检索结果-南通市图书馆

Evaluation of Daily Tumor Motion by Measuring Fiducial Length on CBCT Images in Pancreatic Stereotactic Body Radiation Therapy

引用

International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2019年第2期8卷 68-79页

作者： Si young jang Min-Sig Hwang Ron Lalonde Dwight E. Heron M. Saiful Huq Department of Radiation Oncology UPMC Hillman Cancer Center University of Pittsburgh School of Medicine Pittsburgh PA USA

We investigated the feasibility of measuring daily fiducial length on cone-beam computed tomography (CBCT) images to assess the variation in daily tumor motion for pancreatic SBRT. Motion data for fifty pancreatic SBRT patients with fiducials were analyzed retrospectively to determine the tumor motion statistics. We also performed a phantom study which involved motion analysis of three gold fiducials placed around a solid target inside the Quasar Phantom as a function of variable tumor motion and breathing period. The end-exhalation CT-50 images were compared with the CBCT images acquired prior to treatment delivery on a TrueBeam STx linear accelerator. Sinusoidal tumor motion and patients’ breathing files acquired from a Varian-RPM system were used to simulate patients’ breathing patterns. The fiducial length was measured to determine its correlation with tumor motion. Patient tumor motions along the superior-inferior (SI), anterior-posterior (AP), and left-right (LR) directions were found to be 0.7 ± 0.4 cm, 0.2 ± 0.3 cm, and 0.1 ± 0.2 cm, respectively. Average breathing period was 4.3 ± 0.8 seconds. For sinusoidal and patients’ breathing patterns, a significant correlation was observed between the fiducial length and tumor motions with R2 of 0.99. However, fiducial length was found to be independent of the variation in breathing periods. This work suggests that measuring the fiducial length on daily CBCT images could provide quantitative daily tumor motion for fiducial-based pancreatic SBRT. A timely decision to modify the motion management strategy could be made prior to daily treatment delivery.

关键词： Pancreas SBRT Fiducial Tumor Motion Inter-Fractional Tumor Motion

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Clinical study of The influence of hysterectomy on LBP investigated through Oriental Medicine theory

引用

世界中医骨科杂志 2007年第1期9卷 12-14页

作者： Kang In Song Joo-hyun Moon Ja-young Lim Myung-jang Cho Jae-hee Lee Hyo-eun Department of Acupuncture ＆ Moxibustion Jaseng Hospital of Oriental Medicine

Objectives: The purpose of this study is to investigate the influence of hysterectomy on LBP and to describe it through Oriental Medicine ***: Research was conducted by history taking of 1849 female LBP patients who visited Jaseng Oriental Medicine *** was focused on the number of patients who underwent hysterectomy, and the length of time developing LBP after the ***; 178 patients (9.6%) underwent hysterectomy among 1849 patients, and it was higher than general rate of *** Oriental medicine, this result can be explained that it is caused by the lack of water function of spleen(肾水) from the absence of uterus, consequently it makes muscle weak and does harm to Blood, meridian Conclusions: History of hysterectomy has a significant influence on the development of LBP.

关键词：子宫切除术中医理论影响因素临床医学低位背部疼痛

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pressure-responsive pH-triggered layer-by-layer coating of paclitaxel-eluting balloon catheters for instant high-dose drug delivery for percutaneous coronary artery intervention

引用

Nano Research 2024年第10期17卷 9141-9151页

作者： Jeong Yu Lee Shonit Nair Sharma Sung-Yu Hong young-Guk Ko Yangsoo jang Minjae Do Michael Christopher Stark Qiwen Peng Benjamin Allen Mossburg Bo Chan Seo Yuhan Lee Department of Materials Science and Engineering Korea Advanced Institute of Science and TechnologyDaejeon 305-701Republic of Korea Department of Anesthesiology Perioperativeand Pain MedicineCenter for Accelerated Medical Innovation&Center for NanomedicineBrigham and Women’s HospitalHarvard Medical SchoolBostonMA 02115USA Department of Biological Engineering Massachusetts Institute of TechnologyCambridgeMA 02139USA Cardiovascular Product Evaluation Center Yonsei University College of MedicineSeoul 120-752Republic of Korea Division of Cardiology Department of Internal MedicineSeverance Cardiovascular HospitalYonsei University College of MedicineSeoul 120-752Republic of Korea

Cardiovascular diseases remain the leading cause of mortality worldwide,with percutaneous coronary interventions(PCI)using drug-eluting stents(DES)as the standard treatment for coronary artery *** advancements in DES technology,challenges such as restenosis and stent thrombosis still necessitate further interventions and carry considerable risks,highlighting an urgent need for a novel therapeutic approach with lower restenosis rates and reduced reintervention *** balloons(DEBs)coated with anti-proliferative agents offer a novel method of local drug delivery for reducing restenosis by directly administering drugs to the lesion ***,efficient delivery of drugs within the brief procedural window while minimizing drug loss during maneuvering to the target site remains a ***,we developed a pressure-responsive and pH-triggered,paclitaxel(PTX)coated DEB catheter for rapid and high-dose delivery of paclitaxel to the lesion sites,overcoming the limitations of drug dispersion and inefficiencies associated with conventional *** the charge reversion of albumin around its isoelectric point,paclitaxel-loaded human serum albumin nanoparticles(PTX-HSA-NPs)and heparin were coated using a layer-by-layer deposition method at pH *** exposure to physiological pH(i.e.,7.4),the coating is rapidly released from the balloon *** with a protective shellac coating,the DEB achieved controlled release of high-dose paclitaxel to the arterial tissue in vivo(up to 400μg per gram tissue),exceeding current DEBs in the *** results suggest the pH-responsive,multi-layer coated DEB’s potential for superior procedural outcomes,addressing a critical unmet need in PCI.

关键词： drug-eluting balloon layer-by-layer coating coronary artery disease paclitaxel

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effects of the aqueous extract of Schizandra chinensis fruit on ethanol withdrawal-induced anxiety in rats

引用

Chinese Medical Journal 2014年第10期127卷 1935-1940页

作者： Wu Yiyan Zhao Zhenglin Yang Yupeng Yang Xudong Eun young jang Nathan D Schilaty David M Hedges Sang Chan Kim Il Je Cho Zhao Rongjie Department of Pharmacology Mudanjiang Medical University Mudanjiang Heilongjiang 157011 China Fourth Affiliated Hospital of Harbin Medical University HarbinHeilongjiang 150001 China Brigham young University Provo Utah 84602 USA Research Center for Biomedical Resource of Oriental Medicine Daegu Haany University Daegu 706-828 South Korea

Background We previously demonstrated that the aqueous extract of the Schizandra chinensis fruit （AESC） ameliorated Cd-induced depletion of monoamine neurotransmitters in the brain through antioxidant *** the present study,we investigated the effect of AESC on anxiety-like behavior and the levels of norepinephrine and 3-methoxy-4-hydroxyphenylglycol （a metabolite of norepinephrine） in different brain regions during ethanol withdrawal in *** Male Sprague-Dawley rats were treated with 3 g/kg of ethanol （20％,w/v） or saline by daily intraperitoneal injection for 28 days followed by three days of *** withdrawal,rats were given AESC （100 *** 1.d-1 or 300 *** 1·d1,P.O.） once a day for three *** minutes after the final dose of AESC,the anxiogenic response was evaluated using an elevated plus maze,and the plasma corticosterone levels were examined by ***,the concentrations of norepinephrine and 3-methoxy-4-hydroxy-phenylglycol in the hypothalamic paraventricular nucleus and hippocampus were also measured by high performance liquid *** Rats undergoing ethanol withdrawal exhibited substantial anxiety-like behavior,which was characterized by both the decrease in time spent in the open arms of the elevated plus maze and the increased level of corticosterone secretion,which were greatly attenuated by doses of AESC in a dose-dependent *** high performance liquid chromatography analysis revealed that ethanol withdrawal significantly increased norepinephrine and 3-methoxy-4-hydroxy-phenylglycol levels in the hypothalamic paraventricular nucleus,while not significantly altering them in the *** to the results from the elevated plus maze test,the AESC significantly inhibited the elevation of norepinephrine and its metabolite in the hypothalamic paraventricular nucleus in a dose-dependent *** These results suggest that AESC attenuates anxiety-like behavior induced b

关键词： Schizandra chinensis fruit ethanol withdrawal anxiety norepinephrine hypothalamic paraventricular nucleus hippocampus

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Neuromodulation of the peripheral nervous system:Bioelectronic technology and prospective developments

引用

BMEMat(BioMedical Engineering Materials) 2024年第1期2卷 88-114页

作者： Hayoung Song Moohyun Kim Enji Kim Jakyoung Lee Inhea Jeong Kyeonghee Lim Seoung young Ryu Myoungjae Oh Younhee Kim jang-Ung Park Department of Materials Science and Engineering Yonsei UniversitySeoulSouth Korea Center for Nanomedicine Institute for Basic Science(IBS)SeoulSouth Korea Department of Neurosurgery Yonsei University College of MedicineSeoulSouth Korea Graduate Program of Nano Biomedical Engineering(NanoBME) Advanced Science InstituteYonsei UniversitySeoulSouth Korea

The peripheral nervous system(PNS)is a fascinatingly complex and crucial component of the human body,responsible for transmitting vital signals throughout the body's intricate network of *** efficient functioning is paramount to our health,with any dysfunction often resulting in serious medical conditions,including motor disorders,neurological diseases,and psychiatric *** strides in science and technology have made neuromodulation of the PNS a promising avenue for addressing these health *** involves modifying nerve activity using a range of techniques,such as electrical,chemical,optical,and mechanical *** plays a critical role in this effort,allowing for precise,controlled,and sustained stimulation of the *** paper provides an overview of the PNS,discusses the current state of neuromodulation devices,and presents emerging trends in the field,including advances in wireless power transfer and materials,that are shaping the future of neuromodulation.

关键词： bioelectronics neuromodulation peripheral nervous system

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Assessment of scoring systems for acute-on-chronic liver failure at predicting short-term mortality in patients with alcoholic hepatitis

引用

World Journal of Gastroenterology 2016年第41期22卷 9205-9213页

作者： Hee Yeon Kim Chang Wook Kim Tae Yeob Kim Do Seon Song Dong Hyun Sinn Eileen L Yoon young Kul Jung Ki Tae Suk Sang Soo Lee Chang Hyeong Lee Tae Hun Kim Jeong Han Kim Hyung Joon Yim Sung Eun Kim Soon Koo Baik Byung Seok Lee Jae young jang young Seok Kim Sang Gyune Kim Jin Mo Yang Joo Hyun Sohn Heon Ju Lee Seung Ha Park Eun Hee Choi Dong Joon Kim Korean Acute-on-Chronic Liver Failure Study Group Department of Internal Medicine College of MedicineThe Catholic University of KoreaSeoul 06591South Kerea Institute of Medical Science Hanyang UniversitySeoul 04763South Kerea Department of Internal Medicine Samsung Medical CenterSeoul 06351South Kerea Department of Internal Medicine Inje University Sanggye Paik HospitalSeoul 01757South Kerea Department of Internal Medicine Korea University Ansan HospitalAnsan 15355South Korea Department of Internal Medicine Hallym University Chuncheon Sacred Heart HospitalChuncheon 24253South Kerea Department of Internal Medicine Gyeongsang National University HospitalJinju 52727South Kerea Department of Internal Medicine Catholic University of Daegu School of MedicineDaegu 42472South Kerea Department of Internal Medicine Ewha Womans University School of MedicineSeoul 07985South Kerea Department of Internal Medicine Konkuk University School of MedicineSeoul 05030South Kerea Department of Internal Medicine Hallym University Sacred Heart HospitalAnyang 14068South Kerea Department of Internal Medicine Yonsei University Wonju College of MedicineWonju 26426South Kerea Department of Internal Medicine Chungnam National UniversitySchool of MedicineDaejeon 35015South Kerea Department of Internal Medicine Soonchunhyang University College of MedicineSeoul 04401South Kerea Department of Internal Medicine Soonchunhyang University Bucheon HospitalBucheon 14584South Kerea Department of Internal Medicine Hanyang University Guri HospitalGuri 11923South Kerea Department of Internal Medicine Yeungnam University College of MedicineDaegu 42415South Kerea Department of Internal Medicine Inje University Haeundae Paik-HospitalInje University College of MedicineBusan 48108South Kerea Institute of Lifestyle Medicine Yonsei University Wonju College of MedicineWonju 26426South Kerea 不详

AIM To assess the performance of proposed scores specific for acute-on-chronic liver failure in predicting shortterm mortality among patients with alcoholic *** We retrospectively collected data from 264 patients with clinically diagnosed alcoholic hepatitis from January to December 2013 at 21 academic hospitals in Korea. The performance for predicting short-term mortality was calculated for Chronic Liver FailureSequential Organ Failure Assessment(CLIF-SOFA), CLIF Consortium Organ Failure score(CLIF-C OFs), Maddrey'sdiscriminant function(DF), age, bilirubin, international normalized ratio and creatinine score(ABIC), Glasgow Alcoholic Hepatitis Score(GAHS), model for end-stage liver disease(MELD), and *** Of 264 patients, 32(12%) patients died within 28 d. The area under receiver operating characteristic curve of CLIF-SOFA, CLIF-C OFs, DF, ABIC, GAHS, MELD, and MELD-Na was 0.86(0.81-0.90), 0.89(0.84-0.92), 0.79(0.74-0.84), 0.78(0.72-0.83), 0.81(0.76-0.86), 0.83(0.78-0.88), and 0.83(0.78-0.88), respectively, for 28-d mortality. The performance of CLIF-SOFA had no statistically significant differences for 28-d mortality. The performance of CLIF-C OFs was superior to that of DF, ABIC, and GAHS, while comparable to that of MELD and MELD-Na in predicting 28-d mortality. A CLIF-SOFA score of 8 had 78.1% sensitivity and 79.7% specificity, and CLIF-C OFs of 10 had 68.8% sensitivity and 91.4% specificity for predicting 28-d *** CLIF-SOFA and CLIF-C OF scores performed well, with comparable predictive ability for short-term mortality compared to the commonly used scoring systems in patients with alcoholic hepatitis.

关键词： Acute-on-chronic liver failure Alcoholic hepatitis Mortality Prognosis Scoring system

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

T型件单边螺栓连接方钢管混凝土柱-钢梁框架抗震性能研究

引用

工程抗震与加固改造 2023年第3期45卷 15-22页

作者：徐红玉李奕昂王新武刘欢欢孙海粟 Ll young jang 河南科技大学土木工程学院河南洛阳471023 洛阳理工学院河南省新型土木工程结构国际联合实验室河南洛阳471023 武汉理工大学湖北武汉430070 金乌国立工科大学土木工程学院韩国龟尾39177

为研究T型件单边螺栓连接方钢管混凝土柱-钢梁组合框架的抗震性能,设计了一榀由T型件与单边螺栓相连的1:2缩尺的组合框架,并通过拟静力加载试验对框架的承载能力、滞回性能、刚度退化、耗能能力和延性性能进行了分析,并与一榀T型件单边... 详细信息

为研究T型件单边螺栓连接方钢管混凝土柱-钢梁组合框架的抗震性能,设计了一榀由T型件与单边螺栓相连的1:2缩尺的组合框架,并通过拟静力加载试验对框架的承载能力、滞回性能、刚度退化、耗能能力和延性性能进行了分析,并与一榀T型件单边螺栓连接方钢管柱-钢梁框架进行了对比分析,结果表明:两试件滞回曲线均较为饱满,无明显捏缩,方钢管混凝土柱-钢梁组合框架要比方钢管柱-钢梁框架的承载力高,且初始刚度要高出19%,但其耗能能力和延性均有所降低,两试件加载后期承载力下降均较缓慢,且水平位移达到了层间位移角1/30,表明两试件均具有良好的抗震性。

关键词：单边螺栓 T型件方钢管混凝土柱抗震性能拟静力试验

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Current Management of Alcoholic Hepatitis and Future Therapies

引用

Journal of Clinical and Translational Hepatology 2016年第2期4卷 113-122页

作者： Behnam Saberi Alia S.Dadabhai Yoon-young jang Ahmet Gurakar Esteban Mezey Division of Gastroenterology and Hepatology The Johns Hopkins University School of MedicineBaltimoreMDUSA Department of Oncology The Johns Hopkins University School of MedicineBaltimoreMDUSA

Alcohol is one of the most common etiologies of liver disease,and alcoholic liver disease overall is the second most common indication for liver transplantation in the United *** encompasses a spectrum of disease,including fatty liver disease,alcoholic hepatitis (AH),and alcoholic *** can range from mild to severe disease,with severe disease being defined as:Discriminant Function (DF) ≥ 32,or Model for End-stage Liver Disease (MELD) ≥ 21,or presence of hepatic *** of the mild disease consists mainly of abstinence and supportive *** AH is associated with significant ***,there is no ideal medical treatment for this *** alcohol cessation,corticosteroids have been used with conflicting results and are associated with an inherent risk of *** steroids have shown short term benefit when compared to placebo,but they have no obvious long term *** does not improve survival in patients with severe AH and is no longer recommended based on the results of the STOPAH (Steroid Or Pentoxifylline for Alcoholic Hepatitis) ***-tumor necrosis factor (TNF) agents are associated with increased risk of life threatening infections and ***,early stage trials are underway,mainly targeting novel pathways based on disease pathogenesis,including modulation of innate immune system,inhibition of gut-liver axis and cell death pathways,and activation of transcription factor farnesyl X receptor (FXR).Future treatment may lie in human induced pluripotent stem cell (iPSC)technology,which is currently under investigation for the study of pathogenesis,drug discovery,and stem cell *** transplantation has been reported with good results in highly selected patients but is controversial due to limited organ Suppply.

关键词： Alcoholic hepatitis Corticosteroids Liver transplantation Induced pluripotent stem cell

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Generation of double knockout cattle via CRISPR-Cas9 ribonucleoprotein(RNP)electroporation

引用

Journal of Animal Science and Biotechnology 2024年第1期15卷 456-462页

作者： Gyeong-Min Gim Kyeong-Hyeon Eom Dong-Hyeok Kwon Dae-Jin Jung Dae-Hyun Kim Jun-Koo Yi Jae-Jung Ha Ji-Hyun Lee Seong-Beom Lee Woo-Jae Son Soo-young Yum Won-Wu Lee Goo jang Laboratory of Theriogenology and Biotechnology Department of Veterinary Clinical ScienceCollege of Veterinary Medicine and the Research Institute of Veterinary ScienceSeoul National UniversitySeoulRepublic of Korea LARTBio Co. Ltd.SeoulRepublic of Korea Gyeongsangbukdo Livestock Research Institute YeongjuRepublic of Korea Comparative Medicine Disease Research Center Seoul National UniversitySeoulRepublic of Korea

Background Genome editing has been considered as powerful tool in agricultural ***,genome editing progress in cattle has not been fast as in other mammal species,for some disadvantages including long gestational periods,single pregnancy,and high raising ***,technically demanding methods such as microinjection and somatic cell nuclear transfer(SCNT)are needed for gene editing in *** this point of view,electroporation in embryos has been risen as an *** First,editing efficiency of our electroporation methods were tested for *** of mutation on embryo was confirmed by T7E1 *** first combination,mutation rates for MSTN and PRNP were 57.6%±13.7%and 54.6%±13.5%,*** case of MSTN/BLG,mutation rates were 83.9%±23.6%for MSTN,84.5%±18.0%for ***,the double-KO embryos were transferred to surrogates and mutation rate was identified in resultant calves by targeted deep *** recipients were transferred for MSTN/PRNP,4 calves were delivered,and one calf underwent an induction for double *** surrogates were given double-KO embryos for MSTN/BLG,and four of the six calves that were born had mutations in both *** These data demonstrated that production of genome edited cattle via electroporation of RNP could be effectively ***,MSTN and PRNP from beef cattle and MSTN and BLG from dairy cattle have been born and they will be valuable resources for future precision breeding.

关键词： Beta-lactoglobulin Cattle CRISPR-Cas9 Electroporation Knockout MSTN PRNP

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

开发用于小型功率逆变器系统的MOSFET模块

引用

电子与电脑 2006年第2期6卷 65-68页

作者： Yo-Chan Son Ki-young jang Bum-Seok Suh 飞兆半导体公司(韩国富川) 飞兆半导体公司(韩国富川) 飞兆半导体公司(韩国富川)

　　近年来,市场对于高性能和高效率的逆变器驱动设备需求飞速增长.今天,直流无刷(BLDC)电机已用于许多消费电子设备中,如:变频空调、洗衣机和风扇电机等,使它们较采用开关控制的交流感应电机速度更快、噪声更低及能效更高.这个进步得...

　　近年来,市场对于高性能和高效率的逆变器驱动设备需求飞速增长.今天,直流无刷(BLDC)电机已用于许多消费电子设备中,如:变频空调、洗衣机和风扇电机等,使它们较采用开关控制的交流感应电机速度更快、噪声更低及能效更高.这个进步得以实现的关键之一,在于采用了逆变技术,特别是集成功率模块.目前,集成功率开关及其门驱动电路的功率模块能提供紧凑、可靠和具成本效益的逆变器解决方案,而市场对这类功率模块的需求正急剧上升.SPM(智能功率模组)系列遂应运而生,能支持消费市场的设计需求,提供更高性能.……

关键词：

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：