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Strengthening mechanisms analysis and tailoring of bimodal grain structures for enhanced strength in CoCrFeMnNi high-entropy alloys

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Rare Metals 2024年第8期43卷 3893-3903页

作者： Jaesoung Lee Seulgi Kim Taehyun Kwon young II Kim Suyeon Kim Sung Ho song bin Lee Dongju Lee Department of Urban Energyand Environmental Engineering Chungbuk National University Division of Advanced Materials Engineering Kongju National University Department of Advanced Materials Engineering for Information and Electronics Integrated-Education Institute for Frontier Science and Technology (BK21 Four)Kyung Hee University

The CoCrFeMnNi high-entropy alloys(HEAs)with a(face-centered cubic) FCC structure has garnered considerable attention for its exceptional ductility and strain hardening ***,its yield strength is insufficient for structural *** this study,strengthening mechanisms in these HEAs were investigated to gain insight into the mechanical properties according to alloy powder ***,we present a novel approach to achieve both high strength and high ductility through the creation of a bimodal structure consisting of both coarse and fine grains via gas atomization and spark plasma sintering processes.A bimodally structured HEA prepared with a mass ratio of 2:8 between coarse particles(75-106 μm) and fine particles(≤25 μm)yielded optimal results,with a strength of 491.95 MPa and elongation of 19.64%.This strength value represents an～41% increase compared with the sample that displayed a fine single microstructure(347.08 MPa for yield strength).The strength enhancement was attributed to the prevention of plastic deformation initiation from the fine particles during *** innovative approach to the creation of HEAs with bimodal structures shows promise for various applications,such as structural components that require a combination of high strength and high ductility.

关键词： High-entropy alloys CrCoFeMoNi Bimodal Gas atomization Mechanical properties

Cell fate regulation governed by p53: Friends or reversible foes in cancer therapy

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Cancer Communications 2024年第3期44卷 297-360页

作者： bin song Ping Yang Shuyu Zhang Laboratory of Radiation Medicine West China Second University HospitalSichuan UniversityChengduSichuanP.R.China The Second Affiliated Hospital of Chengdu Medical College China National Nuclear Corporation 416 HospitalChengduSichuanP.R.China Laboratory of Radiation Medicine NHC Key Laboratory of Nuclear Technology Medical TransformationWest China School of Basic Medical Sciences&Forensic MedicineSichuan UniversityChengduSichuanP.R.China

Cancer is a leading cause of death *** therapies aimed at key oncogenic driver mutations in combination with chemotherapy and radiother-apy as well as immunotherapy have benefited cancer patients *** protein p53(TP53),a crucial tumor suppressor gene encoding p53,reg-ulates numerous downstream genes and cellular phenotypes in response to various *** affected genes are involved in diverse processes,includ-ing cell cycle arrest,DNA repair,cellular senescence,metabolic homeostasis,apoptosis,and ***,accumulating recent studies have contin-ued to reveal novel and unexpected functions of p53 in governing the fate of tumors,for example,functions in ferroptosis,immunity,the tumor microenvi-ronment and microbiome *** the possibilities,the evolutionary plasticity of p53 is the most controversial,partially due to the dizzying array of biological functions that have been attributed to different regulatory mechanisms of p53 *** 40 years after its discovery,this key tumor suppressor remains somewhat *** intricate and diverse functions of p53 in reg-ulating cell fate during cancer treatment are only the tip of the iceberg with respect to its equally complicated structural biology,which has been painstak-ingly ***,TP53 mutation is one of the most significant genetic alterations in cancer,contributing to rapid cancer cell growth and tumor ***,we summarized recent advances that implicate altered p53 in modulating the response to various cancer therapies,including chemotherapy,radiotherapy,and ***,we also discussed potential strategies for targeting p53 as a therapeutic option for cancer.

关键词： cancer chemotherapy drug targeting immunotherapy p53 tumor suppressor

Hyperpolarized ^(13)C MRI in hepatocellular carcinoma:Unmet questions during clinical translation

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Chinese Medical Journal 2024年第13期137卷 1516-1518页

作者： Zheng Ye bin song Christoffer Laustsen Department of Radiology West China HospitalSichuan UniversityChengduSichuan 610041China The MR Research Center Department of Clinical MedicineAarhus UniversityAarhus N 8200Denmark

Hyperpolarized(HP)^(13)C magnetic resonance imaging(MRI)is a powerful molecular imaging *** dissolution dynamic nuclear polarization(d-DNP),it can achieve dramatic signal increase and allows for dynamic and quantitative investigation of real-time metabolism in vivo.[1]The typical HP^(13)C MRI workflow begins with formulating the^(13)C probe,and then placing it in the hyperpolarization equipment to achieve the desired signal amplification level,which typically amounts to an increase in the MRI signal by more than 10,000 *** subsequent data acquisition is supported by a specialized^(13)C coil and^(13)C acquisition sequence,and finally quantitative and visualized metabolic information is obtained through a post-processing *** date,research of HP^(13)C MRI has focused on diabetes,cardiovascular diseases,and cancers,[2]showing great promises in tumor detection and the evaluation of therapeutic efficacy.

关键词： metabolism polarized specialized

Resource Allocation in Multi-User Cellular Networks:A Transformer-Based Deep Reinforcement Learning Approach

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China Communications 2024年第5期21卷 77-96页

作者： Zhao Di Zheng Zhong Qin Pengfei Qin Hao song bin State Key Laboratory of Integrated Services Networks Xidian University710071China China Academy of Space Technology Beijing 100081China

To meet the communication services with diverse requirements,dynamic resource allocation has shown increasing *** this paper,we consider the multi-slot and multi-user resource allocation(MSMU-RA)in a downlink cellular scenario with the aim of maximizing system spectral efficiency while guaranteeing user *** first model the MSMURA problem as a dual-sequence decision-making process,and then solve it by a novel Transformerbased deep reinforcement learning(TDRL)***,the proposed TDRL approach can be achieved based on two aspects:1)To adapt to the dynamic wireless environment,the proximal policy optimization(PPO)algorithm is used to optimize the multi-slot RA strategy.2)To avoid co-channel interference,the Transformer-based PPO algorithm is presented to obtain the optimal multi-user RA scheme by exploring the mapping between user sequence and resource *** results show that:i)the proposed approach outperforms both the traditional and DRL methods in spectral efficiency and user fairness,ii)the proposed algorithm is superior to DRL approaches in terms of convergence speed and generalization performance.

关键词： dynamic resource allocation multi-user cellular network spectrum efficiency user fairness

A method for extracting the preseismic gravity anomalies over the Tibetan Plateau based on the maximum shear strain using GRACE data

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Earth and Planetary Physics 2024年第4期8卷 589-608页

作者： Hui Wang DongMei song XinJian Shan bin Wang College of Oceanography and Space Informatics China University of Petroleum(East China)Qingdao 266580China PCI Technology Group Co. Ltd.Guangzhou 510660China Laboratory for Marine Mineral Resources Qingdao National Laboratory for Marine Science and TechnologyQingdao 266200China State Key Laboratory of Earthquake Dynamics Beijing 100029China

The occurrence of earthquakes is closely related to the crustal geotectonic movement and the migration of mass,which consequently cause changes in *** Gravity Recovery And Climate Experiment(GRACE)satellite data can be used to detect gravity changes associated with large ***,previous GRACE satellite-based seismic gravity-change studies have focused more on coseismic gravity changes than on preseismic gravity ***,the noise of the north–south stripe in GRACE data is difficult to eliminate,thereby resulting in the loss of some gravity information related to tectonic *** explore the preseismic gravity anomalies in a more refined way,we first propose a method of characterizing gravity variation based on the maximum shear strain of gravity,inspired by the concept of crustal *** offset index method is then adopted to describe the gravity anomalies,and the spatial and temporal characteristics of gravity anomalies before earthquakes are analyzed at the scales of the fault zone and plate,*** this work,experiments are carried out on the Tibetan Plateau and its surrounding areas,and the following findings are obtained:First,from the observation scale of the fault zone,we detect the occurrence of large-area gravity anomalies near the epicenter,oftentimes about half a year before an earthquake,and these anomalies were distributed along the fault ***,from the observation scale of the plate,we find that when an earthquake occurred on the Tibetan Plateau,a large number of gravity anomalies also occurred at the boundary of the Tibetan Plateau and the Indian ***,the aforementioned experiments confirm that the proposed method can successfully capture the preseismic gravity anomalies of large earthquakes with a magnitude of less than 8,which suggests a new idea for the application of gravity satellite data to earthquake research.

关键词： Gravity Recovery And Climate Experiment(GRACE)data maximum shear strain offset index K preseismic gravity anomalies Tibetan Plateau fault zone

Underwater image clarifying based on human visual colour constancy using double-opponency

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CAAI Transactions on Intelligence Technology 2024年第3期9卷 632-648页

作者： bin Kong Jing Qian Pinhao song Jing Yang Amir Hussain Institute of Intelligent Machines Chinese Academy of SciencesHefeiChina Peng Cheng Laboratory ShenzhenChina Anhui Key Laboratory of Biomimetic Sensing and Advanced Robot Technology HefeiChina University of Science and Technology of China HefeiChina Peking University Shenzhen Graduate School ShenzhenChina Edinburgh Napier University EdinburghScotland

Underwater images are often with biased colours and reduced contrast because of the absorption and scattering effects when light propagates in *** images with degradation cannot meet the needs of underwater *** main problem in classic underwater image restoration or enhancement methods is that they consume long calcu-lation time,and often,the colour or contrast of the result images is still *** of using the complicated physical model of underwater imaging degradation,we propose a new method to deal with underwater images by imitating the colour constancy mechanism of human vision using ***,the original image is converted to the LMS *** the signals are linearly combined,and Gaussian convolutions are per-formed to imitate the function of receptive fields(RFs).Next,two RFs with different sizes work together to constitute the double-opponency ***,the underwater light is estimated to correct the colours in the *** contrast stretching on the luminance is *** show that the proposed method can obtain clarified underwater images with higher quality than before,and it spends significantly less time cost compared to other previously published typical methods.

关键词： computers computer vision image processing image reconstruction

Current progress of research on heat -resistant Mg alloys: A review

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International Journal of Minerals,Metallurgy and Materials 2024年第6期31卷 1406-1425页

作者： Hong Yang Wenlong Xie Jiangfeng song Zhihua Dong Yuyang Gao bin Jiang Fusheng Pan National Engineering Research Center for Magnesium Alloys Chongqing UniversityChongqing 400044China College of Materials Science and Engineering Chongqing UniversityChongqing 400044China

With the increasing attention received by lightweight metals,numerous essential fields have increased requirements for mag-nesium(Mg)alloys with good room-temperature and high-temperature mechanical ***,the high-temperature mechanic-al properties of commonly used commercial Mg alloys,such as AZ91D,deteriorate considerably with increasing *** the past several decades,extensive efforts have been devoted to developing heat-resistant Mg *** approaches either inhibit the gen-eration of thermally unstable phases or promote the formation of thermally stable precipitates/phases in matrices through solid solution or precipitation *** this review,numerous studies are systematically introduced and *** alloy systems,includ-ing those based on Mg–Al,Mg–Zn,and Mg–rare earth,are carefully classified and compared to reveal their mechanical properties and strengthening *** emphasis,limitations,and future prospects of these heat-resistant Mg alloys are also pointed out and dis-cussed to develop heat-resistant Mg alloys and broaden their potential application areas in the future.

关键词： magnesium alloys mechanical properties heat resistance microstructures high temperatures strengthening mechanisms

Identification of transient receptor potential channel genes and functional characterization of TRPA1 in Spodoptera frugiperda

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Journal of Integrative Agriculture 2024年第6期23卷 1994-2005页

作者： Yutong Zhang Hangwei Liu song Cao bin Li Yang Liu Guirong Wang State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100193China Shenzhen Branch Guangdong Laboratory of Lingnan Modern AgricultureGenome Analysis Laboratory of the Ministry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518120China Institute of Evolution and Ecology School of Life SciencesCentral China Normal UniversityWuhan 430079China

Spodoptera frugiperda is a highly destructive pest that has become a global problem due to its robust reproductive and migratory *** receptor potential(TRP)channels,which constitute a vast ion channel family,play pivotal roles in sensing the external environment and maintaining internal homeostasis in *** channels have been widely investigated for their critical roles in regulating various insect behaviors in recent *** this study,we identified 15 TRP gene loci encoding 26 transcripts in the genome of *** and analyzed their expression profiles at different developmental *** results revealed that *** possesses four TRPC genes,six TRPA genes,one TRPM gene,two TRPV genes,one TRPN gene,and one TRPML gene,while a canonical TRPP is ***,the SfruTRPA1 was functionally characterized using the Xenopus oocyte expression *** results showed that SfruTRPA1 is activated by temperature increases from 20 to 45℃,and there is no significant desensitization after repeated stimuli within the same temperature ***,SfruTRPA1 is activated by certain natural chemicals,including allyl isothiocyanate(AITC)and cinnamaldehyde(CA).These findings provide valuable insights to the TRP genes in ***.

关键词： Spodoptera frugiperda transient receptor potential channel expression profile TRPA1 Xenopus oocyte

Recent progress in the research on magnesium and magnesium alloy foils:A short review

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International Journal of Minerals,Metallurgy and Materials 2024年第5期31卷 842-854页

作者： Qiuyan Shen Yongxing Ba Peng Zhang Jiangfeng song bin Jiang Fusheng Pan National Engineering Research Center for Magnesium Alloys Chongqing UniversityChongqing 400044China College of Materials Science and Engineering Chongqing UniversityChongqing 400044China National Key Laboratory of Advanced Casting Technologies Chongqing UniversityChongqing 400044China

Magnesium and magnesium alloy foils have great potential for application in battery anodes,electromagnetic shielding,optics and acoustics,and biology because of their excellent specific damping,internal dissipation coefficients,magnetic and electrical conductivities,as well as high theoretical specific ***,magnesium alloys exhibit poor deformation ability due to their hexagonal close-packed crystal *** magnesium and magnesium alloy foils with thicknesses of less than 0.1 mm is difficult because of surface oxidation and grain growth at high temperatures or severe anisotropy after cold rolling that leads to *** methods have been applied to prepare magnesium alloy *** include warm rolling,cold rolling,accumulative roll bonding,electric plastic rolling,and on-line heating *** of magnesium and magnesium alloy foils during preparation,such as edge cracks and breakage,are important factors for ***,the current status of the research on magnesium and magnesium alloy foils is summarized from the aspects of foil preparation,defect control,performance characterization,and application *** advantages and disadvantages of different preparation methods and defect(edge cracks and breakage)mechanisms in the preparation of foils are identified.

关键词： magnesium alloy foil rolling defect performance application