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Inhibiting SHP2 reduces glycolysis, promotes microglial M1 polarization, and alleviates secondary inflammation following spinal cord injury in a mouse model

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Neural Regeneration Research 2025年第3期20卷 858-872页

作者： Xintian Ding Chun Chen Heng Zhao Bin Dai Lei Ye tao Song Shuai Huang Jia Wang tao you Department of Orthopedics The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Orthopedics Provincial Hospital Affiliated to Anhui Medical UniversityHefeiAnhui ProvinceChina

Reducing the secondary inflammatory response, which is partly mediated by microglia, is a key focus in the treatment of spinal cord injury. Src homology 2-containing protein tyrosine phosphatase 2(SHP2), encoded by PTPN11, is widely expressed in the human body and plays a role in inflammation through various mechanisms. Therefore, SHP2 is considered a potential target for the treatment of inflammation-related diseases. However, its role in secondary inflammation after spinal cord injury remains unclear. In this study, SHP2 was found to be abundantly expressed in microglia at the site of spinal cord injury. Inhibition of SHP2 expression using siRNA and SHP2 inhibitors attenuated the microglial inflammatory response in an in vitro lipopolysaccharide-induced model of inflammation. Notably, after treatment with SHP2 inhibitors, mice with spinal cord injury exhibited significantly improved hind limb locomotor function and reduced residual urine volume in the bladder. Subsequent in vitro experiments showed that, in microglia stimulated with lipopolysaccharide, inhibiting SHP2 expression promoted M2 polarization and inhibited M1 polarization. Finally, a co-culture experiment was conducted to assess the effect of microglia treated with SHP2 inhibitors on neuronal cells. The results demonstrated that inflammatory factors produced by microglia promoted neuronal apoptosis, while inhibiting SHP2 expression mitigated these effects. Collectively, our findings suggest that SHP2 enhances secondary inflammation and neuronal damage subsequent to spinal cord injury by modulating microglial phenotype. Therefore, inhibiting SHP2 alleviates the inflammatory response in mice with spinal cord injury and promotes functional recovery postinjury.

关键词： apoptosis glycolysis inflammatory response microglia neurons polarization spinal cord injury Src homology 2-containing protein tyrosine phosphatase 2

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Boundedness in a chemotaxis system with nonlinear signal production

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Applied Mathematics(A Journal of Chinese Universities) 2016年第4期31卷 379-388页

作者： LIU Dong-mei tao you-shan College of Information Science & Technology Dong Hua University Department of Applied Mathematics Dong Hua University

This work deals with the zero-Neumann boundary problem to a fully parabolic chemotaxis system with a nonlinear signal production function f（s） fulfilling 0 〈 f（s）〈 Ksα for all s 〉 0, where K and α are positive parameters. It is shown that whenever 0 〈 α 〈 2/n （where n denotes the spatial dimension） and under suitable assumptions on the initial data, this problem admits a unique global classical solution that is uniformly-in-time bounded in any spatial dimension. The proof is based on some a priori estimate techniques.

关键词： Keller-Segel model nonlinear signal production prevention of blow-up.

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Phase-Field Modeling of Thermal Fracture and Shear Heating in Rocks with Degraded Thermal Conductivity Across Crack

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Acta Mechanica Solida Sinica 2024年第5期37卷 711-726页

作者： tao you Qizhi Zhu Weijian Li Jianfu Shao Key Laboratory of Ministry of Education for Geomechanics and Embankment Engineering Hohai UniversityNanjing210024China Department of Environmental Informatics Helmholtz Centre for Environmental Research-UFZ04318LeipzigGermany College of Civil and Transportation Engineering Hohai UniversityNanjing210024China College of Civil and Transportation Engineering Shenzhen UniversityShenzhen518060China University of Lille CNRSCentrale LilleLaMcubeUMR9013F-59000LilleFrance

By incorporating two different fracture mechanisms and salient unilateral effects in rock materials,we propose a thermomechanical phase-field model to capture thermally induced fracture and shear heating in the process of rock *** heat conduction equation is derived,from which the plastic dissipation is treated as a heat *** then ascertain the effect of the non-associated plastic flow on frictional dissipation and show how it improves the predictive capability of the proposed *** advantage of the multiscale analysis,we propose a phase-field-dependent thermal conductivity with considering the unilateral effect of *** proposing a robust algorithm for solving involved three-field coupling and damage-plasticity coupling problems,we present three numerical examples to illustrate the abilities of our proposed model in capturing various thermo-mechanically coupled behaviors.

关键词： Phase-field Micromechanics Heat transfer Thermal conductivity degradation Shear heating

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Sustainable Polyamides Enabled by Controlled Ring-opening Polymerization of 4-Hydroxyproline-derived Lactams

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Chinese Journal of Polymer Science 2023年第5期41卷 728-734,I0008页

作者： Jian-Qun Wang Xian-Hong Wang you-Hua tao Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China University of Science and Technology of China Hefei 230026China

Aliphatic polyamides have been considered as eco-friendly materials,useful for a wide range of ***,it still presents obstacle to produce sustainable aliphatic polyamides from abundant renewable ***,we describe that 4-hydroxyproline(4-HYP),a renewable resource,was readily converted to its corresponding bicyclic bridged lactam monomers bearing pendant Boc-protected secondary amino group,and oligo-ethylene glycol *** hexamethyldisilazide(LiHMDS)-mediated polymerization of the resulting monomers exhibited a controlled feature,affording sustainable aliphatic polyamides with number-average molecular weight up to 73 kg/mol and a low molecular weight distribution?<***,this work can lead to a novel kind of functional and sustainable polyamides with potential applications,including degradable plastics,and drug delivery.

关键词： Polyamides Renewable Ring-opening polymerization 4-Hydroxyproline

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OBSERVATION AND ANALYSIS ON CHARACTERISTIC OF NATURAL RIVERS

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Journal of Hydrodynamics 2005年第5期17卷 615-620页

作者： LU Jin-you XU Hai-tao YAO Shi-ming Yangtze River Scientific Research Institute Wuhan 430010 China

Based on the previous study on turbulent structure, field experiments on fluctuation velocity were carried out in section Huanglingmiao of main stream of Yangtze River with a 3-D Doppler velocimeter. And a number of data such as velocity of different discharge and different vertical line were obtained. According to the field experiment data, period, frequency, period function and probability density function of large-scale coherent structure in natural river were prescribed by means of quantitative analysis. And the problem about distribution of time average velocity, turbulent intensity and Reynolds stress along depth were further analyzed and calculated. The results in this paper will deepen the understand of large-scale turbulent structure in natural river and so make the base for applying“turbulence theory” to water conservancy, hydroelectric, environment engineering and so on.

关键词： natural river large scale turbulence turbulent mechanism

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Squeezing in the Thermal Jaynes-Cummings Model

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Chinese Physics Letters 1996年第6期13卷 432-435页

作者： XIE Rui-hua ZOU you-tao LIU Dun-huan Department of Physics Nanjing UniversityNanjing 210008 Department of Physics Wuhan UniversityWuhan 430072 National Laboratory of Solid State Microstructures Institute for Solid State Physics Center for Advanced Studies in Science and Technology of Microstructures Nanjing UniversityNanjing 210008

We have studied the influence of thermal photons on the symmetry between the field and atomic squeezing(SFAS)exposed in the resonant vacuum-field Jaynes-Cummings model with an initially coherent *** have shown that when the number of thermal photons(Nav)is less than 0.01,the SFAS is not sensitive to the presence of thermal photons;when Nav≥0.01,the broken SFAS can be seen;when Nav≥0.1,the squeezed atom cannot radiate a squeezed field any ***,we have discussed the possibility of detection of the boken symmetry in superconducting maser cavity.

关键词： symmetry Cummings resonant

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Preparation and Field Emission Properties of Titanium Polysulfide Nanobelt Films

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Nano Research 2009年第7期2卷 558-564页

作者： Xing Cai Wu you Rong tao Qi Xiu Gao School of Chemistry and Chemical Engineering and Key Laboratory of Mesoscopic Chemistry of Ministry of EducationNanjingUniversityNanjing 210093China

TiS_(3) nanobelt films,with widths of about 0.112μm,thickness of about 20250 nm,and lengths of up to 200μm,have been grown on Ti substrates by a surface-assisted chemical-vapor-transport at 450°C for 8 *** TiS_(3) nanobelt films were converted into TiS_(1.71) nanobelt films by pyrolysis in a vacuum at 600°C for 2 *** work functions of the two films were determined by ultraviolet photoelectron spectroscopy measurements to be 4.60 and 4.44 eV,*** field emission experiments using the nanostructures as cold electron cathodes showed that both materials gave significant emission *** turn-on fields(defined as the electric field required to produce a current density of 10μA/cm^(2))were about 1.0 and 0.9 V/μm,respectively,whereas the threshold fields(defined as the electric field required to produce a current density of 1 mA/cm^(2))were about 5.6 and 4.0 V/μm,*** data reveal that both materials have potential applications in field emission devices.

关键词： Nanowire film titanium sulfide chemical vapor-transport field emission

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Nutrient Release from Weathering of Purplish Rocks in the Sichuan Basin,China

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Pedosphere 2008年第2期18卷 257-264页

作者： ZHU Bo WANG tao you Xiang GAO Mei-Rong Institute of Mountain Hazards and Environment Chinese Academy of Sciences Chengdu 610041 （China）

Purplish soils having high fertility with mineral nutrients inherited from the parent rock are widely distributed in the hills along the Yangtze River,especially in the Sichuan *** and field weathering experiments were conducted to mimic rock weathering and nutrient release processes in order to better understand soil fertility and nutrient compensation. Three types of purplish rock formations formed in the Jurassic period,Shaximiao(J_2s),Suining(J_3s),and Penglaizhen (J_3p),as well as one type formed in the Cretaceous period,the Chengqiangyan group(K_1c),were used in this study. Results showed that the soil formation rate was in the range from 11.2 to 19.6 mm every year,and rock weathering was in the order of J_3s>J_3p>J_2s>K_*** more rock surface was exposed to sunlight and rainfall in field conditions,pot weathering was slower than field *** release rates increased with rock weathering and was in the order similar to that of rock weathering:J_3p>J_3s>J_2s>K_*** release was the most important in all rocks;after 2 years of weathering,19.4% to 46.9% of K was released from the initial parent rocks,which suggested that K release from weathering could meet most of the crop K requirement in purplish ***,rapid release of nutrients from weathering of purplish rocks was key to nutrient replenishment and fertility of purplish soils.

关键词： nutrient release purplish rock soil formation weathering

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Method of reliability tolerance design based on EDA technology and its application on DC hybrid contactor

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第3期8卷 426-433页

作者： WANG Shu-juan SHA you-tao ZHANG Hui ZHAI Guo-fu School of Electrical Engineering and Automation Harbin Institute of Technology Harbin 150001 China

Tolerance design, including tolerance analysis and distribution, is an important part of the electronic system’s reli- ability design. The traditional design needs to construct mathematic model of material circuit, which involves large amount of workload and lacks of practicability. This paper discusses the basic theory of electronic system’s reliability tolerance design and presents a new design method based on EDA (Electronic Design Automatic) software. This method has been validated through the application research on reliability tolerance design of the DC hybrid contactor’s control circuit.

关键词： Reliability Tolerance analysis EDA (Electronic Design Automatic)

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Crowdsourcing intelligent design

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Frontiers of Information Technology & Electronic Engineering 2018年第1期19卷 126-138页

作者： Wei XIANG Ling-yun SUN Wei-tao you Chang-yuan YANG State Key Lab of CAD & CG Zhejiang University Hangzhou 310058 China Modern Industrial Design Institute Zhejiang University Hangzhou 310027 China International User Experience Business Unit Alibaba Group Hangzhou 310000 China

Design intelligence,namely,artificial intelligence to solve creative problems and produce creative ideas,has improved rapidly with the new generation artificial ***,existing methods are more skillful in learning from data and have limitations in creating original ideas different from the training *** offers a promising method to produce creative designs by combining human inspiration and machines' computational *** propose a crowdsourcing intelligent design method called ‘flexible crowdsourcing design'.Design ideas produced through crowdsourcing design can be unreliable and inconsistent because they rely solely on selection among participants' submissions of *** contrast,the flexible crowdsourcing design method employs a cultivation procedure that integrates the ideas from crowd participants and cultivates these ideas to improve design quality at the same *** introduce a series of studies to show how flexible crowdsourcing design can produce original design ideas ***,we will describe the typical procedure of flexible crowdsourcing design,the refined crowdsourcing tasks,the factors that affect the idea development process,the method for calculating idea development potential,and two applications of the flexible crowdsourcing design ***,it summarizes the design capabilities enabled by crowdsourcing intelligent *** method enhances the performance of crowdsourcing design and supports the development of design intelligence.

关键词： Crowdsourcing Flexible crowdsourcing design Design intelligence

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