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Improvement of diabetes and hypertension after gastrectomy: A nationwide cohort study

World Journal of Gastroenterology 2015年第4期21卷 1173-1181页

作者： Eun Kyung Lee So young Kim You Jin Lee Mi Hyang Kwak Hak Jin Kim Il Ju choi Soo-Jeong Cho young Woo Kim Jong Yeul Lee Chan Gyoo Kim Hong Man Yoon Bang Wool Eom Sun-young Kong Min Kyong Yoo Jong Hyock Park Keun Won Ryu Department of Internal Medicine National Cancer CenterGoyang 410-769South Korea College of Medicine/Graduate School of Health Science Business ConvergenceChungbuk National UniversityCheongju 361-763South Korea Department of Surgery National Cancer CenterGoyang 410-769South Korea Department of Laboratory Medicine National Cancer CenterGoyang 410-769South Korea Department of Clinical Nutrition National Cancer CenterGoyang 410-769South Korea

AIM: To evaluate the effect of gastrectomy on diabetes mellitus(DM) and hypertension(HTN) in non-obese gastric cancer patients. METHODS: A total of 100000 patients, diagnosed with either type 2 DM or HTN, were randomly selected from the 2004 Korean National Health Insurance System claims. Among them, 360 diabetes and 351 hypertensive patients with gastric cancer who had been regularly treated without chemotherapy from January 2005 to December 2010 were selected. They were divided into three groups according to their treatment methods: total gastrectomy(TG), subtotal gastrectomy(STG) and endoscopic resection(ER). RESULTS: The drug discontinuation rate of antidiabetic and anti-hypertensive agents after gastric cancer treatment was 9.7% and 11.1% respectively. DM appeared to be improved more frequently(22.8%) and earlier(mean ± SE 28.6 ± 1.8 mo) in TG group than in the two other groups [improved in 9.5% of ER group(37.4 ± 1.1 mo) and 6.4% of STG group(47.0 ± 0.8 mo)]. The proportion of patients treated with multiple drugs decreased more notably in TG group compared to others(P = 0.001 in DM, and P = 0.035 in HTN). In TG group, adjusted hazard ratio for theimprovement of DM was 2.87(95%CI: 1.15-7.17) in a multi-variate analysis and better control of DM was observed with survival analysis(P < 0.001).CONCLUSION: TG was found to decrease the need for anti-diabetic medications which can be reflective of improved glycemic control, to a greater extent than either ER or STG in non-obese diabetic patients.

关键词： Diabetes Hypertension Gastrectomy Gastric cancer N

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喷墨印刷／软光刻技术结合气相聚合法制备聚3，4-乙撑二氧噻吩图像

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中国印刷与包装研究 2010年第4期2卷 99-100页

作者： Jong Seob choi Kuk young Cho Jin-Heong Yim 孟维华(编译) Division of Advanced Materials Engineering Kongju National University 182 Sinkwan-dong Gongju City Chungnam 314- 701 Republic of Korea 不详

采用气相聚合,以咪唑衍生物为辅助料可以成功制备高导电透明的聚3,4-乙撑二氧噻吩(PEDOT)薄膜。带有1～2个烷基官能团的咪唑衍生物的加入可以显著提高PEDOT的电导率。为了研制一种易于实现的PEDOT成像法,本文采用了喷墨印刷或软光刻技... 详细信息

采用气相聚合,以咪唑衍生物为辅助料可以成功制备高导电透明的聚3,4-乙撑二氧噻吩(PEDOT)薄膜。带有1～2个烷基官能团的咪唑衍生物的加入可以显著提高PEDOT的电导率。为了研制一种易于实现的PEDOT成像法,本文采用了喷墨印刷或软光刻技术结合气相聚合法,并以带取代基的对甲苯磺酸铁为氧化剂,3,4-乙撑二氧噻吩为聚合单体来制备PEDOT图像。这种新型方法的实现将为制得本征导电高分子材料图像提供一个高效便捷的方法。

关键词：咪唑衍生物喷墨印刷聚3,4-乙撑二氧噻吩软光刻技术气相聚合

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Shape Estimation of Soft Manipulator Using Stretchable Sensor

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Cyborg and Bionic Systems 2021年第1期2021卷 159-168页

作者： Jinho So Uikyum Kim Yong Bum Kim Dong-Yeop Seok Sang Yul Yang Kihyeon Kim Jae Hyeong Park Seong Tak Hwang young Jin Gong Hyouk Ryeol choi Mechatronics R&D Center Samsung ElectronicsRepublic of Korea Korea Institute of Machinery&Materials DaejeonRepublic of Korea AIDIN ROBOTICS Inc. SuwonRepublic of Korea School of Mechanical Engineering Sungkyunkwan UniversityRepublic of Korea

The soft robot manipulator is attracting attention in the surgical fields with its intrinsic softness,lightness in its weight,and safety toward the human ***,it cannot be used widely because of its difficulty of *** control a soft robot manipulator accurately,shape sensing is *** paper presents a method of estimating the shape of a soft robot manipulator by using a skin-type stretchable sensor composed of a multiwalled carbon nanotube(MWCNT)and silicone(p7670).The sensor can be easily fabricated and applied by simply attaching it to the surface of the soft *** its fabrication,MWCNT is sprayed on a teflon sheet,and liquid-state silicone is poured on *** curing,we turn it over and cover it with another silicone *** sensor is fabricated with a sandwich structure to decrease the hysteresis of the *** calibration and determining the relationship between the resistance of the sensor and the strain,three sensors are attached at 120°*** the obtained data,the curvature of the manipulator is calculated,and the entire shape is *** validate its accuracy,the estimated shape is compared with the camera *** experiment with three,six,and nine sensors attached,and the result of the error of shape estimation is *** a result,the minimum tip position error is approximately 8.9 mm,which corresponded to 4.45%of the total length of the manipulator when using nine sensors.

关键词： robot attached attracting

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Inhibition of pacemaker activity in interstitial cells of Cajal by LPS via NF-κB and MAP kinase

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World Journal of Gastroenterology 2013年第8期19卷 1210-1218页

作者： Dong Chuan Zuo Seok choi Pawan Kumar Shahi Man Yoo Kim Chan Guk Park young Dae Kim Jun Lee In Yeoup Chang Insuk So Jae Yeoul Jun Department of Physiology College of MedicineChosun UniversityGwangju 501-759South Korea Department of Internal Medicine College of MedicineChosun UniversityGwangju 501-759South Korea Department of Anatomy College of MedicineChosun UniversityGwangju 501-759South Korea Department of Physiology and Biophysics College of MedicineSeoul National UniversitySeoul 56-1South Korea

AIM:To investigate lipopolysaccharide(LPS) related signal transduction in interstitial cells of Cajal(ICCs) from mouse small ***:For this study,primary culture of ICCs was prepared from the small intestine of the *** was treated to the cells prior to measurement of the membrane currents by using whole-cell patch clamp *** was used to examine the expression of the proteins in ***:LPS suppressed the pacemaker currents of ICCs and this could be blocked by AH6809,a prostaglandin E2-EP2 receptor antagonist or NG-Nitro-Larginine Methyl Ester,an inhibitor of nitric oxide(NO) ***-like receptor 4,inducible NO synthase or cyclooxygenase-2 immunoreactivity by specific antibodies was detected on ***(antioxidant agent) had no action on LPS-induced action in *** actions were blocked by nuclear factor kB(NF-kB) inhibitor,actinomycin D(a gene transcription inhibitor),PD 98059(a p42/44 mitogen-activated protein kinases inhibitor) or SB 203580 [a p38 mitogen-activated protein kinases(MAPK) inhibitor].SB 203580 also blocked the prostaglandin E2-induced action on pacemaker currents in ICCs but not ***:LPS inhibit the pacemaker currents in ICCs via prostaglandin E2-and NO-dependent mechanism through toll-like receptor 4 and suggest that MAPK and NF-kB are implicated in these actions.

关键词： Interstitial cells of Cajal Lipopolysaccharide Mitogen-activated protein kinases Nuclear factor kB Small intestine

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Si-On-ONO（SOONO） Devices Realized on Bulk Si Wafers for Fully-Depleted SOI Transistor and 4-Bit Flash Memory Applications

Si-On-ONO（SOONO） Devices Realized on Bulk Si Wafers for Fu...

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2006 8th International Conference on Solid-State and Integrated Circuit Technology

作者： Chang Woo Oh Sung Hwan Kim Yong Lack choi Na young Kim Sung In Hong Hyun Jun Bae Dong-Won Kim Donggun Park Device Research Team R＆D CenterSamsung Electronics Co.San 24Nongseo-DongKiheung-EupYongin-CityKyungki-DoKOREA449-711

ISBN: (纸本)1424401607

＜正＞We proposed and successfully demonstrated Si-on-ONO（SOONO） devices *** depleted SOI transistor and 4 bit flash memory *** terms of HP transistor,SOONO MOSFETs showed good SCE immunity and high driving *** terms of a 4-bit flash memory,SOONO MOSFETs with ONO layers as their gate dielectrics showed clear 4-bit operation using the physically separated 4 storage nodes of double ONO layers.

关键词： 4-bit flash memories Gate dielectrics Transistor Device Component silicon-on-insulator styrene oxide isomerase Wafer Dosage Form Wafers

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Butein effects in colitis and interleukin-6/signal transducer and activator of transcription 3 expression

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World Journal of Gastroenterology 2015年第2期21卷 465-474页

作者： Sehe Dong Lee Jung Wan Choe Beom Jae Lee Myoung Hee Kang Moon Kyung Joo Ji hoon Kim Jong Eun Yeon Jong-Jae Park Jae Seon Kim young-Tae Bak Division of Gastroenterology Department of Internal MedicineKorea University Medical CenterSeoul 152-703South Korea

AIM: To evaluate the effects of butein on inflammatory cytokines, matrix metalloproteinase-9(MMP-9), andcolitis in interleukin(IL)-10-/- ***: To synchronize colitis, 8- to 10-wk-old IL-10-/- mice were fed pellet-chow containing piroxicam for 2 wk. Subsequently, phosphate-buffered saline or butein(1 mg/kg per day, ip) was injected for 4 wk. Histologic scores, inflammatory cytokines, MMP-9 and phosphorylated signal transducer and activator of transcription 3(p STAT3) expressions were analyzed in IL-10-/- mice and in Colo 205 ***: Butein reduced the colonic inflammatory score by > 50%. Expression levels of IL-6, IL-1β, interferon(IFN)-γ and MMP-9 were decreased in the colons of mice exposed to butein, whereas other inflammatory cytokines(IL-17 A, IL-21 and IL-22) were unchanged. Immunohistochemical staining for p STAT3 and MMP-9 was significantly decreased in the buteintreated groups compared with the controls. Butein inhibited IL-6-induced activation of STAT3 in Colo 205 ***: Butein ameliorated colitis in IL-10-/-mice by regulating IL-6/STAT3 and MMP-9 activation.

关键词： Butein Interleukin-6/signal transducer and activat

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A Study on Emotional Design for Vitamin C Dietary Supplements(Chinese Market,Generation Z Consumers)

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Psychology Research 2023年第11期13卷 527-536页

作者： Suimeng Qin Albert young choi Hanyang University ERICA AnsanSouth Korea

China,recognized as the world’s largest developing nation,displays considerably lower per capita consumption of dietary supplements in comparison to Asian nations such as Japan and South ***,in recent years,there has been a substantial surge in health consciousness among the Chinese *** trend is not confined to the middle-aged and elderly;even younger consumer demographics are exhibiting increased health ***,the target demographic for dietary supplements is transitioning towards a younger *** the Chinese dietary supplement industry,vitamin C has consistently held the largest market share,commanding a broad consumer *** underscores the substantial role of vitamin C in the dietary supplement *** response to the trend towards a younger target demographic in the dietary supplement industry,adjustments are required to accommodate the preferences of this younger consumer *** research,guided by Norman’s emotional design framework,executed a survey of over 200 respondents to investigate the preferences of Generation Z consumers in *** research encompassed packaging,product forms,and brand imagery,corresponding to the emotional design’s visceral,behavioral,and reflective layers,with a primary focus on optimally meeting the emotional needs of Generation *** findings indicated that consumers favor products in capsule form,packaged in *** predominant color scheme is clean white,accented by vibrant orange elements,while emphasizing the product’s health and scientific *** study offers valuable insights for the continued evolution of the vitamin C dietary supplement market in China.

关键词： Generation Z consumers vitamin C products emotional design

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Endoscopic papillary balloon dilation:Revival of the old technique

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World Journal of Gastroenterology 2013年第45期19卷 8258-8268页

作者： Seung Uk Jeong Sung-hoon Moon Myung-Hwan Kim Department of Internal Medicine Jeju National University School of Medicine Jeju 690-767 South Korea Department of Internal Medicine Hallym University Sacred Heart Hospital Hallym University College of Medicine Anyang 431-070 South Korea Department of Gastroenterology Asan Medical Center University of Ulsan College of Medicine Seoul 138-736 South Korea

Radiologists first described the removal of bile duct stones using balloon dilation in the early ***,there has been renewed interest in endoscopic balloon dilation with a small balloon to avoid the complications of endoscopic sphincterotomy(EST)in young patients undergoing laparoscopic ***,there is a disparity in using endoscopic balloon papillary dilation(EPBD)between the East and the West,depending on the origin of the *** the early 2000s,EST followed by endoscopic balloon dilation with a large balloon was introduced to treat large or difficult biliary *** balloon dilation with a large balloon has generally been recognized as an effective and safe method,unlike ***,fatal complications have occurred in patients with endoscopic papillary large balloon dilation(EPLBD).The safety of endoscopic balloon dilation is still a debatable ***,guidelines of indications and techniques have not been established in performing endoscopic balloon dilation with a small balloon or a large *** this article,we discuss the issue of conventional and large balloon endoscopic *** also suggest the indications and optimal techniques of EPBD and EPLBD.

关键词： Endoscopic papillary balloon dilation Endoscopic papillary large balloon dilation Common bile duct stone Endoscopic sphincterotomy Mechanical lithotripsy

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Prognostic value of inflammation-based markers in patients with pancreatic cancer administered gemcitabine and erlotinib

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World Journal of Gastrointestinal Oncology 2016年第7期8卷 555-562页

作者： Jae Min Lee Hong Sik Lee Jong Jin Hyun Hyuk Soon choi Eun Sun Kim Bora Keum Yeon Seok Seo Yoon Tae Jeen hoon Jai Chun Soon Ho Um Chang Duck Kim Division of Gastroenterology and Hepatology Department of Internal Medicine Korea University College of Medicine

AIM: To evaluate the value of systemic inflammationbased markers as prognostic factors for advanced pancreatic cancer(PC). METHODS: Data from 82 patients who underwent combination chemotherapy with gemcitabine and erlotinib for PC from 2011 to 2014 were collected retrospectively. Data that included the neutrophil-to-lymphocyte ratio(NLR), the platelet-to-lymphocyte ratio, and the C-reactive protein(CRP)-to-albumin(CRP/Alb) ratio were analyzed. Kaplan-Meier curves, and univariate and multivariate Cox proportional hazards regression analyses were used to identify the prognostic factors associated with progression-free survival(PFS) and overall survival(OS). RESULTS: The univariate analysis demonstrated the prognostic value of the NLR(P = 0.049) and the CRP/Alb ratio(P = 0.047) in relation to PFS, and a positiverelationship between an increase in inflammation-based markers and a poor prognosis in relation to OS. The multivariate analysis determined that an increased NLR(hazard ratio = 2.76, 95%CI: 1.33-5.75, P = 0.007) is an independent prognostic factor for poor OS. There was no association between the PLR and the patients' prognoses in those who had received chemotherapy that comprised gemcitabine and erlotinib in combination. The Kaplan-Meier method and the log-rank test determined significantly worse outcomes in relation to PFS and OS in patients with an NLR > 5 or a CRP/Alb ratio > ***: Systemic inflammation-based markers, including increases in the NLR and the CRP/Alb ratio, may be useful for predicting PC prognoses.

关键词： Pancreatic cancer Neutrophil-to-lymphocyte ratio C-reactive protein Albumin Prognostic factor

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Absolute monocyte and lymphocyte count prognostic score for patients with gastric cancer

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World Journal of Gastroenterology 2015年第9期21卷 2668-2676页

作者： Wan Kyu Eo Da Wun Jeong Hye Jung Chang Kyu Yeoun Won Sung Il choi Se Hyun Kim Sung Wook Chun young Lim Oh Tae Hwa Lee young Ok Kim Ki Hyung Kim Yong Il Ji Ari Kim Heung Yeol Kim Department of Hematology/Medical Oncology Kyung Hee University Hospital at GangdongSeoul 134727South Korea Department of Pathology Kyung Hee University Hospital at GangdongSeoul 134727South Korea Department of Surgery Kyung Hee University Hospital at GangdongSeoul 134727South Korea Graduate School Dankuk UniversityYongin 448701South Korea Department of Obstetrics and Gynecology Inje University College of MedicineBusan 612896South Korea Department of Obstetrics and Gynecology Kosin University College of MedicineBusan 602702South Korea Department of Pathology Kosin University College of MedicineBusan 602702South Korea Department of Obstetrics and Gynecology Pusan National University HospitalPusan National University School of Medicineand Biomedical Research Institute and Pusan Cancer CenterBusan 602739South Korea Department of Obstetrics and Gynecology Institute of Wonkwang Medical ScienceCollege of MedicineWonkwang UniversityIksan 570749South Korea

AIM:To measure the prognostic significance of absolute monocyte count/absolute lymphocyte count prognostic score(AMLPS) in patients with gastric ***:We retrospectively examined the combination of absolute monocyte count(AMC) and absolute lymphocyte count(ALC) as prognostic variables in a cohort of 299 gastric cancer patients who underwent surgical resection between 2006 and 2013 and were followed at a single *** AMC and ALC were dichotomized into two groups using cut-off points determined by receiving operator characteristic curve *** AMLPS was generated,which stratified patients into three risk groups:low risk(both low AMC and high ALC),intermediate risk(either high AMC or low ALC),and high risk(both high AMC and low ALC).The primary objective of the study was to validate the impact of AMLPS on both disease-free survival(DFS) and overall survival(OS),and the second objective was to assess the AMLPS as an independent prognostic factor for survival in comparison with known prognostic ***:Using data from the entire cohort,the most discriminative cut-off values of AMC and ALC selected on the receiver operating characteristic curve were 672.4/μL and 1734/μL for DFS and *** risk groups included 158(52.8%) patients in the lowrisk,128(42.8%) in the intermediate-risk,and 13(4.3%) in the high-risk *** a median followup of 37.2 mo(range:1.7-91.4 mo),five-year DFS rates in the low-,intermediate-,and high-risk groups were 83.4%,78.7%,and 19.8%,*** fiveyear OS rates in the low-,intermediate-,and high-risk groups were 89.3%,81.1%,and 14.4%,*** multivariate analysis performed with patient- and tumor-related factors,we identified AMLPS,age,and pathologic tumor-node-metastasis stage as the most valuable prognostic factors impacting DFS and ***:AMLPS identified patients with a poor DFS and OS,and it was independent of age,pathologic stage,and various inflammatory markers.

关键词： Monocytes Absolute lymphocyte count Stomach neopla

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