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High-dose dexamethasone regulates microglial polarization via the GR/JAK1/STAT3 signaling pathway after traumatic brain injury

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Neural Regeneration Research 2025年第9期20卷 2611-2623页

作者： Mengshi Yang Miao Bai Yuan Zhuang Shenghua Lu Qianqian Ge Hao Li Yu Deng Hongbin Wu Xiaojian Xu Fei Niu Xinlong Dong bin Zhang Baiyun Liu Beijing Tiantan Hospital Capital Medical UniversityBeijingChina Department of Neurology The First Hospital of Tsinghua UniversityBeijingChina Department of Neurotrauma and Beijing Key Laboratory of Central Nervous System Injury Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Department of Critical Care Medicine Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Center for Nerve Injury and Repair Beijing Institute of Brain DisordersChina National Clinical Research Center for Neurological DiseasesBeijingChina

Although microglial polarization and neuroinflammation are crucial cellular responses after traumatic brain injury,the fundamental regulatory and functional mechanisms remain insufficiently *** potent anti-inflammato ry agents,the use of glucoco rticoids in traumatic brain injury is still controversial,and their regulatory effects on microglial polarization are not yet *** the present study,we sought to determine whether exacerbation of traumatic brain injury caused by high-dose dexamethasone is related to its regulatory effects on microglial polarization and its mechanisms of *** vitro cultured BV2 cells and primary microglia and a controlled cortical impact mouse model were used to investigate the effects of dexamethasone on microglial ***,dexamethasone,RU486(a glucocorticoid receptor antagonist),and ruxolitinib(a Janus kinase 1 antagonist)were ***-sequencing data obtained from a C57BL/6 mouse model of traumatic brain injury were used to identify potential targets of *** Morris water maze,quantitative reverse transcription-polymerase chain reaction,western blotting,immunofluorescence and confocal microscopy analysis,and TUNEL,Nissl,and Golgi staining were performed to investigate our ***-throughput sequencing results showed that arginase 1,a marker of M2 microglia,was significantly downregulated in the dexamethasone group compared with the traumatic brain injury group at3 days post-traumatic brain *** dexamethasone inhibited M1 and M2 microglia,with a more pronounced inhibitory effect on M2microglia in vitro and in *** receptor plays an indispensable role in microglial polarization after dexamethasone treatment following traumatic brain ***,glucocorticoid receptor activation increased the number of apoptotic cells and neuronal death,and also decreased the density of dendritic spines.A possible downstream receptor signaling mechanism is th

关键词： apoptosis BV2 microglia dexamethasone glucocorticoid receptor glucocorticoids innate immune system microglial polarization neuroinflammation primary microglia traumatic brain injury

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The dynamics of landscape-scale ecological connectivity based on least-cost model in Dongshan Island,China

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Journal of Mountain Science 2017年第2期14卷 336-345页

作者： WU Li-yun he Dong-jin you Wei-bin JI Zhi-rong TAN Yong ZHAO Li-li Forestry College Fujian Agriculture and Forestry UniversityFuzhou 350002China

As a hot topic in Landscape Ecology study,ecological connectivity is an important indicator for regional land sustainable use and biological protection. This paper conducted a systematic assessment of ecological connectivity using remote sensing images of Dongshan Island in 1994, 2003 and2011. Based on least-cost modelling, the method takes into consideration the type of barrier, the distance impact, and the adjacent land use types to obtain the Barrier Effect Index(BEI) and Ecological Connectivity Index(ECI). The application of this method to Dongshan Island showed the ecological connectivity index(ECI) was low in 1994, improved in 2003, and decreased significantly in 2011. The results of the dynamic analysis of landscape structure showed farmland and roads were the main landscape classes that caused the low observed ECI in 1994 and 2003;these tended to divide the landscape and cause fragmentation. Construction land and roads were the main landscape classes resulting in low ECI in 2011,while forest and grassland had a high ECI. Trajectory analysis showed ECI tended to decrease in the low mountain forest zone of the northwestern and southeastern parts of Dongshan Island as well as in the coastal protection forest area. The areas where ECI became high were located in the northeastern part of Dongshan Island where cities and towns are concentrated with high human ***, rapid urbanization has been the most important factor driving changes in landscape structure and patterns during the last 17 years on Dongshan Island. The approach not only assists us in revealing the driving mechanism of landscape dynamics from another aspect, but also can assess the impacts of regional and urban plans on landscape structure and function.

关键词： Cost-distance model Dongshan Island Ecological connectivity Spatio-temporal dynamics

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Insight into the possible mechanism of the summer diapause of Delia antiqua （Diptera： Anthomyiidae） through digital gene expression analysis

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Insect Science 2016年第3期23卷 438-451页

作者： you-Jin Hao Yu-Juan Zhang Feng-Ling Si Dan-Ying Fu Zheng-Bo he bin Chen Institute of Entomology and Molecular Biology College of Life Sciences Chongqing Normal University Chongqing China

The onion fly, Delia antiqua, is a major underground agricultural pest that can enter pupal diapause in the summer and winter seasons. However, little is known about its molecular regulation due to the lack of genomic resources. To gain insight into the possible mechanism of summer diapause （SD）, high-throughput RNA-Seq data were generated from non-diapause （ND） and SD （initial, maintenance and quiescence phase） pupae. Three pair-wise comparisons were performed and identified, 1380, 1471 and 435, and were significantly regulated transcripts. Further analysis revealed that the enrichment of several functional terms related to juvenile hormone regulation, cell cycle, carbon hydrate and lipid metabolism, innate immune and stress responses, various signalling transductions, ubiquitin-dependent proteosome, and variation in cuticular and cytoskeleton components were found between ND and SD and between different phases of SD. Global characterization oftranscriptome profiling between SD and ND contributes to the in-depth elucidation of the molecular mechanism of SD. Our results also offer insights into the evolution of insect diapause and support the importance of using the onion fly as a model to compare the molecular regulation events of summer and winter diapauses.

关键词： Delia antiqua digital gene expression possible mechanism qPCR RNA-Seq summer diapause

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Tunable Emission and Energy Transfer of the Novel KY_(1-x)(MoO_(4))_(2-y)(WO_(4))y:xLn^(3+)(Ln^(3+)=Dy^(3+),Eu^(3+),and Tm^(3+))Single-phase White Luminescence Phosphor for White LEDs

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Journal of Wuhan University of Technology(Materials Science) 2023年第6期38卷 1278-1286页

作者： ZHU Hai he bin HUANG Weigang Department of Oncology The Third People's Hospital of ChengduAfiliated Hospital of Southwest Jiaotong University&The Second Affiliated Hospital of ChengduChongqing Medical UniversityChengdu 610031China Medical Research Center The Third People's Hospital of ChengduAfiliated Hospital of Southwest Jiaotong University&The Second Afiliated Hospital of ChengduChongqing Medical UniversityChengdu 610031China National Engineering Research Center for Biomaterials College of Biomedical MaterialsSichuan UniversityChengdu 610064China College of Materials Science and Engineering Sichuan UniversityChengd 610064China

The phosphors of KY_(1-x)(MoO_(4))_(2-y)(WO_(4))y:xLn^(3+)(Ln^(3+)=Tm^(3+),Dy^(3+),Eu^(3+))were synthesized by using a sol-gel ***,the crystal structure,luminescence properties,energy transfer,and white emission of the prepared materials were *** molar ratio of the anion group on the photoluminescence(PL)emission and excitation intensity were investigated,revealing that the optimum intensity could be obtained by using=3:*** optimal Dy^(3+) doping concentration of KY(MoO_(4))1.5(WO4)0.5was *** addition,the color-tunable emissions of Dy^(3+)/Eu^(3+)-codoped KY(MoO_(4))1.5(WO4)0.5phosphors were observed because of the effective energy transfer(ET)from Dy^(3+)to Eu^(3+)***,by doping appropriate concentrations of Tm^(3+),Dy^(3+),and Eu^(3+)and different concentrations of(WO_(4))^(2-),white light emitting phosphors KY_(0.92)(WO_(4))2:0.01Tm^(3+),0.06Dy^(3+),0.01Eu^(3+)with excellent color-rending properties were *** chromaticity coordinate was calculated as(x=0.3238,y=0.3173),closing to the artificial daylight(D65,x=0.313,y=0.329)illuminant,and which indicates the potential application of near ultraviolet White light-emitting diodes(WLEDs).

关键词： rare earth phosphors white LEDs energy transfer sol-gel method

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Vertically ordered silica mesochannels as preconcentration materials for the electrochemical detection of methylene blue

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Science China Chemistry 2015年第10期58卷 1593-1599页

作者： Yayun he Longhua Ding bin Su Institute of Microanalytical Systems Department of Chemistry Zhejiang University (Zijin’gang Campus)

Silica mesochannels(SMCs) vertically and regularly oriented to the surface of indium tin oxide(ITO) electrodes were prepared and utilized for preconcentration and detection of methylene blue(MB) in aqueous solution. The positively charged MB can be adsorbed to the SMCs by following the pseudo-first-order kinetic model. The negative value of ?G=?34.73 k J/mol derived from the Langmuir adsorption isotherm indicated the thermodynamic feasibility of the adsorption and the spontaneous nature of the process. Moreover, the adsorbed MB can undergo an electrochemical reaction on the ITO electrode at a suitable potential and the resulting electrical current can be utilized to quantify the MB in aqueous solution. A good analytical performance for MB with a linear range from 10 nmol/L to 1.0 ?mol/L and a detection limit at the nmol/L level was obtained. We believe that such a platform consisting of SMCs perpendicularly tethered to the underlying electrode surface simultaneously allows enrichment and electrochemical detection and can be extended for the detection of various charged dyes, as well as many other charged species.

关键词： methylene blue silica mesochannels preconcentration adsorption electrochemical detection

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Cluster Effect and Intermittency

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Chinese Physics Letters 1994年第6期11卷 329-332页

作者： GAO Chongshou he bin CCAST(World Laboratory) P.O.Box 8730Beijing 100080 Department of Physics Peking UniversityBeijing 100871 Institute of Theoretical Physics Academia SinciaBeijing 100080

A new method is used to obtain two parameters about the size of hadron *** comparison with the results from another method it is found that the intermittency behaviors are closely related with short-range correlation ... 详细信息

关键词： cluster hadron method

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Studies on the Displacement Reaction of Trialkylaluminum with Ethylene Catalyzed by Nitrogen Chelate Cobalt Complexes

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Chinese Chemical Letters 2003年第2期14卷 135-137页

作者： bin ZHOU Ren he State Key Laboratory of Fine Chemicals Dalian University of TechnologyDalian 116012

The catalytic properties of a series of cobalt complexes containing bidenated nitrogen ligand for displacement reaction of trialkylaluminum with ethylene is reported. Effect of different reaction time, temperature an... 详细信息

关键词： Ethylene displacement reaction trialkylaluminum cobalt complex.

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Influence of cross correlation step length on the surface stress of thin laser cladding Fe314 alloy coatings

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International Journal of Minerals,Metallurgy and Materials 2012年第6期19卷 549-554页

作者： bin Liu Shi-yun Dong bin-shi Xu Peng he State Key Laboratory of Advanced Welding and Joining Harbin Institute of Technology Harbin 150001 China National Key Laboratory for Remanufacturing Academy of Armored Forces Engineering Beijing 100072 China

To measure the surface stress of thin laser cladding coatings with Rayleigh waves based on the cross correlation function, this pa- per introduced the influence of cross correlation step length on the stress measurement. Flat-shaped specimens made of laser cladding Fe314 alloy coatings were performed by static tensile tests, and Rayleigh wave signals were collected during the test process with an ultrasonic pulser and receiver instrument combined with two Rayleigh wave transducers. The difference in time of flight between two signals was de- termined based on the cross correlation function. The microstructure was observed by scanning electronic microscopy. The influence of the stress on the propagation velocity of Rayleigh waves and the relationship between the difference in time of flight and tensile stress under dif- ferent cross correlation step lengths were analyzed. The inhomogeneous deformation of the coatings affects the relationship between the dif- ference in time of flight and tensile stress; the stress measurement of the coatings is nearly constant with the increase of cross correlation step length when it attains one cycle.

关键词： iron alloys metal cladding laser cladding surface stress Rayleigh waves

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FCC DeSO_x and DeNO_x additive technology

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Journal of Environmental Sciences 2000年第3期12卷 310-318页

作者： WEN bin he Min-yuan Research Institute of Petroleum Processing SINOPECBeijing 100083China.

The fluid catalytic cracking(FCC) is the principal gasoline producing process in the refinery. Considerable amounts of harmful sulfur oxides and nitrogen oxides (SO x and NO x) are generated with the FCC operation. Impacted by strengthening environmental regulations and the current global emphasis on environmental protection and pollution abatement, refiners have been meaning to look for effective ways to control and reduce SO x and NO x emissions. FCC DeSO x and DeNO x additives is the most promising measure. The present paper reviews the developments in FCC DeSO x and DeNO x additive technology based on the respective authors' works, the future directions of the technology are also discussed.

关键词： FCC DeSO_x SO_x DeSO_x additive DeNO_x additive

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Stability Analysis of Cross-Channel Excavation for Existing Anchor Removal Project in Subway Construction

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Computer Modeling in Engineering & Sciences 2017年第1期113卷 57-69页

作者： Li bin Fang Hongyuan he Wei Sun bin College of Water Conservancy&Environmental Engineering Zhengzhou University.Zhengzhou450001China National local joint engineering laboratory of major infrastructure testing and rehabilitation technology Zhengzhou450001China Collaborative Innovation Center of Water Conservancy and Transportation Infrastructure Safety Henan ProvinceZhengzhou450001China Zhengzhou metro co.LTD Henan ProvinceZhengzhou450001China

The cutter head will be stuck when the shield machine pass through the area existing anchor left by foundation construction of surrounding high-rise *** excavation method is an efficient way to remove the existed *** this paper,a three-dimensional finite element model is developed to study stability of cross-channel *** time-spatial effects of arch crown settlement,intrados uplift and side wall horizontal convergence are analyzed according to different excavation size,lining thickness and lining *** results show that the excavation size is the main factor to control the deformation of the surrounding soil,especially in arch crown settlement;The influence of lining thickness on the spatial effect of surrounding soil deformation is obvious when the excavation size is large,but little on the time effect;The influence of the lining order on the deformation of the surrounding soil is obvious,in particular,the larger the excavation size,the more obvious advantages of the lining ***,based on the time-spatial effects comparison of nine excavation schemes of the cross-channel,an optimum excavation scheme is adopted in the actual project.

关键词： Existed anchor removal project ABAQUS cross-channel excavation time-spatial effect

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