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AZD1775 synergizes with SLC7A11 inhibition to promote ferroptosis

Science China Life Sciences 2024年

作者： Chen Xiong Hong Ling Yingdan Huang Hanzhi Dong Bangxiang xie Qian Hao xiang Zhou Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences Fudan University Department of Oncology Shanghai Medical College Fudan University Department of Breast Surgery Fudan University Shanghai Cancer Center Fudan University Department of Oncology First Affiliated Hospital of Nanchang University Beijing Institute of Hepatology Beijing Youan Hospital Capital Medical University Beijing Engineering Research Center for Precision Medicine and Transformation of Hepatitis and Liver Cancer Key Laboratory of Breast Cancer in Shanghai Fudan University Shanghai Cancer Center Fudan University Shanghai Key Laboratory of Medical Epigenetics International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology) Institutes of Biomedical Sciences Fudan University

Tumor suppressor p53-mediated cell cycle arrest and DNA damage repair may exert cytoprotective effects against cancer therapies, including WEE1 inhibition. Considering that p53 activation can also lead to multiple types of cell death, the role of this tumor suppressor in WEE1 inhibitor-based therapies remains disputed. In this study, we reported that nucleolar stress-mediated p53 activation enhanced the WEE1 inhibitor AZD1775-induced ferroptosis to suppress lung cancer growth. Our findings showed that AZD1775 promoted ferroptosis by blocking cystine uptake, an action similar to that of Erastin. Meanwhile, inhibition of WEE1 by the WEE1 inhibitors or siRNAs induced compensatory upregulation of SLC7A11, which conferred resistance to ferroptosis. Mechanistically, AZD1775 prevented the enrichment of H3K9me3, a histone marker of transcriptional repression, on the SLC7A11 promoter by repressing the expression of the histone methyltransferase SETDB1, thereby enhancing NRF2-mediated SLC7A11 transcription. This finding was also validated using the H3K9me3 inhibitor BRD4770. Remarkably, we found that the nucleolar stress-inducing agent Actinomycin D(Act. D) inhibited SLC7A11 expression by activating p53, thus augmenting AZD1775-induced ferroptosis. Moreover, the combination of AZD1775 and Act. D synergistically suppressed wild-type p53-harboring lung cancer cell growth both in vitro and in vivo. Altogether, our study demonstrates that AZD1775promotes ferroptosis by targeting cystine uptake but also mediates the adaptive activation of SLC7A11 through the WEE1-SETDB1 cascade and NRF2-induced transcription, and inhibition of SLC7A11 by Act. D boosts the anti-tumor efficacy of AZD1775 by enhancing ferroptosis in cancers with wild-type p53.

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Single and combined effects of secondary polyethylene microplastic on the growth of Pak choi and the soil microbiome composition

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Frontiers of Environmental Science & Engineering 2024年第5期18卷 1-12页

作者： Jiamin Hu Zhenwen xie Jiane Zuo State Key Joint Laboratory of Environmental Simulation and Pollution Control School of EnvironmentTsinghua UniversityBeijing100084China Tsinghua Shenzhen International Graduate School Tsinghua UniversityShenzhen518055China

It has been confirmed that microplastics(MPs)are present in the *** study simulated secondary PE-MPs via aging and mechanical processes to evaluate their effects on Pak choi(Brassica rapa L.)over 21 *** common pollutants,dichlorodiphenyltrichloroethane(DDT)and naphthalene,were used in the combined toxicity *** results indicated that the growth of Pak choi was significantly inhibited after exposure to secondary PE-MPs,and the combined effects were antagonistic,owing to the adsorption capacity of secondary PE-MPs to DDT and *** stress in Pak choi can be markedly affected,leading to oxidative damage to plant *** moisture content,soil bulk density,soil density,cation exchange capacity(CEC),and FDA hydrolase in the planted soils increased in the treated groups,and the TOC content changed *** also found that the microbial composition of the soil in the DDT and naphthalene groups showed more significant alterations than that in the other *** diversity analysis showed that species diversity increased in the combined groups but indicated a clear downward trend in the single MPs *** study suggests that secondary PE-MPs harm the growth of Pak choi and can change soil properties,revealing the harm to the ecosystem of MPs in the soil.

关键词： Secondary PE-MPs Combined effects Oxidative stress Soil properties Bacterial community

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Recent Advance in Synaptic Plasticity Modulation Techniques for Neuromorphic Applications

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Nano-Micro Letters 2024年第10期16卷 403-434页

作者： Yilin Sun Huaipeng Wang Dan xie School of Integrated Circuits and Electronics Beijing Institute of TechnologyBeijing 100081People's Republic of China School of Integrated Circuits Beijing National Research Center for Information Science and Technology(BNRist)Tsinghua UniversityBeijing 100084People's Republic of China

Manipulating the expression of synaptic plasticity of neuromorphic devices provides fascinating opportunities to develop hardware platforms for artifi-cial ***,great efforts have been devoted to exploring biomimetic mechanisms of plasticity simulation in the last few *** progress in various plasticity modulation techniques has pushed the research of synaptic electronics from static plasticity simulation to dynamic plasticity modulation,improving the accuracy of neuromorphic computing and providing strategies for implementing neuromorphic sensing ***,several fascinating strategies for synap-tic plasticity modulation through chemical techniques,device structure design,and physical signal sensing are *** chemical techniques,the underly-ing mechanisms for the modification of functional materials were clarified and its effect on the expression of synaptic plasticity was also *** on device structure design,the reconfigurable operation of neuromorphic devices was well demonstrated to achieve programmable neuromorphic ***,integrating the sensory units with neuromorphic processing circuits paved a new way to achieve human-like intelligent perception under the modulation of physical signals such as light,strain,and ***,considering that the relevant technology is still in the basic exploration stage,some prospects or development suggestions are put forward to promote the development of neuromorphic devices.

关键词： Plasticity modulation Dynamic plasticity Chemical techniques Programmable operation Neuromorphic sensing

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An Improved Northern Goshawk Optimization Algorithm for Feature Selection

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Journal of Bionic Engineering 2024年第4期21卷 2034-2072页

作者： Rongxiang xie Shaobo Li Fengbin Wu State Key Laboratory of Public Big Data College of Computer Science and TechnologyGuizhou UniversityGuiyang550025China State Key Laboratory of Public Big Data Guizhou UniversityGuiyang550025China

Feature Selection(FS)is an important data management technique that aims to minimize redundant information in a *** work proposes DENGO,an improved version of the Northern Goshawk Optimization(NGO),to address the FS *** NGO is an efficient swarm-based algorithm that takes its inspiration from the predatory actions of the northern *** order to overcome the disadvantages that NGO is prone to local optimum trap,slow convergence speed and low convergence accuracy,two strategies are introduced in the original NGO to boost the effectiveness of ***,a learning strategy is proposed where search members learn by learning from the information gaps of other members of the population to enhance the algorithm's global search ability while improving the population ***,a hybrid differential strategy is proposed to improve the capability of the algorithm to escape from the trap of the local optimum by perturbing the individuals to improve convergence accuracy and *** prove the effectiveness of the suggested DENGO,it is measured against eleven advanced algorithms on the CEC2015 and CEC2017 benchmark functions,and the obtained results demonstrate that the DENGO has a stronger global exploration capability with higher convergence performance and ***,the proposed DENGO is used for FS,and the 29 benchmark datasets from the UCL database prove that the DENGO-based FS method equipped with higher classification accuracy and stability compared with eight other popular FS methods,and therefore,DENGO is considered to be one of the most prospective FS ***'s code can be obtained at https://***/matlabcentral/fileexchange/158811-project1.

关键词： Northern goshawk optimization Learning strategy Hybrid differential strategy Numerical optimization Feature selection

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Optimizing urban block morphologies for net-zero energy cities:Exploring photovoltaic potential and urban design prototype

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Building Simulation 2024年第4期17卷 607-624页

作者： Xiaotian Geng Dong xie Zhonghua Gou School of Urban Design Wuhan UniversityWuhanChina

The morphology of urban areas plays a crucial role in determining solar potential,which directly affects photovoltaic capacity and the achievement of net-zero *** study focuses on the City of Melbourne to investigate the utilization of solar energy across different urban densities and proposes optimized *** analysis encompasses blocks with diverse population densities,examining medium and high-density *** utilizing a multi-objective genetic optimization approach,the urban morphology of these blocks is *** findings indicate that low-density blocks exhibit photovoltaic potential ranging from 1 to 6.6 times their total energy *** and high-density blocks achieve photovoltaic potential levels approximately equivalent to 40%-85%of their overall energy ***,significant variations in photovoltaic potential are observed among different urban forms within medium and high-density ***“elevated corners with central valley”prototype is proposed as an effective approach,enhancing the overall photovoltaic potential by approximately 14%.This study introduces novel analytical concepts,shedding light on the intricate relationship between urban morphologies and photovoltaic potential.

关键词： net-zero energy solar energy urban density urban morphology multi-objective optimization photovoltaic potential

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Hot Compressive Deformation Characteristics of Al-9.3Zn-2.4Mg-1.1Cu Alloy

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Journal of Wuhan University of Technology(Materials Science) 2024年第3期39卷 754-765页

作者：刘鹏茹郝世明 xie Jingpei School of Physics and Engineering Henan University of Science and TechnologyLuoyang 471023China School of Materials Science and Engineering Henan University of Science and TechnologyLuoyang 471023China Provincial and Ministerial Co-Construction of Collaborative Innovation Center for Non-Ferrous Metal New Materials and Advanced Processing Technology Luoyang 471023China

To understand the hot compression deformation characteristics of the self-developed Al-9.3Zn-2.4Mg^(-1).1Cu alloy,the hot compression tests of Al-9.3Zn-2.4Mg^(-1).1Cu alloy were investigated by Gleeble 1500 thermo-mechanical simulator to determine the best hot processing *** hot deformation temperatures were 300,350,400,and 450℃,and the strain rates were 1,0.1,0.01,and 0.003 s^(-1),*** on the experimental results,the constitutive equation and hot processing maps are established,and the corresponding strain rate and temperature-sensitive index are *** results show that Al-9.3Zn-2.4Mg^(-1).1Cu alloy has a dynamic softening trend and high strain rate sensitivity during the isothermal compression *** hot deformation behavior can be described by an Arrhenius-type equation after strain *** temperature has a negligible effect on the hot processing properties,while a low strain rate is favorable for the hot working of *** processing maps and microstructure show that the optimal processing conditions were in the temperature range of 400-450℃and strain rate range of 0.003-0.005 s^(-1).

关键词： Al-Zn-Mg-Cu alloy hot working hot deformation behavior constitutive equations processing maps

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Literature overview of basic characteristics and flotation laws of flocs

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International Journal of Minerals,Metallurgy and Materials 2024年第5期31卷 943-958页

作者： Wanzhong Yin Yu xie Zhanglei Zhu School of Resources and Civil Engineering Northeastern UniversityShenyang 110819China College of Chemistry and Chemical Engineering Xi’an University of Science and TechnologyXi’an 710054China

Flocculation flotation is the most efficient method for recovering fine-grained minerals,and its essence lies in flotation and recovery of *** physical characteristics of flocs are mainly determined by their apparent particle size and structure(density and morphology).Substantial researches have been conducted regarding the effect of floc characteristics on particle settling and water ***,the influence of floc characteristics on flotation has not been widely *** on the floc formation and flocculation flotation,this study reviews the fundamental physical characteristics of flocs from the perspectives of floc particle size and structure,summarizing the interaction between floc particle size and ***,it thoroughly discusses the effect of floc particle size and structure on floc floatability,further revealing the influence of floc characteristics on bubble collision and adhesion and elucidating the mechanisms of interaction between flocs and ***,it is observed that floc particle size is not the only factor influencing flocculation *** the appropriate apparent particle size range,flocs with a compact structure exhibit higher efficiency in bubble collision and adhesion during flotation,thereby resulting in enhanced flotation *** study aims to provide a reference for flocculation flotation,targeting the development of more efficient and refined flocculation flotation processes in the future.

关键词： flocs basic characteristics particle size and structure flotation laws bubbles

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Toluene Processed All-Polymer Solar Cells with 18% Efficiency and Enhanced Stability Enabled by Solid Additive:Comparison Between Sequential-Processing and Blend-Casting

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Energy & Environmental Materials 2024年第04期7卷 247-254页

作者： Guoping Zhang Chaoyue Zhao Liangxiang Zhu Lihong Wang Wenzhao Xiong Huawei Hu Qing Bai Yaping Wang Chen xie Peng you He Yan Dan Wu Tao Yang Mingxia Qiu Shunpu Li Guangye Zhang College of New Materials and New Energies Shenzhen Technology University Department of Chemistry and Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction The Hong Kong University of Science and Technology State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Center for Advanced Low-dimension Materials College of Materials Science and Engineering Donghua University Julong College Shenzhen Technology University

The emergence of polymerized small molecule acceptors (PSMAs) has significantly improved the performance of all-polymer solar cells (all-PSCs).However,the pace of device engineering lacks behind that of materials deve... 详细信息

关键词： all-polymers solar cells sequential processing solid additive

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Optimal Coordination of Transportable Power Sources and Repair Crews for Service Restoration of Distribution Networks Considering Uncertainty of Traffic Congestion

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Journal of Modern Power Systems and Clean Energy 2024年第1期12卷 189-201页

作者： Zhao Shi Yan Xu Dunjian xie Shiwei xie Amer M.Y.M.Ghias Nanyang Technological University Singapore the School of Electrical Engineering and Automation Fuzhou UniversityFuzhou 350108China

This paper proposes a new method for service restoration of distribution network with the support of transportable power sources(TPSs)and repair crews(RCs).Firstly,a coupling model of distribution networks and vehicle routing of TPSs and RCs is proposed,where the TPSs serve as emergency power supply sources,and the RCs are used to repair the faulted *** the uncertainty of traffic congestion,the probability distribution of the travel time spent on each road is derived based on the Nesterov user equilibrium model,and a two-stage stochastic program is formulated to determine the optimal routings of TPSs and *** efficiently solve the proposed stochastic mixed-integer linear program(MILP),a two-phase scenario reduction method is then developed to scale down the problem size,and an adaptive progressive hedging algorithm is used for an efficient *** effectiveness of the proposed methods and algorithms has been illustrated in a modified IEEE 33-bus system.

关键词： Service restoration distribution network traffic uncertainty transportable power source repair crew stochastic program

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Analysis of a class of globally divergence-free HDG methods for stationary Navier-Stokes equations

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Science China Mathematics 2024年第5期67卷 1133-1158页

作者： Gang Chen Xiaoping xie School of Mathematics Sichuan University Chengdu 610064China

In this paper,we analyze a class of globally divergence-free(and therefore pressure-robust)hybridizable discontinuous Galerkin(HDG)finite element methods for stationary Navier-Stokes *** methods use the P_(k)/P_(k-1)(k≥1)discontinuous finite element combination for the velocity and pressure approximations in the interior of elements,piecewise Pm(m=k,k-1)for the velocity gradient approximation in the interior of elements,and piecewise P_(k)/P_(k) for the trace approximations of the velocity and pressure on the inter-element *** show that the uniqueness condition for the discrete solution is guaranteed by that for the continuous solution together with a sufficiently small mesh *** on the derived discrete HDG Sobolev embedding properties,optimal error estimates are *** experiments are performed to verify the theoretical analysis.

关键词： Navier-Stokes equations HDG methods divergence-free uniqueness condition error estimates

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