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Ceramide is involved in alcohol-induced neural proliferation

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Neural Regeneration Research 2013年第23期8卷 2178-2189页

作者： Zhixin Wang Tongxing deng Jiexin deng Jinbo deng Xiaoqun Gao Yuanyuan Shi bin Liu Zhanyou Ma Haixiao Jin Institute of Neurobiology Henan University Department of Anatomy Basic Medical CollegeZhengzhou University Department of Anatomy Luohe Medical College

Prenatal alcohol exposure, especially during early pregnancy, can lead to fetal alcohol syndrome. The pharmacological and toxicological mechanisms of ethanol are related to the effects of ceramide In this study, we established an alcohol exposure model in wild-type mice and in knockout mice for the key enzyme involved in ceramide metabolism, sphingomyelin synthase 2. This model received daily intragastric administration of 25% ethanol, and pups were used at postnatal days 0, 7, 14, 30 for experiments. Serology and immunofluorescence staining found that ethanol exposure dose-dependently reduced blood sphingomyelin levels in two genotypes of pups, and increased neural cell proliferation and the number of new neurons in the hippocampal dentate gyrus. Western blot analysis showed that the relative expression level of protein kinase C e increased in two genotypes of pups after ethanol exposure. Compared with witd-type pups, the expression level of the important activator protein of the ceramide/ceramide-l-phosphate pathway, protein kinase C a, was reduced in the hippocampus of sphingomyelin synthase 2 knockouts. Our findings illustrate that ceramide is involved in alcohol-induced neural proliferation in the hippocampal dentate gyrus of pups after prenatal ethanol exposure, and the mechanism may be associated with increased ex- pression of protein kinase C a activating the ceramide/ceramide-l-phosphate pathway.

关键词： neural regeneration brain injury ceramide neural cells proliferation prenatal alcohol exposure sphingomyelin synthase 2 knockout mice sphingomyelin sphingomyelin synthase cera-mide-l-phosphate fetal alcohol syndrome grants-supported paper neuroregeneration

Microdynamic mechanical properties and fracture evolution mechanism of monzogabbro with a true triaxial multilevel disturbance method

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International Journal of Mining Science and Technology 2024年第3期34卷 385-411页

作者： Zhi Zheng bin deng Hong Liu Wei Wang Shuling Huang Shaojun Li State Key Laboratory of Featured Metal Materials and Life-cycle Safety for Composite Structures Key Laboratory of Disaster Prevention and Structural Safety of Ministry of EducationCollege of Civil Engineering and ArchitectureGuangxi UniversityNanning 530004China State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan 430071China Key Laboratory of Ministry of Education for Geomechanics and Embankment Engineering Hohai UniversityNanjing 210098China Key Laboratory of Geotechnical Mechanics and Engineering of Ministry of Water Resources Changjiang River Scientific Research InstituteWuhan 430015China

The far-field microdynamic disturbance caused by the excavation of deep mineral resources and underground engineering can induce surrounding rock damage in high-stress conditions and even lead to ***,the mechanical properties and damage/fracture evolution mechanisms of deep rock induced by microdynamic disturbance under three-dimensional stress states are ***,a true triaxial multilevel disturbance test method is proposed,which can completely simulate natural geostress,excavation stress redistribution(such as stress unloading,concentration and rotation),and subsequently the microdynamic disturbance triggering damaged rock *** on a dynamic true triaxial test platform,true triaxial microdynamic disturbance tests under different frequency and amplitudes were carried out on *** results show that increasing amplitude or decreasing frequency diminishes the failure strength of *** modulus gradually decreases during disturbance *** frequency and amplitude increase,the degradation rate of deformation modulus decreases slightly,disturbance dissipated energy increases significantly,and disturbance deformation anisotropy strengthens obviously.A damage model has been proposed to quantitatively characterize the disturbance-induced damage evolution at different frequency and amplitude under true triaxial *** disturbance failure,the micro-tensile crack mechanism is dominant,and the micro-shear crack mechanism increases significantly at *** the increase of amplitude and frequency,the micro-shear crack mechanism *** approaching disturbance failure,the acoustic emission fractal dimension changes from a stable value to local large oscillation,and finally increases sharply to a high value at ***,the disturbance-induced failure mechanism of surrounding rock in deep engineering is clearly elucidated.

关键词： True triaxial disturbance test Mechanical properties Fracture evolution mechanism Disturbance-induced damage evolution Failure mechanism and precursor

Gas flow and filter ventilation of an unlit cigarette: model building,numerical solution and experimental validation

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烟草科技 2018年第A1期51卷 62-70页

作者： WANG Le CUI Xiaomeng you Min YI bin XIE Guoyong LU Duanfeng deng Nan ZHANG Ke ZHANG Mingjian LI bin WANG bing Zhengzhou Tobacco Research Institute of CNTC No.2 Street Zhengzhou 450001 China Ningbo Cigarette Factory China Tobacco Zhejiang Industrial Co. Ltd.No. 102 Shuguang RoadNingbo 315500 ZhejiangChina Huaiyin Cigarette Factory China Tobacco Jiangsu Industrial Co. Ltd.No.32 Yipinmei RoadHuai'an 223002 Jiangsu China China Tobacco Yunnan Industrial Co. Ltd.No.367 Hongjin Road Kunming 650231China Technology Center China Tobacctt Hunan Industrial Co. Ltd. No.426 Laodong Road Changsha 410007 China

Understanding the fundamcntal relationship betwecn gas dilution rate of a cigarette and key cigarette design parameters is important in the overall control of smoke *** this work,an equation was derived to express the total gas dilution with the cigarette rod length,cigarette paper air permeability,and the filter ventilation *** relationship was validated using experimental *** accuracy of the developed model was dependent on the regression method used,i.e.,linear or a *** expression provides a quantitative description of the interactions between filter ventilation level,cigarette length,cigarette circumference and cigarette paper air permeability and the total air dilution at the cigarette's mouth end.

关键词： Cigarette paper permeability Filter ventilation Gas flow dilution Total ventilation rate Cigarette design Non-linear fitting

Upper gastrointestinal bleeding from a Mallory-Weiss tear associated with transesophageal echocardiography during successful cardiopulmonary resuscitation:A case report

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World Journal of Clinical Cases 2022年第9期10卷 2954-2960页

作者： Miao-Miao Tang deng-Feng Fang bin Liu Department of Anesthesiology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND In recent years,it has been recognized that transesophageal echocardiography(TEE)is of great value in resuscitation of cardiac ***,its safety has rarely been *** SUMMARY We present a 59-year-old male patient scheduled to undergo cardiac surgery for rheumatic heart *** gastrointestinal bleeding from a Mallory-Weiss tear appeared following cardiopulmonary resuscitation,TEE,and percutaneous cardiopulmonary bypass resuscitation when he suffered from aesthesia-related cardiac *** injury was diagnosed promptly and treated ***,the exact etiology of gastrointestinal injury was unclear;the interaction of closed-chest cardiac massage and the application of TEE may be involved as a most possible mechanism of *** Serious complications should be considered when TEE is used in patients with special pathophysiological conditions.

关键词： Transesophageal echocardiography Upper gastrointestinal bleeding Cardiopulmonary resuscitation Mallory-Weiss tear Percutaneous cardiopulmonary bypass resuscitation Case report

Early monitoring of response to antimetabolic treatment of gemcitabine:A comparison of ^(18)F-FLT and ^(18)F-FDG uptake in Patu 8988 human pancreatic carcinoma cells

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Nuclear Science and Techniques 2011年第5期22卷 293-298页

作者： deng Shengming ZHANG bin WU Yiwei ZHANG Wei Department of Nuclear Medicine No.1 Hospital Affiliated to Sooehow University Suzhou 215006 China

It is essential to predict the treatment efficacy of pancreatic carcinoma *** purpose of this study was to examine whether ^(18)F-FDG(2'-deoxy-2'-[^(18)F]fiuoro-D-glucose) or ^(18)F-FLT(3'-deoxy-3'-^(18)F-fluorothymidine) PET can be used for chemosensitivity testing by investigating the binding characteristic of ^(18)F-FDG or ^(18)F-FLT with Patu 8988 human pancreatic carcinoma cell and the influence of gemcitabine in the uptake of ^(18)F-FDG or ^(18)F-FLT on Patu *** the conditions of 1×10~6 cells,3.7 kBq ^(18)F-FDG or ^(18)F-FLT,and incubation at 37℃for 100 min,the cell uptake of ^(18)F-FDG and ^(18)F-FLT was(60.60±3.05)%and(50.57±2.81)%,*** was a significant decrease in TKl-LI(thymidine kinase 1 labeling index) 24 h after administration of *** uptakes of ^(18)F-FDG and ^(18)F-FLT were negatively correlated with the doses of gemcitabine(r= -0.928 for ^(18)F-FDG,r= -0.876 for ^(18)F-FLT,Pbine were administered,the ^(18)F-FLT uptake inhibition rate was significantly higher than that of ^(18)F-FDG(Pbine could be predicted as early as 24 h by ^(18)F-FDG or ^(18)F-FLT PET scans.^(18)F-FLT is more sensitive than ^(18)F-FDG to predict the response to therapy.

关键词：细胞摄取早期预测治疗效果 FDG 癌细胞胰腺癌 LSF 药物敏感性

Magnetic resonance imaging-based artificial intelligence model in rectal cancer

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World Journal of Gastroenterology 2021年第18期27卷 2122-2130页

作者： Pei-Pei Wang Chao-Lin deng bin Wu Department of General Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China

Rectal magnetic resonance imaging(MRI)is the preferred method for the diagnosis of rectal cancer as recommended by the *** MRI can accurately evaluate the tumor location,tumor stage,invasion depth,extramural vascular invasion,and circumferential resection *** summarize the progress of research on the use of artificial intelligence(AI)in rectal cancer in recent ***,represented by machine learning,is being increasingly used in the medical *** application of AI models based on high-resolution MRI in rectal cancer has been increasingly *** addition to staging the diagnosis and localizing radiotherapy,an increasing number of studies have reported that AI models based on high-resolution MRI can be used to predict the response to chemotherapy and prognosis of patients.

关键词： Artificial intelligence Deep learning Colorectal cancer Magnetic resonance imaging Radiomics

Imaging features of solid pseudopapillary tumor of the pancreas on multi-detector row computed tomography

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World Journal of Gastroenterology 2009年第7期15卷 829-835页

作者： deng-bin Wang Qing-bing Wang Wei-Min Chai Ke-Min Chen Xia-Xing deng Department of Radiology Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200025 China Department of General Surgery Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200025 China

AIM： To retrospectively analyze the imaging features of solid-pseudopapillary tumors （SPTs） of the pancreas on multi-detector row computed tomography （MDCT） and define the imaging findings suggestive of malignant potential. METHODS： A total of 24 consecutive cases with surgically and pathologically confirmed SPTs of the pancreas underwent preoperative abdominal MDCT studies in our hospital. All axial CT images, CT angiographic images, and coronally and sagittally reformed images were obtained. The images were retrospectively reviewed at interactive picture archiving and communication system workstations. RESULTS： Of the 24 cases of SPTs, 11 cases （45.8%） occurred in the pancreatic head and seven （29.1%） in the tail. Eighteen were pathologically diagnosed as benign and six as malignant. MDCT diagnosis of SPTs was well correlated with the surgical and pathological results （Kappa = 0.6, P 〈 0.05）. The size of SPTs ranged from 3 to 15 cm （mean, 5.8 cm）. When the size of the tumor was greater than 6 cm （including 6 cm）, the possibilities of vascular （8 vs 1） and capsular invasion （9 vs 0） increased significantly （P 〈 0.05）.Two pathologically benign cases with vascular invasion and disrupted capsule on MDCT presented with local recurrence and hepatic metastases during follow-up about 1 year after the resection of the primary tumors. CONCLUSION： Vascular and capsular invasion with superimposed spread into the adjacent pancreatic parenchyrna and nearby structures in SPTs of the pancreas can be accurately revealed by MDCT preoperatively. These imaging findings are predictive of the malignant potential associated with the aggressive behavior of the tumor, even in the pathologically benign cases.

关键词： Solid pseudopapillary tumor Pancreas Multi-detector row computed tomography Malignantpotential Aggressive behaviors

Removal of clofibric acid from aqueous solution by polyethylenimine-modified chitosan beads

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Frontiers of Environmental Science & Engineering 2014年第5期8卷 675-682页

作者： Yao NIE Shubo deng bin WANG Jun HUANG Gang YU POPs Research Center School of Environment Tsinghua University Beijing 100084 China State Key Joint Laboratory of Environment Simulation and Pollution Control Tsinghua University Beijing 100084 China

Polyethylenimine （PEI）-modified chitosan was prepared and used to remove clofibric acid （CA） from aqueous solution. PEI was chemically grafted on the porous chitosan through a crosslinking reaction, and the effects of PEI concentration and reaction time in the preparation on the adsorption of clofibric acid were optimized. Scanning electron microscopy （SEM） showed that PEI macromolecules were uniformly grafted on the porous chitosan, and the analysis of pore size distribution indicated that more mesopores were formed due to the crosslinking of PEI molecules in the macropores of chitosan. The PEI-modified chitosan had fast adsorption for CA within the initial 5 h, while this adsorbent exhibited an adsorption capacity of 349 mg· g^-1 for CA at pH 5.0 according to the Langmuir fitting, higher than 213 mg· g^-1 on the porous chitosan. The CA adsorption on the PEI- modified chitosan was pH-dependent, and the maximum adsorption was achieved at pH 4.0. Based on the surface charge analysis and comparison of different pharmaceu- ticals adsorption, electrostatic interaction dominated the sorption of CA on the PEI-modified chitosan. The PEI- modified chitosan has a potential application for the removal of some anionic rnicropollutants from water or wastewater.

关键词： clofibric acid PEI-modified chitosan adsorption capacity adsorption mechanism electrostatic interaction

Identification of fruit and branch in natural scenes for citrus harvesting robot using machine vision and support vector machine

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International Journal of Agricultural and Biological Engineering 2014年第2期7卷 115-121页

作者： Lü Qiang Cai Jianrong Liu bin deng Lie Zhang Yajing Citrus Research Institute Chinese Academy of Agricultural SciencesChongqing 400712China School of Food&Biological Engineering Jiangsu UniversityZhenjiang 212013JiangsuChina Chinese Academy of Agricultural Mechanization Sciences Beijing 100083China

With the decrease of agricultural labor and the increase of production cost,the researches on citrus harvesting robot(CHR)have received more and more attention in recent *** the success of robotic harvesting and the safety of robot,the identification of mature citrus fruit and obstacle is the priority of robotic *** this work,a machine vision system,which consisted of a color CCD camera and a computer,was developed to achieve these *** of citrus trees were captured under sunny and cloudy *** to varying degrees of lightness and position randomness of fruits and branches,red,green,and blue values of objects in these images are changed *** traditional threshold segmentation is not efficient to solve these ***-class support vector machine(SVM),which succeeds by morphological operation,was used to simultaneously segment the fruits and branches in this *** recognition rate of citrus fruit was 92.4%,and the branch of which diameter was more than 5 pixels,could be *** results showed that the algorithm could be used to detect the fruits and branches for CHR.

关键词： citrus machine vision citrus harvesting robot(CHR) branch identification multi-class support vector machine(SVM)