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Selenium deficiency exacerbates ROS/ER stress mediated pyroptosis and ferroptosis induced by bisphenol A in chickens thymus

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Journal of Environmental Sciences 2025年第2期148卷 13-26页

作者： kun Wang Xu Shi Hongjin lin Tong Xu Shiwen Xu College of Veterinary Medicine Northeast Agricultural UniversityHarbin 150030China Key Laboratory of the Provincial Education Department of Heilongjiang for Common Animal Disease Prevention and Treatment Harbin 150030China

Bisphenol A(BPA)is an industrial pollutant that can cause immune *** acts as an antioxidant,as selenium deficiency often accompanies oxidative stress,resulting in organ *** study is the first to demonstrate that BPA and/or selenium deficiency induce pyroptosis and ferroptosis-mediated thymic injury in chicken and chicken lymphoma cell(MDCC-MSB-1)via oxidative stress-induced endoplasmic reticulum(ER)*** established a broiler chicken model of BPA and/or selenium deficiency exposure and collected thymus samples as research subjects after 42 *** results demonstrated that BPA or selenium deficiency led to a decrease in antioxidant enzyme activities(T-AOC,CAT,and GSH-Px),accumulation of peroxides(H2O2 and MDA),significant upregulation of ER stress-relatedmarkers(GRP78,IER 1,PERK,EIF-2α,ATF4,and CHOP),a significant increase in iron ion levels,significant upregulation of pyroptosis-related gene(NLRP3,ASC,Caspase1,GSDMD,IL-18 and IL-1β),significantly increase ferroptosis-related genes(TFRC,COX2)and downregulate GPX4,HO-1,FTH,*** vitro experiments conducted in MDCC-MSB-1 cells confirmed the results,demonstrating that the addition of antioxidant(NAC),ER stress inhibitor(TUDCA)and pyroptosis inhibitor(Vx765)alleviated oxidative stress,endoplasmic reticulum stress,pyroptosis,and ***,this study concludes that the combined effects of oxidative stress and ER stress mediate pyroptosis and ferroptosis in chicken thymus induced by BPA exposure and selenium deficiency.

关键词： Bisphenol A Selenium deficiency ROS/ER stress Pyroptosis Ferroptosis Thymic injury

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Highly Oxidized Molecules Make a Significant Contribution to Enhanced Aromatic-Derived Secondary Organic Aerosol under a Humid Environment

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ADVANCES IN ATMOSPHERIC SCIENCES 2025年第4期42卷 641-652页

作者： Yang, Zhaomin Li, kun Du, lin Shandong Univ Environm Res Inst Qingdao 266237 Peoples R China

Enhanced mass concentrations of aromatic-derived secondary organic aerosol (SOA) are frequently observed during humid-haze events. However, the influencing mechanism of relative humidity (RH) in aromatic-derived SOA formation remains incompletely understood. Here, the RH dependence of SOA formation in the presence of NOx was explored by a series of chamber experiments for toluene (TOL) and 1,3,5-trimethylbenzene (TMB) photooxidation. The yield of TOL SOA and TMB SOA increased by 221% and 52% with increasing RH from similar to 8% to similar to 70%, respectively. Analytical results from a high-resolution mass spectrometer showed that SOA constituents with high oxygen content (O/C > 0.6) were more abundant in SOA formed in the similar to 70% RH experiment. The elevated yields and O/C of SOA could be attributed to the promoted formation and particle-phase diffusivity of highly oxidized molecules. In addition, in comparison with TMB, TOL could produce more unsaturated aldehydes, which are oxidized into carboxylic acids with high O/C, leading to a more sensitive response of TOL SOA formation to the change in RH. Our work provides mechanistic insights into RH roles in aromatic SOA formation and is helpful for a better understanding of humid-haze events.

关键词： secondary organic aerosol aromatic hydrocarbons highly oxidized molecules relative humidity

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Roles of serum uric acid on the association between arsenic exposure and incident metabolic syndrome in an older Chinese population

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Journal of Environmental Sciences 2025年第1期147卷 332-341页

作者： Haiyan Jiang Simei Zhang Yaoyao lin lin Meng Jiayi Li Wenqing Wang Kaixuan Yang Mingjuan Jin Jianbing Wang Mengling Tang kun Chen Department of Public Health Fourth Affiliated HospitalZhejiang University School of MedicineHangzhou 310058China Department of Public Health Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310058China Department of Public Health National Clinical Research Center for Child Health of Children’s HospitalZhejiang University School of MedicineHangzhou 310058China

Growing evidences showed that heavy metals exposure may be associated with metabolic ***,themechanism underlying arsenic(As)exposure and metabolic syndrome(MetS)risk has not been fully *** we aimed to prospectively investigate the role of serum uric acid(SUA)on the association between blood As exposure and incident MetS.A sample of 1045 older participants in a community in China was *** determined As at baseline and SUA concentration at follow-up in the Yiwu Elderly *** events were defined according to the criteria of the International Diabetes Federation(IDF).Generalized linear model with log-binominal regression model was applied to estimate the association of As with incident *** investigate the role of SUA in the association between As andMetS,amediation analysiswas *** the fully adjusted log-binominal model,per interquartile range increment of As,the risk of MetS increased *** with the lowest quartile of As,the adjusted relative risk(RR)of MetS in the highest quartile was 1.42(95%confidence interval,CI:1.03,2.00).Additionally,blood As was positively associated with SUA,while SUA had significant association with MetS *** mediation analysis demonstrated that the association of As and MetS risk was mediated by SUA,with the proportion of 15.7%.Our study found higher As was remarkably associated with the elevated risk of MetS in the Chinese older adults *** analysis indicated that SUA might be a mediator in the association between As exposure and MetS.

关键词： Arsenic(As)exposure Metabolic syndrome(MetS) Serum uric acid(SUA) Cohort study Mediation effect Older adults

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Highly Oxidized Molecules Make a Significant Contribution to Enhanced Aromatic-Derived Secondary Organic Aerosol under a Humid Environment

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Advances in Atmospheric Sciences 2025年第04期 641-652页

作者： Zhaomin YANG kun LI lin DU Environment Research Institute Shandong University

Enhanced mass concentrations of aromatic-derived secondary organic aerosol(SOA) are frequently observed during humid-haze events. However, the influencing mechanism of relative humidity(RH) in aromatic-derived SOA formation remains incompletely understood. Here, the RH dependence of SOA formation in the presence of NOx was explored by a series of chamber experiments for toluene(TOL) and 1,3,5-trimethylbenzene(TMB) photooxidation. The yield of TOL SOA and TMB SOA increased by 221% and 52% with increasing RH from ～8% to ～70%, respectively. Analytical results from a high-resolution mass spectrometer showed that SOA constituents with high oxygen content(O/C > 0.6) were more abundant in SOA formed in the ～70% RH experiment. The elevated yields and O/C of SOA could be attributed to the promoted formation and particle-phase diffusivity of highly oxidized molecules. In addition, in comparison with TMB,TOL could produce more unsaturated aldehydes, which are oxidized into carboxylic acids with high O/C, leading to a more sensitive response of TOL SOA formation to the change in RH. Our work provides mechanistic insights into RH roles in aromatic SOA formation and is helpful for a better understanding of humid-haze events.

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A comparative study on the formation of nitrogen-containing organic compounds in cloud droplets and aerosol particles

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Journal of Environmental Sciences 2025年第3期149卷 456-464页

作者： Guohua Zhang TaoWang Qinhao lin kun Liu Wei Sun Duohong Chen Lei Li Xinming Wang Xinhui Bi State Key Laboratory of Organic Geochemistry and Guangdong Provincial Key Laboratory of Environmental Protection and Resources Utilization Guangzhou Institute of GeochemistryChinese Academy of Sciences(CAS)Guangzhou 510640China Guangdong-Hong Kong-Macao Joint Laboratory for Environmental Pollution and Control Guangzhou Institute of GeochemistryCASGuangzhou 510640China University of Chinese Academy of Sciences Beijing 100049China School of Environmental Science and Engineering Institute of Environmental Health and Pollution ControlGuangdong University of TechnologyGuangzhou 510006China State Environmental Protection Key Laboratory of Regional Air Quality Monitoring Guangdong Environmental Monitoring CenterGuangzhou 510308China Institute of Mass Spectrometer and Atmospheric Environment Jinan UniversityGuangzhou 510632China

Nitrogen-containing organic compounds(NOCs)may potentially contribute to aqueous secondary organic aerosols,yet the different formation of NOCs in aerosol particles and cloud droplets remains *** the in-situ measurements performed at a mountain site(1690 m a.s.l.)in southern China,we investigated the formation of NOCs in the cloud droplets and the cloud-free particles,based on their mixing state information of NOCscontaining particles by single particle mass *** relative abundance of NOCs in the cloud-free particles was significantly higher than those in cloud residual(cloud RES)*** were highly correlated with carbonyl compounds(including glyoxalate and methylglyoxal)in the cloud-free particles,however,limited correlation was observed for cloud RES *** of their mixing state and temporal variations highlights that NOCs was mainly formed from the carbonyl compounds and ammonium in the cloud-free particles,rather than in the cloud RES *** results support that the formation of NOCs from carbonyl compounds is facilitated in concentrated solutions in wet aerosols,rather than cloud *** addition,we have identified the transport of biomass burning particles that facilitate the formation of NOCs,and that the observed NOCs is most likely contributed to the light *** findings have implications for the evaluation of NOCs formation and their contribution to light absorption.

关键词： Nitrogen-containing organic compounds Individual particles Cloud Carbonyl compounds Mixing state

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Rosaceae phylogenomic studies provide insights into the evolution of new genes

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Horticultural Plant Journal 2025年第1期11卷 389-405页

作者： Lan Jiang Xiaoxu Li kun Lyu Han Wang Zhiyuan Li Wang Qi lin Zhang Yunpeng Cao Anhui Province Key Laboratory of Non-coding RNA Basic and Clinical Transformation(Wannan Medical College) Central LaboratoryYijishan Hospital of Wannan Medical CollegeWuhuAnhui 241000China Beijing Life Science Academy Beijing 102209China CAS Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture Wuhan Botanical GardenChinese Academy of SciencesWuhanHubei 430074China Center of Economic Botany Core Botanical GardensChinese Academy of SciencesWuhanHubei 430074China Key Laboratory for Tobacco Gene Resources Tobacco Research InstituteChinese Academy of Agricultural SciencesQingdaoShangdong 266000China school of Life Sciences Anhui Agricultural UniversityHefeiAnhui 230036China School of Basic Medical Sciences Hubei University of Chinese MedicineWuhanHubei 430065China

Rosa banksiae,known as Lady Banks'rose,is a perennial ornamental crop and a versatile herb in traditional Chinese *** the lack of genomic resources,we assembled a Hi Fi and Nanopore sequencing-derived 458.58 Mb gap-free telomere-to-telomere high-quality *** genome with a scaffold N50=63.90 *** genome of *** exhibited no lineage-specific whole-genome duplication compared with other *** phylogenomic analysis of 13 Rosaceae and Arabidopsis through a comparative genomics study showed that numerous gene families were lineage-specific both before and after the diversification of *** of these genes are candidates for new genes that have evolved from parental genes through fusion *** genes are divided into three types:Type-I and Type-II genes contain two parental genes that are generated by duplication,distributed in the same and different regions of the genome,respectively;and Type-III can only be detected in one parental ***,Type-I genes are found to have more relaxed selection pressure and lower Ks values than Type-II,indicating that these newly evolved Type-I genes may play important roles in driving phenotypic *** analysis exhibited that newly formed fusion genes can regulate the phenotype traits of plant growth and development,suggesting the functional significance of these *** study identifies new fusion genes that could be responsible for phenotype evolution and provides information on the evolutionary history of recently diverged species in the Rosa *** data represents the major progress in understanding the new fusion genes evolution pattern of Rosaceae and provides an invaluable resource for phylogenomic studies in plants.

关键词： Rosa banksiae Gap-free genome Rosaceae Phenotype Evolutionary patterns

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Structural analysis of a neutral polysaccharide ATP-1 from the red seaweed Asparagopsis taxiformis and its immunomodulatory effects on RAW264.7 macrophages

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Food Science and Human Wellness 2025年

作者： kun Yang Baojun Xu Wei Hu Yifan Tang Amy Hui-Mei lin Saiyi Zhong College of Food Science and Technology， Guangdong Ocean University， Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety，Guangdong Province Engineering Laboratory for Marine Biological Products， Guangdong Provincial Engineering Technology Research Center of Seafood Guangdong Provincial Engineering Technology Research Center of Prefabricated Seafood Processing and Quality Control Food Science and Technology Program， Department of Life Sciences， BNU-HKBU United International College Singapore Institute of Food and Biotechnology Innovation (SIFBI) Shenzhen Research Institute， Guangdong Ocean University

As a seaweed supplement， the powdered， entire herb of Asparagopsis taxiformis can effectively promote immune response in animals. However， the active factors responsible for this effect are currently unknown. A novel polysaccharide， ATP-1， was isolated and purified from the red alga A. taxiformis， and its structural and immunomodulatory properties were determined. ATP-1 is a neutral polysaccharide with a molecular weight of 307.978 kDa and is primarily composed of galactose (94.07%)， glucose (1.27%)， and xylose (4.66%). Scanning electron microscopy and atomic force microscopy revealed that ATP-1 had an amorphous structure and was composed of molecular chain entanglement and intramolecular hydrogen bonding interactions. The microstructure of ATP-1 exhibited asymmetric sheet–like cracks and pores. Results from immunomodulatory activity showed that ATP-1 promoted inducible nitric oxide (NO) synthase and cyclooxygenase (COX)-2 protein expression in RAW264.7 macrophages， improved macrophage phagocytic ability， and stimulated cytokine production (NO， tumor necrosis factor [TNF]-α， and interleukin [IL]-6). Quantitative proteome analysis identified 178 differentially expressed proteins (70 upregulated and 108 downregulated) that were involved in various molecular pathways， among which， TNF was one of the 20 most common and significant signaling pathways in inflammation and immunoregulation. Western blotting indicated that ATP-1 significantly upregulated the expression of IKKα， IKKβ， COX-2， and TNF-α proteins in the TNF pathway. In contrast， ATP-1 downregulated the expression of IκBα， Fas， and AIPI. Results from molecular docking suggested that hydrogen bonding predominantly contributed to the affinity between TNF-α and galactose， glucose， and xylose. These findings indicated that ATP-1 may play an immunomodulatory role by activating the TNF signaling pathway. ATP-1 enhanced macrophage phagocytic capacity and stimulated the production of cytokines NO， TNF-α， and IL-6， thereb

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The Influence of Heterogeneous Processes on the Physicochemical Properties of Atmospheric Aerosols

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ADVANCES IN ATMOSPHERIC SCIENCES 2025年第4期42卷 623-640页

作者： Ge, Maofa Tong, Shengrui Du, lin Wu, lingyan Lei, Ting Li, kun Xu, Minglan Tsona, Narcisse T. Zhang, Wenqian Zhang, Hailiang Chinese Acad Sci Inst Chem Beijing Natl Lab Mol Sci BNLMS State Key Lab Struct Chem Unstable Stable Species Beijing 100190 Peoples R China Univ Chinese Acad Sci Beijing 100049 Peoples R China Shandong Univ Environm Res Inst Qingdao 266237 Peoples R China Chinese Acad Meteorol Sci State Key Lab Severe Weather Beijing 100081 Peoples R China Chinese Acad Meteorol Sci Key Lab Atmospher Chem CMA Beijing 100081 Peoples R China

With the rapid development of the world economy, complex air pollution has increasingly become a serious threat;for example, with haze events occurring frequently in various regions of the globe. Recent evidence has indicated that secondary aerosols play an important role in haze formation, and that heterogeneous processes are among the main forces driving their explosive growth. In this regard, this paper reviews recent advances in the understanding of the impact of heterogeneous processes on haze chemistry, including the impact on NO2 chemistry, marine aerosols, and the hygroscopicity and optical properties of atmospheric aerosols. It is distinguished from past reviews on this topic by focusing mainly on new insights from the past five years. We summarize the main findings of the impacts of heterogeneous processes on NO2 chemistry, marine aerosols, and the physicochemical properties of atmospheric aerosols, and propose several future research directions.

关键词： heterogeneous chemistry atmosphere aerosols physicochemical properties

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Insufficient MIRO1 contributes to declined oocyte quality during reproductive aging

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Science China Life Sciences 2025年

作者： Zhen-Nan Pan Hao-lin Zhang kun-Huan Zhang Jia-Qian Ju Jing-Cai Liu Shao-Chen Sun College of Animal Science and Technology Nanjing Agricultural University Reproductive Medicine Centre The Affiliated Yantai Yuhuangding Hospital of Qingdao University

Mitochondrial Rho-GTPase 1 (MIRO1) is an outer mitochondrial membrane protein which regulates mitochondrial transport and mitophagy in mitosis. In present study, we reported the crucial roles of MIRO1 in mammalian oocyte meiosis and its potential relationship with aging. We found that MIRO1 expressed in mouse and porcine oocytes, and its expression decreased in aged mice. MIRO1 deficiency caused the failure of meiotic resumption and polar body extrusion in both mouse and porcine oocytes, which could be rescued by exogenous MIRO1supplementation. Mass spectrometry data indicated that MIRO1 associated with several cytoskeleton and cell cycle-related proteins, and MIRO1 regulated motor protein Dynein for microtubule-organizing centers (MTOCs) dynamics at germinal vesicle (GV) stage, which determined meiotic resumption. Furthermore, we found that MIRO1 regulated Aurora A and kinesin family member 11 (KIF11) for meiotic spindle assembly in oocytes. Besides, MIRO1 associated with several mitochondria-related proteins dynamic-related protein 1 (DRP1),Parkin and lysosomal-associated membrane protein 2 (LAMP2) for mitochondrial dynamics and mitophagy during oocyte meiosis. Taken together, our results suggested that MIRO1 played pivotal roles in meiotic resumption, spindle assembly and mitochondrial function in mouse and porcine oocytes, and its insufficiency might contribute to the oocyte maturation defects during aging.

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The Influence of Heterogeneous Processes on the Physicochemical Properties of Atmospheric Aerosols

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Advances in Atmospheric Sciences 2025年第04期 623-640页

作者： Maofa GE Shengrui TONG lin DU lingyan WU Ting LEI kun LI Minglan XU Narcisse T.TSONA Wenqian ZHANG Hailiang ZHANG State Key Laboratory for Structural Chemistry of Unstable and Stable Species Beijing National Laboratory for Molecular Sciences (BNLMS) Institute of Chemistry Chinese Academy of Sciences University of Chinese Academy of Sciences Environment Research Institute Shandong University State Key Laboratory of Severe Weather & Key Laboratory of Atmospheric Chemistry of CMA Chinese Academy of Meteorological Sciences

With the rapid development of the world economy, complex air pollution has increasingly become a serious threat; for example, with haze events occurring frequently in various regions of the globe. Recent evidence has indicated that secondary aerosols play an important role in haze formation, and that heterogeneous processes are among the main forces driving their explosive growth. In this regard, this paper reviews recent advances in the understanding of the impact of heterogeneous processes on haze chemistry, including the impact on NO2chemistry, marine aerosols, and the hygroscopicity and optical properties of atmospheric aerosols. It is distinguished from past reviews on this topic by focusing mainly on new insights from the past five years. We summarize the main findings of the impacts of heterogeneous processes on NO2chemistry, marine aerosols, and the physicochemical properties of atmospheric aerosols, and propose several future research directions.

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