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Inhibition of pacemaker activity in interstitial cells of Cajal by LPS via NF-κB and MAP kinase

Inhibition of pacemaker activity in interstitial cells of Cajal by LPS via NF-κB and MAP kinase

作     者:Dong Chuan Zuo Seok Choi Pawan Kumar Shahi Man Yoo Kim Chan Guk Park Young Dae Kim Jun Lee In Yeoup Chang Insuk So Jae Yeoul Jun 

作者机构:Department of PhysiologyCollege of MedicineChosun UniversityGwangju 501-759South Korea Department of Internal MedicineCollege of MedicineChosun UniversityGwangju 501-759South Korea Department of AnatomyCollege of MedicineChosun UniversityGwangju 501-759South Korea Department of Physiology and BiophysicsCollege of MedicineSeoul National UniversitySeoul 56-1South Korea 

出 版 物:《World Journal of Gastroenterology》 (世界胃肠病学杂志(英文版))

年 卷 期:2013年第19卷第8期

页      面:1210-1218页

核心收录:

学科分类:1001[医学-基础医学(可授医学、理学学位)] 100101[医学-人体解剖与组织胚胎学] 10[医学] 

基  金:Supported by Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education Science and Technology No.2012-0001335 

主  题:Interstitial cells of Cajal Lipopolysaccharide Mitogen-activated protein kinases Nuclear factor kB Small intestine 

摘      要:AIM:To investigate lipopolysaccharide(LPS) related signal transduction in interstitial cells of Cajal(ICCs) from mouse small ***:For this study,primary culture of ICCs was prepared from the small intestine of the *** was treated to the cells prior to measurement of the membrane currents by using whole-cell patch clamp *** was used to examine the expression of the proteins in ***:LPS suppressed the pacemaker currents of ICCs and this could be blocked by AH6809,a prostaglandin E2-EP2 receptor antagonist or NG-Nitro-Larginine Methyl Ester,an inhibitor of nitric oxide(NO) ***-like receptor 4,inducible NO synthase or cyclooxygenase-2 immunoreactivity by specific antibodies was detected on ***(antioxidant agent) had no action on LPS-induced action in *** actions were blocked by nuclear factor kB(NF-kB) inhibitor,actinomycin D(a gene transcription inhibitor),PD 98059(a p42/44 mitogen-activated protein kinases inhibitor) or SB 203580 [a p38 mitogen-activated protein kinases(MAPK) inhibitor].SB 203580 also blocked the prostaglandin E2-induced action on pacemaker currents in ICCs but not ***:LPS inhibit the pacemaker currents in ICCs via prostaglandin E2-and NO-dependent mechanism through toll-like receptor 4 and suggest that MAPK and NF-kB are implicated in these actions.

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