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Synergistic anticancer properties of docosahexaenoic acid and 5-fluorouracil through interference with energy metabolism and cell cycle arrest in human gastric cancer cell line AGS cells

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World Journal of Gastroenterology 2016年第10期22卷 2971-2980页

作者： Kun Gao Qi liang Zhi-Hao Zhao you-fen li Shu-feng Wang The Key Laboratory of Biomedical Information Engineering of Ministry of Education School of Life Science and Technology Xi'an Jiaotong University Xi'an 710049 Shaanxi Province China Department of Anesthesiology Xi'an Traditional Chinese Medicine Hospital Xi'an 710021 Shaanxi Province China Department of General Surgery The First Affiliated Hospital of Xi'an Jiaotong University Xi'an 710061 Shaanxi Province China

AIM: To explore the synergistic effect of docosahexaenoic acid(DHA)/5-fluorouracil(5-FU) on the human gastric cancer cell line AGS and examine the underlying ***: AGS cells were cultured and treated with a series of concentrations of DHA and 5-FU alone or in combination for 24 and 48 h. To investigate the synergistic effect of DHA and 5-FU on AGS cells, the inhibition of cell proliferation was determined by MTT assay and cell morphology. Flow cytometric analysis was also used to assess cell cycle distribution, and the expression of mitochondrial electron transfer chain complexes(METCs)?Ⅰ, Ⅱ and Ⅴ in AGS cells was further determined by Western blot analysis. RESULTS: DHA and 5-FU alone or in combination could markedly suppress the proliferation of AGS cells in a significant time and dose-dependent manner. DHA markedly strengthened the antiproliferative effect of 5-FU, decreasing the IC50 by 3.56-2.15-fold in an apparent synergy. The morphological changes of the cells were characterized by shrinkage, cell membrane blebbing and decreased adherence. Cell cycle analysis showed a shift of cells into the G0/G1 phase from the S phase following treatment with DHA or 5-FU(G0/G1 phase: 30.04% ± 1.54% vs 49.05% ± 6.41% and 63.39% ± 6.83%, respectively, P < 0.05; S phase: 56.76% ± 3.14% vs 34.75% ± 2.35% and 25.63% ± 2.21%, respectively, P < 0.05). Combination treatment of DHA and 5-FU resulted in a significantly larger shift toward the G0/G1 phase and subsequent reduction in S phase(G0/G1 phase: 69.06% ± 2.63% vs 49.05% ± 6.41% and 63.39% ± 6.83%, respectively, P < 0.05; S phase: 19.80% ± 4.30% vs 34.75% ± 2.35% and 25.63% ± 2.21%, respectively, P < 0.05). This synergy was also reflected in the significant downregulation of the expression of METCs in AGS ***: Synergistic anticancer properties of DHA and 5-FU may involve interference with energy production of AGS cells via downregulation of METCs and cell cycle arrest.

关键词： Docosahexaenoic acid Gastric cancer 5-fluorouracil Cell line Mitochondria

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Yb^(3+),Tb^(3+)共掺杂Sr_2B_2O_5荧光粉的制备及其下转换发光性能的研究

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无机材料学报 2016年第10期31卷 1081-1086页

作者：戴智刚李友芬李刚杨儒北京化工大学材料电化学过程与技术北京市重点实验室北京100029 北京化工大学碳纤维及功能高分子教育部重点实验室北京100029

采用高温固相法合成了Tb^(3+),Yb^(3+)共掺杂的Sr_2B_2O_5荧光粉。通过X射线衍射(XRD)和荧光光谱(PL)对样品的物相结构和发光性质进行了表征。XRD结果表明,合成样品为单斜结构的Sr_2B_2O_5相。分别使用543 nm和980 nm的监测波长,得到的... 详细信息

采用高温固相法合成了Tb^(3+),Yb^(3+)共掺杂的Sr_2B_2O_5荧光粉。通过X射线衍射(XRD)和荧光光谱(PL)对样品的物相结构和发光性质进行了表征。XRD结果表明,合成样品为单斜结构的Sr_2B_2O_5相。分别使用543 nm和980 nm的监测波长,得到的激发光谱均在354 nm、374 nm处有较强的激发峰,其中374 nm处最强,说明Sr_2B_2O_5荧光材料在近紫外光区对太阳光有很强的吸收;在374 nm(Tb^(3+):~7F_6→~5D_3)紫外光激发下,观察到Tb^(3+):~5D_4→~7F_J(J=6,5,4,3)可见光区发射光,并检测到Yb^(3+):~2F_(5/2)→~2F_(7/2)的近红外发射光。通过研究激发光谱和发射光谱与Yb^(3+)掺杂浓度的关系,发现在单斜晶体Sr_2B_2O_5中,Yb^(3+)具有很高的猝灭浓度。

关键词： Sr2B2O5 Tb^3+ Yb^3+ 下转换发光材料

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Micro-strain regulation strategy to stabilize perovskite lattice based on the categories and impact of strain on perovskite solar cells

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Journal of Energy Chemistry 2025年第1期100卷 578-604页

作者： Caixia li Wenwu liu Shiji Da lingbin Kong fen Ran State Key Laboratory of Advanced Processing and Recycling of Nonferrous Metals Lanzhou University of Technology School of Materials Science and Engineering Lanzhou University of Technology

Photovoltaic metal halide perovskite solar cells(PSCs) convert light to electricity more efficiently than crystalline silicon cells, and the cost of materials used to make them is lower than that of silicon *** efficiency is not a core issue affecting the application of perovskite solar cells in special *** present, stability is the major technical encounters that hinders its further commercial development. Microstrain in PSCs is currently a significant factor responsible for the device's instability. Strain-induced ion migration is widely believed to accelerate perovskite degradation even when external stimuli are ***, it is imperative to study strain to enhance the stability of PSCs. This paper reviews recent developments to understand strain's origin and effect mechanisms on performance of PSCs, including ion migration,failure behavior, defect formation, and its effect on photoelectric properties, stability, and ***, several well-known strain management strategies are systematically introduced based on the strain effect mechanism and strain engineering on the film, providing more clues for further preparation with increased stability. The manipulation of external physical strain applied from films to entire devices has been extensively studied. Furthermore, recommendations for future research directions and chemical approaches have been provided. It is emphasized that strain engineering plays a crucial role in improving the efficiency and longevity of PSCs. Tensile strain causes rapid degradation, while moderate compressive strain and external strain control could improve properties and stability. Efforts should focus on controlling compressive strain to mitigate residual tensile strain and introducing it in a controlled manner. Future research endeavors may focus on exploring these pathways to improve the efficiency and lifespan of PSCs.

关键词： Halide perovskite solar cells Strain origins Strain effects Strain management

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Atomically precise nickel-sulfur clusters for efficient electrochemical 2,5-hydroxymethylfurfural oxidation

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Nano Research 2025年第1期18卷 140-148页

作者： fen Wang Lu-Yu liu Sha-Sha Cui Ting-Ting li Xiao-Meng Yang Zhijuan liu Yanyong Wang Henan Key Laboratory of Crystalline Molecular Functional Materials Henan International Joint Laboratory of Tumor Theranostical Cluster MaterialsGreen Catalysis Centerand College of ChemistryZhengzhou UniversityZhengzhou 450001China State Key Laboratory of Chem/Bio-sensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China

Nickel sulfide exhibits excellent catalytic activity in the electrochemical 2,5-hydroxymethylfurfural oxidation reaction(HMFOR).However,due to the polydispersity of nanoparticles,it is difficult to establish a clear structure-activity relationship at the atomic *** this work,we have successfully synthesized atomically precise Ni_(6)(PET)_(12)and Ni_(4)(PET)_(8)clusters(PET:2-phenylethanethiol)for ***^(2+)and S_(2)-with atomic ratio of 1:2 was mainly existed in Ni_(6)(PET)_(12)and Ni_(4)(PET)_(8)to form Ni-S *** electrochemical test results have suggested both Ni_(6)(PET)_(12)and Ni_(4)(PET)_(8)displayed outstanding electrocatalytic ability for *** Ni_(6)(PET)_(12)exhibited better electrocatalytic ability than Ni_(4)(PET)_(8)with higher current density,lower overpotential and faster reaction *** superior electrochemical ability of Ni_(6)(PET)_(12)may be due to the enhanced adsorption towards HMF molecule with strong interaction towards hydroxyl group and furan ***,it found that the Ni^(2+)species in Ni_(6)(PET)_(12)could rapidly oxidized into Ni^(3+)species,which could spontaneously capture electron and proton from HMF for *** theoretical calculation demonstrated that the Ni_(6)(PET)_(12)process lower free energy barrier than Ni_(4)(PET)_(8)to display excellent electrocatalytic *** work is of great significance for designing efficient electrocatalysts for HMFOR.

关键词： atomically precise nickel nanoclusters 2 5-hydroxymethylfurfural electro-oxidation Ni3+species

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基于图像特征的车脸栅格的定位方法

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传感器与微系统 2017年第9期36卷 64-66页

作者：张有芬李玉惠潘艺昆明理工大学信息工程与自动化学院云南昆明650500 云南省智能交通系统工程技术研究中心智能图像处理研究室云南昆明650500

为了解决智能交通系统中车型识别的瓶颈,找到能够准确定位车标的方法,提出了在Adaboost算法定位出的车脸的基础上,对车脸图像进行二值化处理,经过二值化图像的水平梯度和垂直梯度的投影定位栅格的方法,为后续车标的识别提供了一种新的... 详细信息

为了解决智能交通系统中车型识别的瓶颈,找到能够准确定位车标的方法,提出了在Adaboost算法定位出的车脸的基础上,对车脸图像进行二值化处理,经过二值化图像的水平梯度和垂直梯度的投影定位栅格的方法,为后续车标的识别提供了一种新的方法。经过实验验证:方法无论从理论上还是实际应用中,具有重要的意义。

关键词： Adaboost 车标识别车标定位栅格定位

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重组人血管内皮抑制素YH-16治疗晚期非小细胞肺癌的临床研究

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中华肿瘤杂志 2006年第2期28卷 138-141页

作者：杨林王金万孙燕朱允中刘晓晴李维廉邸立军李佩文王友良宋恕平姚晨游丽芬中国医学科学院中国协和医科大学肿瘤研究所肿瘤医院内科北京100021 北京胸部肿瘤结核病医院内科军事医学科学院附属医院肿瘤科天津第二中心医院肿瘤科北京市肿瘤医院内科北京中日友好医院肿瘤科江苏常州市第二人民医院呼吸科山东省肿瘤医院内科北京大学第一医院统计教研室烟台麦得津生物工程股份有限公司临床部

目的评价重组人血管内皮抑制素YH-16治疗复治的晚期非小细胞肺癌的有效率、肿瘤进展时间(TTP)、对生活质量的影响及不良反应,并为临床确定合适的用药剂量。方法本研究为随机对照多中心试验。患者随机分为7.5mg/m2或15mg/m2两个剂量组,... 详细信息

目的评价重组人血管内皮抑制素YH-16治疗复治的晚期非小细胞肺癌的有效率、肿瘤进展时间(TTP)、对生活质量的影响及不良反应,并为临床确定合适的用药剂量。方法本研究为随机对照多中心试验。患者随机分为7.5mg/m2或15mg/m2两个剂量组,均采用静脉滴注YH-163h,每天1次,连续给药28d。结果共入组68例,可评价疗效的患者60例。7.5mg/m2剂量组和15mg/m2剂量组有效率均为3.0%(P>0.05);中位TTP在意向治疗(ITT)人群分别为60d和71d(P>0.05),对生活质量的影响以及不良事件发生率分别为48.6%和38.7%(P>0.05)。无预期以外的不良事件发生。结论YH-16对多程化疗后复发的非小细胞肺癌显示出一定的抗肿瘤活性,安全性较好,临床受益率高;建议采用7.5mg/m2作为临床常规使用剂量。

关键词：重组人血管内皮抑制素YH-16 非小细胞肺癌

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Anlotinib-induced sick sinus syndrome:Two case reports

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World Journal of Clinical Cases 2025年第6期13卷 30-34页

作者： Cheng-feng Fu li-fen Yang Lei Tian Song Deng Qi Zhang Biao Yao Department of Oncology Tongren People’s HospitalTongren 554300Guizhou ProvinceChina Department of Oncology Guizhou Provincial People’s HospitalGuiyang 550000Guizhou ProvinceChina

BACKGROUND This manuscript describes the first known cases of sick sinus syndrome(SSS)associated with the use of anlotinib in non-small cell lung cancer patients,highlighting the need for increased vigilance and cardiac *** SUMMARY Two patients with non-small cell lung cancer developed SSS after 15 months and 5 months of anlotinib treatment,respectively,presenting with syncope and *** confirmed SSS,and different treatment approaches were taken for each *** patient received a dual-chamber permanent pacemaker,while the other discontinued the medication and experienced symptom *** Anlotinib can induce SSS,suggesting that cardiac monitoring is crucial during anlotinib *** management strategies are necessary for affected individuals.

关键词： Lung cancer Anlotinib Sick sinus syndrome Cardiac pacemaker Adverse drug reaction Case report

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Influence of dissolved organic carbon on multimedia distribution and toxicity of fipronil and its transformation products in lotic waterways

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Journal of Environmental Sciences 2023年第8期130卷 52-64页

作者： Weizong li Hao Hu fen liu Huizhen li Jing you School of Environment and Guangdong Key Laboratory of Environmental Pollution and Health Jinan UniversityGuangzhou 511443China

Environmental fate and ecological impacts of fipronil and its transformation products(FIPs)in aquatic environment have caused worldwide attention,however,the influence of dissolved organic carbon(DOC)on multimedia distribution,bioavailability,and toxicity of FIPs in field waterways was largely ***,we collected 11 companion water and sediment samples along a lotic stream in Guangzhou,South *** were ubiquitous with total water concentrations ranging from 1.22 to 43.2 ng/L(14.8±12.9 ng/L)and fipronil sulfone was predominant in both water and *** than 70%of FIPs in aqueous phase were bound to DOC and the KDOC values of FIPs were approximately 1–2 orders of magnitude higher than K_(d-s)/K_(OC),emphasizing the significance of DOC in phase partitioning and transport of FIPs in aquatic *** and sediment samples were more toxic to Chironomus dilutus than Hyallela azteca,and FIPs(especially fipronil sulfone)pronouncedly contributed toxicity to *** units(TU)based on freely dissolved concentrations in water determined by solid phase microextraction significantly improved toxicity estimation of FIPs to the invertebrates compared to TUs based on aqueous *** present study highlights the significance of DOC association on fate and ecological risk of hydrophobic insecticides in lotic ecosystem.

关键词： Hydrophobic organic contaminant Bioavailability Partitioning Aquatic toxicity Passive sampler

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Influence of structure and material on the vibration modal characteristics of novel combined flexible road wheel

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Defence Technology（防务技术） 2022年第7期18卷 1179-1189页

作者： Yao-ji Deng you-qun Zhao fen lin li-guo Zang College of Mechanical Engineering Yangzhou UniversityYangzhou 225127China College of Energy and Power Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016China School of Automobile&Rail Transit Nanjing Institute of TechnologyNanjing 211167China

Aiming at the independent development of tracked vehicles,it is urgent to improve its mobility,passability and ride comfort,a new type of flexible road wheel with a“wheel-hinge-hub”combined structure is proposed in this *** vibration model characteristics of the flexible road wheel were studied by the combination of numerical simulation and *** superelasticity of rubber is obtained through uniaxial tensile experiment of the material and a detail three-dimensional nolinear finite element model of the flexible road wheel is established through finite element software *** free vibration equation of the flexible road wheel is solved by Lanczos vector direct superposition method,and its predicted modes and natural frequencies are compared with experimental results,which verifies the accuracy and reliability of the established finite element *** this basis,the effects of various key structural or material factors on the natural frequencies of the flexible road wheel are studied using orthogonal experimental design ***,the vibration modal characteristics of the flexible road wheel are also compared with those of the rigid road *** research results provide a theoretical basis for the vibration and noise reduction of flexible road wheel.

关键词： Flexible road wheel Orthogonal experimental design Vibration modal Tracked vehicle Finite element analysis

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加速康复外科理念对人工膝关节置换术患者膝关节功能及生活质量的影响

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透析与人工器官 2021年第2期32卷 75-76,79页

作者：杨宝燕张菊肖敏游丽芬陈洪亮联勤保障部队第909医院伤病员就医管理科福建漳州363000 杭州师范大学钱江学院护理分院浙江杭州310018 联勤保障部队第909医院医保科福建漳州363000

目的探讨加速康复外科(ERAS)理念对人工膝关节置换术(TKA)患者膝关节功能及生活质量的影响。方法选取2019年8月至2020年9月我院收治的TKA患者162例,按随机数字表法将其分为两组,每组各81例。对照组给予常规护理,观察组给予ERAS护理。比... 详细信息

目的探讨加速康复外科(ERAS)理念对人工膝关节置换术(TKA)患者膝关节功能及生活质量的影响。方法选取2019年8月至2020年9月我院收治的TKA患者162例,按随机数字表法将其分为两组,每组各81例。对照组给予常规护理,观察组给予ERAS护理。比较两组膝关节功能、生活质量及并发症。结果观察组HSS膝关节评分、生活质量评价量表评分均高于对照组,并发症发生率(4.94%)低于对照组(16.05%),差异有统计学意义(P<0.05)。结论ERAS能够改善TKA患者膝关节功能,提高生活质量,减少并发症,促进术后恢复。

关键词：人工膝关节置换术加速康复外科理念膝关节功能生活质量

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