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Toll-like receptor signaling:gene-and signal-specific regulators.

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Toll-like receptor signaling:gene-and signal-specific regula...

第六届全国免疫学学术大会

作者： youhai h.chen University of Pennsylvania School of Medicine PhiladelphiaPAUSA

Toll-like receptors (TLRs) are key sensors of microbial products and are essential for the development of innate immunity to *** activation induces the expression of

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TIPE2 Serves As A Molecular Rheostat Of Phagocytosis And Oxidative Burst During Infection

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TIPE2 Serves As A Molecular Rheostat Of Phagocytosis And Oxi...

第二届中国免疫学会青年学者论坛

作者：王兆军 Peng Wang honghong Sun Svetlana Fayngerts Derek Johnson Qingguo Ruan Wei Guo youhai h.chen 上海交通大学基础医学院病原生物学教研室 Department of Pathology and Laboratory Medicine University of Pennsylvania School of MedicinePhiladelphia P.A. 19104 USA Department of Biology University of PennsylvaniaPhiladelphia P.A. 19104 USA Department of Pathology and Laboratory Medicine University of Pennsylvania School of Medicine

Phagocytosis and oxidative burst are two major effector arms of the innate immunity. Although it is known that both are activated by Toll-like receptors(TLRs) and Rac GTPases, how their strengths are controlled in quiescent and TLR-activated cells is not clear. We report here that TIPE2 serves as the rheostat of innate immunity by linking TLRs to Rac. TLRs control the expression levels of TIPE2, which in turn dictates the strengths of phagocytosis and oxidative burst by binding to and blocking Rac GTPases. Consequently, TIPE2 knockout cells have enhanced phagocytic and bactericidal activities and TIPE2 knockout mice are resistant to bacterial infection. Thus TIPE2 sets the strengths of phagocytosis and oxidative burst, and may be targeted to effectively control infections.

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Prevention and Treatment of Autoimmune Psoriasis by Directly Targeting c-Rel

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Prevention and Treatment of Autoimmune Psoriasis by Directly...

第十届全国免疫学学术大会

作者： Tingting Fan Shaowen Wang Linjian Yu Ruilin Liu Wenwen Geng Xiaochun Wan huqiang Yi Yifan Ma Lintao Cai youhai h.chen Aishun Jin Qingguo Ruan Shenzhen Laboratory of Fully human Antibody Engineering Institute of Biomedicine and Biotechnology Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences Shenzhen Key Laboratory of Cancer Nanotechnology Institute of Biomedicine and Biotechnology Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences Department of Pathology and Laboratory of Medicine University of Pennsylvania School of Medicine Department of Immunology Harbin Medical University

Objective:Psoriasis is a chronic inflammatory disorder of the *** evidence suggests that IL-17A may play an important role in the pathology of *** other members of the NF-κB family that are ubiquitously expressed,c-Rel is preferentially expressed by inflammatory cells and is used to directly control the expression of multiple inflammatory genes including *** therefore reasoned that targeting c-Rel may be a better strategy for the prevention and treatment of autoimmune ***:BMDCs were cultured with micelles-formulated si Rel/PEG-PLL-PLLeu or si NC/PEG-PLL-PLLeu complex and then stimulated or unstimulated with ***/C mice received a daily topical of imiquimod cream on the shaved back for 7 consecutive *** were then systemically administrated with si NC or si ***,scaling and thickening of the back skin were measured *** back skin were obtained for h&E *** expression level of c-Rel and its target gene m RNA were measured by q RT-PCR;The nuclear expression level of c-Rel was determined by western *** level of IL23p19 or IL-17A was determined using ***:si Rel treatment in vitro can effectively silencing the expression of c-Rel m RNA and protein in *** expression of both IL-23p19 m RNA and protein were also *** Rel treatment in vivo resulted in substantially lower scores for erythema,scaling,and thickening.h&E-stained sections of skin demonstrated decreased epidermal thickening in si Rel treated ***,splenocyte from si Rel treated mice produced significantly less ***,the expression of IL-23p19、IL-17A、IL-1βand IL-6 m RNA were significantly decreased in the skin of the si Rel treated ***:Treatment with si Rel can significantly decrease the severity of imiquimod induced autoimmune psoriasis,which appears to be related to decreased expression of multiple inflammatory cytokines including ***,c-Rel may be a potential therapeutic

关键词： c-Rel psorasis IL-17A siRNA nanoparticle

TIPE3 Is The Transfer Protein Of Lipid Second Messengers That Promote Cancer

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TIPE3 Is The Transfer Protein Of Lipid Second Messengers Tha...

第九届全国免疫学学术大会

作者： Svetlana A.Fayngerts Jianping Wu Camilla L.Oxley Xianglan Liu Anastassios Vourekas Terry Cathopoulis Zhaojun Wang Jian Cui Suxia Liu honghong Sun Mark A.Lemmon Lining Zhang Yigong Shi youhai h.chen Perelman School of Medicine University of Pennsylvania School of Life Sciences Tsinghua University Department of Immunology School of MedicineShandong University

More than half of human cancers have aberrantly upregulated phosphoinositide signals;yet how phospholipid signals are controlled during tumorigenesis is not fully *** TNFAIP8 family of proteins is newly described risk factors for cancer and *** report here that TIPE3(TNFAIP8L3)is a transfer protein for phosphoinositide

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Effects of oxide stringers on the β-phase depletion behaviour in thermally sprayed CoNiCrAlY coatings during isothermal oxidation

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Journal of Materials Science & Technology 2020年第10期42卷 108-116页

作者： h.chen A.Rushworth Department of Mechanical Materials and Manufacturing EngineeringFaculty of Science and EngineeringUniversity of Nottingham Ningbo ChinaNingbo 315100China

This paper details an investigation of the effects of oxide stringers on theβ-phase depletion behaviour in thermally sprayed CoNiCrAlY *** Plasma Sprayed(VPS)Co NiCrAlY coatings,which are free of oxide stringers,are used as the reference materials in comparison with high-Velocity Oxy-Fuel(hVOF)sprayed CoNiCrAlY coatings during isothermal oxidation at 1100℃.An outer layer of spinel oxides and an inner layer of alumina are formed in the as-sprayed coatings,while only a single alumina scale is found in the heat-treated ***β-phase depletion occurred in the hVOF coatings than in the VPS *** was found that theβphases tend to coalesce at the oxide stringers in the hVOF coatings,which is likely due to the internal oxide particles and stringers acting as short diffusion barriers to tie up theβphase and inhibit theβ-phase depletion.

关键词： MCrAlY β-Phase depletion Oxidation Diffusion

MicroRNA immunobiology: when microRNA chemists meet immunologists

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Cellular & Molecular Immunology 2011年第5期8卷 369-370页

作者： youhai h.chen Department of Pathology and Laboratory of Medicine University of Pennsylvania School of MedicinePhiladelphiaPAUSA

Although interdisciplinary research has been heralded as the engine of basic discovery for decades,many in the immunology community have been taken back by the recent marriage between microRNA(miRNA)and *** were first discovered by Ambros and colleagues in 1993.1 They are small untranslated RNAs,highly conserved between different eukaryotic species.2–5 They are encoded by specific genes in the genome,which are controlled at the transcriptional level in a manner similar to protein-encoding genes.2 Following the synthesis of the primary miRNA by RNA polymerase Ⅱ or Ⅲ,nuclear processing by the enzyme Drosha produces a primary miRNA transcript which can be shuttled into the cytoplasm2 Final production of the mature miRNA species requires further cytoplasmic processing by an RNase Ⅲ enzyme called Dicer,producing a 19-to 24-base pair product,capable of being incorporated into the RNA-induced silencing *** RNA-induced silencing complex,in turn,is able to use the‘seed sequence’of the miRNA to recognize complementary mRNAtranscripts for degradation or translational *** date,more than 800 human miRNAs have been identified,regulating an estimated 50%of all human *** miRNA appears to regulate the expression of tens to hundreds of genes,thereby functioning as‘master-switches’that regulate and coordinate multiple cellular pathways in important processes such as embryonic development and oncogenesis,as well as cellular growth and proliferation.

关键词： hundreds marriage thereby

A portable device for studying the effects of fluid flow on degradation properties of biomaterials inside cell incubators

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Regenerative Biomaterials 2019年第1期6卷 39-48页

作者： Wensen Jiang Jiajia Lin Alex h.chen Jianwei Pan huinan Liu Department of Bioengineering Materials Science and Engineering ProgramStem Cell Center Department of Mechanical Engineering University of CaliforniaRiversideRiversideCA 92521USA Department of Bioengineering University of CaliforniaRiversideRiversideCA 92521USA Department of Neurosurgery The First Affiliated Hospital of Zhejiang UniversityHangzhou 310003China

A portable device was designed and constructed for studying the properties of biomaterials in physiologically relevant fluids under controllable flow conditions that closely simulate fluid flow inside the *** device can fit entirely inside a cell incubator;and,thus,it can be used directly under standard cell culture *** impedance-driven pump was built in the sterile flow loop to control the flow rates of fluids,which made the device small and portable for easy deployment in the *** demonstrate the device functions,magnesium(Mg)as a representative biodegradable material was tested in the flow device for immersion degradation under flow versus static conditions,while the flow module was placed inside a standard cell *** flow rate was controlled at 0.1760.06 ml/s for this study;and,the flow rate is adjustable through the controller module outside of incubators for simulating the flow rates in the ranges of blood flow in human artery(0.050.43 ml/s)and vein(0.020.08 ml/s).Degradation of Mg under flow versus static conditions was characterized by measuring the changes of sample mass and thickness,and Mg2t ion concentrations in the immersion *** chemistry and morphology of Mg after immersion under flow versus static conditions were *** portable impedance-driven flow device is easy to fit inside an incubator and much smaller than a peristaltic pump,providing a valuable solution for studying biomaterials and implants(*** or ureteral stents)in body fluids under flow versus static conditions with or without cells.

关键词： portable flow device impedance-driven pump biomaterials body fluids magnesium(Mg)degradation

Alloy solidification: Assessment and improvement of an easy-to-apply model

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Journal of Materials Science & Technology 2022年第35期130卷 1-11页

作者： h.Liu Y.Liu S.L.Lu Y.Zhang h.chen Y.chen M.Qian School of Materials Science and Engineering Southwest Jiaotong UniversityChengdu 610031China Centre for Additive Manufacturing School of EngineeringRMIT UniversityMelbourneVIC 3000Australia School of Materials Science and Engineering Sichuan UniversityChengdu 610065China

It has been a central task of solidification research to predict solute microsegregation. Apart from the Lever rule and the Scheil-Gulliver equation, which concern two extreme cases, a long list of microsegregation models has been proposed. however, the use of these models often requires essential experimental input information, e.g., the secondary dendrite arm spacing(λ), cooling rate( ˙T) or actual solidification range(△T). This requirement disables these models for alloy solidification with no measured values for λ,˙T and △T. Furthermore, not all of these required experimental data are easily obtainable. It is therefore highly desirable to have an easy-to-apply predictive model that is independent of experimental input,akin to the Lever rule or Scheil-Gulliver model. Gong, chen, and co-workers have recently proposed such a model, referred to as the Gong-chen model, by averaging the solid fractions(f_(s)) of the Lever rule and Scheil-Gulliver model as the actual solid fraction. We provide a systematic assessment of this model versus established solidification microsegregation models and address a latent deficiency of the model, i.e.,it allows the Lever rule solid fraction fsto be greater than one(f_(s)> 1). It is shown that the Gong-chen model can serve as a generic model for alloy solidification until fsreaches about 0.9, beyond which(f_(s)> 0.9) its applicability is dictated by both the equilibrium solute partition coefcient(k) and the solute diffusion coefcient in the solid(Ds), which has been tabulated in detail.

关键词： Solidification Microsegregation Solute Back diffusion Eutectic formation

Review on hydrogen Embrittlement of Press-hardened Steels for Automotive Applications

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Acta Metallurgica Sinica(English Letters) 2023年第7期36卷 1123-1143页

作者： Z.Wang Q.Lu Z.h.Cao h.chen M.X.huang J.F.Wang General Motors China Science Lab Shanghai201206China Department of Mechanical Engineering The University of Hong KongPokfulam RoadHong Kong999077China Key Laboratory for Advanced Materials of Ministry of Education School of Materials Science and EngineeringTsinghua UniversityBeijing100084China

Press-hardened steel(PhS)with an ultimate tensile strength(UTS)of 1500 MPa has been widely used in automotive body-in-white in the last two decades,due to its ultra-high strength and excellent formability that is achieved by hot stamping ***,the application of PhS with UTS exceeding 1500 MPa in automotive industry could be deferred due to the increased risk of hydrogen *** reduce this kind of risk,recent research efforts have been focused on various ways to optimize the microstructure of *** present review intends to summarize these efforts,to highlight present solutions to address hydrogen embrittlement,and to shed light on directions for future *** influence of microstructure on the hydrogen embrittlement of PhS has been discussed in terms of both the steel substrate and the surface *** substrate part covers the influence of martensite,carbides,inclusions,and retained austenite,while the surface part covers decarburization and oxidation,pre-coating,and trimming.

关键词： hot stamping Press-hardened steels Coating-free hydrogen embrittlement Fracture Al-Si coating