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Effect of lens surgery on health-related quality of life in preschool children with congenital ectopia lentis

International Journal of Ophthalmology(English edition) 2024年第1期17卷 66-72页

作者： Yan-Qiao Huang Qian-zhong Cao yi-Yao Wang yi-Jing Zhou Dan-ying Zheng State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangdong Provincial Clinical Research Center for Ocular DiseasesGuangzhou 510060Guangdong ProvinceChina

AIM:To evaluate the effect of lens surgery on health-related quality of life(HRQoL)of preschool children with congenital ectopia lentis(CEL).METHODS:A prospective self-controlled study was conducted in zhongshan Ophthalmic *** aged from 5 to 7y whom were diagnosed with CEL and underwent phacoemulsification with scleral-fixated posterior chamber intraocular lens implantation and their parents were enrolled in this *** of them completed the child and proxy(parental)PedsQL™4.0 before and after the *** preoperative scores were compared to their postoperative *** analyses were performed based on gender and preoperative bilateral presenting visual acuity of the ***:Thirty-two children with CEL successfully underwent surgery without any complications,among whom 8 had monocular surgery and 24 had binocular *** and postoperative questionnaires were completed by 32 child-parent *** intervention could significantly improve the vision of affected children(P<0.001).The medians of physical,psychosocial and total health scores self-reported by the children were 68.75(62.50,81.25),65.00(60.00,80.00)and 67.39(60.87,78.26)preoperatively and were 93.75(87.50,100.00),90.00(83.33,96.67)and 89.13(85.32,95.65)*** preoperative scores of the affected children were significantly lower in all scales than age-matched healthy children(P<0.001).All the postoperative scores were significantly higher than the preoperative scores in affected children and their parents(P<0.001).In the physical functioning evaluation,the preoperative score reported by parents of girls was higher than parents of boys(P=0.041),and the postoperative score of girls was higher than that of boys(P=0.036).CONCLUSION:CEL is associated with significantly worse quality of life in preschool *** intervention can significantly improve the HRQoL in affected children from both personal and family perspective.

关键词： congenital ectopia lentis surgical intervention health-related quality of life preschool children

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Paradoxical herniation associated with hyperbaric oxygen therapy after decompressive craniectomy: A case report

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World Journal of Clinical Cases 2024年第10期12卷 1793-1798页

作者： zhong-Xing Ye Xin-Xin Fu Yang-Zong Wu Ling Lin Liang-Qi Xie Yu-Ling Hu yi Zhou Zhu-Gui you Hai Lin Department of Neurosurgery The Second People's Hospital of Fujian Province(The Second Affiliated Hospital of Fujian University of Traditional Chinese Medicine)Fuzhou 350001Fujian ProvinceChina Department of Neurosurgery The Second Hospital of LongyanLongyan 364000Fujian ProvinceChina Department of Neurosurgery Zhangping City HospitalLongyan 364400Fujian ProvinceChina

BACKGROUND Whether hyperbaric oxygen therapy(HBOT)can cause paradoxical herniation is still *** SUMMARY A 65-year-old patient who was comatose due to brain trauma underwent decompressive craniotomy and gradually regained consciousness after *** was administered 22 d after surgery due to speech *** herniation appeared on the second day after treatment,and the patient’s condition worsened after receiving mannitol treatment at the rehabilitation *** timely skull repair,the paradoxical herniation was resolved,and the patient regained consciousness and had a good recovery as observed at the follow-up *** Paradoxical herniation is rare and may be caused by ***,the underlying mechanism is unknown,and the understanding of this phenomenon is *** use of mannitol may worsen this *** skull repair can treat paradoxical herniation and prevent serious complications.

关键词： Decompressive craniectomy Hyperbaric oxygen therapy Mannitol Paradoxical herniation Case report

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The principle and amelioration of lithium plating in fast-charging lithium-ion batteries

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Journal of Energy Chemistry 2024年第10期97卷 453-459页

作者： yi Yang Xia-Lin zhong Lei Xu Zhuo-Lin Yang Chong Yan Jia-Qi Huang School of Materials Science and Engineering Beijing Institute of Technology Advanced Research Institute of Multidisciplinary Science Beijing Institute of Technology Beijing Key Laboratory of Green Chemical Reaction Engineering and Technology Department of Chemical Engineering Tsinghua University Yangtze River Delta Graduate School of Beijing Institute of Technology

Fast charging is restricted primarily by the risk of lithium（Li） plating,a side reaction that can lead to the rapid capacity decay and dendrite-induced thermal runaway of lithium-ion batteries（LIBs）.Investigation on the intrinsic mechanism and the position of Li plating is crucial to improving the fast rechargeability and safety of ***,we investigate the Li plating behavior in porous electrodes under the restricted transport of Li+.Based on the theoretical model,it can be concluded that the Li plating on the anodeseparator interface（ASI） is thermodynamically feasible and kinetically ***,the prior deposition of metal Li on the ASI rather than the anode-current collector interface（ACI） is verified *** order to facilitate the transfer of Li+among the electrode and improve the utilization of active materials without Li plating,a bilayer asymmetric anode composed of graphite and hard carbon（GH） is *** and simulation results suggest that the GH hybrid electrode homogenizes the lithiated-rate throughout the electrode and outperforms the pure graphite electrode in terms of the rate performance and inhibition of Li *** work provides new insights into the behavior of Li plating and the rational design of electrode structure.

关键词： Fast charging Graphite Hard carbon Lithium plating Lithium-ion batteries

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Prediction of contact resistance of electrical contact wear using different machine learning algorithms

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Friction 2024年第6期12卷 1250-1271页

作者： Zhen-bing CAI Chun-lin LI Lei you Xu-dong CHEN Li-ping HE zhong-qing CAO Zhi-nan ZHANG Tribology Research Institute Southwest Jiaotong UniversityChengdu 610031China State Key Laboratory of Mechanical System and Vibration Shanghai Jiao Tong UniversityShanghai 200240China

H62 brass material is one of the important materials in the process of electrical energy transmission and signal transmission,and has excellent performance in all *** the wear behavior of electrical contact pairs is particularly complex when they are in service,we evaluated the effects of load,sliding velocity,displacement amplitude,current intensity,and surface roughness on the changes in contact *** learning(ML)algorithms were used to predict the electrical contact performance of different factors after wear to determine the correlation between different factors and contact *** forest(RF),support vector regression(SVR)and BP neural network(BPNN)algorithms were used to establish RF,SVR and BPNN models,respectively,and the experimental data were trained and *** was proved that BP neural network model could better predict the stable mean resistance of H62 brass alloy after *** analysis shows that the load and current have great influence on the predicted electrical contact *** wear behavior of electrical contacts is influenced by factors such as load,sliding speed,displacement amplitude,current intensity,and surface roughness during *** learning algorithms can predict the electrical contact performance after wear caused by these *** results indicate that an increase in load,current,and surface roughness leads to a decrease in stable mean resistance,while an increase in displacement amplitude and frequency results in an increase in stable mean resistance,leading to a decline in electrical contact *** reduce testing time and costs and quickly obtain the electrical contact performance of H62 brass alloy after wear caused by different factors,three algorithms(random forest(RF),support vector regression(SVR),and BP neural network(BPNN))were used to train and test experimental results,resulting in a machine learning model suitable for predicting the stable mean

关键词： electrical contact wear contact resistance machine learning(ML) neural network

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Reaction mechanism between Al_(2)O_(3)–MgO refractory materials and rare earth high-carbon heavy rail steel

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Journal of Iron and Steel Research International 2024年第5期31卷 1153-1163页

作者： yi Wang Guang-jie Song Ping Shen Jian-zhong He Da-xian Zhang Jian-xun Fu Center for Advanced Solidification Technology(CAST) School of Materials Science and EngineeringState Key Laboratory of Advanced Special SteelShanghai UniversityShanghai200444China State Key Laboratory of Baiyunebo Rare Earth Resources Research and Comprehensive Utilization Baotou014030Inner MongoliaChina Inner Mongolia Baotou Steel Union Co. Ltd.Baotou014030Inner MongoliaChina

Submerged entry nozzle(SEN)clogging is a major problem affecting the production quality of rare earth steel,and finding a suitable refractory outlet can significantly reduce production *** explore the relationship between refractory composition and interface interaction,unprotected coated Al_(2)O_(3)–MgO refractories and SiO2-coated Al_(2)O_(3)–MgO refractories were added to rare earth high-carbon heavy rail steel under laboratory conditions,and the Al_(2)O_(3)–MgO refractory was found to be more *** results show that,from the epoxy resin side to the refractory side,the contour of the refractory interface reaction layer can be divided into two main layers:an iron-rich reaction layer and an iron-poor reaction *** based on the spherical model suggest that the adhesion force is proportional to the size of the refractory particles and inclusions,and the same result applies to the surface *** the inclusions at a smaller size has a specific effect on alleviating the erosion of *** with the erosion mechanism of Al_(2)O_(3)–MgO refractories,the interface reaction mechanism between Al_(2)O_(3)–MgO refractories and molten steel was proposed,which provides ideas for solving SEN clogging.

关键词： Rare earth high-carbon heavy rail steel Al_(2)O_(3)-MgO refractory Adhesion Surface tension Interface interaction

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High-Efficiency Dynamic Scanning Strategy for Powder Bed Fusion by Controlling Temperature Field of the Heat-Affected Zone

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Chinese Journal of Mechanical Engineering 2024年第1期37卷 203-214页

作者： Xiaokang Huang Xiaoyong Tian Qi zhong Shunwen He Cunbao Huo yi Cao Zhiqiang Tong Dichen Li State Key Laboratory of Manufacturing Systems Engineering Xi’an Jiaotong UniversityXian 710049China

Improvement of fabrication efficiency and part performance was the main challenge for the large-scale powder bed fusion(PBF)*** this study,a dynamic monitoring and feedback system of powder bed temperature field using an infrared thermal imager has been established and integrated into a four-laser PBF equipment with a working area of 2000 mm×2000 *** heat-affected zone(HAZ)temperature field has been controlled by adjusting the scanning speed ***,the relationship among spot size,HAZ temperature,and part performance has been *** fluctuation of the HAZ temperature in four-laser scanning areas was decreased from 30.85℃to 17.41℃.Thus,the consistency of the sintering performance of the produced large component has been *** on the controllable temperature field,a dynamically adjusting strategy for laser spot size was proposed,by which the fabrication efficiency was improved up to 65.38%.The current research results were of great significance to the further industrial applications of large-scale PBF equipment.

关键词： Powder bed fusion Efficiency Large-scale Spot size Heat-affected zone(HAZ)

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Plasma metabolites and risk of myocardial infarction:a bidirectional Mendelian randomization study

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Journal of Geriatric Cardiology 2024年第2期21卷 219-231页

作者： Dong-Hua LI Qiang WU Jing-Sheng LAN Shuo CHEN you-yi HUANG Lan-Jin WU Zhi-Qing QIN ying HUANG Wan-zhong HUANG Ting ZENG Xin HAO Hua-Bin SU Qiang SU Department of Cardiovascular Medicine Minzu Hospital of Guangxi Zhuang Autonomous RegionGuangxiChina Senior Department of Cardiology the Sixth Medical CenterChinese PLA General HospitalBeijingChina Library of Graduate School Chinese PLA General HospitalBeijingChina Department of Cardiology Jiangbin Hospital of Guangxi Zhuang Autonomous RegionGuangxiChina Health Management Institute the Second Medical CenterChinese PLA General HospitalBeijingChina

BACKGROUND Myocardial infarction(MI)is a critical cardiovascular event with multifaceted etiology,involving several genetic and environmental *** is essential to understand the function of plasma metabolites in the development of MI and unravel its complex *** This study employed a bidirectional Mendelian randomization(MR)approach to investigate the causal relationships between plasma metabolites and MI *** used genetic instruments as proxies for plasma metabolites and MI and conducted MR analyses in both directions to assess the impact of metabolites on MI risk and vice *** addition,the large-scale genome-wide association studies datasets was used to identify genetic variants associated with plasma metabolite(1400 metabolites)and MI(20,917 individuals with MI and 440,906 individuals without MI)*** variance weighted was the primary method for estimating causal *** estimates are expressed as beta coefficients or odds ratio(OR)with 95%*** We identified 14 plasma metabolites associated with the occurrence of MI(P<0.05),among which 8 plasma metabolites[propionylglycine levels(OR=0.922,95%CI:0.881–0.965,P<0.001),gamma-glutamylglycine levels(OR=0.903,95%CI:0.861–0.948,P<0.001),hexadecanedioate(C16-DC)levels(OR=0.941,95%CI:0.911–0.973,P<0.001),pentose acid levels(OR=0.923,95%CI:0.877–0.972,P=0.002),X-24546 levels(OR=0.936,95%CI:0.902–0.971,P<0.001),glycine levels(OR=0.936,95%CI:0.909–0.964,P<0.001),glycine to serine ratio(OR=0.930,95%CI:0.888–0.974,P=0.002),and mannose to trans-4-hydroxyproline ratio(OR=0.912,95%CI:0.869–0.958,P<0.001)]were correlated with a decreased risk of MI,whereas the remaining 6 plasma metabolites[1-palmitoyl-2-arachidonoyl-GPE(16:0/20:4)levels(OR=1.051,95%CI:1.018–1.084,P=0.002),behenoyl dihydrosphingomyelin(d18:0/22:0)levels(OR=1.076,95%CI:1.027–1.128,P=0.002),1-stearoyl-2-docosahexaenoyl-GPE(18:0/22:6)levels(OR=1.067,95%CI:1.027–1.109,P=0.001),alpha-ketobutyrate levels(OR=1.108,95%

关键词： infarction alterations diagnosis

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Metabolic and proteostatic differences in quiescent and active neural stem cells

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Neural Regeneration Research 2024年第1期19卷 43-48页

作者： Jiacheng Yu Gang Chen Hua Zhu yi zhong Zhenxing Yang Zhihong Jian Xiaoxing Xiong Department of Neurosurgery Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

Adult neural stem cells are neurogenesis progenitor cells that play an important role in ***,neural regeneration may be a promising target for treatment of many neurological *** regenerative capacity of adult neural stem cells can be chara cterized by two states:quiescent and *** adult neural stem cells are more stable and guarantee the quantity and quality of the adult neural stem cell *** adult neural stem cells are chara cterized by rapid proliferation and differentiation into neurons which allow for integration into neural *** review focuses on diffe rences between quiescent and active adult neural stem cells in nutrition metabolism and protein ***,we discuss the physiological significance and underlying advantages of these diffe *** to the limited number of adult neural stem cells studies,we refe rred to studies of embryonic adult neural stem cells or non-mammalian adult neural stem cells to evaluate specific mechanisms.

关键词： adult neurogenesis cell metabolic pathway cellular proliferation neural stem cell niches neural stem cells neuronal differentiation nutrient sensing pathway proteostasis

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Neuroprotective effects of chaperone-mediated autophagy in neurodegenerative diseases

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Neural Regeneration Research 2024年第6期19卷 1291-1298页

作者： Qi Jia Jin Li Xiaofeng Guo yi Li you Wu Yuliang Peng Zongping Fang Xijing Zhang Department of Anesthesiology and Perioperative Medicine and Department of Intensive Care Unit Xijing Hospital The Fourth Military Medical University Department of Critical Care Medicine Translational Research Institute of Brain and Brain-Like Intelligence Shanghai Fourth People's Hospital School of Medicine Tongji University

Chaperone-mediated autophagy is one of three types of autophagy and is characterized by the selective degradation of proteins. Chaperone-mediated autophagy contributes to energy balance and helps maintain cellular homeostasis, while providing nutrients and support for cell survival. Chaperone-mediated autophagy activity can be detected in almost all cells, including neurons. Owing to the extreme sensitivity of neurons to their environmental changes, maintaining neuronal homeostasis is critical for neuronal growth and survival. Chaperone-mediated autophagy dysfunction is closely related to central nervous system diseases. It has been shown that neuronal damage and cell death are accompanied by chaperone-mediated autophagy dysfunction. Under certain conditions, regulation of chaperone-mediated autophagy activity attenuates neurotoxicity. In this paper, we review the changes in chaperone-mediated autophagy in neurodegenerative diseases, brain injury, glioma, and autoimmune diseases. We also summarize the most recent research progress on chaperone-mediated autophagy regulation and discuss the potential of chaperone-mediated autophagy as a therapeutic target for central nervous system diseases.

关键词： chaperone-mediated autophagy neurodegenerative disease neuronal homeostasis neuroprotection

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Neuroprotective and anti-inflammatory effects of eicosane on glutamate and NMDA-induced retinal ganglion cell injury

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International Journal of Ophthalmology(English edition) 2024年第4期17卷 638-645页

作者： Zhen-Kai Wu Huan-Yu Li you-Lin Zhu Meng-Qin Xiong Jing-Xiang zhong Department of Ophthalmology the First Affiliated Hospital of Jinan UniversityGuangzhou 510632Guangdong ProvinceChina Changde Hospital Xiangya School of MedicineCentral South University(the First People’s Hospital of Changde City)Changde 415000Hunan ProvinceChina

AIM:To investigate the protective effects,antioxidant potential,and anti-inflammatory mechanisms of eicosane on glutamate-induced cell damage and on N-methyl-Daspartate(NMDA)-induced retinal ganglion cell(RGC)injury in a mouse model of ***:The protective effects of eicosane on the rat R28 retinal precursor cell line were assessed using cell counting kit-8 assays and Hoechst-propidium iodide *** reactive oxygen species(ROS)production was measured using the fluorescent probe 2'-7'-dichlorofluorescin diacetate and flow *** protective role of eicosane on NMDA-induced RGC injury in a mouse glaucoma model was determined by immunostaining of frozen sections of *** effects of eicosane on the metabolome of the retina in mice with NMDA-induced RGC damage were evaluated by liquid chromatographymass spectroscopy(LC-MS)and untargeted metabolomics ***:Eicosane treatment significantly attenuated glutamate-induced damage to R28 cells in *** also protected RGCs against NMDA-induced injury in a mouse glaucoma *** metabolomics analyses showed that eicosane increased multiple metabolites,including L-arginine and L-carnitine,in the ***:Eicosane has protective effects,antioxidant potential,and anti-inflammatory properties in an in vitro model of glutamate-induced cell damage and in an in vivo model of NMDA-induced RGC injury in mouse glaucoma through modulation of L-arginine and/or L-carnitine metabolism.

关键词： glaucoma metabolites eicosane

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