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Trace elements in magmatic and hydrothermal quartz:Implications on the genesis of the Xingluokeng Tungsten Deposit,South China

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Acta Geochimica 2024年第3期43卷 441-458页

作者： Qing-Qing Zhang you-Wei chen Jian-Feng Gao State Key Laboratory of Ore Deposit Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China University of Chinese Academy of Sciences Beijing 100049China

The Xingluokeng deposit is the largest gran-ite-related tungsten deposit within the Wuyi metallogenic belt in South *** Xingluokeng intrusion primarily consists of porphyritic biotite granite,biotite granite,andfine-grained *** deposit is represented by veinlet-disseminated mineralization with K-feldspathization and biotitization,alongside quartz-vein mineralization with gre-isenization and *** study investigates in-situ analyses of quartz compositions from both the intrusion and hydrothermal veinlets and *** element correlations indicate that trivalent Al^(3+)and Fe^(3+)replace Si^(4+)within the quartz lattice,with monovalent cations(such as Li^(+),Na^(+),and K^(+))primarily serving as charge *** Ge/Al ratios(<0.013)of quartz from granites suggest a mag-matic *** low Al/Ti and Ge/Ti ratios,accompanied by high Ti contents in quartz,suggest that the porphyritic biotite granite and biotite granite are characterized by rela-tively low levels of differentiation and high crystallization *** contrast,thefine-grained granite exhibits a higher degree of fractionation,lower crystallization tem-peratures,and a closer association with tungsten *** contents in quartz from quartz veins indicate Qz-Ⅰformed at temperatures above 400°C,while Qz-Ⅱto Qz-Ⅴformed at temperatures below 350°*** in different generations of quartz,as indicated by Al content and(Al+Fe)/(Li+Na+K)ratio,suggest that Qz-Ⅰprecipi-tated from a less acidicfluid with a stable pH,whereas Qz-Ⅱto Qz-Ⅴoriginated from a more acidicfluid with notable pH ***,alkaline alteration and acidic alteration supplied the essential Ca and Fe for the precipita-tion of scheelite and wolframite,respectively,highlighting a critical mechanism in tungsten mineralization at the Xin-gluokeng deposit.

关键词： Quartz Xingluokeng Tungsten deposit Trace elements South China

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Effect of nano-CaO particle on the microstructure,mechanical properties and corrosion behavior of lean Mg-1Zn alloy

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Journal of Magnesium and Alloys 2024年第2期12卷 794-814页

作者： Guangxin Shen Shaoyuan Lyu Leiting Yu Tianlu Li chen you Xuewei Wang Minfang chen Bin Jiang School of Materials Science and Engineering Tianjin University of TechnologyTianjin 300384China Key Laboratory of Display Materials and Photoelectric Device(Ministry of Education) Tianjin University of TechnologyTianjin 300384China National Demonstration Center for Experimental Function Materials Education Tianjin University of TechnologyTianjin 300384China National Engineering Research Center for Magnesium Alloys Chongqing UniversityChongqing 400044China

The effects of nano-CaO contents on the microstructure,mechanical properties and corrosion resistance of lean Mg-1Zn alloy were *** results showed that the addition of nano-CaO significantly refined the grain size and improved mechanical properties of the Mg-1Zn *** the same time,CaO reacted with molten Mg in situ to form nano-MgO,whose corrosion product in SBF solution was the same with the degradation product of Mg matrix,resulting in the enhanced compactness of the Mg(OH)_(2) layer and reduced corrosion rate of *** Mg-1Zn alloy had lower corrosion resistance due to excessively large grain size and shedding of corrosion *** composite with 0.5 wt.%CaO had the best corrosion resistance with a weight loss of 9.875 mg·y^(-1)·mm^(-2)due to the small number of Ca_(2)Mg_(6)Zn_(3) phase and suitable grain *** for composites with high content of CaO(0.7 wt.%and 1.0 wt.%),they had lower corrosion resistance due to the coexistence of large number of Ca_(2)Mg_(6)Zn_(3) and Mg_(2)Ca at grain boundaries,especially for 1.0 wt.%CaO composite,resulting from the strong micro-galvanic corrosion.

关键词： Lean Mg alloy In situ MgO Nanoparticles Grain refinement Corrosion resistance

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Hydrogen sulfide responsive nanoplatforms: Novel gas responsive drug delivery carriers for biomedical applications

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Asian Journal of Pharmaceutical Sciences 2024年第1期19卷 1-17页

作者： Jiafeng Zou Zeting Yuan Xiaojie chen you chen Min Yao Yang chen Xiang Li Yi chen Wenxing Ding Chuanhe Xia Yuzheng Zhao Feng Gao Shanghai Frontier Science Research Base of Optogenetic Techniques for Cell Metabolism School of PharmacyEast China University of Science and TechnologyShanghai 200237China Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province School of Pharmaceutical SciencesZhejiang Chinese Medical UniversityHangzhou 310053China Shanghai Key Laboratory of Functional Materials Chemistry East China University of Science and TechnologyShanghai 200237China Shanghai Key Laboratory of New Drug Design School of PharmacyEast China University of Science and TechnologyShanghai 200237China Optogenetics and Synthetic Biology Interdisciplinary Research Center State Key Laboratory of Bioreactor EngineeringEast China University of Science and TechnologyShanghai 200237China CAS Center for Excellence in Brain Science Shanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200031China Research Unit of New Techniques for Live-cell Metabolic Imaging Chinese Academy of Medical SciencesBeijing 100050China

Hydrogen sulfide(H_(2)S)is a toxic,essential gas used in various biological and physical processes and has been the subject of many targeted studies on its role as a new gas *** studies have mainly focused on the production and pharmacological side effects caused by H_(2)***,effective strategies to remove H_(2)S has become a key research ***,the development of novel nanoplatforms has provided new tools for the targeted removal of H_(2)*** paper was performed to review the association between H_(2)S anddisease,relatedH_(2)S inhibitory drugs,aswell as H_(2)S responsive nanoplatforms(HRNs).This review first analyzed the role of H_(2)S in multiple tissues and ***,common drugs used to eliminate H_(2)S,as well as their potential for combination with anticancer agents,were *** only the existing studies on HRNs,but also the inhibition H_(2)S combined with different therapeutic methods were both sorted out in this ***,this review provided in-depth analysis of the potential of HRNs about treatment or detection in ***,potential challenges of HRNs were *** study demonstrates the excellent potential of HRNs for biomedical applications.

关键词： Hydrogen sulfide Disease mechanisms Removal of hydrogen sulfide Responsive nanoplatforms Challenges Biomedical applications

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Impacts of angiotensin II on retinal artery changes in apolipoprotein E deficient mice

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International Journal of Ophthalmology(English edition) 2024年第1期17卷 16-24页

作者： Li-Hui Meng Shi-Yu cheng He chen Yue-Lin Wang Wen-Fei Zhang Huan chen Xin-Yu Zhao you-Xin chen Department of Ophthalmology Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100730China Key Lab of Ocular Fundus Diseases Chinese Academy of Medical SciencesBeijing 100730China

AIM:To investigate the impacts of angiotensin II(Ang II)on retinal artery changes in apolipoprotein E deficient(apoE^(-/-))***:ApoE^(-/-)male mice were infused by minipumps with Ang II at 1000 ng/kg·min(Ang II group)or saline(control group)for *** were underwent ophthalmic fundus examination on day 0,14,and 28 of *** examination,ribonucleic acid(RNA)sequencing and local Ang II measurement of retinas were ***:Ophthalmic fundus examination showed Ang II infusion promoted the formation of retinal arterial aneurysm-like lesions on day *** coherence tomography revealed the ganglion cell and inner plexiform layer(GCIPL)thickness in the control group was significantly thinner than that in Ang II group(P<0.001).Hematoxylin-eosin staining demonstrated diffused swelling of GCIPL layer and its disordered structure in Ang II *** electron microscopy showed Ang II infusion caused aggravation of atherosclerotic lesions,including increased swelling,roughness,disorganization of the retinal vasculature,and vacuoles ***-sequencing and gene ontology enrichment analysis demonstrated that the structure and function of cellular membrane might be disturbed and visual function might be compromised by Ang *** local level of Ang II was higher in Ang II infusion group but did not show significant differences compared to the control group(P=0.086).CONCLUSION:Ang II infusion promotes the formation of retinal arterial aneurysm-like lesions in apoE^(-/-)mice,causing aggravation of atherosclerotic lesions,more severe disorganization of the retinal vasculature and disturbance of the cellular membrane.

关键词： angiotensin II retinal artery aneurysm apoE^(-/-)mice

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Fast Fourier transform convolution neural network accelerator based on overlap addition

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The Journal of China Universities of Posts and Telecommunications 2024年

作者： you chen Li Dejian Feng Xi Shen Chongfei Wei Jizeng Liu Yu School of Microelectronics Tianjin University College of Intelligence and Computing Tianjin University Beijing Smart-Chip Microelectronics Technology Company Limited

In convolutional neural networks（CNNs）， the floating point computation in the traditional convolution layer is enormous， and the execution speed of the network is limited by intensive computing， which makes it challenging to meet the real-time response requirements of complex applications. This work is based on the principle that the time domain convolution result equals the frequency domain dot multiplication result to reduce the amount of floating-point calculations for convolution. The input feature map and the convolution kernel are converted to the frequency domain by the fast Fourier transform（FFT）， and the corresponding dot multiplication is performed. Then the frequency domain result is converted back to the time domain， and the output result of the convolution is obtained. In the shared CNN， the input feature map is much larger than the convolution kernel， resulting in many invalid operations. The overlap addition method is proposed to reduce invalid calculations and speed up network execution better. This work designs a hardware accelerator for frequency domain convolution and verifies its efficiency on the Xilinx ZYNQ UltraScale+MPSoC ZCU102 board: comparing the calculation time of Visual Geometry Group16(VGG16) under the ImageNet dataset， compared to traditional convolution accelerators， the hardware acceleration of frequency-domain convolution has improved performance by 8.5 times.

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新质生产力视角下职业教育驱动供应链创新与价值链跃升的内涵解释、现实挑战与破解策略

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中国职业技术教育 2024年第12期 22-30页

作者：陈游湖州职业技术学院金融科技应用教研室

在全球化和技术革新的双重推动下,供应链与价值链的发展已成为企业乃至国家竞争力的重要标志。职业教育作为人才培养的重要途径,与供应链价值链产生紧密结合,能为企业提供更加适配的技能型人才。然而,在实践中,我国职业教育赋能供应链... 详细信息

在全球化和技术革新的双重推动下,供应链与价值链的发展已成为企业乃至国家竞争力的重要标志。职业教育作为人才培养的重要途径,与供应链价值链产生紧密结合,能为企业提供更加适配的技能型人才。然而,在实践中,我国职业教育赋能供应链与价值链的双提升仍面临诸多隐忧,仍存在提升的空间。为此,职业院校应继续深化与供应链企业紧密合作,共同推动职业教育的改革和发展,为供应链和价值链的提升供给更有力的支持。

关键词：职业教育供应链价值链新质生产力协同创新

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Identification of marker genes associated with N6-methyladenosine and autophagy in ulcerative colitis

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World Journal of Clinical Cases 2024年第10期12卷 1750-1765页

作者： Xiao-Yan Liu Dan Qiao Ya-Li Zhang Zi-Xuan Liu you-Lan chen Ren-Ye Que Hong-Yan Cao Yan-cheng Dai Department of Gastroenterology Shanghai Traditional Chinese Medicine-Integrated HospitalShanghai University of Traditional Chinese MedicineShanghai 200082China Institute of Digestive Diseases Long Hua Hospital Shanghai University of Traditional Chinese MedicineShanghai 200032China Department of Gastroenterology Shu Guang HospitalShanghai University of Traditional Chinese MedicineShanghai 201203China

BACKGROUND Both N6-methyladenosine(m6A)methylation and autophagy are considered relevant to the pathogenesis of ulcerative colitis(UC).However,a systematic exploration of the role of the com-bination of m6A methylation and autophagy in UC remains to be *** To elucidate the autophagy-related genes of m6A with a diagnostic value for *** The correlation between m6A-related genes and autophagy-related genes(ARGs)was ***,gene set enrichment analysis(GSEA)was performed on the characteristic ***,the expression levels of four characteristic genes were verified in dextran sulfate sodium(DSS)-induced colitis in *** GSEA indicated that BAG3,P4HB and TP53INP2 were involved in the inflammatory response and TNF-αsignalling via nuclear factor ***,polymerase chain reaction results showed significantly higher mRNA levels of BAG3 and P4HB and lower mRNA levels of FMR1 and TP53INP2 in the DSS group compared to the control *** This study identified four m6A-ARGs that predict the occurrence of UC,thus providing a scientific reference for further studies on the pathogenesis of UC.

关键词： Ulcerative colitis m6A Autophagy Characteristic genes Immune infiltration

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耦合渗流-变形的数值流形法裂隙岩质边坡稳定性分析

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岩土力学 2024年第1期45卷 313-324页

作者：屈小磊张云开陈悠然陈悠扬戚承志北京建筑大学北京市节能减排关键技术协同创新中心北京100044 北京建筑大学土木与交通工程学院北京100044 伦敦大学学院土木、环境和测绘工程系英国伦敦

岩石裂隙渗流问题作为影响岩石边坡失稳的重要因素吸引了越来越多研究者采用不同的数值方法模拟其力学行为。提出了一种基于渗流-变形耦合模型的数值流形方法,并相应地讨论了岩体裂隙网络中地下水的流动、渗透压力和岩石变形的耦合效应... 详细信息

岩石裂隙渗流问题作为影响岩石边坡失稳的重要因素吸引了越来越多研究者采用不同的数值方法模拟其力学行为。提出了一种基于渗流-变形耦合模型的数值流形方法,并相应地讨论了岩体裂隙网络中地下水的流动、渗透压力和岩石变形的耦合效应。基于最小能量原理,分别推导渗流条件下单元边界流体压力和系统的整体平衡方程,以及块体接触算法求解任意岩石裂缝的局部安全系数。通过一系列验证实例对所提出的数模模型进行检验,验证了该数值模型的鲁棒性和有效性。利用该方法模拟了一个岩石边坡由于渗流作用而发生的坍塌事故,再现了岩石边坡的破坏过程。模拟结果表明,过大的水力压力导致垂直裂缝张开,增加岩体变形量,最终导致边坡破坏。研究表明,该方法在模拟大规模工程问题方面具有很大的潜力。

关键词：数值流形法裂隙渗流岩石边坡稳定渗流-变形耦合

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行政区划改革的国际实践与研究评述

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世界地理研究 2024年第5期33卷 111-122页

作者：游晨廖超超中共浙江省委党校(浙江行政学院)公共管理教研部杭州311121 中共浙江省委党校(浙江行政学院)浙江省“八八战略”创新发展研究院杭州311121 中共杭州市委党校余杭分校杭州311121 浙江工业大学公共管理学院杭州310023

行政区划是国家治理的空间基础,其改革实践则重塑区域政治经济格局,是国内外实务界与学术界共同关注的重要议题。但国内学界对国外行政区划改革的关注却相对不足。基于对英文文献的梳理,评述国外行政区划改革的实践进程与研究进展。研... 详细信息

行政区划是国家治理的空间基础,其改革实践则重塑区域政治经济格局,是国内外实务界与学术界共同关注的重要议题。但国内学界对国外行政区划改革的关注却相对不足。基于对英文文献的梳理,评述国外行政区划改革的实践进程与研究进展。研究发现,合并与拆分是国外行政区划改革的两种主要模式,改革的动因研究、影响因素及绩效研究是现有研究的三个核心议题,而精确评估改革绩效、扩展研究视角是未来研究的重点方向,同时国外行政区划改革的实践也可为当前中国的行政区划改革提供一定的参考。

关键词：国外行政区划改革合并拆分研究评述

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Risk factors and predictive model of cerebral edema after road traffic accidents-related traumatic brain injury

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Chinese Journal of Traumatology 2024年第3期27卷 153-162页

作者： Di-you chen Peng-Fei Wu Xi-Yan Zhu Wen-Bing Zhao Shi-Feng Shao Jing-Ru Xie Dan-Feng Yuan Liang Zhang Kui Li Shu-Nan Wang Hui Zhao Institute for Traffic Medicine Daping HospitalArmy Medical UniversityChongqing400042China Department of Radiology Daping HospitalArmy Medical UniversityChongqing400042China Chongqing Key Laboratory of Traffic Injury and Vehicle Ergonomics Chongqing400042China Wound Trauma Medical Center State Key Laboratory of TraumaBurns and Combined InjuryInstitute of Surgery ResearchDaping HospitalArmy Medical UniversityChongqing.400042China

Purpose:Cerebral edema(CE)is the main secondary injury following traumatic brain injury(TBI)caused by road traffic accidents(RTAs).It is challenging to be predicted *** this study,we aimed to develop a prediction model for CE by identifying its risk factors and comparing the timing of edema occurrence in TBI patients with varying levels of ***:This case-control study included 218 patients with TBI caused by *** cohort was divided into CE and non-CE groups,according to CT results within 7 *** data,imaging data,and clinical data were collected and *** variables that follow normal distribution were presented as mean±standard deviation,those that do not follow normal distribution were presented as median(Q1,Q3).Categorical variables were expressed as *** Chi-square test and logistic regression analysis were used to identify risk factors for *** curve fitting was performed to predict the time to secondary CE in TBI patients with different levels of *** efficacy of the model was evaluated using the receiver operator characteristic ***:According to the study,almost half(47.3%)of the patients were found to have *** risk factors associated with CE were bilateral frontal lobe contusion,unilateral frontal lobe contusion,cerebral contusion,subarachnoid hemorrhage,and abbreviated injury scale(AIS).The odds ratio values for these factors were 7.27(95%confidence interval(CI):2.08-25.42,p=0.002),2.85(95%CI:1.11-7.31,p=0.030),2.62(95%CI:1.12-6.13,p=0.027),2.44(95%CI:1.25-4.76,p=0.009),and 1.5(95%CI:1.10-2.04,p=0.009),*** also observed that patients with mild/moderate TBI(AIS≤3)had a 50%probability of developing CE 19.7 h after injury(χ^(2)=13.82,adjusted R2=0.51),while patients with severe TBI(AIS>3)developed CE after 12.5 h(χ^(2)=18.48,adjusted R2=0.54).Finally,we conducted a receiver operator characteristic curve analysis of CE time,which showed an area under the curve of 0

关键词： Road traffic accident Traumatic brain injury Cerebral edema Risk factors Time window

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