How sugar instigates macrophages to be evils in tumor

作     者：Houjun Xia Youhai H.Chen Houjun Xia;Youhai H.Chen

作者机构：Center for Cancer ImmunologyInstitute of Biomedicine and BiotechnologyShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenChina 

出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)

年 卷 期：2022年第19卷第12期

页      面：1325-1327页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported in part by grants from the Shenzhen Institute of Advanced Technology (HX) and the National Natural Science Foundation of China (No.32130040) (YHC) 

主　　题：metabolism tumor 

摘      要：In a recent issue of the journal Cancer Cell,Shi et *** that glucose metabolism remodels pro-tumoral functions of tumor-associated macrophages(TAMs)to support cancer metastasis and ***,the consumption of glucose fuels hexosamine biosynthetic pathway(HBP)and enhances O-GlcNAcylation of Cathepsin B in macrophages,which upon secretion disrupts the tumor microenvironment(TME)[1].