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Increased CD4^+CD45RA^-FoxP3^(low) cells alter the balance between Treg and Th17 cells in colitis mice

World Journal of Gastroenterology 2016年第42期22卷 9356-9367页

作者： Ya-Hui Ma Jie Zhang Xue Chen you-fu xie Yan-Hua Pang Xin-Juan Liu Department of Gastroenterology Beijing Anzhen Hospital Capital Medical University Department of Gastroenterology Beijing Chaoyang Hospital Capital Medical University

AIM To investigate the role of regulatory T cell(Treg) subsets in the balance between Treg and T helper 17(Th17) cells in various tissues from mice with dextran sulfate sodium-induced *** T r e g c e l l s, T r e g c e l l s u b s e t s, T h 1 7 c e l l s, a n d CD4+CD25+FoxP 3+IL-17+ cells from the lamina propria of colon(LPC) and other ulcerative colitis(UC) mouse tissues were evaluated by flow cytometry. Forkhead box protein 3(FoxP 3), interleukin 17A(IL-17A), and RORC m RNA levels were assessed by real-time PCR, while interleukin-10(IL-10) and IL-17 A levels were detected with a Cytometric Beads *** In peripheral blood monocytes(PBMC), mesenteric lymphnode(MLN), lamina propria of jejunum(LPJ) and LPC from UC mice, Treg cell numbers were increased(P < 0.05), and FoxP 3 and IL-10 mR NA levels were decreased. Th17 cell numbers were also increased in PBMC and LPC, as were IL-17 A levels in PBMC, LPJ, and serum. The number of FrI subset cells(CD4+CD45RA+FoxP 3low) was increased in the spleen, MLN, LPJ, and LPC. FrI I subset cells(CD4+CD45RA-Fox P3high) were decreased among PBMC, MLN, LPJ, and LPC, but the number of Fr III cells(CD4+CD45RA-FoxP 3low) and CD4+CD25+FoxP 3+IL-17A+ cells was increased. Fox P3 m RNA levels in CD4+CD45RA-Fox P3 low cells decreased in PBMC, MLN, LPJ, and LPC in UC mice, while IL-17 A and RORC mR NA increased. In UC mice the distribution of Treg, Th17 cells, CD4+CD45RA-FoxP 3high, and CD4+CD45RA-FoxP 3low cells was higher in LPC relative to other *** Increased numbers of CD4+CD45RA-FoxP 3low cells may cause an imbalance between Treg and Th17 cells that is mainly localized to the LPC rather than secondary lymphoid tissues.

关键词： Ulcerative colitis Regulatory T cells Treg cells subsets T helper 17 cells

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Numerical simulation of temperature field in horizontal core-filling continuous casting for copper cladding aluminum rods

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International Journal of Minerals,Metallurgy and Materials 2013年第7期20卷 684-692页

作者： Ya-jun Su Xin-hua Liu Yong-fu Wu Hai-you Huang Jian-xin xie Key Laboratory for Advanced Materials Processing (Ministry of Education) Institute of Advanced Materials and Technology Uni- versity of Science and Technology Beijing

The steady-state temperature field of horizontal core-filling continuous casting （HCFC） for producing copper cladding aluminum rods was simulated by finite element method to investigate the effects of key processing parameters on the positions of solid-liquid interfaces （SLIs） of copper and aluminum. It is found that mandrel tube length and mean withdrawing speed have significant effects on the SLI positions of both copper and aluminum. Aluminum casting temperature （TAI）（1003-1123 K） and secondary cooling water flux （600-900 L.h-1） have little effect on the SLI of copper but cause the SLI of aluminum to move 2-4 mm. When TA1 is in a range of 1043-1123 K, the liquid aluminum can fill continuously into the pre-solidified copper tube. Based on the numerical simulation, reasonable processing parameters were determined.

关键词： metal cladding copper aluminum continuous casting interfaces computer simulation

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Ultra-homogeneous Cu_(2-x)Se nanoparticles as near-infraredⅡplasmonic phototheranstics for photothermal/chemodynamic synergistic therapy of liver cancer

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Particuology 2023年第5期76卷 23-31页

作者： Bei Li Jing Li Yi fu Xiwen Ye Maodi xie Lei Feng Xiaoya Niu Zhen you Division of Biliary Surgery Department of General SurgeryWest China HospitalSichuan UniversityChengdu610041China Research Center for Biliary Diseases West China HospitalSichuan UniversityChengdu610041China Department of Operating Room West China Hospital of Sichuan UniversityChengdu610041China Department of Physiology and Pathophysiology School of Basic Medical SciencesPeking UniversityBeijing100191China West China-Washington Mitochondria and Metabolism Center West China Hospital of Sichuan UniversityChengdu610041China

Laser mediated photothermal/chemodynamic co-therapy is widely applied for anti-cancer treatment due to its good therapeutic ***,the laser wavelength for effectively targeting deep tumor tissues can decide whether or not it is a key premise of irradiation *** this study,a super-homogenous and highly dispersive spherical nanoparticle Cu_(2-x)Se was prepared,which displayed a strong surface plasmon resonance(SPR)peak in the near-infrared region(NIR)-Ⅱand high Fenton catalytic *** results of in vitro experiments showed that Cu_(2-x)Se nanoparticles exhibited high photothermal conversion efficiency under the excitation of NIR-Ⅱlaser irradiation,which significantly improved its ability to produce *** a tumor-bearing mouse model,the combination of Cu_(2-x)Se and photothermal/chemodynamic co-therapy guided by the real-time photoacoustic imaging in the NIR-Ⅱcould effectively inhibit tumor growth and exhibit good in vivo/in vitro *** summary,this Cu_(2-x)Se nanoparticle-based NIR-Ⅱlaser-mediated photothermal/chemodynamic co-therapy strategy is expected to provide a new option for the diagnosis and treatment of liver cancer.

关键词： NIR-Ⅱ Cu_(2-x)Se Photothermal therapy Chemodynamic therapy Liver cancer

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fuzzy-immune control strategy of a hydro-viscous soft start device of a belt conveyor

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Mining Science and Technology 2009年第4期19卷 544-548页

作者： xie Fang-wei HOU you-fu XU Zhi-peng ZHAO Rui School of Mechanical and Electrical Engineering China University of Mining ＆ Technology Xuzhou Jiangsu 221008 China Test Branch of Beijing Coal Research Institute Beijing 100013 China

Considering the control difficulties of a hydro-viscous trol algorithm was derived. A fuzzy-immune PID controller was soft start （HVSS） device of a belt conveyor, a fuzzy-immune con- designed based on immune feedback regulations and adaptability of the fuzzy logic inference. Using MATLAB software, we simulated the controller and compared the HVSS device with a conven- tional PID controller and a fuzzy PID controller. The simulation results show that the controller is not only very reliable as a PID controller, robust and requires only a short adjustment time of fuzzy control, but possesses also capacity of global optimization of the immune algorithm. To verify our theoretical analysis and simulation, a HVSS test-bed was developed. The experimental results demonstrate that the fuzzy-immune PID controller managed to start the belt conveyor softly and to follow an S-shaped curve while the output speed correctly followed the preset speed with only small fluctuations in speed.

关键词： fuzzy-immune hydro-viscous soft-start control strategy belt conveyor PID

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A New Degraded Sesquiterpene from Marine Actinomycete Streptomyces sp. 0616208

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Chinese Chemical Letters 2006年第11期17卷 1463-1465页

作者： Xiu Chao xie Wen Li MEI you Xing ZHAO Kui HONG Hao fu DAI State Key Laboratory. of Tropical Crops Biotechnology Institute of Tropical Bioscience and Biotechnology Chinese Academy of Tropical Agriculture Sciences Haikou 571101 State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of Botany Chinese Academy of Sciences Kunming 650204

A new degraded sesquiterpene was isolated from the marine actinomycete Streptomyces sp. 0616208. Its structure was elucidated as （1α; 4aα; 5α, 7β, 8aβ）-5, 8a-dimethyl-decahydrona- phthalene-1, 4a, 7-triol on th... 详细信息

关键词： Marine actinomycete, Streptomyces sp., degraded sesquiterpene, (1α 4aα 5α, 7β, 8aβ)-5, 8a-dimethyl-decahydronaphthalene- 1,4a,7-triol.

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Some Special Solutions of Three Nonlinear Lattices

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Communications in Theoretical Physics 2005年第2X期44卷 293-296页

作者： xie fu-Ding Department of Computer Science Liaoning Normal University Dalian 116029 China Key Laboratory of Mathematical Mechanization Academy of Mathematics and System Sciences the Chinese Academy of Sciences Beijing 100080 China

Some soliton solutions and periodic solutions of hybrid lattice, discretized mKdV lattice, and modified Volterra lattice have been obtained by introducing a new method. This approach allows us to directly construct so... 详细信息

关键词： nonlinear lattices soliton solution symbolic computation

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Microstructure and properties evolution of in-situ fiber-reinforced Ag-Cu-Ni-Ce alloy during deformation and heat treatment

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International Journal of Minerals,Metallurgy and Materials 2022年第11期29卷 2000-2011页

作者： Xingqun He Huadong fu Jianxin xie Beijing Advanced Innovation Center for Materials Genome Engineering University of Science and Technology BeijingBeijing 100083China Beijing Laboratory of Metallic Materials and Processing for Modern Transportation University of Science and Technology BeijingBeijing 100083China Key Laboratory for Advanced Materials Processing(Ministry of Education) University of Science and Technology BeijingBeijing 100083China

Silver-based alloys are significant light-load electrical contact materials(ECMs).The trade-off between mechanical properties and electrical conductivity is always an important issue for the development of silver-based *** this paper,we proposed an idea for the regulation of the mechanical properties and the electrical conductivity of Ag-11.40Cu-0.66Ni-0.05Ce(wt%)alloy using in-situ composite *** alloy was processed using rolling,heat treatment,and heavy drawing,the strength and electrical conductivity were tested at different deformation stages,and the microstructures during deformation were observed using field emission scanning electron microscope(FESEM),transmission electron microscope(TEM)and electron backscatter diffraction(EBSD).The results show that the method proposed in this paper can achieve the preparation of in-situ composite fiber-reinforced Ag-Cu-Ni-Ce *** the heavy deformation drawing,the room temperature Vickers hardness of the as-cast alloy increased from HV 81.6 to HV 169.3,and the electrical conductivity improved from 74.3%IACS(IACS,i.e.,international annealed copper standard)to 78.6%*** the deformation increases,the alloy strength displays two different strengthening mechanisms,and the electrical conductivity has three stages of *** research provides a new idea for the comprehensive performance control of high-performance silver-based ECMs.

关键词： silver alloy electrical contact materials drawing in-situ fiber-reinforced

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Sintering kinetics involving grain growth and densification of Mg-PSZ nanopowders

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Journal of Iron and Steel Research International 2022年第7期29卷 1138-1144页

作者： Yi-ming She Jie-fu Lang Di An Chao-wei Si Xu-dong Luo Zhi-peng xie Jie-gang you School of Materials and Metallurgy University of Science and Technology LiaoningAnshan 114051LiaoningChina Institute of Advanced Structures Beijing Institute of TechnologyBeijing 100081China State Key Lab of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China

Sintering kinetics have been found to be effective in judging the evolution of *** using magnesium oxide-partially stabilized zirconia(Mg-PSZ)powder prepared by co-precipitation as raw materials,the evolution of densification and grain growth for Mg-PSZ ceramics were *** results indicated that the densification of samples was mainly controlled by grain boundary diffusion in intermediate sintering *** the sintering process,the grain growth mechanisms included normal grain growth,abnormal grain growth and solid solution drag-controlled grain ***,the apparent activation energy for grain growth of Mg-PSZ ceramics is lower than that of ZrO_(2)–Y_(2)O_(3)ceramics in the solid solution drag-controlled grain grow process,which will cause grain to grow *** sintering kinetics and microstructure of Mg-PSZ ceramics were studied,and the kinetic equation of grain growth at different temperatures was *** results show that the strength difference between Mg-PSZ and yttrium oxide-stabilized zirconia is closely related to the easy grain growth of Mg-PSZ ceramics.

关键词： Magnesium oxide-partially stabilized zirconia Sintering kinetics Grain growth mechanism Densification mechanism Sizing nozzle

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Response of Nitrate Metabolism in Seedlings of Oilseed Rape(Brassica napus L.) to Low Oxygen Stress

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Journal of Integrative Agriculture 2014年第11期13卷 2416-2423页

作者： YU Chang-bing xie Yu-yun HOU Jia-jia fu you-qiang SHEN Hong LIAO Xing Key Laboratory of Biology and Genetic Improvement of Oil Crops Ministry of Agriculture/Oil Crops Research Institute Chinese Academy of Agricultural Sciences College of Resources and Environment South China Agricultural University

In order to understand the response of nitrate metabolism in seedlings of oilseed rape （Brassica napus L.） to low oxygen stress （LOS）, two cultivars were studied at different light, LOS time and exogenous nitrate concentrations under hydroponic stress. Results show that N-uptake and dry matter of rape seedlings were decreased after LOS stress while nitrate accumulation （NA） under LOS was induced by darkness. Nitrate accumulation peaked at 3 d while root activity （RA, deifned as dehydrogenase activity） decreased with prolonged waterlogging exposure. Exogenous nitrate signiifcantly elevated NA and RA. Tungstate （TS） and LOS inhibited nitrate reductase （NR） activity while NR transcription and activity were enhanced by exogenous nitrate. Low oxygen stress stimulated the activity of superoxide dismutase （SOD） and peroxidase （POD） slightly, but inhibited that of catalase （CAT）. B. napus L. Zhongshuang 10 （ZS10）, a LOS tolerant cultivar, displayed smaller decrease upon dry matter under LOS, higher NA in darkness and lower NA in light than B. napus L. Ganlan CC （GAC）, a LOS sensitive variety. ZS10 had lower NA and higher RA after waterlogging and exogenous nitrate treatment, and higher NR activity under TS inhibition than GAC, but the activity of antioxidant enzymes did not change under LOS. The results indicate that nitrate metabolism involved tolerance of rape seedlings to LOS, with lower accumulation and higher reduction of nitrate being related to higher LOS tolerance of rape seedlings exposed to waterlogging.

关键词： Brassica napus low oxygen stress nitrate accumulation nitrate reductase gene expression

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混合量子-经典算法的配电网灾后拓扑重构方法

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西安交通大学学报 2025年第1期59卷 1-16页

作者：付炜谢海鹏王鹤峰陈晨别朝红西安交通大学电气工程学院西安710049 西安交通大学物理学院西安710049

为及时有效地制定配电网拓扑重构策略以提升负荷快速恢复能力,基于量子计算的优越性,提出混合量子-经典(HQC)算法的弹性配电网灾后拓扑重构方法。首先,构建基于HQC算法的灾后配电网拓扑重构模型,以实现实际场景、优化问题、嵌入算法相... 详细信息

为及时有效地制定配电网拓扑重构策略以提升负荷快速恢复能力,基于量子计算的优越性,提出混合量子-经典(HQC)算法的弹性配电网灾后拓扑重构方法。首先,构建基于HQC算法的灾后配电网拓扑重构模型,以实现实际场景、优化问题、嵌入算法相应模块在量子计算和经典计算环境下的协作交互过程。然后,将配电网拓扑重构问题构造为无约束离散优化子问题和有约束连续优化子问题,提出量子退火嵌入式交替方向乘子(QA-ADMM)算法,将离散子问题等效映射成量子可解释的伊辛模型后,部署在D-Wave量子退火计算机中,并与经典计算机中连续子问题迭代求解,采用自适应惩罚因子调节机制加速算法收敛。最后,通过IEEE 14、33、69、123以及改进的205节点的不同规模配电系统,分析验证了QA-ADMM算法的有效性、稳定性与可扩展性。结果表明,惩罚因子、目标函数惩罚项系数、量子退火中采样读取次数会影响所提算法的精度和收敛速度;优化问题规模扩大后,所提混合量子-经典算法计算优势更加明显,205节点配电系统算例下,计算效率较经典计算可提升约34%。

关键词：弹性配电网拓扑重构混合量子-经典算法量子计算量子退火

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