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Astrocytic endothelin-1 overexpression impairs learning and memory ability in ischemic stroke via altered hippocampal neurogenesis and lipid metabolism

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Neural Regeneration Research 2024年第3期19卷 650-656页

作者： Jie Li Wen jiang Yuefang Cai Zhenqiu Ning Yingying zhou Chengyi Wang Sookja Ki Chung Yan Huang Jingbo Sun Minzhen Deng Lihua zhou Xiao Cheng Guangzhou University of Traditional Chinese Medicine GuangzhouGuangdong ProvinceChina State Key Laboratory of Dampness Syndrome of Chinese Medicine The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina Guangdong Provincial Key Laboratory of Research on Emergency in TCM GuangzhouGuangdong ProvinceChina Department of Anesthesiology West China HospitalSichuan UniversityChengduSichuan ProvinceChina Department of Anatomy Sun Yat-Sen School of MedicineSun Yat-Sen UniversityShenzhenGuangdong ProvinceChina Faculty of Medicine Macao University of Science and TechnologyMacao Special Administration RegionChina

Vascular etiology is the second most prevalent cause of cognitive impairment ***-1,which is produced and secreted by endothelial cells and astrocytes,is implicated in the pathogenesis of ***,the way in which changes in astrocytic endothelin-1 lead to poststroke cognitive deficits following transient middle cerebral artery occlusion is not well ***,using mice in which astrocytic endothelin-1 was overexpressed,we found that the selective overexpression of endothelin-1 by astrocytic cells led to ischemic stroke-related dementia(1 hour of ischemia;7 days,28 days,or 3 months of reperfusion).We also revealed that astrocytic endothelin-1 overexpression contributed to the role of neural stem cell proliferation but impaired neurogenesis in the dentate gyrus of the hippocampus after middle cerebral artery *** proteome profiles and western blot analysis confirmed that levels of glial fibrillary acidic protein and peroxiredoxin 6,which were differentially expressed in the brain,were significantly increased in mice with astrocytic endothelin-1 overexpression in comparison with wild-type mice 28 days after ischemic ***,the levels of the enriched differentially expressed proteins were closely related to lipid metabolism,as indicated by Kyoto Encyclopedia of Genes and Genomes pathway *** chromatography-mass spectrometry nontargeted metabolite profiling of brain tissues showed that astrocytic endothelin-1 overexpression altered lipid metabolism products such as glycerol phosphatidylcholine,sphingomyelin,and phosphatidic ***,this study demonstrates that astrocytic endothelin-1 overexpression can impair hippocampal neurogenesis and that it is correlated with lipid metabolism in poststroke cognitive dysfunction.

关键词： astrocytic endothelin-1 dentate gyrus differentially expressed proteins hippocampus ischemic stroke learning and memory deficits lipid metabolism neural stem cells neurogenesis proliferation

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Non-proteolytic ubiquitination of HBx controls HBV replication

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Virologica Sinica 2024年第2期39卷 338-342页

作者： Xiangpeng Sheng Yi Yang Min Zhu Linlin zhou Fang Zhu Yuanfei Zhu Siying Dong Hui Kong Honghua Wang Ji jiang Mingyue Wan Mingyang Feng Qiang Deng Yumin Xu Qing you Ronggui Hu State Key Laboratory for Animal Disease Control and Prevention Harbin Veterinary Research InstituteChinese Academy of Agricultural SciencesHarbin 150069China State Key Laboratory of Molecular Biology Shanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesShanghai 200031China Key Laboratory of Systems Health Science of Zhejiang Province School of Life ScienceHangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China Department of Thoracic Surgery Ruijin HospitalShanghai Jiaotong University School of MedicineShanghai 200025China Shanghai Key Laboratory of Plant Molecular Sciences College of Life SciencesShanghai Normal UniversityShanghai 200234China Department of Pathogenic Biology West China School of Basic Medical Sciences&Forensic MedicineSichuan UniversityChengdu 610041China School of Medicine Guizhou UniversityGuiyang 550025China Key Laboratory of Medical Molecular Virology(MOE&MOH) School of Basic Medical SciencesFudan UniversityShanghai 200032China Department of Hospital Infection Management Department of Infectious DiseasesRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China School of Biomedical Engineering Shanghai Jiao Tong UniversityShanghai 200240China

Dear Editor,Although effective vaccines and antiviral therapies are available,hepatitis B virus(HBV)infection is still a serious global health *** HBV infection remains the principal cause of liver cirrhosis and hepatocellular carcinoma(HCC).HBV is a small DNA virus,owning a~3.2 kb genome that encodes several proteins:viral DNA polymerase,core antigen(HBcAg),E antigen(HBeAg),three surface antigens(PreS1/PreS2/HBsAg),and a regulatory X protein(HBx)(Lamontagne et al.,2016).X protein,named for its lack of homology with any known proteins,is a 154 aa protein that plays an essential role in HBV biology and regulates the development of HCC(Yang et al.,2022).Although previous studies have strongly expanded our understanding of HBx,the regulation of HBx is not completely elucidated.

关键词： infection cirrhosis

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Simulation of Rotating Asymmetric Sideways Forces during Vertical Displacement Events in CFETR

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Chinese Physics Letters 2024年第8期41卷 39-44页

作者： Changzhi jiang Shunwen Wang Zhenyu zhou Di Hu Bo Li JOREK team School of Physics Beihang UniversityBeijing 100191China

Tokamak plasmas with elongated cross sections are susceptible to vertical displacement events(VDEs),which can damage the first wall via heat flux or electromagnetic(EM)*** present a 3D nonlinear reduced magnetohydrodynamic(MHD)simulation of CFETR plasma during a cold VDE following the thermal quench,focusing on the relationship among the EM force,plasma displacement,and the n=1 *** dominant mode,identified as m/n=2/1,becomes destabilized when most of the current is contracted within the q=2 *** displacement of the plasma current centroid is less than that of the magnetic axis due to the presence of SOL current in the open field line ***,the symmetric component of the induced vacuum vessel current is significantly *** direction of the sideways force keeps a constant phase approximately compared to the asymmetric component of the vacuum vessel current and the SOL current,which in turn keep in-phase with the dominant 2/1 *** amplitudes are also closely associated with the growth of the dominant *** findings provide insights into potential methods for controlling the phase and amplitude of sideways forces during VDEs in the future.

关键词： CFETR displacement vacuum

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Recent achievements in selenium-based transition metal electrocatalysts for pH-universal water splitting

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Nano Research 2024年第7期17卷 5763-5785页

作者： Yuwei jiang Sanshuang Gao Xijun Liu Yin Wang Shuxing zhou Qian Liu Abdukader Abdukayum Guangzhi Hu Xinjiang Key Laboratory of Novel Functional Materials Chemistry College of Chemistry and Environmental SciencesKashi UniversityKashi 844000China Institute for Ecological Research and Pollution Control of Plateau Lakes School of Ecology and Environmental ScienceYunnan UniversityKunming 650504China MOE Key Laboratory of New Processing Technology for Non-ferrous Metals and Materials Guangxi Key Laboratory of Processing for Non-ferrous Metals and Featured MaterialsGuangxi UniversityNanning 530004China Hubei Key Laboratory of Low Dimensional Optoelectronic Materials and Devices Hubei University of Arts and ScienceXiangyang 441053China Institute for Advanced Study Chengdu UniversityChengdu 610106China

The electrolysis of water to produce hydrogen is an important technique to replace traditional fossil fuel-based hydrogen *** method efficiently converts electrical energy into chemical energy,it is ostensibly a promising candidate for addressing the energy *** effort has been devoted to developing efficient electrocatalysts for water *** exploration of suitable catalytic materials for the hydrogen evolution reaction(HER),oxygen evolution reaction(OER),and other bifunctional electrocatalytic reactions is *** metal selenides(TMSes)have emerged as potential HER and OER electrocatalysts because of their unique electronic structures,which are beneficial for charge transfer,tuneable bandgaps,distinctive morphologies,and *** review discusses the mechanisms and performance comparisons of TMSes in overall water splitting under various pH *** an industrial and commercial perspective,the catalytic performance of TMSes for the HER and OER is not *** for preparing electrocatalytic materials and optimizing materials for overall water decomposition and modulation mechanisms have been introduced to improve electrocatalytic performance,such as element doping,carbon composites,bimetallic systems,morphology control,and heterogeneous interface ***,the challenges and prospects of TMSes were discussed.

关键词： hydrogen energy source electrocatalysis water splitting selenium-based materials transition metal

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Brain Pathology in COVID-19:Clinical Manifestations and Potential Mechanisms

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Neuroscience Bulletin 2024年第3期40卷 383-400页

作者： Zhixing Xu Hui Wang Siya jiang Jiao Teng Dongxu zhou Zhong Chen Chengping Wen Zhenghao Xu First School of Clinical Medicine Zhejiang Chinese Medical UniversityHangzhou 310053China School of Pharmaceutical Sciences Zhejiang Chinese Medical UniversityHangzhou 310053China Second School of Clinical Medicine Zhejiang Chinese Medical UniversityHangzhou 310053China Afliated Lin’an People’s Hospital of Hangzhou Medical College First People’s Hospital of Hangzhou Lin’an DistrictLin’anHangzhou 311300China School of Life Sciences Zhejiang Chinese Medical UniversityHangzhou 310053China Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province College of Pharmaceutical ScienceZhejiang Chinese Medical UniversityHangzhou 310053China Laboratory of Rheumatology and Institute of TCM Clinical Basic Medicine College of Basic Medical ScienceZhejiang Chinese Medical UniversityHangzhou 310053China

Neurological manifestations of coronavirus disease 2019(COVID-19)are less noticeable than the respiratory symptoms,but they may be associated with disability and mortality in *** though Omicron caused less severe disease than Delta,the incidence of neurological manifestations is *** than 30%of patients experienced“brain fog”,delirium,stroke,and cognitive impairment,and over half of these patients presented abnormal neuroimaging *** this review,we summarize current advances in the clinical findings of neurological manifestations in COVID-19 patients and compare them with those in patients with influenza *** also illustrate the structure and cellular invasion mechanisms of SARS-CoV-2 and describe the pathway for central SARS-CoV-2 *** addition,we discuss direct damage and other pathological conditions caused by SARS-CoV-2,such as an aberrant interferon response,cytokine storm,lymphopenia,and hypercoagulation,to provide treatment *** review may offer new insights into preventing or treating brain damage in COVID-19.

关键词： COVID-19 SARS-CoV-2 Brain Neurological pathology

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Marker Ki-67 is a potential biomarker for the diagnosis and prognosis of prostate cancer based on two cohorts

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World Journal of Clinical Cases 2024年第1期12卷 32-41页

作者： Zhen Song Qi zhou jiang-Lei Zhang Jun Ouyang Zhi-Yu Zhang Department of Urology Taixing People’s HospitalTaizhou 225400Jiangsu ProvinceChina Department of Urology The First Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Reproductive Medicine Center The First Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina

BACKGROUND Prostate cancer(PCa)is a widespread malignancy,predominantly affecting elderly males,and current methods for diagnosis and treatment of this disease continue to fall *** marker Ki-67(MKI67)has been previously demonstrated to correlate with the proliferation and metastasis of various cancer cells,including those of ***,verifying the association between MKI67 and the diagnosis and prognosis of PCa,using bioinformatics databases and clinical data analysis,carries significant clinical *** To explore the diagnostic and prognostic efficacy of antigens identified by MKI67 expression in *** For cohort 1,the efficacy of MKI67 diagnosis was evaluated using data from The Cancer Genome Atlas(TCGA)and Genotype-Tissue Expression(GTEx)*** cohort 2,the diagnostic and prognostic power of MKI67 expression was further validated using data from 271 patients with clinical *** In cohort 1,MKI67 expression was correlated with prostate-specific antigen(PSA),Gleason Score,T stage,and N *** receiver operating characteristic(ROC)curve showed a strong diagnostic ability,and the Kaplan-Meier method demonstrated that MKI67 expression was negatively associated with the progression-free interval(PFI).The time-ROC curve displayed a weak prognostic capability for MKI67 expression in *** cohort 2,MKI67 expression was significantly related to the Gleason Score,T stage,and N stage;however,it was negatively associated with the *** time-ROC curve revealed the stronger prognostic capability of MKI67 in patients with *** COX regression analysis was performed to select risk factors,including PSA level,N stage,and MKI67 expression.A nomogram was established to predict the 3-year *** MKI67 expression was positively associated with the Gleason Score,T stage,and N stage and showed a strong diagnostic and prognostic ability in PCa.

关键词： Marker Ki-67 Prostate cancer Biomarker Diagnosis Prognosis

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Phase field modeling of grain stability of nanocrystalline alloys by explicitly incorporating mismatch strain

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Rare Metals 2024年第7期43卷 3370-3382页

作者： Min zhou Hong-Hui Wu Yuan Wu Hui Wang Xiong-Jun Liu Sui-He jiang Xiao-Bin Zhang Zhao-Ping Lu Beijing Advanced Innovation Center for Materials Genome Engineering State Key Laboratory for Advanced Metals and MaterialsUniversity of Science and Technology BeijingBeijing 100083Cnina Institute for Carbon Neutrality University of Science and TechnologyBeijing 100083China Institute of Materials Intelligent Technology Liaoning Academy of MaterialsShenyang 110004China

Ab st ra ct Nanocrystalline materials exhibit unique properties due to their extremely high grain boundary(GB) ***,this high-density characteristic induces grain coarsening at elevated temperatures,thereby limiting the widespread application of nanocrystalline *** experimental observations revealed that GB segregation and second-phase pinning effectively hinder GB migration,thereby improving the stability of nanocry stalline *** this study,a mouified phase-field model that integrates mismatch strain,solute segregation and precipitation was developed to evaluate the influence of lattice misfit on the thermal stability of nanocrystalline *** simulation results indicated that introducing a suitable mismatch strain can effectively enhance the microstructural stability of nanocrystalline *** synergizing precipitation with an appropriate lattice misfit,the formation of second-phase particles in the bulk grains can be suppressed,thereby facilitating solute segregation/precipitation at the *** concentrated solute segregation and precipitation at the GBs effectively hinders grain migration,thereby preventing grain *** findings provide a new perspective on the design and regulation of nanocrystalline alloys with enhanced thermal stability.

关键词： Phase field model Mismatch strain Second-phase precipitation Grain boundary segregation Nanocrystalline alloys

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Supramolecular phenolic network-engineered C-CeO_(2) nanofibers for simultaneous determination of isoniazid and hydrazine in biological fluids

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Chinese Chemical Letters 2024年第6期35卷 496-501页

作者： Gang Lang Jing Feng Bo Feng Junlan Hu Zhiling Ran Zhiting zhou Zhenju jiang Yunxiang He Junling Guo School of Science Xihua UniversityChengdu 610039China BMI Center for Biomass Materials and Nanointerfaces College of Biomass Science and EngineeringSichuan UniversityChengdu 610065China Southwest Computer Co. Ltd.Chongqing 400060China Bioproducts Institute Department of Chemical and Biological EngineeringThe University of British ColumbiaVancouver V6T 1Z4Canada State Key Laboratory of Polymer Materials Engineering Sichuan UniversityChengdu 610065China National Engineering Laboratory for Clean Technology of Leather Manufacture Sichuan University Chengdu 610065China

Electrochemical sensing provides a powerful technological means for the therapeutic drug monitoring of drug-resistant tuberculosis but requires a functionalized electrode to capture the analytes and catalyze their redox ***,we construct a nickel-tannic acid supramolecular network(Ni-TA)on the surface of electrospun-derived C-CeO_(2) nanofiber for the sensitive and simultaneous detection of isoniazid(INZ)and hydrazine(HYD).Mechanistic investigations demonstrate that Ni-TA is electronegative and hydrophilic,thus facilitating an efficient mass and electron ***-TA/C-CeO_(2) has higher adsorption rate constants(0.091 g mg^(-1)h^(-1)for INZ,and 0.062 g mg^(-1)h^(-1)for HYD)than native C-CeO_(2)(0.075 g mg^(-1)h^(-1)for INZ,and 0.047 g mg^(-1)h^(-1)for HYD).Moreover,Ni-TA/C-CeO_(2)(56Ω)has lower charge transfer resistances than C-CeO_(2)(417Ω).Ni-TA/C-CeO_(2) performs low detection limits and wide linearity ranges for INZ(0.012μmol/L and 0.1-400μmol/L,respectively)and HYD(0.008μmol/L and 0.015-1420μmol/L,respectively),coupled with high selectivity,cycle stability and *** research demonstrated the promising applications of Ni-TA/C-CeO_(2) by analyzing human-collected plasma and urine samples.

关键词： Electrochemical detection Therapeutic drug monitoring Isoniazid Hydrazine Tuberculosis

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CmMYB3-like negatively regulates anthocyanin biosynthesis and flower color formation during the post-flowering stage in Chrysanthemum morifolium

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Horticultural Plant Journal 2024年第1期10卷 194-204页

作者： Lijie zhou Shenhui Liu Yiguang Wang Yuxi Wang Aiping Song Jiafu jiang Sumei Chen Zhiyong Guan Fadi Chen State Key Laboratory of Crop Genetics and Germplasm Enhancement The Key Laboratory of LandscapingMinistry of Agriculture and Rural AffairsCollege of HorticultureNanjing Agricultural UniversityNanjingJiangsu 210095China

Color fading caused by a decrease in anthocyanin accumulation during the post-flowering stage significantly affects postharvest quality of ***,the underlying mechanism by which anthocyanin accumulation decreases during the post-flowering stage still unclear,which greatly restricts design of molecular breeding in ***,a chrysanthemum SG7 R2R3 MYB transcription factor(TF),CmMYB3-like,was identified to have a function in regulating anthocyanin biosynthesis during the post-flowering *** real time PCR(qRT-PCR)assays showed that the expression of CmMYB3-like was gradually downregulated when anthocyanin content increased during the flowering stage and was significantly upregulated during the post-flowering *** transformation of chrysanthemum and dual-luciferase assays in *** leaves showed that CmMYB3-like suppressed anthocyanin accumulation by inhibiting the transcription of CmCHS and CmANS directly and that of CmF3H ***,overexpression or suppression of CmMYB3-like did not affect the biosynthesis of flavones or *** transformation of chrysanthemum revealed that the overexpression of CmMYB3-like inhibited anthocyanin accumulation,but its suppression prevented the decrease in anthocyanin accumulation during the post-flowering *** results revealed a crucial role of CmMYB3-like in regulating the color of petals during the post-flowering stage and provided a target gene for molecular design breeding to improve the postharvest quality of chrysanthemum.

关键词： Post-flowering stage Color fading Anthocyanins CmMYB3-like Chrysanthemum Molecular breeding

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Research advances in enhanced coal seam gas extraction by controllable shock wave fracturing

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International Journal of Coal Science & Technology 2024年第3期11卷 1-31页

作者： Chaojun Fan Hao Sun Sheng Li Lei Yang Bin Xiao Zhenhua Yang Mingkun Luo Xiaofeng jiang Lijun zhou College of Mining Liaoning Technical UniversityFuxin123000China College of Safety Science and Engineering Liaoning Technical UniversityFuxin123000China Energy Business Department Shanxi Lu’an Chemical GroupChangzhi046200China

With the continuous increase of mining in depth,the gas extraction faces the challenges of low permeability,great ground stress,high temperature and large gas pressure in coal *** controllable shock wave(CSW),as a new method for enhancing permeability of coal seam to improve gas extraction,features in the advantages of high efficiency,eco-friendly,and low *** order to better utilize the CSW into gas extraction in coal mine,the mechanism and feasibility of CSW enhanced extraction need to be *** this paper,the basic principles,the experimental tests,the mathematical models,and the on-site tests of CSW fracturing coal seams are reviewed,thereby its future research directions are *** on the different media between electrodes,the CSW can be divided into three categories:hydraulic effect,wire explosion and excitation of energetic materials by detonating *** the process of propagation and attenuation of the high-energy shock wave in coal,the shock wave and bubble pulsation work together to produce an enhanced permeability effect on the coal *** stronger the strength of the CSW is,the more cracks created in the coal is,and the greater the length,width and area of the cracks *** repeated shock on the coal seam is conducive to the formation of complex network fracture system as well as the reduction of coal seam strength,but excessive shock frequency will also damage the coal structure,resulting in the limited effect of the enhanced gas *** the influence of ground stress,the crack propagation in coal seam will be *** difference of horizontal principal stress has a significant impact on the shape,propagation direction and connectivity of the CSW induced *** permeability enhancement effect of CSW is affected by the breakage degree of coal *** shock wave is absorbed by the broken coal,which may hinder the propagation of CSW,resulting in a poor effect of permeability *** arranging two a

关键词： Controllable shock wave Permeability enhancement Gas extraction Basic principle Experimental test Mathematical models On-site test

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