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Advancements in hemostatic strategies for managing upper gastrointestinal bleeding: A comprehensive review

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World Journal of Gastroenterology 2024年第15期30卷 2087-2090页

作者： Ah young lee Joo young Cho Division of Gastroenterology Department of Internal MedicineCha Gangnam Medical CenterCha University College of MedicineSeoul 06135Korea

Upper gastrointestinal(GI)hemorrhage presents a substantial clinical *** management typically involves resuscitation and endoscopy within 24 h,although the benefit of very early endoscopy(leeding,preventing rebleeding,and using a multimodal approach encompassing endoscopic,pharmacological,angiographic,and surgical *** agents such as vasopressin,prostaglandins,and proton pump inhibitors are effective,but the increase in antithrombotic use has increased GI bleeding *** hemostasis,particularly for nonvariceal bleeding,employs techniques such as electrocoagu-lation and heater probes,with concerns over tissue injury from monopolar *** methods such as Hemospray and Endoclot show promise in creating mechanical tamponades but have ***,the first-line therapy includes thermal probes and hemoclips,with over-the-scope clips emerging for larger ulcer *** gold probe,combining bipolar electrocoagulation and injection,offers targeted coagulation but has faced device-related *** advancements involve combining techniques and improving endoscopic imaging,with studies exploring combined approaches showing *** research is crucial for developing standardized and effective hemorrhage management strategies.

关键词： Upper gastrointestinal bleeding Hemostasis Endoscopy Probe Spray Clip

Cloning,expression in Escherichia coli,and enzymatic properties of laccase from Aeromonas hydrophila WL-11

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Journal of Environmental Sciences 2010年第4期22卷 635-640页

作者： Jing Wu Kyoung-Sook Kim Jai-Heon lee young-Choon lee Department of Biotechnology Dong-A University Busan 604-714 South Korea. Brain Korea 21 Center for Silver-Bio Industrialization Dong-A University Busan 604-714 South Korea

A strain WL-11 with high laccase activity was isolated from activated sludge collected from the effluent treatment plant of a textile and dyeing industry. It was identified as Aeromonas hydrophila by physiological test and 16S rDNA sequence analysis. A gene encoding of laccase from a newly isolated Aeromonas hydrophila WL-11 was cloned and characterized. Nucleotide sequence analysis showed an open reading frame of 1605 bp encoding a polypeptide comprised of 534 amino acids. The primary structure of the enzyme predicted the structural features characteristic of other laccases, including the conserved regions of four histidine-rich copper-binding sites. The predicted amino acid sequence showed a high homology （more than 60%） with bacterial laccases in the genome and protein databases and the highest degree of similarity （61% identity） was observed with the multicopper oxidase of KlebsieUa sp. 601. When expressed in Escherichia coli, the recombinant enzyme was overproduced in the cytoplasm as soluble and active form. The purified enzyme had an optimum pH of 2.6 and 8.0 for ABTS （2,2＇-azino-bis（3-ethylbenzthiazolinesulfonic acid） and DMP （2,6-dimethoxyphenol）, respectively. The kinetic study on ABTS revealed a higher affinity of this enzyme to this substrate than DMP.

关键词： cloning expression enzymatic properties laccase Aeromonas hydrophila

Epidemic obesity in children and adolescents:risk factors and prevention

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Frontiers of Medicine 2018年第6期12卷 658-666页

作者： Eun young lee Kun-Ho Yoon Division of Endocrinology and Metabolism Department of Internal MedicineSeoul St.Mary's HospitalCollege of MedicineThe Catholic University of KoreaSeoul 06591Korea Institute of Catholic Ubiquitous Health Care The Catholic University of KoreaSeoul 06591Korea

The prevalence of obesity among children and adolescents (aged 2–18 years) has increased rapidly, with more than 100 million affected in 2015. Moreover, the epidemic of obesity in this population has been an important public health problem in developed and developing countries for the following reasons. Childhood and adolescent obesity tracks adulthood obesity and has been implicated in many chronic diseases, including type 2 diabetes, hypertension, and cardiovascular disease. Furthermore, childhood and adolescent obesity is linked to adulthood mortality and premature death. Although an imbalance between caloric intake and physical activity is a principal cause of childhood and adolescent obesity, environmental factors are exclusively important for development of obesity among children and adolescents. In addition to genetic and biological factors, socioenvironmental factors, including family, school, community, and national policies, can play a crucial role. The complexity of risk factors for developing obesity among children and adolescents leads to difficulty in treatment for this population. Many interventional trials for childhood and adolescent obesity have been proven ineffective. Therefore, early identification and prevention is the key to control the global epidemic of obesity. Given that the proportion of overweight children and adolescents is far greater than that of obesity, an effective prevention strategy is to focus on overweight youth, who are at high risk for developing obesity. Multifaceted, comprehensive strategies involving behavioral, psychological, and environmental risk factors must also be developed to prevent obesity among children and adolescents.

关键词： obesity children adolescents epidemiology risk factor prevention

Risk factors affecting pancreatic fistulas after pancreaticoduodenectomy

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World Journal of Gastroenterology 2008年第45期14卷 6970-6974页

作者： Yun-Mee Choe Keon-young lee Cheong-Ah Oh Joung-Bum lee Sun Keun Choi Yoon-Seok Hur Sei-Joong Kim young Up Cho Seung-ik Ahn Kee-Chun Hong Seok-Hwan Shin Kyung-Rae Kim Department of Surgery Inha University Hospital

AIM: To analyze the risk factors of pancreatic leakage after ***: We retrospectively reviewed 172 consecutive patients who had undergone pancreatico-duodenectomy at Inha University Hospital between April 1996 and March 2006. We analyzed the pancreatic fistula rate according to the clinical characteristics, the pathologic and laboratory findings, and the anastomotic ***: The incidence of developing pancreatic fistulas in patients older than 60 years of age was 21.7% (25/115), while the incidence was 8.8% (5/57) for younger patients; the difference was significant (P = 0.03). Patients with a dilated pancreatic duct had a lower rate of post-operative pancreatic fistulas than patients with a non-dilated duct (P = 0.001). Other factors, including clinical features, anastomotic methods, and pathologic diagnosis, did not show any statistical difference. CONCLUSION: Our study demonstrated that pancreatic fistulas are related to age and a dilated pancreatic duct. The surgeon must take these risk factors into consideration when performing a pancre-aticoduodenectomy.

关键词： Pancreaticoduodenectomy Pancreatic fistula Pancreatic leakage

The Influx of the Tsushima Current into the Central Ulleung Basin of East Sea (Sea of Japan), Korea

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Acta Geologica Sinica(English Edition) 2014年第6期88卷 1846-1851页

作者： young-Suk BAK Seong-Joo lee The Earth and Environmental System Research Center Chonbuk National University Department of Geology Kyungpook National University

A total of 85 samples, collected from the UBGH1-9 core taken from the Ulleung Basin, East Sea, Korea, were analyzed using diatom assemblages. 111 diatom species belonging to 46 genera were identified, and three diatom assemblage zones were established on the basis of occurrence and distribution pattern of diatoms. Diatom assemblage zone I（134.10–174 m） is characterized by a relatively high abundance of marine species, while the increased number of the brackish species is recorded in diatom assemblage zone II（75–125 m）. The assemblage zones IIIa became drastic drop of valve abundances and brackish planktons, whereas it became increase during the IIIb. High Td values which indicate an influence of warm current are recorded both in diatom assemblage zone I and III, and low Td values in diatom assemblage zone II. Analysis of diatom assemblages indicating that the depositional condition moved from oceanic to littoral-neritic environments and that paleotemperature underwent a shift from warm to cold condition at the middle interval, and from cold to warm condition in the upper interval of the UBGH1-9 core. This suggests that the lower（130–162 m） and upper intervals（0–20 m） of the UBGH1-9 core were deposited in the warm current condition（Tsushima Warm Current）.

关键词： assemblage depositional littoral drastic genera abundance oceanic Korea valve preservation

Electrochemically Deposited CZTSSe Thin Films for Monolithic Perovskite Tandem Solar Cells with Efficiencies Over 17%

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Energy & Environmental Materials 2024年第1期7卷 147-152页

作者： Sun Kyung Hwang ik Jae Park Se Won Seo Jae Hyun Park So Jeong Park Jin young Kim Department of Materials Science and Engineering Seoul National UniversitySeoul 08826Korea Department of Applied Physics Sookmyung Women's UniversitySeoul 04310Korea Research Institute of Advanced Materials and Systems Sookmyung Women's UniversitySeoul 04310Korea Research Institute of Advanced Materials(RIAM) Seoul National UniversitySeoul 08826Korea

In spite of the high potential economic feasibility of the tandem solar cells consisting of the halide perovskite and the kesterite Cu2ZnSn(S,Se)4(CZTSSe),they have rarely been demonstrated due to the difficulty in implementing solution-processed perovskite top cell on the rough surface of the bottom ***,we firstly demonstrate an efficient monolithic two-terminal perovskite/CZTSSe tandem solar cell by significantly reducing the surface roughness of the electrochemically deposited CZTSSe bottom *** surface roughness(R_(rms))of the CZTSSe thin film could be reduced from 424 to 86 nm by using the potentiostatic mode rather than using the conventional galvanostatic mode,which can be further reduced to 22 nm after the subsequent ion-milling *** perovskite top cell with a bandgap of 1.65 eV could be prepared using a solution process on the flattened CZTSSe bottom cell,resulting in the efficient perovskite/CZTSSe tandem solar *** the current matching between two subcells involving the thickness control of the perovskite layer,the best performing tandem device exhibited a high conversion efficiency of 17.5%without the hysteresis effect.

关键词： CZTSSe monolithic tandem solar cells perovskite solution process surface roughness control

Estimation of Turbulent Sensible Heat and Momentum Fluxes over a Heterogeneous Urban Area Using a Large Aperture Scintillometer

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Advances in Atmospheric Sciences 2015年第8期32卷 1092-1105页

作者： Sang-Hyun lee Jun-Ho lee Bo-young KIM Department of Atmospheric Science Kongju National University Department of Optical Engineering Kongju National University

The accurate determination of surface-layer turbulent fluxes over urban areas is critical to understanding urban boundary layer （UBL） evolution. In this study, a remote-sensing technique using a large aperture scintillometer （LAS） was investigated to estimate surface-layer turbulent fluxes over a highly heterogeneous urban area. The LAS system, with an optical path length of 2.1 km, was deployed in an urban area characterized by a complicated land-use mix （residential houses, water body, bare ground, etc.）. The turbulent sensible heat （QH） and momentum fluxes （z） were estimated from the scintillation measurements obtained from the LAS system during the cold season. Three-dimensional LAS footprint modeling was introduced to identify the source areas （＂footprint＂） of the estimated turbulent fluxes. The analysis results showed that the LAS-derived turbulent fluxes for the highly heterogeneous urban area revealed reasonable temporal variation during daytime on clear days, in comparison to the land-surface process-resolving numerical modeling. A series of sensitivity tests indicated that the overall uncertainty in the LAS-derived daytime QH was within 20%-30% in terms of the influence of input parameters and the non- dimensional similarity function for the temperature structure function parameter, while the estimation errors in z were less sensitive to the factors of influence, except aerodynamic roughness length. The 3D LAS footprint modeling characterized the source areas of the LAS-derived turbulent fluxes in the heterogeneous urban area, revealing that the representative spatial scales of the LAS system deployed with the 2.1 km optical path distance ranged from 0.2 to 2 km2 （a ＂micro-a scale＂）, depending on local meteorological conditions.

关键词： heterogeneous surface large aperture scintillometer mesoscale modeling surface energy balance turbulentexchange

Efficient photovoltaic effect in graphene/h-BN/silicon heterostructure self-powered photodetector

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Nano Research 2021年第6期14卷 1967-1972页

作者： Ui Yeon Won Boo Heung lee young Rae Kim Won Tae Kang Ilmin lee Ji Eun Kim young Hee lee Woo Jong Yu Department of Electrical and Computer Engineering Sungkyunkwan UniversitySuwon16419Republic of Korea Center for Integrated Nanostructure Physics Institute for Basic Science(IBS)Suwon16419Republic of Korea

Graphene(Gr)/Si-based optoelectronic devices have attracted a lot of academic attention due to the simpler fabrication processes,low costs,and higher performance of their two-dimensional(2D)/three-dimensional(3D)hybrid interfaces in Schottky junction that promotes electron-hole ***,due to the built-in potential of Gr/Si as a photodetector,the Iph/Idark ratio is often hindered near zero-bias at relatively low illumination *** is a major drawback in self-powered *** this study,we have demonstrated a self-powered van der Waals heterostructure photodetector in the visible range using a Gr/hexagonal boron nitride(h-BN)/Si structure and clarified that the thin h-BN insertion can engineer asymmetric carrier transport and avoid interlayer coupling at the *** dark current was able to be suppressed by inserting an h-BN insulator layer,while maintaining the photocurrent with minimal decrease at near *** a result,the normalized photocurrent-to-dark ratio(NPDR)is improved more than 104 ***,both Iph/Idark ratio and detectivity,increase by more than 104 times at−0.03 V drain *** proposed Gr/h-BN/Si heterostructure is able to contribute to the introduction of next-generation photodetectors and photovoltaic devices based on graphene or silicon.

关键词： graphene hexagonal boron nitride van der Waals heterostructure self-powered Research

Therapeutic strategy targeting host lipolysis limits infection by SARS-CoV-2 and influenza A virus

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Signal Transduction and Targeted Therapy 2022年第11期7卷 4223-4234页

作者： Yeong-Bin Baek Hyung-Jun Kwon Muhammad Sharif Jeongah Lim In-Chul lee young Bae Ryu Jae-In lee Ji-Sun Kim young-Seung lee Dong-Hoon Kim Sang-ik Park Don-Kyu Kim Jeong-Sun Kim Hyon EChoy Sunwoo lee Hueng-Sik Choi Timothy FOsborne Tae-Il Jeon Kyoung-Oh Cho Laboratory of Veterinary Pathology College of Veterinary MedicineChonnam National UniversityGwangju61186Republic of Korea Functional Biomaterial Research Center Korea Research Institute of Bioscience&BiotechnologyJeongeup-siJeollabuk-do56212Republic of Korea Department of Chemistry Chonnam National UniversityGwangju61186Republic of Korea Korean Collection for Type Cultures Korea Research Institute of Bioscience&BiotechnologyJeongeup-siJeollabuk-do56212Republic of Korea Department of Animal Science Chonnam National UniversityGwangju61186Republic of Korea Department of Pharmacology Korea University College of MedicineSeoul02841Republic of Korea Department of Integrative Food Bioscience and BiotechnologyChonnam National UniversityGwangju61186Republic of Korea Department of Microbiology Chonnam National University Medical SchoolGwangju61486Republic of Korea School of Biological Sciences and Technology Chonnam National UniversityGwangju61186Republic of Korea Institute for Fundamental Biomedical Research Department of Medicine and Biological ChemistryJohns Hopkins University School of MedicineSt.PetersburgFL33701USA

The biosynthesis of host lipids and/or lipid droplets(LDs)has been studied extensively as a putative therapeutic target in diverse viral ***,directly targeting the LD lipolytic catabolism in virus-infected cells has not been widely ***,we show the linkage of the LD-associated lipase activation to the breakdown of LDs for the generation of free fatty acids(FFAs)at the late stage of diverse RNA viral infections,which represents a broad-spectrum antiviral *** of membrane transporter systems due to virus-induced cell injury results in intracellular malnutrition at the late stage of infection,thereby making the virus more dependent on the FFAs generated from LD storage for viral morphogenesis and as a source of *** replication of SARS-CoV-2 and influenza A virus(IAV),which is suppressed by the treatment with LD-associated lipases inhibitors,is rescued by supplementation with *** administration of lipase inhibitors,either individually or in a combination with virus-targeting drugs,protects mice from lethal IAV infection and mitigates severe lung lesions in SARS-CoV-2-infected ***,the lipase inhibitors significantly reduce proinflammatory cytokine levels in the lungs of SARS-CoV-2-and IAV-challenged animals,a cause of a cytokine storm important for the critical infection or mortality of COVID-19 and IAV *** conclusion,the results reveal that lipase-mediated intracellular LD lipolysis is commonly exploited to facilitate RNA virus replication and furthermore suggest that pharmacological inhibitors of LD-associated lipases could be used to curb current COVID-19-and future pandemic outbreaks of potentially troublesome RNA virus infection in humans.

关键词： linkage furthermore thereby