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Protein & Cell 2014年第6期5卷 469-479页

作者： youguang luo Dengwen Li Jie Ran Bing Yan Jie Chen Xin Dong Zhu Liu Ruming Liu Jun Zhou Min Liu State Key Laboratory of Medicinal Chemical Biology College of Life Sciences Nankai University Tianjin 300071 China Tianjin Key Laboratory of Medical Epigenetics and Department of Biochemistry School of Basic Medical Sciences Tianjin Medical University Tianjin 300070 China

Paclitaxel is a microtubule-targeting agent widely used for the treatment of many solid tumors. However, patients show variable sensitivity to this drug, and effective diagnostic tests predicting drug sensitivity remain to be investigated. Herein, we show that the expression of end-binding protein 1 （EB1）, a regulator of microtubule dynamics involved in multiple cellular activities, in breast tumor tissues correlates with the pathological response of tumors to paclitaxel-based chemotherapy. In vitro cell proliferation assays reveal that EB1 stimulates paclitaxel sensitivity in breast cancer cell lines. Our data further demonstrate that EB1 increases the activity of paclitaxel to cause mitotic arrest and apoptosis in cancer cells. In addition, microtubule binding affinity analysis and polymerization/ depolymerization assays show that EB1 enhances paclitaxel binding to microtubules and stimulates the ability of paclitaxel to promote microtubule assembly and stabilization. These findings thus reveal EB1 as a critical regulator of paclitaxel sensitivity and have important implications in breast cancer chemotherapy.

关键词： breast cancer paclitaxel microtubule cell proliferation apoptosis end-binding protein 1,chemotherapy

Phosphoregulation of the dimerization and functions of end-binding protein 1

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Protein & Cell 2014年第10期5卷 795-799页

作者： Jie Chen youguang luo Lixin Li Jie Ran Xincheng Wang Siqi Gao Min Liu Dengwen Li Wenqing Shui Jun Zhou State Key Laboratory of Medicinal Chemical Biology College ofLife Sciences Nankai University Tianjin 300071 China High-Throughput Molecular Drug Discovery Center Tianjin JointAcademy of Biotechnology and Medicine Tianjin 300457 China

Dear Editor, End-binding protein 1 （EB1）, a member of microtubule plus- end tracking proteins （＋TIPs）, plays an important role in the regulation of microtubule dynamics and has been implicated in cancer development （Dong et al., 2010; Gouveia and Ak- hmanova, 2010; Wang et al., 2005）. However, it remains poorly understood how EB1 functions are regulated by phosphorylation in mammalian cells. To map the phosphory- lation pattern of EB1, we overexpressed GST-EB1 in HeLa cells and enriched GST-EB1 from cell lysates by GST pull- down. The pulldown preparations showed strong serine, threonine, and tyrosine phosphorylation signals in the immu- noblots （Fig. SlA）. GST-EB1 purified from cells was clearly visualized on the gel prior to in-gel digestion （Fig. S 1B）.

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矫治力对正畸拔牙术后牙槽骨修复影响的探讨

智慧健康 2023年第10期9卷 246-249页

作者：罗有广南宁市第一人民医院口腔科广西南宁530022

目的研究分析矫治力对正畸拔牙术后牙槽骨修复的影响。方法选择我院2020年1月-2022年1月接诊的50名进行正畸拔牙术后牙槽骨修复的患者为研究对象,所有患者均行常规矫治,并分别在矫治1个月、3个月、6个月及矫治结束后对患者行X线检查,获... 详细信息

目的研究分析矫治力对正畸拔牙术后牙槽骨修复的影响。方法选择我院2020年1月-2022年1月接诊的50名进行正畸拔牙术后牙槽骨修复的患者为研究对象,所有患者均行常规矫治,并分别在矫治1个月、3个月、6个月及矫治结束后对患者行X线检查,获得相应的全颌影像。对比研究每位患者的影像材料,评估患者牙槽骨修复情况,分析矫治力对正畸拔牙术后牙槽骨修复的影响。结果在正畸拔牙术后1个月、3个月、6个月内患者的牙槽骨愈合程度良好。结论矫治力和正畸拔牙术后牙槽骨修复有密切的关系,将矫治力的加力调整到最佳的状态,有利于牙槽骨修复,提高恢复速度,从而保证牙齿整齐,提高治疗的效果。

关键词：牙齿矫治正畸治疗牙槽骨康复

Emodin suppresses LPS-induced proinflammatory responses and nuclear factor-B activation by disruption of lipid rafts and TLR-4 recruitment in endothelial cells

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Emodin suppresses LPS-induced proinflammatory responses and ...

Exploring practical methods for detecting k-nonseparability in multipartite quantum states

第九届全国生物力学学术会议

作者： Guoquan MENG,Yiyao LIU,youguang luo,Hong Yang(Department of Biophysics,School of Life Science and Technology,University of Electronic Science and Technology of China,Chengdu 610054)

Emodin[1,3,8-Trihydroxy-6-methylanthraquinone]has been reported to exhibit vascular anti-inflammatory properties. However,the relevant anti-inflammatory mechanisms are not well *** present studywas design to explore the molecular target(s)of emodin in modifying lipopolysaccharide(LPS)-associated signal transduction pathway in human umbilical vein endothelial cells(HUVECs).Cultured HUVECs were pre-incubated with 1 to 50μg/ml emodin for

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 255-256页

作者： Shunlong luo Academy of Mathematics and Systems Science Chinese Academy of Sciences

Quantum entanglement, referred to as “spooky action at a distance” by Einstein, is not only an intriguing and fascinating feature of quantum theory challenging our classical intuitions about locality and correlations, but also has practical and profound implications for quantum technologies. Initially described by Einstein, Podolsky and Rosen, as well as by Schro¨dinger, entanglement now has become a basic and crucial ingredient for both foundational and experimental investigations of the quantum world.

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In situ polymerization of poly(3,4-ethylenedioxythiophene)protective layer towards stable zinc anode

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Nano Research 2025年第1期18卷 382-394页

作者： Debin luo Peng Zhou Xiaowei Lv Panpan Sun Xiaohua Sun Hewei Zhao College of Materials and Chemical Engineering Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion MaterialsChina Three Gorges UniversityYichang 443002China Hubei Three Gorges Laboratory Yichang 443007China School of Chemistry Beihang UniversityBeijing 100191China

Aqueous zinc-ion devices are considered promising candidates for energy storage due to their high safety,low cost and relatively high energy ***,the dendrite growth,hydrogen evolution reaction(HER)and corrosion of the zinc anode significantly limit the development of Zn-ion ***,an inexpensive poly(3,4-ethylenedioxythiophene)(PEDOT)protective layer was constructed in situ on the Zn surface using electropolymerization to suppress dendrite growth and side reactions,thereby enhancing the reversibility of *** and theoretical calculations revealed that this hydrophilic protective layer promotes the desolvation process of hydrated Zn^(2+)and facilitates the transport of zinc ions,thus improving the thermodynamic and kinetic properties of Zn^(2+)deposition and inhibiting interfacial side ***,the optimized PEDOT@Zn symmetric battery exhibited a cycling stability exceeding 1250 h at 0.5 mA·cm^(-2)and 0.25 mAh·cm^(-2),with a significantly reduced overpotential(from 91.8 to 35 mV).With the assistance of the PEDOT protective layer,the PEDOT@Zn//Cu battery maintained approximately 99.5%Coulombic efficiency after 450 ***-situ scanning electron microscopy(SEM)and in situ optical microscopy characterizations further confirmed that the PEDOT protective layer can effectively suppress the growth of zinc ***,the Zn-ion capacitors assembled by the PEDOT@Zn and activated carbon also demonstrated outstanding cycling stability.

关键词： zinc-ion devices zinc anode poly(3 4-ethylenedioxythiophene)(PEDOT) dendrite desolvation process

Tilting homeostatic and dyshomeostatic microglial balance in health and disease:transforming growth factor-beta1 as a critical protagonist

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Neural Regeneration Research 2025年第10期20卷 2895-2897页

作者： Nicolas Hugues Yu luo Department of Molecular and Cellular Biosciences University of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program University of CincinnatiCincinnatiOHUSA Division of Immunobiology Cincinnati Children’s Hospital Medical CenterUniversity of Cincinnati College of MedicineCincinnatiOHUSA

Adult microglia,by continuously sensing changes in their environment and communicating with nearly all brain cell types,are considered to be the immune sentinels of the *** the healthy central nervous system(CNS),microglia display a unique molecular homeostatic signature(i.e.,Tmem119,P2ry12,Sall1,Siglech,Gpr34,and Hexb)(Figure 1A).

关键词： Figure signature critical

P2Y1 receptor in Alzheimer’s disease

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Neural Regeneration Research 2025年第2期20卷 440-453页

作者： Shan luo Yifei Wang Tatsuhiro Hisatsune Department of Integrated Biosciences The University of TokyoKashiwaJapan

Alzheimer’s disease is the most frequent form of dementia characterized by the deposition of amyloid-beta plaques and neurofibrillary tangles consisting of hyperphosphorylated *** amyloid-beta plaques has been a primary direction for developing Alzheimer’s disease treatments in the last ***,existing drugs targeting amyloid-beta plaques have not fully yielded the expected results in the clinic,necessitating the exploration of alternative therapeutic *** evidence unravels that astrocyte morphology and function alter in the brain of Alzheimer’s disease patients,with dysregulated astrocytic purinergic receptors,particularly the P2Y1 receptor,all of which constitute the pathophysiology of Alzheimer’s *** receptors are not only crucial for maintaining normal astrocyte function but are also highly implicated in neuroinflammation in Alzheimer’s *** review delves into recent insights into the association between P2Y1 receptor and Alzheimer’s disease to underscore the potential neuroprotective role of P2Y1 receptor in Alzheimer’s disease by mitigating neuroinflammation,thus offering promising avenues for developing drugs for Alzheimer’s disease and potentially contributing to the development of more effective treatments.

关键词： astrocytes neuroinflammation P2Y1 receptor purinergic receptor

Retrospective analysis of pathological types and imaging features in pancreatic cancer: A comprehensive study

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 121-129页

作者： Yang-Gang luo Mei Wu Hong-Guang Chen Pathology Department Xuanhan County People’s HospitalDazhou 636150Sichuan ProvinceChina

BACKGROUND Pancreatic cancer remains one of the most lethal malignancies worldwide,with a poor prognosis often attributed to late *** the correlation between pathological type and imaging features is crucial for early detection and appropriate treatment *** To retrospectively analyze the relationship between different pathological types of pancreatic cancer and their corresponding imaging *** We retrospectively analyzed the data of 500 patients diagnosed with pancreatic cancer between January 2010 and December 2020 at our *** types were determined by histopathological examination of the surgical spe-cimens or biopsy *** imaging features were assessed using computed tomography,magnetic resonance imaging,and endoscopic *** analyses were performed to identify significant associations between pathological types and specific imaging *** There were 320(64%)cases of pancreatic ductal adenocarcinoma,75(15%)of intraductal papillary mucinous neoplasms,50(10%)of neuroendocrine tumors,and 55(11%)of other rare *** imaging features were identified in each pathological *** ductal adenocarcinoma typically presents as a hypodense mass with poorly defined borders on computed tomography,whereas intraductal papillary mucinous neoplasms present as characteristic cystic lesions with mural *** tumors often appear as hypervascular lesions in contrast-enhanced *** analysis revealed significant correlations between specific imaging features and pathological types(P<0.001).CONCLUSION This study demonstrated a strong association between the pathological types of pancreatic cancer and imaging *** findings can enhance the accuracy of noninvasive diagnosis and guide personalized treatment approaches.

关键词： Pancreatic cancer Pathological types Imaging features Retrospective analysis Diagnostic accuracy

Brain endothelial cyclic GMP-AMP synthase(cGAS)-stimulator of interferon genes(STING)signaling pathway in aging and neurodegeneration

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Neural Regeneration Research 2025年第7期20卷 2005-2007页

作者： Bryan Sun Lulin Li Jian luo Palo Alto Veterans Institute for Research VA Palo Alto Health Care SystemPalo AltoCAUSA Polytrauma System of Care VA Palo Alto Health Care SystemPalo AltoCAUSA

The cyclic GMP-AMP synthase(cGAS)-stimulator of interferon genes(STING)signaling pathway has emerged as a key mediator of *** current studies primarily attribute its effects to neurons and glial cells,emerging research suggests that cGAS-STING signaling may play a critical role in cerebral vasculature,particularly in brain endothelial ***,studying the role 7of inflammation caused by the cGAS-STING pathway in brain endothelial cells could provide a more comprehensive understanding of neuroinflammatory disease and new avenues for therapeutic ***,we review the multifaceted role of global cGAS-STING signaling in various neurological and neuroinflammatory diseases and the potential contribution of cGAS-STING in brain endothelial cells.

关键词： stimulator interferon inflammation