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Recent Advance in Synaptic Plasticity Modulation Techniques for Neuromorphic Applications

Nano-Micro Letters 2024年第10期16卷 403-434页

作者： Yilin sun Huaipeng Wang Dan Xie School of Integrated Circuits and Electronics Beijing Institute of TechnologyBeijing 100081People's Republic of China School of Integrated Circuits Beijing National Research Center for Information Science and Technology(BNRist)Tsinghua UniversityBeijing 100084People's Republic of China

Manipulating the expression of synaptic plasticity of neuromorphic devices provides fascinating opportunities to develop hardware platforms for artifi-cial ***,great efforts have been devoted to exploring biomimetic mechanisms of plasticity simulation in the last few *** progress in various plasticity modulation techniques has pushed the research of synaptic electronics from static plasticity simulation to dynamic plasticity modulation,improving the accuracy of neuromorphic computing and providing strategies for implementing neuromorphic sensing ***,several fascinating strategies for synap-tic plasticity modulation through chemical techniques,device structure design,and physical signal sensing are *** chemical techniques,the underly-ing mechanisms for the modification of functional materials were clarified and its effect on the expression of synaptic plasticity was also *** on device structure design,the reconfigurable operation of neuromorphic devices was well demonstrated to achieve programmable neuromorphic ***,integrating the sensory units with neuromorphic processing circuits paved a new way to achieve human-like intelligent perception under the modulation of physical signals such as light,strain,and ***,considering that the relevant technology is still in the basic exploration stage,some prospects or development suggestions are put forward to promote the development of neuromorphic devices.

关键词： Plasticity modulation Dynamic plasticity Chemical techniques Programmable operation Neuromorphic sensing

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Heparin-binding protein as a predictor of mortality in patients with diabetes mellitus and community-acquired pneumonia in intensive care unit:a propensity score matched study

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World Journal of Emergency Medicine 2024年第4期15卷 263-272页

作者： Yuhan sun Baoqing sun Zhigang Ren Mingshan Xue Changju Zhu Qi Liu Translational Medicine Center Department of Emergency Medicinethe First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory Healththe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510230China Department of Infectious Disease the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Henan Medical Key Laboratory of Emergency and Trauma Research Department of Emergency Medicinethe First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China

BACKGROUND:Patients with diabetes mellitus(DM)are vulnerable to community-acquired pneumonia(CAP),which have a high mortality *** aimed to investigate the value of heparin-binding protein(HBP)as a prognostic marker of mortality in patients with DM and ***:This retrospective study included CAP patients who were tested for HBP at intensive care unit(ICU)admission from January 2019 to April *** were allocated to the DM or non-DM group and paired with propensity score *** characteristics and clinical outcomes up to 90 days were *** primary outcome was the 10-day *** operating characteristic(ROC)curves,Kaplan-Meier analysis,and Cox regression were used for statistical ***:Among 152 enrolled patients,60 pairs were successfully *** was no significant difference in 10-day mortality,while more patients in the DM group died within 28 d(P=0.024)and 90 d(P=0.008).In the DM group,HBP levels at ICU admission were higher in 10-day non-survivors than in 10-day survivors(median 182.21[IQR:55.43-300]ng/ml *** 66.40[IQR:34.13-107.85]ng/mL,P=0.019),and HBP levels could predict the 10-day mortality with an area under the ROC curve of *** cut-off value,sensitivity,and specificity were 160.6 ng/mL,66.7%,and 90.2%,*** Cox regression analysis indicated that HBP was an independent prognostic factor for 10-day(HR 7.196,95%CI:1.596-32.455,P=0.01),28-day(HR 4.381,95%CI:1.449-13.245,P=0.009),and 90-day mortality(HR 4.581,95%CI:1.637-12.819,P=0.004)in patients with ***:Plasma HBP at ICU admission was associated with the 10-day,28-day,and 90-day mortality,and might be a prognostic factor in patients with DM and CAP.

关键词： Community-acquired pneumonia Diabetes mellitus Heparin-binding protein Propensity score match

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KoNA:Korean Nucleotide Archive as A New Data Repository for Nucleotide Sequence Data

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Genomics, Proteomics & Bioinformatics 2024年第1期22卷 161-167页

作者： Gunhwan Ko Jae Ho Lee young Mi Sim Wangho Song Byung-Ha Yoon Iksu Byeon Bang Hyuck Lee Sang-Ok Kim Jinhyuk Choi Insoo Jang Hyerin Kim Jin Ok Yang Kiwon Jang Sora Kim Jong-Hwan Kim Jongbum Jeon Jaeeun Jung Seungwoo hwang Ji-Hwan Park Pan-Gyu Kim Seon-young Kim Byungwook Lee Korea Bioinformation Center Korea Research Institute of Bioscience&BiotechnologyDaejeon 34141Republic of Korea

During the last decade,the generation and accumulation of petabase-scale high-throughput sequencing data have resulted in great challenges,including access to human data,as well as transfer,storage,and sharing of enormous amounts of *** promote data-driven biological research,the Korean government announced that all biological data generated from government-funded research projects should be deposited at the Korea BioData Station(K-BDS),which consists of multiple databases for individual data ***,we introduce the Korean Nucleotide Archive(KoNA),a repository of nucleotide sequence *** of July 2022,the Korean Read Archive in KoNA has collected over 477 TB of raw next-generation sequencing data from national genome *** ensure data quality and prepare for international alignment,a standard operating procedure was adopted,which is similar to that of the International Nucleotide Sequence Database *** standard operating procedure includes quality control processes for submitted data and metadata using an automated pipeline,followed by manual *** ensure fast and stable data transfer,a high-speed transmission system called GBox is used in ***,the data uploaded to or downloaded from KoNA through GBox can be readily processed using a cloud computing service called *** seamless coupling of KoNA,GBox,and Bio-Express enhances the data experience,including submission,access,and analysis of raw nucleotide *** not only satisfies the unmet needs for a national sequence repository in Korea but also provides datasets to researchers globally and contributes to advances in *** KoNA is available at https://***/kona/.

关键词： Korea BioData Station Nucleotide sequence Next-generation sequencing repository Genomics Deposition and access of big data

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Analyses of Political Crisis Impact on Tourism:A Panel Counterfactual Approach with Internet Search Index

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Journal of Systems Science & Complexity 2024年第4期37卷 1581-1603页

作者： HUANG Bai sun Yuying YANG Boyu School of Statistics and Mathematics Central University of Finance&EconomicsBeijing 102206China Academy of Mathematics and Systems Science Chinese Academy of SciencesBeijing 100190China Center for Forecasting Science Chinese Academy of SciencesBeijing 100190China School of Economics and Management University of Chinese Academy of SciencesBeijing 100190China

Existing research has shown that political crisis events can directly impact the tourism ***,the current methods suffer from potential changes of unobserved variables,which poses challenges for a reliable evaluation of the political crisis *** paper proposes a panel counterfactual approach with Internet search index,which can quantitatively capture the change of crisis impacts across time and disentangle the effect of the event of interest from the *** also provides a tool to examine potential channels through which the crisis may affect tourist *** research empirically applies the framework to analyze the THAAD event on tourist flows from the Chinese Mainland to South *** highlight the strong and negative short-term impact of the political crisis on the tourists' intentions to visit a *** paper provides essential evidence to help decision-makers improve the management of the tourism crisis.

关键词： Composite search index counterfactual analysis political crisis search query data tourism demand

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Probabilistic seismic inversion based on physics-guided deep mixture density network

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Petroleum Science 2024年第3期21卷 1611-1631页

作者： Qian-Hao sun Zhao-Yun Zong Xin Li National Key Laboratory of Deep Oil and Gas China University of Petroleum(East China)Qingdao266580ShandongChina Laoshan Laboratory Qingdao266580ShandongChina CNOOC Research Institute Ltd. Beijing100028China

Deterministic inversion based on deep learning has been widely utilized in model parameters *** by logging data,seismic data,wavelet and modeling operator,deterministic inversion based on deep learning can establish nonlinear relationships between seismic data and model ***,seismic data lacks low-frequency and contains noise,which increases the non-uniqueness of the *** conventional inversion method based on deep learning can only establish the deterministic relationship between seismic data and parameters,and cannot quantify the uncertainty of *** order to quickly quantify the uncertainty,a physics-guided deep mixture density network(PG-DMDN)is established by combining the mixture density network(MDN)with the deep neural network(DNN).Compared with Bayesian neural network(BNN)and network dropout,PG-DMDN has lower computing cost and shorter training time.A low-frequency model is introduced in the training process of the network to help the network learn the nonlinear relationship between narrowband seismic data and low-frequency *** addition,the block constraints are added to the PG-DMDN framework to improve the horizontal continuity of the inversion *** illustrate the benefits of proposed method,the PG-DMDN is compared with existing semi-supervised inversion *** synthetic data examples of Marmousi II model are utilized to quantify the influence of forward modeling part,low-frequency model,noise and the pseudo-wells number on inversion results,and prove the feasibility and stability of the proposed *** addition,the robustness and generality of the proposed method are verified by the field seismic data.

关键词： Deep learning Probabilistic inversion Physics-guided Deep mixture density network

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Evidence for distortion-induced local electric polarization in α-RuCl_(3)

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Science China(Physics,Mechanics & Astronomy) 2024年第9期67卷 165-173页

作者： Xinrun Mi De Hou Xiao Wang Sabreen Hammouda Caixing Liu Zijian Xiong Han Li Yan Liu Guiwen Wang Aifeng Wang Yisheng Chai Yang Qi Wei Li Xiaoyuan Zhou Yixi Su DIKhomskii Mingquan He Zhigao Sheng young sun College of Physics Center of Quantum Materials and DevicesChongqing UniversityChongqing 401331China Anhui Key Laboratory of Condensed Matter Physics at Extreme Conditions High Magnetic Field LaboratoryHefei Institutes of Physical ScienceAnhuiChinese Academy of SciencesHefei 230031 China University of Science and Technology of China Hefei 230026China Jülich Centre for Neutron Scienceat Heinz Maier-Leibnitz Zentrum(JCNS-MLZ) Forschungszentrum Jülich GmbHGarching D-85747Germany School of Physics Beihang UniversityBeijing 100191China Analytical and Testing Center Chongqing UniversityChongqing 401331China State Key Laboratory of Surface Physics Department of PhysicsFudan UniversityShanghai 200433China CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China Ⅱ.Physikalisches Institut Universität zu KölnKöln D-50937Germany

The spin-orbit assisted Mott insulator α-RuCl_(3) is a prime candidate for material realization of the Kitaev quantum spin *** little attention has been paid to charge degrees of freedom,charge effects,such as electric polarization,may arise in this ***,we report distortion-induced local electric polarization in α-RuCl_(3) as evidenced by single-crystal X-ray diffraction,second harmonic generation(SHG)and dielectric *** SHG signal appears at room temperature and develops substantially in the Kitaev paramagnetic state when short-range spin correlations come into *** sizable pyroelectric currents in the Kitaev paramagnetic state,the absence of hysteresis in the polarization-electric field(P-E)points to the shortrange nature of electric *** localized electric polarization is likely the result of distortion-induced charge dimerization,achieved through virtual hopping-induced charge *** addition,the electric polarization is boosted by short-range spin correlations via spin-phonon coupling in the Kitaev paramagnetic *** results emphasize the importance of charge degrees of freedom in α-RuCl_(3),which establish a novel platform to investigate charge effects in Kitaev materials.

关键词： Mott insulator Kitaev quantum spin liquid electric polarization

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OsPDR20 is an ABCG metal transporter regulating cadmium accumulation in rice

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Journal of Environmental Sciences 2024年第2期136卷 21-34页

作者： He Li Chao Li Di sun Zhi Min Yang Department of Biochemistry and Molecular Biology College of Life SciencesNanjing Agricultural UniversityNanjing 210095China

Cadmium(Cd)is a non-essential toxic heavy metal,seriously posing high environmental risks to human *** genetic resources relevant to functional genes is important for understanding the metal absorption and accumulation in crops and bioremediation of Cd-polluted *** study investigated a functionally uncharacterized ATP binding cassette transporter G family(ABCG)gene encoding a Pleiotropic Drug Resistance 20(PDR20)type metal transporter which is localized to the plasma membrane of ***20 was transcriptionally expressed in almost all tissues and organs in lifespan and was strongly induced in roots and shoots of young rice under Cd *** expression of OsPDR20 in a yeast mutant ycf1 sensitive to Cd conferred cellular tolerance with less Cd *** of OsPDR20 by RNA interference(RNAi)moderately attenuated root/shoot elongation and biomass,with reduced chlorophylls in rice grown under hydroponic medium with 2 and 10μmol/L Cd,but led to more Cd accumulation.A field trial of rice grown in a realistic Cd-contaminated soil(0.40 mg/kg)showed that RNAi plants growth and development were also compromised compared to wild-type(WT),with smaller panicles and lower spikelet fertility but little effect on yield of ***,OsPDR20 suppression resulted in unexpectedly higher levels of Cd accumulation in rice straw including lower leaves and culm and *** results suggest that OsPDR20 is actively involved in Cd accumulation and homeostasis in rice *** increased Cd accumulation in the RNAi plants has the potential application in phytoremediation of Cd-polluted wetland soils.

关键词： Rice ABCG transporter Cadmium accumulation Phytoremediation

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White Matter Lesions in young-Middle Aged Migraineurs with Patent Foreman Ovale: A Case-Control Study

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Congenital Heart Disease 2024年第3期19卷 279-291页

作者： Yang Hua Jinyu sun Yuxuan Lou Hao Zhang Jing Shi Wei sun Department of Cardiology The First Affiliated Hospital of Nanjing Medical UniversityNanjing210000China

Background:White matter lesion(WML)is common in aging brain and is associated with cognitive impairment and ***,recent studies reported an association between patent foramen ovale(PFO)and WML in migraineurs,especially in young,middle-aged *** retrospective,case-control study aims to describe the clinical characteristics of WML in this population and to explore potential risk ***:226 patients with migraine and PFO were consecutively initially *** factors were selected by the least absolute shrinkage and selection operator(LASSO)regression and multivariable logistic regression model.A Nomogram was employed to visualize the prediction model *** discrimination and calibration abilities were evaluated using the Receiver Operating Characteristic(ROC)curve,the Hosmer-Lemeshow test,and calibration ***:One hundred and nineteen participants were ultimately enrolled in our study,with a median age of 36.9±12.7 years and 80.7%of *** magnetic resonance imaging MRI showed 67(56.3%)patients had WML,whereas 52(43.7%)patients were categorized into the non-WML *** regression screened out potential variables and subsequent multivariate analysisfinally identified age,mean platelet volume,andfibri-nogen(FIB)as independent predictive factors of *** area under the ROC curve(AUC)was ***-mer-Lemeshow test and calibration curve verified a consistency between the predicted and actual ***:The predictive nomogram established and validated in our study may assist clinicians in screening WML among young middle-aged migraineurs with PFO and developing individualized preventive and treatment strategies.

关键词： White matter lesion migraine patent foreman ovale nomogram predictive model

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Mechanics and physics under supergravity conditions

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Acta Mechanica Sinica 2024年第6期40卷 1-2页

作者： Chaofeng Lü Chao sun Shengqiang Cai Faculty of Mechanical Engineering and Mechanics Ningbo UniversityNingbo 315211China New Cornerstone Science Laboratory Center for Combustion EnergyDepartment of Energy and Power EngineeringTsinghua UniversityBeijing 100084China Department of Mechanical and Aerospace Engineering University of CaliforniaSan DiegoLa Jolla CA 92093USA

"Supergravity"refers to the conditions where the effective gravity is greater than that of *** conditions are generally relevant to stellar evolution,geophysical movement,astrophysical flows,and *** also frequently occur in various engineering scenarios involving acceleration,such as the launch of space shuttles,operation of rotor engines,impacts and explosions,chemical separation processes,and overloaded testing *** is already demonstrated in physiological experiments that living organisms of animals or plants could be damaged,either temporarily or permanently,when subjected to *** create supergravity conditions for scientific research on the Earth,centrifugal equipment or rapidly rotating devices are omnipresent in various fields,such as aerospace engineering,geophysical science,chemical and biomedical engineering,nuclear engineering,rotating flows,and physical modeling tests.

关键词： geophysical Earth stellar

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SARS-CoV-2 aberrantly elevates mitochondrial bioenergetics to induce robust virus propagation

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2702-2715页

作者： Hye Jin Shin Wooseong Lee Keun Bon Ku Gun young Yoon Hyun-Woo Moon Chonsaeng Kim Mi-Hwa Kim Yoon-sun Yi Sangmi Jun Bum-Tae Kim Jong-Won Oh Aleem Siddiqui Seong-Jun Kim Department of Convergent Research of Emerging Virus Infection Korea Research Institute of Chemical TechnologyDaejeon 34114Republic of Korea Gyeongnam Biohealth Research Center Gyeongnam Branch InstituteKorea Institute of ToxicologyJinju 52834Republic of Korea Center for Research Equipment Korea Basic Science InstituteCheongjuChungcheongbuk-do 28119Republic of Korea Department of Biotechnology Yonsei UniversitySeoul 03722Republic of Korea Division of Infectious Diseases School of MedicineUniversity of CaliforniaSan DiegoLa JollaCA 92093USA Present address:Department of Microbiology Chungnam National University School of MedicineDaejeon 35015Republic of Korea

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is a‘highly transmissible respiratory pathogen,leading to severe multiorgan ***,knowledge regarding SARS-CoV-2-induced cellular alterations is *** this study,we report that SARSCoV-2 aberrantly elevates mitochondrial bioenergetics and activates the EGFR-mediated cell survival signal cascade during the early stage of viral ***-CoV-2 causes an increase in mitochondrial transmembrane potential via the SARS-CoV-2 RNAnucleocapsid cluster,thereby abnormally promoting mitochondrial elongation and the OXPHOS process,followed by enhancing ATP ***,SARS-CoV-2 activates the EGFR signal cascade and subsequently induces mitochondrial EGFR trafficking,contributing to abnormal OXPHOS process and viral *** EGFR inhibitors remarkably reduce SARS-CoV-2 propagation,among which vandetanib exhibits the highest antiviral *** of SARS-CoV-2-infected cells with vandetanib decreases SARS-CoV-2-induced EGFR trafficking to the mitochondria and restores SARS-CoV-2-induced aberrant elevation in OXPHOS process and ATP generation,thereby resulting in the reduction of SARS-CoV-2 ***,oral administration of vandetanib to SARS-CoV-2-infected hACE2 transgenic mice reduces SARS-CoV-2 propagation in lung tissue and mitigates SARS-CoV-2-induced lung *** also exhibits potent antiviral activity against various SARS-CoV-2 variants of concern,including alpha,beta,delta and omicron,in in vitro cell culture *** together,our findings provide novel insight into SARS-CoV-2-induced alterations in mitochondrial dynamics and EGFR trafficking during the early stage of viral infection and their roles in robust SARS-CoV-2 propagation,suggesting that EGFR is an attractive host target for combating COVID-19.

关键词： alterations aberrant thereby

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