collected to evaluate biochemical profiles before and after supplementation. Results Serum concentrations of HDL-cholesterol, and HDL- to LDL-cholesterol ratio were significantly increased by 27% （P〈0.0001） and 52% （P〈0.0001）, respectively. The LDL-cholesterol concentration and the atherogenic index were significantly reduced by 10% （P=0.0007） and 24.2% （P〈0.0001）, respectively without affecting body mass index, waist and hip circumferences, or nutrient intakes after three months of supplementation. While there was no difference in the concentration of malondialdehyde, significant increase in glutathione peroxidase activity （P=0.0005） were accompanied by a significant increase in the serum selenium level （P=0.0132）. It was also found that the responses of these risk factors to kale juice administration were dependent on smoking status. Conclusion Regular meals supplementation with kale juice can favorably influence serum lipid profiles and antioxidant systems, and hence contribute to reduce the risks of coronary artery disease in male subjects with hyperlipidemia.

关键词： Kale juice Hyperlipidemia Coronary artery disease Lipid profile Antioxidant system

Detection of Graphene Cracks By Electromagnetic Induction,Insensitive to Doping Level

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Computer Modeling in Engineering & Sciences 2019年第8期120卷 351-361页

作者： Taeshik yoon Sumin Kang Tae Yeob Kang Taek-soo Kim Department of Mechanical Engineering KAISTDaejeon 34141Korea Graphene Research Center KAISTDaejeon 34141Korea

Detection of cracks is a great concern in production and operation processes of graphene based devices to ensure uniform ***,we show a detection method for graphene cracks by electromagnetic *** time varying magnetic field leads to induced voltage signals on graphene,and the signals are detected by a *** measured level of induced voltage is correlated with the number of cracks in graphene *** correlation is attributed to the increasing inductive characteristic of defective graphene,and it is verified by electromagnetic simulation and radio frequency ***,we demonstrate that the induced voltage signal is insensitive to the doping level of *** work can potentially lead to the development of a high-throughput and reliable crack inspection technique for mass production of graphene applications.

关键词： Graphene,crack detection inductance electromagnetic induction insensitive to doping

Efficacy of 14-d vs 7-d moxifloxacin-based triple regimens for second-line Helicobacter pylori eradication

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2015年第18期21卷 5568-5574页

作者： Jae Jin Hwang Dong Ho Lee Ae-Ra Lee Hyuk yoon Cheol Min Shin young soo Park Nayoung Kim Department of Internal Medicine Seoul National University Bundang Hospital Gyeonggi-do 463-707 South Korea

AIM: To evaluate the efficacy of the 14-d moxifloxacinbased triple therapy for the second-line eradication of Helicobacter pylori(H. pylori) ***: Between 2011 and 2013, we conducted a retrospective review of the medical records of 160 patients who had experienced failure of their first-line proton pump inhibitor-based eradication therapy and subsequently received the moxifloxacin-based triple therapy as a second-line eradication treatment regimen. The patients who were treated with the moxifloxacinbased triple therapy(oral 20 mg rabeprazole b.i.d., 1000 mg amoxicillin b.i.d., and 400 mg moxifloxacin q.d.) for 7 d were assigned to the RAM-7 group(n = 79) while those who took them for 14 days were assigned to RAM-14 group(n = 81). The eradication rates for both groups were determined by intentionto-treat(ITT) and per-protocol(PP) analyses. ITT analysis compared the treatment groups as originally allocated while the PP analysis including only those patients who had completed the treatment as originally allocated. Successful eradication therapy for H. pylori infection was defined as the documentation of a negative 13C-urea breath test 4 wk after the end of the eradication ***: The overall ITT eradication rate was 76.2%(122/160). The final ITT eradication rates were 70.8%(56/79; 95%CI: 63.3%-77.1%) in the RAM-7 group and 81.4%(66/81; 95%CI: 74.6%-88.3%) in the RAM-14 group(P = 0.034). The overall PP eradication rate was 84.1%(122/145), and the final PP eradication rates were 77.7%(56/72; 95%CI: 70.2%-85.3%) in the RAM-7 group and 90.4%(66/73; 95%CI: 82.8%-98.1%) in the RAM-14 group(P = 0.017). The H. pylori-eradication rates in the RAM-14 group were significantly higher compared with that of the RAM-7 group according to both the ITT(P = 0.034) and the PP analyses(P = 0.017). Both groups exhibited good treatment compliance(RAM-7/RAM-14 group: 100%/100%). The adverse event rates were19.4%(14/72)and 20.5%(15/73)in the RAM-7 and RAM-14 groups,resp

关键词： Helicobacter pylori Treatment failure Second-line treatment Moxifloxacin Eradication rate

Predictors of poor outcomes in patients with wild mushroom-induced acute liver injury

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2017年第7期23卷 1262-1267页

作者： Taerim Kim Danbi Lee Jae Ho Lee yoon-Seon Lee Bum Jin Oh Kyoung soo Lim Won young Kim Department of Emergency Medicine University of Ulsan College of MedicineAsan Medical Center Department of Gastroenterology Asan Medical CenterUniversity of Ulsan College of Medicine

To identify early predictive markers of poor outcomes in patients with acute liver injury from wild mushroom *** observational, retrospective record review involved adults aged ≥ 18 years admitted to emergency department with mushroom intoxication from January 2005 to December 2015. The diagnosis of mushroom intoxication was based on the following: (1) a positive history of recent wild mushroom intake (either raw or cooked); (2) the onset of gastrointestinal symptoms, such as watery diarrhea, vomiting, and/or abdominal pain, after ingestion; and (3) the exclusion of other possible causes of acute liver injury. Acute liver injury was defined by a > 5-fold elevation of liver enzymes or moderate coagulopathy [international normalized ratio (INR) > 2.0]. Clinical and laboratory findings were compared in survivors and *** 93 patients with mushroom intoxication, 23, 11 men (47.8%) and 12 women (52.2%), of median age 61 years, developed acute liver injury. The overall in-hospital mortality rate was 43.5% (10/23). Among the laboratory variables, mean serum alkaline phosphatase (73.38 ± 10.89 mg/dL vs 180.40 ± 65.39 mg/dL, P 5 mg/dL or aPTT > 50 s on day 3 *** of bilirubin concentrations and aPTT may help in predicting clin

关键词： Mushroom Liver Outcome Intoxication Bilirubin

Efficacy of moxifloxacin-based sequential therapy for first-line eradication of Helicobacter pylori infection in gastrointestinal disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2015年第16期21卷 5032-5038页

作者： Jae Jin Hwang Dong Ho Lee Ae-Ra Lee Hyuk yoon Cheol Min Shin young soo Park Nayoung Kim Department of Internal Medicine Seoul National University Bundang Hospital

AIM:To evaluate the efficacy of 14-d moxifloxacinbased sequential therapy as first-line eradication treatment of Helicobacter pylori(***) ***:From December 2013 to August 2014, 161 patients with confirmed *** infection randomly received 14 d of moxifloxacin-based sequential group(MOX-ST group, n = 80) or clarithromycin-based sequential group(CLA-ST group, n = 81) *** infection was defined on the basis of at least one of the following three tests:a positive 13C-urea breath test; histologic evidence of *** by modified Giemsa staining; or a positive rapid urease test(CLOtest; Delta West, Bentley, Australia) by gastric mucosal *** eradication therapy for *** infection was defined as a negative 13C-urea breath test four weeks after the end of eradication *** was defined as good when drug intake was at least 85%.*** eradication rates, patient compliance with drug treatment, adverse event rates, and factors influencing the efficacy of eradication therapy were ***:The eradication rates by intention-to-treat analysis were 91.3%(73/80;95%CI:86.2%-95.4%)in the MOX-ST group and 71.6%(58/81;95%CI:65.8%-77.4%)in the CLA-ST group(P=0.014).The eradication rates by per-protocol analysis were 93.6%(73/78;95%CI:89.1%-98.1%)in the MOX-ST group and 75.3%(58/77;95%CI:69.4%-81.8%)in the CLAST group(P=0.022).Compliance was 100%in both *** adverse event rates were 12.8%(10/78)and 24.6%(19/77)in the MOX-ST and CLA-ST group,respectively(P=0.038).Most of the adverse events were mild-to-moderate in intensity;there was none serious enough to cause discontinuation of treatmentin either *** multivariate analysis,advanced age(≥60 years)was a significant independent factor related to the eradication failure in the CLA-ST group(adjusted OR=2.13,95%CI:1.97-2.29,P=0.004),whereas there was no significance in the MOX-ST ***:The 14-d moxifloxacin-based sequential therapy is effective.M

关键词： Helicobacter pylori First-line eradicationtreatment Moxifloxacin Sequential therapy Eradicationrate

Efficacy of moxifloxacin-based sequential and hybrid therapy for first-line Helicobacter pylori eradication

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2015年第35期21卷 10234-10241页

作者： Jae Jin Hwang Dong Ho Lee Ae-Ra Lee Hyuk yoon Cheol Min Shin young soo Park Nayoung Kim Department of Internal Medicine Seoul National University Bundang Hospital

AIM: To evaluate the efficacy of moxifloxacin-based sequential therapy(MBST) versus hybrid therapy as a first-line treatment for Helicobacter pylori(H. pylori) ***: From August 2014 to January 2015, 284 patients with confirmed H. pylori infection were randomized to receive a 14-d course of MBST(MBST group, n = 140) or hybrid(Hybrid group, n = 144) therapy. The MBST group received 20 mg rabeprazole and 1 g amoxicillin twice daily for 7 d, followed by 20 mg rabeprazole and 500 mg metronidazole twice daily, and 400 mg moxifloxacin once daily for 7 d. The Hybrid group received 20 mg rabeprazole and 1 g amoxicillin twice daily for 14 d. In addition, the Hybrid group received 500 mg metronidazole and 500 mg clarithromycin twice daily for the final 7 d. Successful eradication of H. pylori infection was defined as a negative 13C-urea breath test 4 wk after the end of treatment. Patient compliance was defined as "good" if drug intake was at least 85%. H. pylori eradication rates, patient compliance with treatment, and adverse event rates were ***: The eradication rates in the intention-totreat(ITT) analysis were 91.4%(128/140; 95%CI: 90.2%-92.9%) in the MBST group and 79.2%(114/144; 95%CI: 77.3%-80.7%) in the Hybrid group(P = 0.013). The eradication rates in the perprotocol(PP) analysis were 94.1%(128/136; 95%CI: 92.9%-95.6%) in the MBST group and 82.6%(114/138; 95%CI: 80.6%-84.1%) in the Hybrid group(P = 0.003). The H. pylori eradication rate in the MBST group was significantly higher than that of the Hybrid group for both the ITT(P = 0.013) and the PP analyses(P = 0.003). Both groups exhibited full compliance with treatment(MBST/Hybrid group: 100%/100%). The rate of adverse events was 11.8%(16/136) and 19.6%(27/138) in the MBST and Hybrid group, respectively(P = 0.019). The majority of adverse events were mild-to-moderate in intensity; none were severe enough to cause discontinuation of treatment in either ***: MBST was more effecti

关键词： Helicobacter pylori First-line treatment eradicati

Fourteen- vs seven-day bismuth-based quadruple therapy for second-line Helicobacter pylori eradication

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2015年第26期21卷 8132-8139页

作者： Jae Jin Hwang Dong Ho Lee Ae-Ra Lee Hyuk yoon Cheol Min Shin young soo Park Nayoung Kim Department of Internal Medicine Seoul National University Bundang Hospital

AIM: To compare the efficacy of 14- and 7-d bismuthbased quadruple therapies as second-line eradication treatment for Helicobacter pylori(***) ***: Between 2004 and 2014,the medical records of 790 patients who had experienced failure of first-line proton pump inhibitor(PPI)-based eradication therapy and were then treated with bismuth-based quadruple therapy were retrospectively *** who received bismuth-based quadruple therapy [PPI,bismuth,metronidazole,and tetracycline(PBMT)] for either 7 d or 14 d were assigned to a PBMT-7 group(n = 543) or a PBMT-14 group(n = 247),*** eradication rates for both groups were determined by intention-to-treat(ITT) and per-protocol(PP) *** analysis compared the treatment groups as originally allocated while the PP analysis including only those patients who had completed the treatment as originally *** eradication therapy for *** infection was defined as a negative 13C-urea breath test 4 wk after the end of eradication ***: The overall ITT eradication rate was 69.1%(546/790).Final ITT eradication rates were 67.4%(366/543; 95%CI: 63.1%-71.7%) in the PBMT-7 group and 72.8%(180/247; 95%CI: 67.4%-78.2%) in the PBMT-14 group(P = 0.028).The overall PP eradication rate was 80.0%(546/682),and the final PP eradication rates were 78.2%(366/468; 95%CI: 72.1%-84.0%) in the PBMT-7 group and 84.1%(180/214; 95%CI: 76.8%-90.8%) in the PBMT-14 group(P = 0.009).The *** eradication rates in the PBMT-14 group weresignificantly higher than in the PBMT-7 group according to both ITT(P = 0.028) and PP analysis(P = 0.009).Compliance was similar in both groups(PBMT-7 group: 97.9%; PBMT-14 group: 96.4%).Adverse event rates were 10.7%(51/478) and 17.1%(38/222) in the PBMT-7 and PBMT-14 groups,respectively(P = 0.487).CONCLUSION: The 14-d bismuth-based quadruple therapy is a significantly more effective second-line eradication treatment for *** infection than the 7-d al

关键词： Helicobacter pylori Treatment failure Second-line treatment Bismuth Eradication rate

Characteristics of gastric cancer in peptic ulcer patients with Helicobacter pylori infection

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2015年第16期21卷 4954-4960页

作者： Jae Jin Hwang Dong Ho Lee Ae-Ra Lee Hyuk yoon Cheol Min Shin young soo Park Nayoung Kim Department of Internal Medicine Seoul National University Bundang Hospital

AIM:To evaluate the incidence and clinical characteristics of gastric cancer(GC) in peptic ulcer patients with Helicobacter pylori(***) ***:Between January 2003 and December 2013, the medical records of patients diagnosed with GC were retrospectively *** with previous gastric ulcer(GU) and *** infection were assigned to the Hp GU-GC group(n = 86) and those with previous duodenal ulcer(DU) disease and *** infection were assigned to the Hp DUGC group(n = 35).The incidence rates of GC in the Hp GU-GC and Hp DU-GC groups were *** on demographics(age, gender, peptic ulcer complications and cancer treatment), GC clinical characteristics [location, pathological diagnosis, differentiation, T stage, Lauren's classification, atrophy of surrounding mucosa and intestinal metaplasia(IM)], outcome of eradication therapy for *** infection, esophagogastroduodenoscopy number and the duration until GC onset were *** and multivariate analyses were performed to identify factors influencing GC *** relative risk of GC was evaluated using a Cox proportional hazards ***:The incidence rates of GC were 3.60%(86/2387) in the Hp GU-GC group and 1.66%(35/2098) in the Hp DU-GC *** annual incidence was 0.41% in the Hp GU-GC group and 0.11% in the Hp DUGC *** rates of moderate-to-severe atrophy of the surrounding mucosa and IM were higher in the Hp GU-GC group than in the Hp DU-GC group(86% vs 34.3%, respectively, and 61.6% vs 14.3%, respectively, P < 0.05).In the univariate analysis, atrophy of surrounding mucosa, IM and eradication therapy for *** infection were significantly associated with the development of GC(P < 0.05).There was no significant difference in the prognosis of GC patients between the Hp GU-GC and Hp DU-GC groups(P = 0.347).The relative risk of GC development in the Hp GUGC group compared to that of the Hp DU-GC group,after correction for age and gender,was 1.71(95%CI:1.

关键词： Gastric cancer Gastric ulcer Duodenalulcer Helicobacter pylori Eradication therapy