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p73 G4C14 to A4T14 polymorphism is associated with colorectal cancer risk and survival

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World Journal of Gastroenterology 2010年第35期16卷 4448-4454页

作者： Kyung-Eun Lee young-Seoub Hong Byoung-Gwon Kim Na-young Kim Kyoung-Mu Lee Jong-young Kwak Mee-sook Roh Department of Clinical Laboratory Science College of Health Sciences Catholic University of Pusan Department of Preventive Medicine Dong-A University College of Medicine Clinical Research Institute Seoul National University College of Medicine Medical Research Center for Cancer Molecular Therapy Dong-A University College of Medicine Department of Pathology Dong-A University College of Medicine

AIM:To analyze the association between the p73 G4C14-to-A4T14 polymorphism(a.k.a.,the GC/AT variation) and colorectal cancer risk and survival in the Korean population,and to evaluate the relationships between p73 polymorphism and the p73 protein expression or clinicopathological characteristics of colorectal ***:Three hundred and eighty-three histologically confirmed cases and 469 healthy controls,recruited at one teaching hospital in Pusan,Korea from 2001 and 2007,were genotyped for p73 G4C14-to-A4T14 by PCR with confronting two-pair primers(PCR-CTPP) and the expression profile of p73 in cancer tissues(n=383) was analyzed by ***:Odds ratios(ORs) and 95% confidence intervals(CIs) were calculated by unconditional logistic regression model adjusted for age and *** with the GC/GC genotypes,the GC/AT and AT/AT genotypes were significantly associated with colorectal cancer risk(GC/AT vs GC/GC:OR = 1.46,95% CI:1.10-1.94;AT/AT vs GC/GC:1.72,0.98-3.03;Ptrend=0.01).When stratified by age and gender,the association was restricted to those less than 60 years of age(GC/AT or AT/AT vs GC/GC:2.22,1.39-3.55) and male(GC/AT or AT/AT vs GC/GC:1.91,1.31-2.77).The expression of p73 was associated with invasion depth(P = 0.003) and advanced Duke's stage(P = 0.06) of colorectal *** patients with the GC/GC genotype were associated with worse survival compared with those with the other genotypes(P = 0.02).However,no signif icant relationship was observed between the p73 G4C14-to-A4T14 polymorphism and p73 protein expression in cancer ***:Our results suggest that the p73 GC/AT polymorphism is associated with an increased colorectal cancer risk and survival in the Korean population.

关键词： p73 G4C14 to A4T14 polymorphism Colorectal cancer

Isolation and characterization of Pseudomonas otitidis WL-13 and its capacity to decolorize triphenylmethane dyes

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Journal of Environmental Sciences 2009年第7期21卷 960-964页

作者： WU Jing JUNG Byung-Gil KIM Kyoung-sook LEE young-Choon SUNG Nak-Chang Department of Biotechnology Dong-A University Busan 604-714 South Korea Brain Korea 21 Center for Silver-Bio Industrialization Dong-A University Busan 604-714 South Korea Department of Environmental Engineering College of Engineering Dong-A University. Busan 604-714 South Korea

Pseudomonas otitidis WL-13, which has a high capacity to decolorize triphenylmethane dyes, was isolated from activated sludge obtained from a wastewater treatment plant of a dyeing industry. This strain exhibited a remarkable color-removal capability when tested against several triphenylmethane dyes under both shaking and static conditions at high concentrations of dyes. More than 95% of Malachite Green and Brilliant Green was removed within 12 h at 500 μmol/L dye concentration under shaking conditions. Crystal Violet lost about 13% of its color under the same conditions tested. The rate of decolorization increased when the M9 medium was supplemented with yeast extract. The optimum pH and temperature for color removal were 7-9 and 35-40℃, respectively. The observed changes in the visible spectra and the inspection of bacterial growth indicated the color-removal by the adsorption of dye to the cells during incubation with strains.

关键词： adsorption decolorization Pseudomonas otitidis WL-13 triphenylmethane dye

Seroprevalence of Helicobacter pylori in female Vietnamese immigrants to Korea

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World Journal of Gastroenterology 2012年第6期18卷 517-521页

作者： Su Jung Baik Sun young Yi Hye sook Park Bo Hyun Park Department of Internal Medicine Ewha Medical Research InstituteSchool of MedicineEwha Womans University911-1 MokdongSeoul 158-710South Korea Department of Preventive Medicine Ewha Medical Research InstituteSchool of MedicineEwha Womans University911-1 MokdongSeoul 158-710South Korea

AIM： To investigate the seroprevalence of Helicobacter pylori （H. pylorl） and its relationship to nutritional fac- tors in female Vietnamese immigrants to Korea. METHODS： A total of 390 female immigrants from Vietnam and 206 Korean male spouses participated in the study. Blood samples from 321 female immigrants and 201 Korean male spouses were analyzed for H. py- Iori antibodies. Data on age, sex, alcohol consumption, smoking status, dietary nutritional factors and gastro- intestinal symptoms were collected using question- naires. The daily intakes of the following nutrients were estimated： energy, protein, niacin, lipid, fiber, calcium, iron, sodium, potassium, zinc, folate, cholesterol, and vitamins A, B1, B2, B6, C and E. RESULTS： The prevalence of H. py/ori positivity was lower in the immigrants than in age-matched Koreanfemales （55.7% vs 71.4%, respectively; P 〈 0.0001） and the domestic population of Vietnam. The preva- lence of H. pylori positivity among married couples was 31.7% for both spouses. There were no statistically sig- nificant differences in the incidence of smoking, amount of alcohol consumed, or nutritional factors between the H. pylori-positive and negative groups. CONCLUSION： The prevalence of H. pylori positivity was lower among female Vietnamese immigrants than among Korean females. Nutritional factors did not differ between the H. pylori-positive and negative groups.

关键词： Vietnam Immigration South Korea Helico-bacter pylori Diet

Asymptomatic lymphangioma involving the spleen and retroperitoneum in adults

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World Journal of Gastroenterology 2009年第44期15卷 5620-5623页

作者： sook Hee Chung young sook Park Yun Ju Jo Seong Hwan Kim Dae Won Jun Byoung Kwan Son Jun young Jung Dae Hyun Baek Dong Hee Kim Yoon young Jung Won Mi Lee Department of Internal Medicine Eulji General Hospital Eulji University School of MedicineSeoul 139-711South Korea Department of General Surgery Eulji General HospitalEulji University School of MedicineSeoul 139-711 South Korea Department of Radiology Eulji General HospitalEulji University School of MedicineSeoul 139-711 South Korea Department of Pathology Eulji General Hospital Eulji University School of MedicineSeoul 139-711 South Korea

Lymphangioma, a benign neoplasm of the lymphatic system, is common in children but rare in adults. Its clinical manifestations include abdominal pain, nausea, vomiting and a palpable mass. However, abdominal sonography or abdominal computed tomography （CT） scan can also incidentally reveal lymphangioma. A larger or symptomatic lymphangioma is treated with total resection to prevent recurrence, infection, torsion and enlargement. Although lymphangioma rarely becomes malignant, its prognosis is generally good. We report a cystic lymphangioma of the spleen and retroperitoneum, which was incidentally found in a 56-year-old man who was hospitalized due to a colon mass. Physical examination showed no specific findings. Abdominal CT revealed a 5.7 cm, non-enhanced multilobulated cystic mass with multiple sepia in the spleen and a 10 cm lobulated cystic mass in the paraaortic area. Splenectomy and retroperitoneal resection of the cystic mass were conducted. The endothelium of splenic and retroperitoneal cyst was immunohistochemically stained with D2-40 antibody. The patient was finally diagnosed with splenic cystic and retroperitoneal cavernous lymphangioma.

关键词： Lymphangioma Retroperitoneum Spleen

Efficacy of Seprafilm~ graft with adhesiolysis in experimentally induced lid adhesion in rabbits

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International Journal of Ophthalmology(English edition) 2013年第1期6卷 44-49页

作者： Sang Wook Jin Hee Bae ahn Mi sook Roh Yoon Hyung Kwon Won Yeol Ryu Department of Ophthalmology College of MedicineDong-A University Department of Pathology College of MedicineDong-A University

AIM:To evaluate the efficacy of Seprafilm transplantation following adhesiolysis for preventing postoperative readhesion and improving surgical outcomes. METHODS:Primary blepharoplasty was carried out on both eyelids of 18 albino rabbits. After 2 weeks, a new skin incision was made, and adhesiolysis was performed on both eyelids. The rabbits were categorized into two groups, one with adhesiolysis alone in the left eyelid (control group), and the other with adhesiolysis with a Seprafilm graft in the right eyelid (Seprafilm group). The degrees of inflammation and fibrosis were examined with hematoxylin-eosin (HE) and Masson’s trichrome stains. Expression of α-smooth muscle actin (α-SMA) was also immunohistochemically examined. RESULTS:Eyelid examination immediately after the operation revealed mild swelling and hemorrhage in both groups, but these symptoms resolved after 1 week-2 weeks, and eyelid shape had recovered completely in both groups. Microscopic assessments demonstrated that the Seprafilm group showed less inflammation and fibrosis than the control group. The Seprafilm group also exhibited fewer α-SMA-positive cells than the control group. CONCLUSION:Based on these findings, we conclude that Seprafilm graft with adhesiolysis is an effective method for preventing postoperative readhesions after eyelid surgery.

关键词： Seprafilm adhesion adhesiolysis

Interleukin-24 is correlated with differentiation and lymph node numbers in rectal cancer

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World Journal of Gastroenterology 2011年第9期17卷 1167-1173页

作者： youngmin Choi Mee-sook Roh young-Seoub Hong Hyung-Sik Lee Won-Joo Hur Department of Radiation Oncology Dong-A University School of Medicine Department of Pathology Dong-A University School of Medicine Department of Preventive Medicine Dong-A University School of Medicine

AIM:To assess the significance of interleukin(IL)-24 and vascular endothelial growth factor(VEGF)expression in lymph-node-positive rectal cancer. METHODS:Between 1998 and 2005,90 rectal adenocarcinoma patients with lymph node involvement were *** patients received radical surgery and postoperative pelvic chemoradiotherapy of 50.4-54.0 *** of 5-fluorouracil and leucovorin or levamisole was given intravenously during the first and last week of radiotherapy,and then monthly for about 6 *** of IL-24 and VEGF was evaluated by immunohistochemical staining of surgical specimens, and their relations with patient characteristics and survival were *** median follow-up of surviving patients was 73 mo(range:52-122 mo). RESULTS:IL-24 expression was found in 81 out of 90 patients;31 showed weak intensity and 50 showedstrong *** expression was found in 64 out of 90 *** and weak intensities of IL-24 expression were classified as negative expression for ***-24 expression was significantly reduced in poorly differentiated tumors in comparison with well or moderately differentiated tumors(P=0.004),N2b to earlier N stages(P=0.016),and stageⅢc to stageⅢ a orⅢb(P=0.028).The number of involved lymph nodes was also significantly reduced in IL-24-positive patients in comparison with IL-24-negative ones. There was no correlation between VEGF expression and patient *** of IL-24 and VEGF was not correlated with survival,but N stage and stages were significantly correlated with survival. CONCLUSION:IL-24 expression was significantly correlated with histological differentiation,and inversely correlated with the degree of lymph node involvement in stageⅢrectal cancer.

关键词： Interleukin-24 Rectal cancer Lymph node Histological differentiation Vascular endothelial growth factor

Successful treatment of multiple hepatocellular adenomas with percutaneous radiofrequency ablation

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World Journal of Gastroenterology 2013年第42期19卷 7480-7486页

作者： Sun young ahn Soo young Park young Oh Kweon Won young Tak Han Ik Bae Seung Hyun Cho Department of Internal Medicine Kyungpook National University HospitalDaegu 700-721South Korea Department of Pathology Kyungpook National University HospitalDaegu 700-721South Korea Department of Radiology Kyungpook National University HospitalDaegu 700-721South Korea

Hepatocellular adenoma (HCA) is one of the important complications of glycogen storage disease type?Ia (GSD-Ia) because it can be transformed into hepatocellular carcinoma. Although surgical resection is a standard treatment of choice for solitary HCA, multiple HCAs in GSD-Ia patients present as therapeutic challenges for curative treatment. Therefore, treatment strategy according to malignant potential is important in management of HCAs in GSD-Ia. The authors present a case of histologically proven multiple HCAs without β-catenin mutations occurred in a GSD-Ia patient treated successfully with percutaneous radiofrequency ablation as a minimally invasive therapy.

关键词： Glycogen storage disease Hepatocellular adenoma Radiofrequency ablation β-catenin activation Glycogen storage disease

AdS/Deep-Learning made easy:simple examples

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Chinese Physics C 2021年第7期45卷 132-141页

作者： Mugeon Song Maverick S.H.Oh Yongjun ahn Keun-young Kima Gwangju Institute of Science and Technology(GIST) Department of Physics and Photon ScienceGwangjuSouth Korea University of California–Merced Department of PhysicsMercedCAUSA

Deep learning has been widely and actively used in various research ***,in gauge/gravity duality,a new deep learning technique called AdS/DL(Deep Learning)has been *** goal of this paper is to explain the essence of AdS/DL in the simplest possible setups,without resorting to knowledge of gauge/gravity *** perspective will be useful for various physics problems:from the emergent spacetime as a neural network to classical mechanics *** prototypical examples,we choose simple classical mechanics *** method is slightly different from standard deep learning techniques in the sense that we not only have the right final answers but also obtain physical understanding of learning parameters.

关键词： gauge/gravity duality holographic principle machine learning

Stereotactic body radiotherapy for oligo-recurrence within the nodal area from colorectal cancer

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World Journal of Gastroenterology 2014年第8期20卷 2005-2013页

作者： young Seok Seo Mi-sook Kim Hyung-Jun Yoo Won-Il Jang Department of Radiation Oncology Korea Cancer Center HospitalKorea Institute of Radiological and Medical SciencesSeoul 139-706South Korea

Recurrence of colorectal cancer(CRC)often presents as solitary metastases,oligometastases or *** resection became the preferred treatment for patients with CRC lung and hepatic ***,surgical treatment for oligo-recurrence within nodal area is not a widely accepted treatment due to due to their relative rarity and high postoperative *** body radiotherapy(SBRT)is one of the emerging radiation treatment techniques in which a high radiation dose can be delivered to the ***-dose SBRT can ablate the tumor with an efficacy similar to that achieved with surgery,especially for small ***,there have been very few studies on SBRT for oligo-recurrence within nodal area,although several studies have evaluated the role of SBRT in the treatment of liver and lung metastases from *** article reviews the current clinical status of and treatment methods for oligo-recurrence within nodal area from CRC,with particular emphasis on SBRT.

关键词： Colorectal cancer Oligo-recurrence Oligometastases Stereotactic radiotherapy Lymph node