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Melatonin modulates adiponectin expression on murine colitis with sleep deprivation

Harmonising Rock Engineering and the Environment—12th ISRM International Congress on Rock Mechanics

作者： Eui-Seob Park So-Keul Chung joong-Ho Synn Woo-Cheol Jeong Taek-Kon kim Seong-Ho Bae Geologic Environment Division Korea Institute of Geoscience and Mineral ResourcesDaejeonKorea

＜正＞In general,either above-ground tanks or in-ground tanks been used worldwide to store *** types of tanks have a number of problems such as the need for a large site for storage tanks,ground settlement,high operating costs,an excessive boil-off ratio due to radiant heat from the sun,and so *** attempts have therefore been made in the past to store LNG underground in unlined containment,though without success. The new system for storing LNG in rock caverns had been developed and verified through the design,construction and operation of a LNG pilot plant in Daejeon,***

关键词： fluid flow ground freezing rock joints cryosuction

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World Journal of Gastroenterology 2016年第33期22卷 7559-7568页

作者： Tae Kyun kim young Sook Park Haing-Woon Baik Jin Hyun Jun Eun Kyung kim Jae Woong Sull Ho joong Sung Jin Woo Choi Sook Hee Chung Myung Chan Gye Ju Yeon Lim Jun Bong kim Seong Hwan kim Department of Gastroenterology Eulji University School of MedicineEulji Hospital Department of Biochemistry and Molecular Biology Eulji University School of Medicine Departemnt of Biomedical Laboratory Science Graduate School of Health ScienceEulji University Departemnt of Senior Healthcare BK21 plus ProgramGraduate SchoolEulji University Department of Pathology Eulji University School of Medicine Department of Gastroenterology Ajou University School of Medicine Department of Life Science and Institute of Natural Sciences Hanyang University

AIM To determine adiponectin expression in colonic tissue of murine colitis and systemic cytokine expression after melatonin treatments and sleep *** The following five groups of C57BL/6 mice were used in this study:(1) group Ⅰ,control;(2) group Ⅱ,2% DSS induced colitis for 7 d;(3) group Ⅲ,2% DSS induced colitis and melatonin treatment;(4) group Ⅳ,2% DSS induced colitis with sleep deprivation(SD) using specially designed and modified multiple platform water baths; and(5) group V,2% DSS induced colitis with SD and melatonin treatment. Melatonin(10 mg/kg) or saline was intraperitoneally injected daily to mice for 4 d. The body weight was monitored daily. The degree of colitis was evaluated histologically after sacrificing the mice. Immunohistochemical staining and Western blot analysis was performed using anti-adiponectin antibody. After sampling by intracardiac punctures,levels of serum cytokines were measured by ELISA. RESULTS Sleep deprivation in water bath exacerbated DSS induced colitis and worsened weight loss. Melatonin injection not only alleviated the severity of mucosal injury,but also helped survival during stressful condition. The expression level of adiponectin in mucosa was decreased in colitis,with the lowest level observed in colitis combined with sleep deprivation. Melatonin injection significantly(P < 0.05) recovered the expression of adiponectin. The expression levels of IL-6 and IL-17 were increased in the serum of mice with DSS colitis but decreased after melatonin injection. CONCLUSION This study suggested that melatonin modulated adiponectin expression in colonic tissue and melatonin and adiponectin synergistically potentiated antiinflammatory effects on colitis with sleep deprivation.

关键词： Colitis Melatonin Adiponectin Sleep deprivation

汽车底涂用聚酯涂料的固化及其表面性能(英文)

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汽车底涂用聚酯涂料的固化及其表面性能(英文)

Study protocol of the Asian XELIRI ProjecT(AXEPT):a multinational,randomized,non-inferiority,phase Ⅲ trial of second-line chemotherapy for metastatic colorectal cancer, comparing the eicacy and safety of XELIRI with or without bevacizumab versus FOLFIRI w

'2010北京国际粘接技术研讨会

作者： PARK cho-hee HWANG hyeon-deuk MOON je-ik kim hyun-joong NOH seung man NAM joon hyun Lab.of Adhesion and Bio-Composites Program in Environmental Materials ScienceSeoul National UniversitySeoul 151-921S.Korea

＜正＞*** Various physical properties are required for automotive *** fulfilling these properties, automotive coatings are made up multi-layers hence coating system is very *** automotive coating process is consisted of electro-deposition,primer,base coat,and clear coat. Car body forming,welding,assembling and phosphate pretreatment are accomplished in order

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Chinese Journal of Cancer 2016年第12期35卷 735-742页

作者： Masahito Kotaka Ruihua Xu Kei Muro young Suk Park Satoshi Morita Satoru Iwasa Hiroyuki Uetake Tomohiro Nishina Hiroaki Nozawa Hiroshi Matsumoto Kentaro Yamazaki Sae-Won Han Wei Wang joong Bae Ahn Yanhong Deng Sang-Hee Cho Yi Ba Keun-Wook Lee Tao Zhang Taroh Satoh Marc E.Buyse Baek-Yeol Ryoo Lin Shen Junichi Sakamoto Tae Won kim Gastrointestinal Cancer Center Sano HospitalHyogo 655-0031Japan. State Key Laboratory of Oncology in South China Department of Medical OncologyCollaborative Innovation Center for Cancer MedicineSun Yat-sen Univer-sity Cancer CenterGuangzhouGuangdong 510060P.R.China. Depart-ment of Clinical Oncology Aichi Cancer Center HospitalNagoya 464-8681Japan. Department of Medicine Samsung Medical CenterSungkyunkwan University School of MedicineSeoul 135-710South Korea. Department of Biomedical Statistics and Bioinformatics Graduate School of MedicineKyoto UniversityKyoto 606-8501Japan. Gastrointestinal Medical Oncology Division National Cancer Center HospitalTokyo 104-0045Japan. Depart-ment of Surgical Specialties Graduate SchoolTokyo Medical and Dental UniversityTokyo 113-8519Japan. Department of Gastrointestinal Medical Oncology National Hospital Organization Shikoku Cancer CenterMatsuy-ama 791-0280Japan. Department of Surgical Oncology The University of TokyoTokyo 113-0033Japan. Department of Surgery Tokyo Metropoli-tan Komagome HospitalTokyo 113-8677Japan. Division of Gastrointestinal Oncology Shizuoka Cancer CenterShizuoka 411-8777Japan. Department of Internal Medicine Seoul National University HospitalSeoul 110-744South Korea. Department of Gastrointestinal Oncology The First People's Hospital of FoshanFoshanGuangdong 528000P.R.China. Department of Inter-nal Medicine Yonsei University College of MedicineSeoul 120-752South Korea. Department of Medical Oncology The Sixth Ailiated HospitalSun Yat-sen UniversityGuangzhouGuangdong 510655P.R.China. Depart-ment of Hematology-Oncology Chonnam National University Medical SchoolGwangju 519-809South Korea. Department of Digestive Oncology Tianjin Medical University Cancer Institute and HospitalTianjin 300060P.R.China. Department of Internal Medicine Seoul National University Bundang Hos-pitalSeoul National University College of MedicineSeongnam 463-707South Korea. Department of Medical Oncology Union Hospital of Tongji Medical College

Background: Capecitabine and irinotecan combination therapy(XELIRI) has been examined at various dose levels to treat metastatic colorectal cancer(m CRC). Recently, in the Association of Medical Oncology of the German Cancer Society(AIO) 0604 trial, tri?weekly XELIRI plus bevacizumab, with reduced doses of irinotecan(200 mg/m^2 on day 1) and capecitabine(1600 mg/m^2 on days 1–14), repeated every 3 weeks, has shown favorable tolerability and eicacy which were comparable to those of capecitabine and oxaliplatin(XELOX) plus bevacizumab. The doses of capecit?abine and irinotecan in the AIO trial are considered optimal. In a phase I/II study, XELIRI plus bevacizumab(BIX) as second?line chemotherapy was well tolerated and had promising eicacy in Japanese ***: The Asian XELIRI Projec T(AXEPT) is an East Asian collaborative, open?labelled, randomized, phase Ⅲ clinical trial which was designed to demonstrate the non?inferiority of XELIRI with or without bevacizumab versus standard FOLFIRI(5?fluorouracil, leucovorin, and irinotecan combination) with or without bevacizumab as second?line chemo?therapy for patients with m CRC. Patients with 20 years of age or older, histologically conirmed m CRC, Eastern Coop?erative Oncology Group performance status 0–2, adequate organ function, and disease progression or intolerance of the irst?line regimen will be eligible. Patients will be randomized(1:1) to receive standard FOLFIRI with or with?out bevacizumab(5 mg/kg on day 1), repeated every 2 weeks(FOLIRI arm) or XELIRI with or without bevacizumab(7.5 mg/kg on day 1), repeated every 3 weeks(XELIRI arm). A total of 464 events were estimated as necessary to show non?inferiority with a power of 80% at a one?sided α of 0.025, requiring a target sample size of 600 patients. The 95% conidence interval(CI) upper limit of the hazard ratio was pre?speciied as less than ***: The Asian XELIRI Projec T is a multinational phase III trial being conducted to provide evidence fo

关键词： Metastatic colorectal cancer Randomized phase Ⅲ clinical trial XELIRI Bevacizumab Second-line therapy

Effect of preoperative biliary drainage on surgical results after pancreaticoduodenectomy in patients with distal common bile duct cancer:Focused on the rate of decrease in serum bilirubin

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World Journal of Gastroenterology 2008年第7期14卷 1102-1107页

作者： Yun Mee Choi Eung-Ho Cho Keon-young Lee Seung-Ik Ahn Sun Keun Choi Sei joong kim Yoon Seok Hur young Up Cho Kee-Chun Hong Seok-Hwan Shin Kyung Rae kim Ze-Hong Woo Department of Surgery College of MedicineInha UniversityIncheonKorea

AIM: To examine if the rate of decrease in serum bilirubin after preoperative biliary drainagecan be used as a predicting factor for surgical complications and postoperative recovery after pancreaticoduodenectomy in patients with distal common bile duct ***: A retrospective study was performed in 49 consecutive patients who underwent pancrea-ticoduodenectomy for distal common bile duct cancer. Potential risk factors were compared between the complicated and uncomplicated groups. Also, the rates of decrease in serum bilirubin were compared pre- and postoperatively. RESULTS: Preoperative biliary drainage (PBD) was performed in 40 patients (81.6%). Postoperative morbidity and mortality rates were 46.9% (23/49) and 6.1% (3/49), respectively. The presence or absence of PBD was not different between the complicated and uncomplicated groups. In patients with PBD, neither the absolute level nor the rate of decrease in serum bilirubin was significantly different. Patients with rapid decrease preoperatively showed faster decrease during the first postoperative week (5.5 ± 4.4 μmol/L vs -1.7 ± 9.9 μmol/L, P = 0.004).CONCLUSION: PBD does not affect the surgical outcome of pancreaticoduodenectomy in patients with distal common bile duct cancer. There is a certain group of patients with a compromised hepatic excretory function, which is represented by the slow rate of decrease in serum bilirubin after PBD.

关键词：胆红素胆管癌手术治疗胰十二指肠切除术

Risk factors affecting pancreatic fistulas after pancreaticoduodenectomy

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World Journal of Gastroenterology 2008年第45期14卷 6970-6974页

作者： Yun-Mee Choe Keon-young Lee Cheong-Ah Oh Joung-Bum Lee Sun Keun Choi Yoon-Seok Hur Sei-joong kim young Up Cho Seung-Ik Ahn Kee-Chun Hong Seok-Hwan Shin Kyung-Rae kim Department of Surgery Inha University Hospital

AIM: To analyze the risk factors of pancreatic leakage after ***: We retrospectively reviewed 172 consecutive patients who had undergone pancreatico-duodenectomy at Inha University Hospital between April 1996 and March 2006. We analyzed the pancreatic fistula rate according to the clinical characteristics, the pathologic and laboratory findings, and the anastomotic ***: The incidence of developing pancreatic fistulas in patients older than 60 years of age was 21.7% (25/115), while the incidence was 8.8% (5/57) for younger patients; the difference was significant (P = 0.03). Patients with a dilated pancreatic duct had a lower rate of post-operative pancreatic fistulas than patients with a non-dilated duct (P = 0.001). Other factors, including clinical features, anastomotic methods, and pathologic diagnosis, did not show any statistical difference. CONCLUSION: Our study demonstrated that pancreatic fistulas are related to age and a dilated pancreatic duct. The surgeon must take these risk factors into consideration when performing a pancre-aticoduodenectomy.

关键词：胰腺疾病胰腺瘘管治疗临床

保障医疗设备硬件系统功能安全的有效方法(英文)

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中国医疗设备 2015年第12期30卷 27-33,15页

作者： kim Gi-young WANG Da-wei PARK Ho-joon JANG joong-soon Department of Industrial Engineering Ajou University Medical Device Evaluation Engineering Center Korea Testing Laboratory

A medical device is an instrument that includes components,parts,or accessories to diagnose or treat *** the complexity of medical devices has increased in recent years,functional safety and basic safety are required to ensure the overall device *** safety is part of the overall safety that relates to the equipment under control(EUC)and to the EUC control system that depends on the correct functionality of the electrical/electronic/programmable electronic(E/E/PE)safety-related *** study proposes approach methods to functional safety of medical devices for which it is important to correctly identify the safety functions and the safety integrity level(SIL).The relationship between the functional safety and essential performance is identified focusing on the safety *** essential performance of E/E/PE systems is defined as the safety function of the functional *** target SIL of the essential performance is determined according to the potential risk levels,based on the classification rules of medical *** approach is applied to the pulse oximeter as a case *** target SIL for the functionality of the power-failure alarm condition is determined to be *** target SILs of other functions are determined as SIL2.

关键词： functional safety medical device essential performance classification rule safety function pulse oximeter

柠檬酸盐法制备(Na_(0.5)Bi_(0.5))_(1-x)Ba_xTiO_3压电陶瓷的极化特性研究

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人工晶体学报 2005年第1期34卷 159-163页

作者：陈书涛徐庆陈文周静金福熙李仲熙武汉理工大学材料科学与工程学院武汉430070 韩国全北国立大学工科大学全州561756

采用柠檬酸盐法合成了具有单一钙钛矿结构的 (Na0. 5Bi0. 5 )1 xBaxTiO3 (x=0,x=0. 04)超细粉料,并研究了陶瓷样品的极化特性、压电性能和铁电性能。研究结果表明,柠檬酸与金属离子的摩尔比(C/M)控制在 1. 2~1. 6、前驱体液的pH值控制在... 详细信息

采用柠檬酸盐法合成了具有单一钙钛矿结构的 (Na0. 5Bi0. 5 )1 xBaxTiO3 (x=0,x=0. 04)超细粉料,并研究了陶瓷样品的极化特性、压电性能和铁电性能。研究结果表明,柠檬酸与金属离子的摩尔比(C/M)控制在 1. 2~1. 6、前驱体液的pH值控制在 7~9范围内可以得到均匀透明的溶胶和凝胶,凝胶在 600℃下热处理 1h后可形成单一钙钛矿结构的超细粉料。XRD研究结果表明,x=0和x=0. 04时陶瓷样品均为三方钙钛矿结构。极化电压和极化温度对陶瓷样品的压电性能有很大影响,而极化时间对压电性能的影响则不显著。Ba2+的固溶改善了陶瓷样品的铁电性能,有利于材料极化性能和压电性能的提高。与常规固相法制备的同种组成样品相比,柠檬酸盐法制备的 (Na0. 5Bi ) BaTiO (x=0,x=0. 04)陶瓷具有较好的压电性能。

关键词：陶瓷样品柠檬酸盐法制备压电性能粉料极化特性超细粉钙钛矿结构铁电性能极化性能

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AMOLED电视机商业化中的新兴技术

现代显示 2010年第6期 9-13,19页

作者： Hye Dong kim Hyun-joong Chung Brian H.Berkeley Sang Soo kim 代永平三星移动显示公司OLED研发中心南开大学

AMOLED在材料、器件结构以及制造方面的发展为新一代电视机铺平了道路,新一代电视机拥有互动性、超轻超薄、绿色环保等特点。

关键词：有源矩阵有机发光二极管电视机背板技术